6461
The W54R substitution , in the substrate binding site , increases kinetic constants ( Ks , by > 10 - fold ) while decreasing turnover numbers by 2 - 7 - fold .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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