3589
Sirtuin 1 ( SIRT1 ) , the mammalian Sir2 homologue , is a class III histone deacetylase shown to act on a wide range of histones and non - histone substrates .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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