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We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.
 a patient with the antiphospholipid syndrome: Subject; skin necrosis: Effect; low-molecular weight heparin therapy at sites distant from injection sites: Treatment; antiphospholipid syndrome: Treatment.Disorder; low-molecular weight heparin: Treatment.Drug; injection: Treatment.Route
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 a patient with the antiphospholipid syndrome: Subject; skin necrosis: Effect; low-molecular weight heparin therapy at sites distant from injection sites: Treatment; antiphospholipid syndrome: Treatment.Disorder; low-molecular weight heparin: Treatment.Drug; injection: Treatment.Route