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Missense mutations in the most ancient residues of the PAX6 paired domain underlie a spectrum of human congenital eye malformations .
 Disease: congenital eye malformations
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease 
Text: {0} 
Answer:
 Disease: congenital eye malformations