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Clozapine is the most efficacious therapy for treatment of refractory schizophrenia , although its use is well recognised to be associated with substantial metabolic dysfunction .
 Chemical: Clozapine
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: Clozapine