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As AP-1 activity is regulated in part by activation of the c-Jun N-terminal kinase ( JNK ), which phosphorylates and subsequently increases the transcriptional activity of c-Jun, we examined whether LPS treatment of macrophages resulted in activation of this kinase .
 macrophages, kinase, c-Jun N-terminal kinase, JNK, AP-1
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: cell line, protein, RNA, DNA, cell type 
Text: {0} 
Answer:
 macrophages, kinase, c-Jun N-terminal kinase, JNK, AP-1