8670
Mutation of the central Tyr497 to Phe blocks the tyrosine phosphorylation of the insulin receptor substrate 1 ( IRS1 ) and diminishes proliferation in response to IL - 4 .
 insulin receptor substrate 1, IRS1, IL - 4
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: GENE 
Text: {0} 
Answer:
 insulin receptor substrate 1, IRS1, IL - 4