2139
A germ line mutation within the coding sequence for the putative 5 - phosphoribosyl - 1 - pyrophosphate binding site of hypoxanthine - guanine phosphoribosyltransferase ( HPRT ) in a Lesch - Nyhan patient : missense mutations within a functionally important region probably cause disease .
 Lesch - Nyhan
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 Lesch - Nyhan