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We report three patients , all of whom had preexisting diabetic dyslipidemia , who showed a profound reduction in plasma HDL cholesterol and apolipoprotein AI levels soon after the initiation of rosiglitazone therapy .
 adverse effect: reduction in plasma HDL cholesterol and apolipoprotein AI levels, rosiglitazone
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: reduction in plasma HDL cholesterol and apolipoprotein AI levels, rosiglitazone