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The prokaryotic CpG - specific DNA methylase from Spiroplasma , SssI methylase , has been extensively used to methylate plasmid DNA in vitro to investigate the effects of methylation in vertebrate systems .
 Anatomy: plasmid
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Anatomy 
Text: {0} 
Answer:
 Anatomy: plasmid