6458
The H44R substitution ( affecting interactions with the coenzyme pyrophosphate ) was previously shown to decrease affinity for coenzymes 2 - 4 - fold and turnover numbers ( V / Et ) by 4 - 6 - fold .
 Chemical: pyrophosphate
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: pyrophosphate