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Together , the results suggest a multimodal mechanism of stress stimuli affecting PFKFB3 transcriptional regulation and kinase activation by protein phosphorylation , resulting in an increase in Fru - 2 , 6 - P2 concentration and stimulation of glycolysis in cancer cells .
 Fru - 2 , 6 - P2
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 Fru - 2 , 6 - P2