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In the vasculature , insulin signaling plays a critical role in normal vascular function via endothelial cell nitric oxide production and modulation of Ca ( 2 + ) handling and sensitivity in vascular smooth muscle cells .
 Chemical: nitric oxide; Chemical: Ca ( 2 + )
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: nitric oxide; Chemical: Ca ( 2 + )