27076
This review , starting from the phases II and III efficacy and safety data that led to these approvals , explores important issues related to dosing , patient selection , and strategies for managing the substantial risk of toxicity associated with the drug ( including life - threatening cardiac events that are the subject of a black - box warning in the United States ) .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 None