9980
An advanced compound 17m with a 5 - carboxy - 2 - thiazole substructure appended to the spirocyclic piperidine scaffold was developed which satisfied the in vitro and in vivo requirements for more detailed studies .
 5 - carboxy - 2 - thiazole, spirocyclic piperidine
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 5 - carboxy - 2 - thiazole, spirocyclic piperidine