19651
They additionally clarify the structural and energetic complementarity between " pocket - forming " and " pocket - occupying " hot - spot residues , and further validate computational fragment mapping as a method for identifying hot spots at PPI interfaces .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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