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Third , the bioactivity of resulting fractions was assessed by determining their influence on cell proliferation and differentiation , thereby allowing for an evaluation of their interaction . The pharmacodynamic contribution ratio of each bioactive compound to the efficacy of the herbal medicine could then be comprehensively and intuitively determined based on the spectra - activity correlations ( VIP values ) of the tested compositions using partial least - squares regression ( PLS - R ) , through which the reliability of the screening and isolation of bioactive compounds by the target cell extraction technique were verified .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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