3327
The disease - causing gain - of - function mutations in the SH3 - binding protein 2 ( SH3BP2 ) gene result in increased myeloid cell responses to macrophage colony stimulating factor and RANK ligand , formation of hyperactive osteoclasts ( giant cells ) , and hyper - reactive macrophages that produce excessive amounts of the inflammatory cytokine tumor necrosis factor alpha ( TNF - alpha ) .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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