23023
In the pharmacokinetic profiles of 1 ' - hydroxy midazolam , the significant , dose - dependent decrease in AUC0 - infinity was observed except at the dose of 2mg / kg , while AUC0 - infinity reduced by 44 . 5 % ( 8mg / kg ) and 49 . 2 % ( 16mg / kg ) , respectively .
 1 ' - hydroxy midazolam
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 1 ' - hydroxy midazolam