20504
Majority of the investigations on phlorotannins derived from brown algae have exhibited their various anti - diabetic mechanisms such as alpha - glucosidase and alpha - amylase inhibitory effect , glucose uptake effect in skeletal muscle , protein tyrosine phosphatase 1B ( PTP 1B ) enzyme inhibition , improvement of insulin sensitivity in type 2 diabetic db / db mice , and protective effect against diabetes complication .
 phlorotannins, glucose, tyrosine
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 phlorotannins, glucose, tyrosine