5770
Herein we report a next generation muscarinic receptor 4 ( M ( 4 ) ) positive allosteric modulator ( PAM ) , ML253 which exhibits nanomolar activity at both the human ( EC ( 50 ) = 56 nM ) and rat ( EC ( 50 ) = 176 nM ) receptors and excellent efficacy by the left - ward shift of the ACh concentration response curve ( fold shift , human = 106 ; rat = 50 ) .
 Chemical: ML253; Chemical: ACh
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: ML253; Chemical: ACh