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Up - regulated genes ( more than 2 - fold ) were primarily related to lipid metabolism and biosynthesis whereas down - regulated genes included several processes such as transcription , cell junction , extra cellular matrix ( ECM ) - receptor interaction and others .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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