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In contrast , in two different trials also performed in patients with severe COPD , roflumilast reduced exacerbation rates in the absence of ICS , indicating that PDE4 inhibition alone is sufficient for therapeutic activity to be realized .
 Chemical: roflumilast
Please list all entity words in the text that fit the category.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
Answer:
 Chemical: roflumilast