1005
Search for novel antiepileptic drugs ( AEDs ) is highly motivated especially for the treatment of neonatal seizures which are often resistant to , or even aggravated by conventional AEDs . This review shows that the antiepileptic effects of loop diuretics described in the pertinent literature are based on widely heterogeneous mechanisms ranging from actions on both neuronal NKCC1 and KCC2 to modulation of the brain extracellular volume fraction .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None