1227
This disease - causing mutation is a single basepair change ( G to A ) in the splice - acceptor region of APC intron 3 that creates a mutant RNA without exon 4 of APC .
 APC
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 APC