12601
We show that accurate IVIVE for acidic compounds with high plasma protein binding and low renal CL can be associated with a low Vd ( i . e . around the Vd of albumin ) and with a low in vivo CL , and that Mw is an important optimization parameter for pharmacokinetic .
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Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
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