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There has been growing research interest in using topology optimization to design bone scaffolds and orthopaedic implants , however significant challenges still remain before these concepts could be used in clinical practice .
 concept or principle: research; engineering feature: topology optimization; engineering feature: design; biomedical: bone scaffolds; application: orthopaedic implants; material: be; application: clinical practice
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: manufacturing standard, machanical property, manufacturing process, material, engineering feature, process parameter, machine or equipment, application, process characterization, enabling technology, biomedical, concept or principle 
Text: {0} 
Answer:
 concept or principle: research; engineering feature: topology optimization; engineering feature: design; biomedical: bone scaffolds; application: orthopaedic implants; material: be; application: clinical practice