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To address the challenge of small sample sizes and GEI study difficulties , we introduce a comprehensive bioinformatics method using genetic variations ( copy number variations and small - scale variations ) and environmental data integration that links with Glioblastoma ( GEG ) to identify : ( 1 ) genes that interact with chemicals and have genetic variants linked to the development of GBM , ( 2 ) important pathways that may be influenced by environmental exposures ( or endogenous chemicals ) , and ( 3 ) genes with variants in GBM that have been understudied in relation to GBM development .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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