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However , he seems to have led a relatively normal life until September 1828 , when new symptoms such as effusions of blood appeared .
 effusions of blood
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: media, plant, vehicle, astronomical object, time, disease, animal, location, person, organization, mythical figure, food, biology, geographical phenomenon, instrument, event 
Text: {0} 
Answer:
 effusions of blood