1949
In hypothalamus of mice administered a high - fat diet , there is a reduction in leptin and insulin - induced Tub - p - tyr and nuclear translocation , which is reversed by reducing protein tyrosine phosphatase 1B expression .
 tyr, tyrosine
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 tyr, tyrosine