325
While doxorubicin was administered , the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum .
 adverse effect: breathing distress, doxorubicin; adverse effect: thoracic pain, doxorubicin
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: breathing distress, doxorubicin; adverse effect: thoracic pain, doxorubicin