28969
In contrast to the reduced activity of the unsubstituted E - ring derivatives , hydrophobic and relatively non - polar substituents approach or match the chloro substituted vancomycin and was insensitive to the electronic character of the substituent ( e . g . Cl vs CN or OMe ) , whereas highly polar substituents fail to provide the enhancements .
 Chemical: chloro substituted vancomycin; Chemical: Cl; Chemical: CN; Chemical: OMe
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: chloro substituted vancomycin; Chemical: Cl; Chemical: CN; Chemical: OMe