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Quantitative PCR and immunocytochemical assays revealed a significant beta 2 - adrenergic receptor down - regulation as well as alpha 2A - adrenergic receptor up - regulation of treated cells ( p < 0 . 001 , maximal significant effect ) .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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