25808
However , castration - resistant prostate cancer ( CRPC ) resistant to anti - androgens invariably develops and can be associated with AR genomic aberrations ( mutations , amplification ) and / or an increase in AR mRNA expression .
 androgens
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 androgens