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The recent focus on protein - protein interaction networks has increasingly been shifted towards the disruption of protein complexes , which either are mediated by the binding of a globular domain in one protein to a short peptide stretch in another , or involve flat , large , and hydrophobic interfaces that classical small - molecule agents are not always ideally suited .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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