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Although adverse reactions to protamine are reported infrequently and are usually mild , we recently observed the first fatal case of type I anaphylaxis resulting from protamine .
 type I anaphylaxis, protamine
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 type I anaphylaxis, protamine