9206
From this effort , the contribution of the core region to the overall topology of the pharmacophore , primarily vector orientation and planarity , was determined , with a set of analogs exhibiting < 10 nM EC ( 50 ) in a genotype 1b replicon assay .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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