2452
The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis, and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities, the combination use of these drugs should be avoided.
 severe and even potentially fatal toxicities: Effect; itraconazole: Treatment; vincristine: Treatment; itraconazole: Treatment.Drug; vincristine: Treatment.Drug; itraconazole: Combination.Drug; vincristine: Combination.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 severe and even potentially fatal toxicities: Effect; itraconazole: Treatment; vincristine: Treatment; itraconazole: Treatment.Drug; vincristine: Treatment.Drug; itraconazole: Combination.Drug; vincristine: Combination.Drug