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During activation with Na + , the Vmax remained unchanged , however the K ( Na ) increased by 50 % , indicating a profound decrease in the affinity of the Na + - binding site in NO - deficient rats .
 Na, K, Na, Na, NO
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease, Chemical 
Text: {0} 
Answer:
 Na, K, Na, Na, NO