8522
Although considerable efforts to delineate the underlying pathophysiological pathways have been made during the last decades , only very limited progress on treatment have been achieved because molecular pathways that drive the aggressive nature of GBM are largely unknown .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None