2169
Two fundamental reasons for this ' Lost in Translation ' problem are the ' Butterfly Effect ' ( chaotic behavior of many animal models ) and the ' Two Cultures ' problem ( differences between the methodologies for preclinical and clinical research ) .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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