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To determine whether SIX5 deficiency contributes to the myotonic dystrophy phenotype , we disrupted mouse Six5 by replacing the first exon with a beta - galactosidase reporter .
 SIX5 deficiency, myotonic dystrophy
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 SIX5 deficiency, myotonic dystrophy