6416
We conclude that four principal mechanisms of action are implicated for these compounds : 1 ) telomere uncapping with subsequent DNA damage response and senescence ; 2 ) inhibition of transcription / translation of oncogenes ; 3 ) genomic instability through telomeric DNA end fusions , resulting in mitotic catastrophe and apoptosis ; and 4 ) induction of chromosomal instability by telomere aggregate formation .
 None
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 None