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To explore the interaction between A2A and nAChRs , we examined if the complete genetic deletion of adenosine A2ARs in mice induces compensatory alterations in the binding of different nAChR subtypes , and whether the long - term effects of nicotine on nAChR regulation are altered in the absence of the A2AR gene .
 Chemical: adenosine; Chemical: nicotine
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: adenosine; Chemical: nicotine