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Cells in which astrin was depleted had decreased murine double minute 2 ( MDM2 ) abundance and increased p53 at the later stages of the DNA damage response .
 Chemical: astrin
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: astrin