5579
Homology - based structural modeling suggests that the F646S mutation disrupts key hydrophobic interactions and may also distort the phosphopeptide - binding face of the SH2 domain , explaining both the reduced thermodynamic stability and impaired biological activity .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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