21599
Compounds 1 - 3 were tested against a panel of luciferase reporter gene assays that assess the activity of many cancer - related signaling pathways , and the Z - isomer ( 1 ) was found to be more potent than the E - isomer ( 2 ) in inhibiting the activation of Stat3 , Smad3 / 4 , myc , Ets , Notch , and Wnt signaling , with IC50 values between 40 and 80 mu M .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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