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Upon Notch - ligand interactions , proteolytic cleavages release the Notch intracellular domain ( NICD ) which translocates to the nucleus to regulate the transcription of target genes , including Hairy enhancer of split ( Hes ) and Hes - related with YRPW - motif ( Hey ) .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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