19545
Another new finding of this study is that Isl - 1 acts as a direct downstream target of leptin signaling molecule STAT3 to influence the effect of leptin on insulin secretion , whereas inversely , insulin has feedback regulating effects on Isl - 1 expression through JAK - STAT3 pathway .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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