429
Among the other 11 unique mutations , 8 were small deletions or insertions predicted to cause frameshifts , 1 was a mutation to a stop codon , 1 was a missense mutation , and 1 was predicted to cause insertion of an isoleucine in the hect domain of the UBE3A protein , which functions in E2 binding and ubiquitin transfer .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease 
Text: {0} 
Answer:
 None