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Furthermore , a bioassay - guided purification procedure allowed the isolation of a chromatographic fraction containing a major component with a molecular mass of 4478 Da from the crude extract , which causes a significant inhibition of whole - cell patch - clamp currents through recombinant Erg1 channels , responsible of the rapid delayed rectifying current crucial for electrical activity in the heart .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None