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Importantly , we show that HMGB1 triggers and helps to sustain this proangiogenic gene expression program in ECs , additionally characterized by increased activity of matrix metalloproteinases , integrins and nuclear factor - kappa B .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None