12586
Further exemplification of the REPLACE ( REplacement with Partial Ligand Alternatives through Computational Enrichment ) strategy for generating inhibitors of protein - protein interactions demonstrated that it can be used to optimize fragment alternatives of key determinants , to combine these in an effective way , and this was achieved for compounds targeting the cyclin - dependent kinase 2 ( CDK2 ) substrate recruitment site on the cyclin regulatory subunit .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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