852
The two clinically unaffected siblings carried the maternal mutation 459 + 1G > A and , on their paternal allele , a novel cytosine to thymidine transition at nucleotide 2435 in exon 8 , resulting in substitution of alanine 464 by valine ( A464V ) .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease 
Text: {0} 
Answer:
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