23548
Nicotine and bupropion metabolism were inhibited by C - 8 - xanthate ( specific CYP2B inhibitor ) but not CYP2A - specific inhibitors , and hepatic levels of CYP2B - like but not CYP2A - like proteins correlated with nicotine ( r = 0 . 52 , p = 0 . 04 ) and bupropion metabolism ( r = 0 . 81 , p < 0 . 001 ) , suggesting CYP2B - mediation of nicotine metabolism as seen in rats .
 Nicotine, bupropion, C - 8 - xanthate, nicotine, bupropion, nicotine
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 Nicotine, bupropion, C - 8 - xanthate, nicotine, bupropion, nicotine