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Using a dominant negative form of Sp3 and transcriptional activation assays in Schneider SL - 2 insect cells , it was confirmed that ERalpha - Sp3 interactions define a pathway for E2 - mediated inhibition of gene expression , and this represents a new mechanism for decreased gene expression by E2 .
 GENE: Sp3; GENE: ERalpha; GENE: Sp3; GENE: E2; GENE: E2
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: GENE 
Text: {0} 
Answer:
 GENE: Sp3; GENE: ERalpha; GENE: Sp3; GENE: E2; GENE: E2