2735
The transmembrane domains are well conserved, but there is striking sequence divergence of the carboxy-terminal cytoplasmic domain essential for B-cell immortalization and interaction with the tumor necrosis factor receptor signaling pathway .
 B-cell, tumor necrosis factor receptor, carboxy-terminal cytoplasmic domain
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: cell line, protein, RNA, DNA, cell type 
Text: {0} 
Answer:
 B-cell, tumor necrosis factor receptor, carboxy-terminal cytoplasmic domain