2320
When statistically analyzed in various subgroupings , the obtained average sedimentation coefficients and polydispersity profiles supported the following conclusions : ( a ) loss of proteoglycan aggregation and sedimentability is confirmed to be a primary sign of cartilage matrix degradation ; ( b ) higher S values for proteoglycans of the high weight ( HW ) - bearing areas and lower values for those of the low weight ( LW ) - bearing areas were a typical finding in normal cartilage samples ; ( c ) inversion of this pattern was indicative of matrix degradation , suggesting that the HW regions are more affected than the LW - bearing areas ; ( d ) the average S value distribution across cartilage thickness tended to resemble the corresponding proteoglycan content versus distance from articular surface ; and ( e ) the deepest cartilage layer had , in most cases , the smallest amount of aggregates while the highest average sedimentability was observed at the middle zone of the normal samples .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: GENE 
Text: {0} 
Answer:
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