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Canavan disease , or spongy degeneration of the brain , is a severe leukodystrophy caused by the deficiency of aspartoacylase ( ASPA ) .
 Canavan disease, spongy degeneration of the brain, leukodystrophy, deficiency of aspartoacylase
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 Canavan disease, spongy degeneration of the brain, leukodystrophy, deficiency of aspartoacylase