2256
It is apparent that some adipokines have beneficial effects whereas others have detrimental properties ; the overall contribution to beta - cell failure of changed concentrations of adipokines in the blood of obese pre - diabetic subjects will be highly dependent on the balance between these effects and the interactions between the adipokines , which act on the beta - cell via a number of intersecting intracellular signalling pathways .
 None
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 None