11012
Herein , we show that Smad3 physically interacts with the HMG box domain of LEF1 and that TGFbeta and Wnt pathways synergize to activate transcription of the Xenopus homeobox gene twin ( Xtwn ) .
 Smad3, HMG, LEF1, TGFbeta, Wnt, twin, Xtwn
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: GENE 
Text: {0} 
Answer:
 Smad3, HMG, LEF1, TGFbeta, Wnt, twin, Xtwn