3145
By inhibiting the cytochrome P450 2D6 , terbinafine had decreased metoprolol ' s clearance , leading in metoprolol accumulation which has resulted in clinically significant sinus bradycardia .
 Chemical: terbinafine; Chemical: metoprolol; Chemical: metoprolol; Disease: sinus bradycardia
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease, Chemical 
Text: {0} 
Answer:
 Chemical: terbinafine; Chemical: metoprolol; Chemical: metoprolol; Disease: sinus bradycardia