20582
The doses identified as best doses from two nicotine dose - response curve determinations were unrelated , and the improvement associated with the best dose observed during the first dose - response curve determination was not reliable when the dose was administered repeatedly .
 Chemical: nicotine
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: nicotine