458
Due to the limited signal to noise ratio in the data at hand , the identified 8 % of all drug targets that show feedback loops has to be seen as a lower limit , i . e . target - regulation appears as a wide - spread biological phenomenon that has to be taken into account during drug development .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Anatomy 
Text: {0} 
Answer:
 None