16858
ITCH is an E3 - ubiquitin ligase that modulates the ubiquitination of several targets , therefore participating to the regulation of several cellular responses , such as the DNA damage response , tumor necrosis factor alpha ( TNF alpha ) , Notch and Hedgehog signaling , and the differentiation of ' naive ' lymphocytes into T helper type 2 cells .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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