8379
Further study on other Oatp1a2 substrates showed that the high affinity component for E - 3 - S is responsible for the interaction with taurocholate , bromsulphthalein , and rifampicin and is sensitive to proton concentration change , whereas the low affinity binding site is only involved in the binding of the antitumor drug methotrexate and had no response to change of pH .
 Chemical: E - 3 - S; Chemical: taurocholate; Chemical: bromsulphthalein; Chemical: rifampicin; Chemical: methotrexate
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: E - 3 - S; Chemical: taurocholate; Chemical: bromsulphthalein; Chemical: rifampicin; Chemical: methotrexate