25494
A cost - effective alternative is proposed , using genotype information equivalent to typing four SNPs ( DR3 , DR4 - DQB1 * 03 : 02 , CTLA - 4 , and INS ) , which achieved an AUC of 0 . 72 in the discovery set and 0 . 69 in the validation set . CONCLUSIONSGenotyping data sufficient to tag DR3 , DR4 - DQB1 * 03 : 02 , CTLA4 , and INS was shown to distinguish between subjects with type 1 diabetes and their unaffected siblings adequately to achieve clinically utility to identify children in multiplex families to be considered for early intervention .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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