13870
Besides the independent , direct effects on the musculoskeletal tissues , estrogen deficiency also reduces the ability to adequately respond and adapt to external mechanical and metabolic stressors , e . g . exercise , which are otherwise the main stimuli that should maintain musculoskeletal integrity and metabolic function .
 Chemical: estrogen
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: estrogen