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Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.
 PPE: Effect; high-dose cytarabine: Treatment; high-dose: Treatment.Dosage; cytarabine: Treatment.Drug; haematologic malignancies: Treatment.Disorder
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 PPE: Effect; high-dose cytarabine: Treatment; high-dose: Treatment.Dosage; cytarabine: Treatment.Drug; haematologic malignancies: Treatment.Disorder