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To identify possible features of the BRCA1 genomic region that may contribute to chromosomal instability as well as potential transcriptional regulatory elements , a 117 , 143 - bp DNA sequence encompassing BRCA1 was obtained by random sequencing of four cosmids identified from a human chromosome 17 specific library .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease 
Text: {0} 
Answer:
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