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This work suggests that mitochondria - targeting metabolic modulators that increase pyruvate dehydrogenase activity , in addition to the recently described pro - apoptotic and anti - proliferative effects , suppress angiogenesis as well , normalizing the pseudo - hypoxic signals that lead to normoxic HIF1 alpha activation in solid tumors .
 Chemical: pyruvate
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: pyruvate