21251
In this study , a bilayered OPF composite hydrogel that mimics the distinctive hierarchical structure of native osteochondral tissue was utilized to investigate the effect of transforming growth factor - beta 3 ( TGF - beta 3 ) with varying release kinetics and / or insulin - like growth factor - 1 ( IGF - 1 ) on osteochondral tissue regeneration in a rabbit full - thickness osteochondral defect model .
 Chemical: OPF
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: OPF