8443
Here we show that Spp1 , a conserved member of the histone H3K4 methyltransferase Set1 complex , is required for normal levels of DSB formation and is associated with chromosome axes during meiosis , where it physically interacts with the Mer2 DSB protein .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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