2179
A glycine250 - - > aspartate substitution in the alpha - subunit of hexosaminidase A causes juvenile - onset Tay - Sachs disease in a Lebanese - Canadian family .
 Tay - Sachs disease
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 Tay - Sachs disease