13523
Collectively , these results suggest that the activation of p53 , JNK or p38 kinase by ZEN metabolites is the main upstream signal required for the mitochondrial alteration of Bcl - 2 / Bax signaling pathways and intracellular ROS generation , while MMP loss and nuclear translocation of AIF are the critical downstream events for ZEN metabolite - mediated apoptosis in macrophages .
 Chemical: ZEN; Chemical: ZEN
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: ZEN; Chemical: ZEN