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The purposes of this study were to determine whether berberine has any effect on phenotype changes and extracellular matrix ( ECM ) production in nasal polyp - derived fibroblasts ( NPDFs ) and to investigate the underlying molecular mechanism .
 Chemical: berberine
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: berberine