3711
The recently described ribonuclease A cleavage procedure , with a polyuridylic acid - paper affinity chromatography step , has been used to identify the mutational lesions in the hypoxanthine phosphoribosyltransferase ( HPRT ) messenger RNAs of patients with Lesch - Nyhan syndrome .
 Lesch - Nyhan syndrome
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 Lesch - Nyhan syndrome