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Here we confirm that result , and extend the approach to examine the effect of deleting EXO1 in a mutator variant ( pol1 - L868M ) of Pol alpha , the proofreading - deficient and least accurate of the three nuclear replicases that is responsible for initiating Okazaki fragment synthesis .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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