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On the basis of experiments with mutant virus and transfection with isolated genes , the herpes simplex virus immediate - early gene product ICP4 is known to positively regulate the transcription of viral early and late genes and negatively regulate expression from its own promoter .
 GENE: herpes simplex virus immediate - early gene; GENE: ICP4; GENE: viral early and late genes
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: GENE 
Text: {0} 
Answer:
 GENE: herpes simplex virus immediate - early gene; GENE: ICP4; GENE: viral early and late genes