2663
This study revealed that ketoconazole affected the disposition of rosiglitazone in humans, probably by the inhibition of CYP2C8 and CYP2C9, leading to increasing rosiglitazone concentrations that could increase the efficacy of rosiglitazone or its adverse events.
 humans: Subject; increasing rosiglitazone concentrations that could increase the efficacy of rosiglitazone or its adverse events: Effect; ketoconazole: Treatment; ketoconazole: Treatment.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 humans: Subject; increasing rosiglitazone concentrations that could increase the efficacy of rosiglitazone or its adverse events: Effect; ketoconazole: Treatment; ketoconazole: Treatment.Drug