4972
The 2012 drug - drug interaction ( DDI ) guidance from the European Medicines Agency ( EMA ) and the draft DDI guidance from the Food and Drug Administration ( FDA ) have proposed that metabolites present at > 25 % of the parent area under the time - concentration curve ( AUC ) ( EMA and FDA ) and > 10 % of the total drug - related exposure ( EMA ) should be investigated in vitro for their DDI potential .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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