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The overall results indicate that ICI may exert agonistic and antagonistic effects on uterine cell proliferation through differential activation of the Akt pathway depending on the administration period during the estrous cycle , and indicates that the mechanism of cell proliferation during the physiological conditions of the estrous cycle , is under a different and more complex regulation than in the ovariectomized + E2 animal model .
 Chemical: ICI
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: ICI