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A culture of stringent validation has been developed for such approaches ( Leist et al . in ALTEX 27 ( 4 ) : 309 - 317 , 2010 ; ALTEX 29 ( 4 ) : 373 - 88 , 2012a ; Toxicol Res 1 : 8 - 22 , 2012b ) , while the quality and usefulness of animal experiments have been little scrutinized .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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