798
Using pharmacologic and molecular approaches that suppress the prolyl - hydroxylase ( PHD ) - mediated inhibition of HIF1 alpha , we show that DCA inhibits HIF1 alpha by both a PHD - dependent mechanism ( that involves a DCA - induced increase in the production of mitochondria - derived alpha - ketoglutarate ) and a PHD - independent mechanism , involving activation of p53 via mitochondrial - derived H ( 2 ) O ( 2 ) , as well as activation of GSK3 beta .
 Chemical: prolyl; Chemical: DCA; Chemical: DCA; Chemical: alpha - ketoglutarate; Chemical: H ( 2 ) O ( 2 )
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: prolyl; Chemical: DCA; Chemical: DCA; Chemical: alpha - ketoglutarate; Chemical: H ( 2 ) O ( 2 )