4702
The following factors appear to predispose to the development of this complication : abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia , and epidural cerebrospinal leakage ; elevated cerebrospinal fluid methothexate concentration related to abnormal cerebrospinal fluid dynamics and to inappropriately high methotrexate doses based on body surface area calculations in older children and adults ; the presence of neurotoxic preservatives in commercially available methotrexate preparations and diluents ; and the use of methotrexate diluents of unphysiologic pH , ionic content and osmolarity .
 Disease: central nervous system leukemia; Chemical: methothexate; Chemical: methotrexate; Disease: neurotoxic; Chemical: methotrexate; Chemical: methotrexate
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease, Chemical 
Text: {0} 
Answer:
 Disease: central nervous system leukemia; Chemical: methothexate; Chemical: methotrexate; Disease: neurotoxic; Chemical: methotrexate; Chemical: methotrexate