28037
Here we demonstrate that activation peptide mutations D19A , D22G , K23R and K23 _ I24insIDK robustly increased the rate of trypsinogen autoactivation , both in the presence and absence of CTRC .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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