what was the most fatal diseases in history?
<answer> The Black Death, or The Black Plague, was one of the most deadly pandemics in human history. <context> The Black Death, or The Black Plague, was one of the most deadly pandemics in human history. It probably began in Central Asia and spread to Europe by the late 1340s. The total number of deaths worldwide from the pandemic is estimated at 75 million people; there were an estimated 20 to 30 million deaths in Europe alone.