13104
While often catalytically competent , the mutated enzymes are unable to efficiently pass the quality control mechanisms of the endoplasmic reticulum , resulting in reduced lysosomal trafficking , substrate accumulation , and cellular dysfunction .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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