12733
This increased accumulation of fat with low physiological concentrations ( 10 - (1) (3) and 10 - (1) (1) M ) was associated with a sequential up - regulation of PPAR gamma 2 ( PPARG ) and FABP4 mRNA , indicating formation of adipocytes , whereas higher concentrations ( >= 10 - 9 M ) reduced all these effects , and the highest concentration ( 10 - 5 M ) appeared to have toxic effects .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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