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Using surface biotinylation , we observed that treatment of N - 38 neurons with estradiol or with a membrane impermeant estradiol elevated plasma membrane ER alpha protein levels , indicating that membrane signaling increased receptor insertion into the cell membrane .
 Chemical: estradiol; Chemical: estradiol
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: estradiol; Chemical: estradiol