10262
To this end , we built pharmacokinetic and pharmacodynamic models that describe the relationship of the concentrations of TAK - 441 plasma to the responses of Gli1 mRNA in the tumor ( target ) and skin ( surrogate ) and to tumor growth inhibition in mice bearing xenografts of human pancreatic tumors ( PAN - 04 ) .
 Chemical: TAK - 441
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: TAK - 441