8660
Dabrafenib plasma exposure was ~ 2 - fold greater in Mdr1 a / b ( - / - ) Bcrp1 ( - / - ) mice as compared with wild - type with an oral dose ( 25 mg / kg ) ; however , the brain distribution was increased by ~ 10 - fold with a resulting K ( p ) of 0 . 25 .
 Chemical: Dabrafenib
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: Dabrafenib