3290
Molecular dynamic ( MD ) simulations showed that the overall effect of the mutation p . Val204Asp is disruption of hydrogen bonding between Gln223 and Glu441 , leading Ser198 and His438 to move away from each other with subsequent disruption of the catalytic triad functionality regardless of the type of substrate .
 Chemical: hydrogen
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease, Chemical 
Text: {0} 
Answer:
 Chemical: hydrogen