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We demonstrate that: 1) RANTES promoter activity is up-regulated by PMA plus ionomycin , coexpression of the p65 subunit of nuclear factor (NF)-kappa B , the proinflammatory cytokines TNF-alpha and IL-1 beta , and the CD28 costimulatory pathway ; 2) the RANTES promoter region contains four NF-kappa B binding sites at positions -30 , -44 , -213 , and -579 relative to the transcription start site ; 3) one site (-213) is an NF-AT ( nuclear factor of activated T cells ) binding site that also has weak affinity to NF-kappa B , and the most distal site (-579) also serves as a CD28-responsive element ; and 4) mutation on any of those NF-kappa B sites or coexpression of I kappa B alpha ( cytoplasmic inhibitor of NF-kappa B ) markedly reduced the promoter activity .
 transcription start site, RANTES, RANTES, proinflammatory cytokines, NF-AT, NF-kappa B binding sites, I kappa B alpha, IL-1 beta, NF-kappa B, NF-kappa B, RANTES promoter region, NF-kappa B, cytoplasmic inhibitor of NF-kappa B, CD28-responsive element, binding sites, NF-AT ( nuclear factor of activated T cells ) binding site, p65 subunit, NF-kappa B, nuclear factor (NF)-kappa B, CD28, nuclear factor of activated T cells, TNF-alpha, NF-kappa B sites
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: cell line, protein, RNA, DNA, cell type 
Text: {0} 
Answer:
 transcription start site, RANTES, RANTES, proinflammatory cytokines, NF-AT, NF-kappa B binding sites, I kappa B alpha, IL-1 beta, NF-kappa B, NF-kappa B, RANTES promoter region, NF-kappa B, cytoplasmic inhibitor of NF-kappa B, CD28-responsive element, binding sites, NF-AT ( nuclear factor of activated T cells ) binding site, p65 subunit, NF-kappa B, nuclear factor (NF)-kappa B, CD28, nuclear factor of activated T cells, TNF-alpha, NF-kappa B sites