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The difficulties of fitting Chinese herbal medicine ( CHM ) into the double blinded RCTs have raised as follows : ( A ) traditional Chinese medicine ( TCM ) as whole systems of healthcare offers unique methodological and theoretical challenges for RCTs ; ( B ) suspicions against the placebo and unwillingness to stop taking other CHMs make recruitment more difficulty , time - consumption , and cost ; ( C ) the shortcomings of the TCM diagnostic process includes the lack of standardization in terminology , disagreement of pattern differentiation ( Bianzheng ) , and neglect of formula corresponding to syndrome ( TCM Zheng ) ; ( D ) It is difficult to design credible herbal placebos with similar appearance , smells and tastes to the experimental CHM and at the same time is absent of any pharmacological activity ; ( E ) the achieving efficacy of CHM complex interventions is often nonspecific and the outcome measures is subjective using Chinese quantitative instrument .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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