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Crosstalk between these elements generates an aggressive environment that leads to cartilage and bone destruction . RA provides represents a model for systemic T - cell mediated systemic autoimmunity leading to local cellular and autoantibody mediated chronic inflammation .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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