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The addition of intrathecal methotrexate to treatment protocols has increased survival rates in children with acute lymphoblastic leukemia but is also associated with varying degrees of neurotoxicity.
 in children with acute lymphoblastic leukemia: Subject; children: Subject.Age; varying degrees of neurotoxicity: Effect; The addition of intrathecal methotrexate to treatment protocols: Treatment; methotrexate: Treatment.Drug; acute lymphoblastic leukemia: Treatment.Disorder
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 in children with acute lymphoblastic leukemia: Subject; children: Subject.Age; varying degrees of neurotoxicity: Effect; The addition of intrathecal methotrexate to treatment protocols: Treatment; methotrexate: Treatment.Drug; acute lymphoblastic leukemia: Treatment.Disorder