2544
The D443N substitution is an activating mutation that increases the activity of SCAP and renders it resistant to inhibition by 25 - hydroxycholesterol .
 GENE: D443N substitution; GENE: SCAP
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: GENE 
Text: {0} 
Answer:
 GENE: D443N substitution; GENE: SCAP