5641
The presence of regulatory sequences for the binding of transcription factors such as NF - kappa B and AP - 2 , whose activation is associated with the immediate response of the cell to an injury , may be an indication of the important role which HO - 1 may play in defense mechanisms against tissue injury .
 NF - kappa B, AP - 2, HO - 1
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: GENE 
Text: {0} 
Answer:
 NF - kappa B, AP - 2, HO - 1