477
We believe that methotrexate represents a relatively effective alternative to surgery in patients with early unruptured tubal pregnancy, but suggest that it be used with caution in view of possible systemic toxicity.
 patients with early unruptured tubal pregnancy: Subject; systemic toxicity: Effect; methotrexate: Treatment; methotrexate: Treatment.Drug; early unruptured tubal pregnancy: Treatment.Disorder
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 patients with early unruptured tubal pregnancy: Subject; systemic toxicity: Effect; methotrexate: Treatment; methotrexate: Treatment.Drug; early unruptured tubal pregnancy: Treatment.Disorder