17861
In the neurons of the central nervous system , TREK-1 channels are important in physiological , pathophysiological , and pharmacological processes , including having a role in electrogenesis , ischemia , and anesthesia .
 ischemia
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: media, plant, vehicle, astronomical object, time, disease, animal, location, person, organization, mythical figure, food, biology, geographical phenomenon, instrument, event 
Text: {0} 
Answer:
 ischemia