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Polyglutamine - containing protein fragments have been shown to accumulate as aggregates in the nucleus and in the cytoplasm , and to induce cell death when expressed in cultured cells , leading to the proposal that polyglutamine aggregation is an important step in the pathogenesis .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: GENE 
Text: {0} 
Answer:
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