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In this light , the rationale behind the currently prevailing single - target - based drug discovery approach might even seem a Utopia , while , conversely , the notion that the complexity of human disease must be tackled with complex polypharmacological therapeutic interventions constitutes a difficult - torefuse argument that is spurring the development of multitarget therapies .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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