1908
We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.
 3 patients: Subject; 3: Subject.Population; acute generalized dystonia and akinetic rigid syndrome: Effect; d-penicillamine 125-500 mg daily: Treatment; d-penicillamine: Treatment.Drug; 125-500 mg daily: Treatment.Dosage
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 3 patients: Subject; 3: Subject.Population; acute generalized dystonia and akinetic rigid syndrome: Effect; d-penicillamine 125-500 mg daily: Treatment; d-penicillamine: Treatment.Drug; 125-500 mg daily: Treatment.Dosage