2874
In patients with impaired renal and liver function , and those who need long - term pain control , pethidine may cause excitatory central nervous system ( CNS ) effects through its neurotoxic metabolite , norpethidine , resulting in irritability and seizure attack .
 Disease: impaired renal and liver function; Disease: pain; Chemical: pethidine; Disease: neurotoxic; Chemical: norpethidine; Disease: irritability; Disease: seizure
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease, Chemical 
Text: {0} 
Answer:
 Disease: impaired renal and liver function; Disease: pain; Chemical: pethidine; Disease: neurotoxic; Chemical: norpethidine; Disease: irritability; Disease: seizure