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The authors describe valproate - induced hyperammonemia and mental status changes in an 88-year - old man , the first known reported case in an elderly patient .
 adverse effect: hyperammonemia, valproate; adverse effect: mental status changes, valproate
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: hyperammonemia, valproate; adverse effect: mental status changes, valproate