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A number of follow - up epidemiological population studies as well as two randomized , controlled clinical studies , one a 5000 - patient retinopathy study and the other a 12 , 000 - patient cardiovascular outcomes trial ( ORIGIN ) , found no higher frequency of malignancy in glargine - treated patients .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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