3274
We propose 2 separate PAI - 1 inductory pathways for PMA and IL - 1alpha in HepG2 , both involving protein tyrosine kinase activation ; the serum - induced signaling pathway may ( partially ) overlap with the PMA - activated protein kinase C / mitogen - activated protein kinase kinase pathway , leading to c - Jun homodimer binding to the PAI - 1 TRE .
 GENE: PAI - 1; GENE: IL - 1alpha; GENE: protein tyrosine kinase; GENE: protein kinase C; GENE: mitogen - activated protein kinase kinase; GENE: c - Jun homodimer; GENE: PAI - 1
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: GENE 
Text: {0} 
Answer:
 GENE: PAI - 1; GENE: IL - 1alpha; GENE: protein tyrosine kinase; GENE: protein kinase C; GENE: mitogen - activated protein kinase kinase; GENE: c - Jun homodimer; GENE: PAI - 1