19984
CNA goes beyond the mere identification of flexible and rigid regions in a biomacromolecule in that it ( I ) provides a refined modeling of thermal unfolding simulations that also considers the temperature - dependence of hydrophobic tethers , ( II ) allows performing rigidity analyses on ensembles of network topologies , either generated from structural ensembles or by using the concept of fuzzy noncovalent constraints , and ( III ) computes a set of global and local indices for quantifying biomacromolecular stability .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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