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Male Wistar rats were randomly assigned to one of 5 groups ( n = 6 ) : normal control and groups were injected isoproterenol after chronic pre - treatment with 0 , 25 , 50 , or 100mg / kg of metformin twice daily for 14 days .
 Chemical: isoproterenol; Chemical: metformin
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease, Chemical 
Text: {0} 
Answer:
 Chemical: isoproterenol; Chemical: metformin