23917
The loss of p53 function in tumor cells leads to aberrant cell proliferation , apoptosis , carcinogenesis , and altered sensitivity to chemotherapeutic drugs , while PXR contributes to chemoresistance in many cancer cells .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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