2115
Loading increased the cortical bone area in the tibia mainly as a result of an increased periosteal bone formation rate ( BFR ) and this osteogenic response was similar in gonadal intact and ovx mice , demonstrating that E2 ( ligand ) is not required for this response .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None