8092
In contrast , mutation c . 1244T > C results in an amino acid substitution ( Ile415Thr ) , which abolishes signal transduction due to structural changes .
 Chemical: amino acid
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: amino acid