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We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by , in the first case intrathecally administered methotrexate and , in the second by intrathecally administered methotrexate and cranial irradiation .
 adverse effect: hydrocephalus, methotrexate; adverse effect: hydrocephalus, methotrexate; adverse effect: leukoencephalopathy, methotrexate; adverse effect: leukoencephalopathy, methotrexate
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: hydrocephalus, methotrexate; adverse effect: hydrocephalus, methotrexate; adverse effect: leukoencephalopathy, methotrexate; adverse effect: leukoencephalopathy, methotrexate