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Examples of the common techniques used to affix biotin , including amide bond formation , [ 3 + 2 ] cycloadditions through " click " chemistry , Staudinger ligation , and thioether formation will be discussed , along with analysis of the wider applications of synthetic methodology that have been applied toward the biotinylation of small molecules .
 biotin, amide, thioether
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 biotin, amide, thioether