2371
We previously showed that this proteolysis 1 ) can be acutely promoted by the phorbol ester phorbol 12 - myristate 13 - acetate ( PMA ) , 2 ) requires a metalloprotease activity , 3 ) generates both shed GHBP and a membrane - associated GHR transmembrane / cytoplasmic domain remnant , and 4 ) results in down - regulation of GHR abundance and GH signaling .
 GENE: metalloprotease; GENE: GHBP; GENE: membrane - associated GHR transmembrane / cytoplasmic domain; GENE: GHR; GENE: GH
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: GENE 
Text: {0} 
Answer:
 GENE: metalloprotease; GENE: GHBP; GENE: membrane - associated GHR transmembrane / cytoplasmic domain; GENE: GHR; GENE: GH