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Because of the fact that HDAC8 is required for expression of both wild - type and mutant p53 , we found that targeted disruption of HDAC8 expression remarkably triggers proliferative defect in cells with a mutant , but not wild - type , p53 .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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