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By applying heteroduplex analysis , nonisotopic SSCP , and direct sequencing , we detected germ - line mutations resulting in premature termination codons or disruption of splice signals in 51 ( 72 % ) of the 71 patients .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Disease 
Text: {0} 
Answer:
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