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When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction , close attention must be paid to avoid life - threatening arrhythmias due to high plasma concentrations of the drug .
 life - threatening arrhythmias, pilsicainide
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 life - threatening arrhythmias, pilsicainide