1329
In conclusion , these data demonstrate that estrogen loss and DMII induced by a high - fat / sugar diet interact to produce osteoporosis and support the hypothesis that the bone loss may be mediated at least in part by concurrent decreases in the insulin signaling proteins in bone .
 Chemical: estrogen; Chemical: sugar
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: estrogen; Chemical: sugar