18085
To investigate this behavior , quantum - mechanical calculations using time - dependent density functional theory ( TDDFT ) , coupled with polarizable continuum and / or atomistic models , were performed in combination with spectroscopic measurements of the probe in the different environments , ranging from a homogeneous solution to the minor groove or intercalation pockets of double stranded nucleic acids .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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