1103
The sustained stimulation of I ( 2 ) - imidazoline receptors with selective drugs ( 10 mg / kg , every 12 h for seven days ) was associated with down - regulation of key components of the extrinsic ( Fas receptor : - 20 % ; Fas associated protein with death domain ( FADD ) adaptor : - 47 - 54 % ) and / or intrinsic ( Bax : - 20 - 23 % ; cytochrome c : - 22 - 28 % ) apoptotic signalling and / or up - regulation of survival anti - apoptotic factors ( p - Ser194 FADD / FADD ratio : + 1 . 6 - 2 . 5 - fold ; and / or Bcl - 2 / Bax ratio : + 1 . 5 - fold ) , which in the long - term could dampen cell death in the brain .
 Chemical: imidazoline; Chemical: Ser194
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: imidazoline; Chemical: Ser194