18205
However , these explanations are mostly based on its downstream - regulated genes or proteins , information on the direct target proteins that mediate the antiproliferative action of berberine remain unclear .
 Chemical: berberine
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: berberine