25983
The two potentially most consequential changes were upregulation of intestinal carboxylesterase in Mdr1a - knockouts and catechol - O - methyltransferase in all tissues of Bcrp - knockout rats .
 Chemical: catechol; Chemical: O
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: catechol; Chemical: O