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We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.
 this metabolic defect: Subject; metabolic defect: Subject.Disorder; unusual presentation of life-threatening toxicity: Effect; topical 5-FU (a drug demonstrating a narrow therapeutic index): Treatment; 5-FU: Treatment.Drug; topical: Treatment.Route
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 this metabolic defect: Subject; metabolic defect: Subject.Disorder; unusual presentation of life-threatening toxicity: Effect; topical 5-FU (a drug demonstrating a narrow therapeutic index): Treatment; 5-FU: Treatment.Drug; topical: Treatment.Route