4992
The present uncertainty means that many questions relating to this area exist , including " How important is protein binding ? " , " Is protein binding always constant ? " , " Do pH and temperature changes alter binding ? " and " How do protein binding changes affect dosing requirements ? " .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None