531
The etiology of neurotoxicity in our two patients remains unclear; however, as CAP is rapidly metabolized to 5-FU in patients with normal liver function, it is likely that 5-FU or its active metabolites (fluoro-beta-alanine) were contributing factors.
 two patients: Subject; two: Subject.Population; neurotoxicity: Effect; 5-FU or its active metabolites (fluoro-beta-alanine): Treatment; 5-FU: Treatment.Drug; fluoro-beta-alanine: Treatment.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 two patients: Subject; two: Subject.Population; neurotoxicity: Effect; 5-FU or its active metabolites (fluoro-beta-alanine): Treatment; 5-FU: Treatment.Drug; fluoro-beta-alanine: Treatment.Drug