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This discovery drastically reduced the adverse effects and improved the efficacy of protease inhibitors and HAART However , because of the general role of CYP3A4 in xenobiotic metabolism , dosing with ritonavir also affects the efficacy of numerous other medications , adding to the challenge of prescribing drugs concurrently .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: location, person, organization 
Text: {0} 
Answer:
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