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Topology optimization exists as a computational design approach but usually demands a manual interpretation and redesign of a CAD model and may not be applicable to problems such as the design of parts with multiple integrated flows .
 Topology optimization, as, design, CAD model, be, as, design
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: manufacturing standard, machanical property, manufacturing process, material, engineering feature, process parameter, machine or equipment, application, process characterization, enabling technology, biomedical, concept or principle 
Text: {0} 
Answer:
 Topology optimization, as, design, CAD model, be, as, design