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We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved .
 cutaneous necrosis, interferon alfa; cutaneous necrosis, pegylated interferon alfa-2b
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 cutaneous necrosis, interferon alfa; cutaneous necrosis, pegylated interferon alfa-2b