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We developed methods to detect the three mutations in the HEXA gene that occur with high frequency among Ashkenazi Jews two mutations cause infantile Tay - Sachs disease , and the third causes the adult - onset form of the disease .
 Tay - Sachs disease
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 Tay - Sachs disease