5231
Thus, changes in the Sp1 binding sites had the most dramatic effects on SIVmac replication in primary macrophage cultures .
 primary macrophage cultures, Sp1 binding sites, Sp1
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: cell line, protein, RNA, DNA, cell type 
Text: {0} 
Answer:
 primary macrophage cultures, Sp1 binding sites, Sp1