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In a previous study we found that a Tay - Sachs disease ( TSD ) causing mutation in the intron 9 donor splice site of the HEXA gene occurs at high frequency in non - Jewish patients and carriers from the British Isles .
 Tay - Sachs disease, TSD
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 Tay - Sachs disease, TSD