18314
Since its identification in 1988 and the recognition of its primary role as a potent vasoconstrictor , endothelin has been extensively studied and is now considered as a ubiquitous protein , involved in important aspects of human homeostasis as well as in several pathophysiological pathways , mostly associated with cardiovascular disease .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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