15971
Wide - ranging exploration of analogues of an ATP - competitive pyrrolopyrimidine inhibitor of Akt led to the discovery of clinical candidate AZD5363 , which showed increased potency , reduced hERG affinity , and higher selectivity against the closely related AGC kinase ROCK .
 AZD5363
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 AZD5363