what medication treat insulin resistance?
<answer> Medications that reduce insulin resistance include metformin and the thiazolidinediones. <context> Pharmacologic Therapy. Medications that reduce insulin resistance (insulin-sensitizing and antihyperglycemic effects) include metformin and the thiazolidinediones. Metformin is a biguanide; it reduces hepatic glucose output and increases the uptake in the peripheral tissues (muscle and adipocytes).