23108
Gain - of - function mutations promote the development of familial hypercholesterolemia , whereas loss - of - function mutations are associated with lower levels of circulating low - density lipoprotein cholesterol ( LDL - C ) and significant protection against coronary heart disease .
 Chemical: cholesterol
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: cholesterol