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Significant increases in mean serum E2 concentration ( 100 to 150 pg / ml ) were noted at 6 and 8 hours after administration on day 1 and at 8 hours on day 4 .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: GENE 
Text: {0} 
Answer:
 None