14447
Sirt1 functions as an intracellular energy sensor to detect the concentration of NAD ( + ) , and controls in vivo metabolic changes under caloric restriction and starvation through its deacetylase activity to many targets including histones , nuclear transcriptional factors , and enzymes .
 NAD ( + )
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 NAD ( + )