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Transgenic overexpression of the Notch1 intracellular domain inhibits osteoblast differentiation and causes osteopenia , and inactivation of Notch1 and Notch2 increases bone volume transiently and induces osteoblastic differentiation .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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