280
The authors describe a case of valvular heart disease in a 48-year - old woman receiving benfluorex ( 150 mg t.i.d . for 8 years ) and leading to surgical mitral valve replacement .
 valvular heart disease, benfluorex
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 valvular heart disease, benfluorex