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Previous studies demonstrate that the activity of the evolutionarily conserved NAD ( + ) - dependent deacetylase SIRT1 declines with age and that pharmacological activators of SIRT1 confer significant anti - aging cardiovascular effects .
 Chemical: NAD ( + )
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: NAD ( + )