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While the specificity and validity of certain cytokines as markers of adverse immune response has been established for chemicals , small and macromolecular drugs , research on their applicability for predicting and monitoring the immunotoxicity of engineered nanomaterials is still ongoing .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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