302
Secondly , there appeared to be an interdependent association between mutations upstream and within the PTPase core motif , the core motif containing the majority of missense mutations , and the involvement of all major organ systems ( central nervous system , thyroid , breast , skin and gastrointestinal tract ) .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease 
Text: {0} 
Answer:
 None