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These results demonstrated for the first time that ISO induces apoptosis in HepG2 cells through inactivating ERK1 / 2 kinase and activating JNK and p38 kinases , and ROS stimulated by ISO is able to activate the MAPK singaling pathway as the upstream signaling molecules .
 Chemical: ISO; Chemical: ISO
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: ISO; Chemical: ISO