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The interactions which block channel opening provide fundamental insight into A beta neurotoxicity and cognition impairment , that could contribute to pathogenic processes in Alzheimer ' s disease , thus paving the way for structure based therapies .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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