What are the causes of aki?
<answer> Prerenal disease and acute tubular necrosis (ATN). <context> Other definitions and severity staging of AKI have also been proposed. These issues are discussed in detail elsewhere. (See Definition of acute kidney injury (acute renal failure).) The two major causes of AKI that occur in the hospital are prerenal disease and acute tubular necrosis (ATN). Together, they account for approximately 65 to 75 percent of cases of AKI.