4220
Using a combined pharmacokinetic - pharmacodynamic model , the impact of various factors on the effective bioavailability and on its estimation , using the intravenous - to - oral dose ratio required to produce the same area under the response time curve after acute administration , are explored .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: GENE 
Text: {0} 
Answer:
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