24692
A number of methods and models are available for examining BBB permeation in vivo and in vitro , and can give valuable information on the mechanisms by which therapeutic agents and constructs permeate , ways to optimize permeation , and implications for drug discovery , delivery and toxicity .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None