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Here , we show that the introduction of a human artificial chromosome ( HAC ) containing the entire genomic human CYP3A locus recapitulates tissue - and stage - specific expression of human CYP3A genes and xenobiotic metabolism in mice .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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