3516
In the 380 patients who were ITC negative and showed low VEGFR - 1 expression , synchronous ( at the time of surgery ) and heterochronous ( recurrent ) metastases were not observed .
 ITC, metastases
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Anatomy 
Text: {0} 
Answer:
 ITC, metastases