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Mutations affecting the Sequestosome 1 ( SQSTM1 ) gene commonly occur in patients with the skeletal disorder Paget ' s disease of bone ( PDB ) , a condition characterised by defective osteoclast differentiation and function .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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