5578
Biochemical characterization demonstrated that the isolated SH2 domain containing the F646S substitution closely resembled the wild - type SH2 domain in secondary structure , but exhibited reduced thermodynamic stability and altered tertiary structure that were intermediate between STAT5b ( A630P ) and STAT5b ( WT ) .
 None
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
 Entities:  
Answer:
 None