7589
Two maximum likelihood estimation ( MLE ) methods were developed for optimizing the analysis of single - molecule trajectories that include phenomena such as experimental noise , photoblinking , photobleaching , and translation or rotation out of the collection plane .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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