11788
Together these data suggest that dysfunction of Drosophila TDP - 43 triggers a cascade of events leading to loss - of - function phenotypes whereby impaired synaptic transmission results in defective motor behavior and progressive deconstruction of neuronal connections , ultimately causing age - related neurodegeneration .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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