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Therefore , attention has also been focused on inhibitors of mitogen - activated protein kinases ( MAPKs ) , signalling enzymes that play key roles in pathogenic cytokine production , and their downstream effector pathways , in order to create safe and effective oral drugs .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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