10231
Lead optimization of this scaffold to improve oral absorption yielded compound 45 , which showed potent cellular IAP1 ( cIAP1 IC ( 50 ) : 1 . 3 nM ) and XIAP ( IC ( 50 ) : 200 nM ) inhibitory activity , in addition to potent tumor growth inhibitory activity ( GI ( 50 ) : 1 . 8 nM ) in MDA - MB - 231 breast cancer cells .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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