18607
Thus , in contrast to VEGF LOF in the developing brain , a process which is detrimental for the growth and survival of blood vessels and leads to massive neuronal apoptosis [ 2 - 4 ] , continued signaling by VEGF in the mature brain is no longer required for maintaining already established cerebral vasculature and its inhibition does not cause appreciable vessel regression , hypoxia or apoptosis [ 4 - 7 ] .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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