8934
Furthermore , numerous anti - aging molecules , including sirtuins and Nrf - 2 are reduced , and pathways such as mTOR and genes such as Klotho have also been shown to be abnormal in the lungs of COPD patients .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None