18435
To gain insights into the role of HIF and the molecular mechanisms underlying RC , we took advantage of a panel of disease - associated VHL mutants and showed that HIF expression is necessary and sufficient for the induction of RC in human renal cell carcinoma ( RCC ) cells .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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