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Since C - pocket is the site where the nicotinamide moiety of NAD ( + ) binds and the hydrolysis takes place , binding of 16 in C - pocket would block the transformation of NAD ( + ) to productive conformation and hence inhibit the deacetylase activity .
 nicotinamide, NAD ( + ), NAD ( + )
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 nicotinamide, NAD ( + ), NAD ( + )