22415
Using cholesterol depletion , pharmacological inhibitors , RNA interference , and dominant - negative mutants , we define the mechanisms involved in perinuclear accumulation of PKC alpha and identify the non - proteasomal mechanism mediating its degradation .
 cholesterol
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 cholesterol