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With the use of optical coherence tomography ( OCT ) , two patients with IFN - associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed .
 adverse effect: macular edema, IFN; adverse effect: macular edema, IFN; adverse effect: reduced visual acuity, IFN; adverse effect: reduced visual acuity, IFN; adverse effect: retinopathy, IFN; adverse effect: retinopathy, IFN
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: macular edema, IFN; adverse effect: macular edema, IFN; adverse effect: reduced visual acuity, IFN; adverse effect: reduced visual acuity, IFN; adverse effect: retinopathy, IFN; adverse effect: retinopathy, IFN