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Concerns about long - term methotrexate ( MTX ) neurotoxicity in the 1990s led to modifications in intrathecal ( IT ) therapy , leucovorin rescue , and frequency of systemic MTX administration in children with acute lymphoblastic leukemia .
 Chemical: methotrexate; Chemical: MTX; Disease: neurotoxicity; Chemical: MTX; Disease: acute lymphoblastic leukemia
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease, Chemical 
Text: {0} 
Answer:
 Chemical: methotrexate; Chemical: MTX; Disease: neurotoxicity; Chemical: MTX; Disease: acute lymphoblastic leukemia