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Previous characterization of a mutant form of HPRT , HPRTYale , from a subject with the Lesch - Nyhan syndrome revealed normal mRNA and protein concentrations , no residual catalytic activity , and cathodal migration upon PAGE .
 Lesch - Nyhan syndrome
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 Lesch - Nyhan syndrome