5549
MMP - 1 caused activation of the nuclear factor - kappa B ( NF - kappa B ) pathway ( p65 / RelA ) in endothelial cells , and this response was dependent upon activation of protease activated receptor - 1 ( PAR - 1 ) .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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