2439
Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.
 new brain lesions: Effect; six weeks and 11 months of penicillamine therapy: Treatment; six weeks and 11 months: Treatment.Duration; penicillamine: Treatment.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 new brain lesions: Effect; six weeks and 11 months of penicillamine therapy: Treatment; six weeks and 11 months: Treatment.Duration; penicillamine: Treatment.Drug