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Because of his philosophical beliefs , René Descartes proposed in 1644 that no empty space can exist and that space must consequently be filled with matter .
 René Descartes
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: media, plant, vehicle, astronomical object, time, disease, animal, location, person, organization, mythical figure, food, biology, geographical phenomenon, instrument, event 
Text: {0} 
Answer:
 René Descartes