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Inherited or sporadic mutations in components of the Notch signaling pathway are associated with spondylocostal and spondylothoracic dysostoses , and recessive brachydactyly , diseases characterized by skeletal patterning defects .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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