16331
The profile of sinusoidal and canalicular drug transporter mRNA expression in short time ( 4h ) - cultured mouse hepatocytes was found to be highly correlated with that of freshly isolated hepatocytes ; by contrast , those of counterparts cultured for a longer time ( until 4days ) either in monolayer configurations on plastic or collagen or in sandwich configuration with matrigel were profoundly altered : uptake drug transporters such as Oct1 , Oatps and Oat2 were thus down - regulated , whereas most of efflux transporters such as Mdr1a / b , Mrp3 , Mrp4 and Bcrp were induced .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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