5578
Biochemical characterization demonstrated that the isolated SH2 domain containing the F646S substitution closely resembled the wild - type SH2 domain in secondary structure , but exhibited reduced thermodynamic stability and altered tertiary structure that were intermediate between STAT5b ( A630P ) and STAT5b ( WT ) .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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