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ORC1 binding sites in HeLa cells were validated as active DNA replication origins ( ORIs ) using Repli - seq , a method that allows identification of ORI - containing regions by parallel sequencing of temporally ordered replicating DNA .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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