11785
Tissue - specific knockdown together with electrophysiological recordings at the larval NMJ also revealed that alterations of TBPH function predominantly affect pre - synaptic efficacy , suggesting that impaired pre - synaptic transmission is one of the earliest events in TDP - 43 - related pathogenesis .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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