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Discovery of the biosynthetic pathways responsible for the production of these compounds has been simplified by using gene based screening approaches , but detection and identification of the natural products the genes produce have been hampered by a lack of high - throughput methods for screening potential producers under various culture conditions .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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