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We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.
 identical twin brothers: Subject; brothers: Subject.Gender; leukoencephalopathy and hydrocephalus: Effect; intrathecally administered methotrexate: Treatment; intrathecally administered methotrexate and cranial irradiation: Treatment; methotrexate: Treatment.Drug; methotrexate: Treatment.Drug; intrathecally: Treatment.Route; intrathecally: Treatment.Route
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 identical twin brothers: Subject; brothers: Subject.Gender; leukoencephalopathy and hydrocephalus: Effect; intrathecally administered methotrexate: Treatment; intrathecally administered methotrexate and cranial irradiation: Treatment; methotrexate: Treatment.Drug; methotrexate: Treatment.Drug; intrathecally: Treatment.Route; intrathecally: Treatment.Route