2033
For example , introduction of immunogenic and purification tag sequences into the C - terminal coding region significantly decreased bop gene mRNA and protein accumulation .
 GENE: bop gene mRNA
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: GENE 
Text: {0} 
Answer:
 GENE: bop gene mRNA