what can cause tight chest with fatigue?
<answer> Ingestion and other exposures to the chemical can cause tight chest with fatigue. <context> Ingestion and other exposures to the chemical can cause various symptoms. Results: 3253 causes of Chest tightness OR Fatigue. A rare metabolic disorder characterized by high levels of a certain chemical (2-Hydroxyglutaric) which causes a serious progressive neurological disease and damage to the brain.