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We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.
 two instances: Subject; two: Subject.Population; systemic allergic reaction: Effect; potential side effects: Effect; aprotinin: Treatment; aprotinin: Treatment.Drug; injections: Treatment.Route
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 two instances: Subject; two: Subject.Population; systemic allergic reaction: Effect; potential side effects: Effect; aprotinin: Treatment; aprotinin: Treatment.Drug; injections: Treatment.Route