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To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.
 25 additional patients with Wilson's disease: Subject; 25: Subject.Population; neurologic disease: Effect; penicillamine: Treatment; penicillamine: Treatment.Drug; Wilson's disease: Treatment.Disorder
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 25 additional patients with Wilson's disease: Subject; 25: Subject.Population; neurologic disease: Effect; penicillamine: Treatment; penicillamine: Treatment.Drug; Wilson's disease: Treatment.Disorder