1843
Cyclophosphamide-induced cardiotoxicity occurred, even though the patient had both shown normal cardiac function before high-dose chemotherapy and had received a lower dose of cyclophosphamide.
 the patient had both shown normal cardiac function: Subject; cardiotoxicity: Effect; Cyclophosphamide: Treatment; high-dose chemotherapy and had received a lower dose of cyclophosphamide: Treatment; Cyclophosphamide: Treatment.Drug; lower dose: Treatment.Dosage
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 the patient had both shown normal cardiac function: Subject; cardiotoxicity: Effect; Cyclophosphamide: Treatment; high-dose chemotherapy and had received a lower dose of cyclophosphamide: Treatment; Cyclophosphamide: Treatment.Drug; lower dose: Treatment.Dosage