97
A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.
 A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma: Subject; hereditary retinoblastoma: Subject.Disorder; cerebral edema and brainstem herniation: Effect; a single dose of intravenous methotrexate: Treatment; intracranial osteosarcoma: Treatment.Disorder; a single dose: Treatment.Freq; intravenous: Treatment.Route; methotrexate: Treatment.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma: Subject; hereditary retinoblastoma: Subject.Disorder; cerebral edema and brainstem herniation: Effect; a single dose of intravenous methotrexate: Treatment; intracranial osteosarcoma: Treatment.Disorder; a single dose: Treatment.Freq; intravenous: Treatment.Route; methotrexate: Treatment.Drug