4505
Conversely the rate of bioavailability was significantly different , because from the Reference patch the release rate is fast in the first 24 h , leading to an E2 peak at 8 h and to a Cmax in average at 23 h .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: GENE 
Text: {0} 
Answer:
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