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Our previous studies pertaining to macrophage response to LPS identified a novel DNA-binding domain located from -550 to -487 in the human TNF-alpha promoter that contains transcriptional activity , but lacks any known NF-kappaB -binding sites .
 TNF-alpha, -binding sites, NF-kappaB, human TNF-alpha promoter, DNA-binding domain
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: cell line, protein, RNA, DNA, cell type 
Text: {0} 
Answer:
 TNF-alpha, -binding sites, NF-kappaB, human TNF-alpha promoter, DNA-binding domain