18709
In support of the hypothesis that TCDD decreases canonical Wnt signaling , we identify inhibitory effects of TCDD on multiple components of the canonical Wnt signaling pathway in the UGS that temporally coincide with the inhibitory effect of TCDD on prostatic bud formation : ( 1 ) expression of R - spondins ( Rspo2 and Rspo3 ) that promote canonical Wnt signaling is reduced ; ( 2 ) expression of Lef1 , Tcf1 , and Wif1 , established canonical Wnt target genes , is decreased ; ( 3 ) expression of Lgr5 , a RSPO receptor that activates canonical Wnt signaling , is reduced ; and ( 4 ) expression of Dickkopfs ( Dkks ) , inhibitors of canonical Wnt signaling , is not increased by TCDD .
 Chemical: TCDD; Chemical: TCDD; Chemical: TCDD; Chemical: TCDD
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
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Answer:
 Chemical: TCDD; Chemical: TCDD; Chemical: TCDD; Chemical: TCDD