19897
The second series of compounds , beta - lactam amino acid amides ( including 10k and 11l ) displayed potent antiproliferative activity in MCF - 7 cells , disrupted microtubules in MCF - 7 cells and also inhibited the polymerisation of tubulin in vitro .
 Chemical: beta - lactam amino acid amides
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 Chemical: beta - lactam amino acid amides