10758
In order to properly assess the clinical implications of such pharmacokinetic changes and recommend safe and effective dosage regimens , there is an urgent need for dose - optimization studies for all recommended first - and second - line agents , along with the different drug formulations , used in paediatric populations with P . falciparum .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None