1202
Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).
 patient: Subject; reaction to the drug became more toxic: Effect; theophylline therapy: Treatment; theophylline: Treatment.Drug; 99.9 and 149.9 micromol/L: Treatment.Dosage; 18 and 27 microg/mL: Treatment.Dosage
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 patient: Subject; reaction to the drug became more toxic: Effect; theophylline therapy: Treatment; theophylline: Treatment.Drug; 99.9 and 149.9 micromol/L: Treatment.Dosage; 18 and 27 microg/mL: Treatment.Dosage