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Accordingly , loss of pip5k1 beta function in FRDA cells was accompanied by decreased PI ( 4 , 5 ) P2 levels and was shown instrumental for destabilization of the actin network and delayed cell spreading .
 PI ( 4 , 5 ) P2
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 PI ( 4 , 5 ) P2