3386
Recent experience using IVIVE approaches to estimate in vivo pharmacokinetics ( Wetmore et al . , 2012 ) identified the need to develop a hepatic clearance equation that explicitly accounted for a broader set of protein binding and membrane transport processes and did not depend on a well - mixed description of the liver compartment .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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