12512
Kinase profiling and structure - based drug design guided the optimization from the initial 1 , 2 , 3 - benzotriazole hit to a potent and selective JNK inhibitor , compound 24f ( JNK1 and 2 IC ( 50 ) = 16 and 66 nM , respectively ) , with bioavailability in rats and suitable for further in vivo pharmacological evaluation .
 Chemical: 1 , 2 , 3 - benzotriazole
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: 1 , 2 , 3 - benzotriazole