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We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved .
 adverse effect: cutaneous necrosis, interferon alfa; adverse effect: cutaneous necrosis, pegylated interferon alfa-2b
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: cutaneous necrosis, interferon alfa; adverse effect: cutaneous necrosis, pegylated interferon alfa-2b