1410
Caco - 2 study indicated the permeability of TAK - 491 was improved by prodrug modification and the compound could be mainly transferred as TAK - 491 .
 Chemical: TAK - 491; Chemical: TAK - 491
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: TAK - 491; Chemical: TAK - 491