865
We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency.
 cancer patient: Subject; life-threatening complications: Effect; have profound DPD deficiency: Effect; topical 5-FU: Treatment; cancer: Treatment.Disorder; 5-FU: Treatment.Drug; topical: Treatment.Route
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 cancer patient: Subject; life-threatening complications: Effect; have profound DPD deficiency: Effect; topical 5-FU: Treatment; cancer: Treatment.Disorder; 5-FU: Treatment.Drug; topical: Treatment.Route