3121
Metfromin markedly lowered isoproterenol - induced elevation in the levels of TLR4 mRNA , myeloid differentiation protein 88 ( MyD88 ) , tumor necrosis factor - alpha ( TNF - a ) , and interleukin 6 ( IL - 6 ) in the heart tissues .
 Chemical: isoproterenol; Disease: tumor; Disease: necrosis
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease, Chemical 
Text: {0} 
Answer:
 Chemical: isoproterenol; Disease: tumor; Disease: necrosis