8659
In vivo , the ratio of area under the concentration - time curve ( AUC ) ( brain ) to AUC ( plasma ) ( K ( p ) ) of dabrafenib after an i . v . dose ( 2 . 5 mg / kg ) was 0 . 023 , which increased by 18 - fold in Mdr1 a / b ( - / - ) Bcrp1 ( - / - ) mice to 0 . 42 .
 Chemical: dabrafenib
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: dabrafenib