2862
Given that significant thyroid disorders may be only mildly symptomatic and thus may escape clinical detection, we suggest that thyroid function should be tested in any patient with otherwise unexplained changes in warfarin dose requirements, particularly if concomitantly treated with amiodarone.
 significant thyroid disorders: Effect; warfarin: Treatment; with amiodarone: Treatment; warfarin: Treatment.Drug; amiodarone: Treatment.Drug; amiodarone: Combination.Drug; warfarin: Combination.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 significant thyroid disorders: Effect; warfarin: Treatment; with amiodarone: Treatment; warfarin: Treatment.Drug; amiodarone: Treatment.Drug; amiodarone: Combination.Drug; warfarin: Combination.Drug