4979
A key objective of this commentary is to stimulate discussions among the scientific community on this important topic , so that appropriate in vitro metabolism studies are conducted on metabolites , to ensure the safety of drugs in development balanced with the desire to avoid creating unnecessary studies that will add little to no value in ensuring patient safety .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None