22380
Hence , in addition to the classical roles associated with cell - surface receptors ( eg , ligand binding , autophosphorylation of the tyrosine kinase domain , activation of insulin receptor substrate 1 ( IRS - 1 ) and additional substrates , protein - protein interactions with membrane and cytoplasm components ) , new data are consistent with nuclear ( genomic ) role ( s ) for both InsR and IGF1R .
 tyrosine
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 tyrosine