4330
A mathematical model incorporating the measured selective advantage against malaria suggests that a counterbalancing selective disadvantage , associated with this enzyme deficiency , has retarded its rise in frequency in malaria - endemic regions .
 malaria, enzyme deficiency, malaria
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 malaria, enzyme deficiency, malaria