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Synaptic spine loss is a feature of neurogeneration resulting in learning and memory deficits , and emerging evidence indicates a role for APP , probably mediated via one or more of its metabolites , in spine structure and functions .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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