1606
In the present study , we describe the proinflammatory effects of bupivacaine on local prostaglandin E2 ( PGE2 ) production and cyclooxygenase ( COX ) gene expression that increases postoperative pain in human subjects .
 Chemical: bupivacaine; Chemical: prostaglandin E2; Chemical: PGE2; Disease: postoperative pain
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease, Chemical 
Text: {0} 
Answer:
 Chemical: bupivacaine; Chemical: prostaglandin E2; Chemical: PGE2; Disease: postoperative pain