1379
We conclude that persons with PROS1 gene defects and protein S deficiency are at increased risk of thrombosis and that free protein S estimation offers the most reliable way of diagnosing the deficiency .
 PROS1 gene defects, protein S deficiency, thrombosis
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 PROS1 gene defects, protein S deficiency, thrombosis