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Here we show that heterozygous disruption of beclin 1 increases the frequency of spontaneous malignancies and accelerates the development of hepatitis B virus - induced premalignant lesions .
 malignancies, premalignant lesions
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Anatomy 
Text: {0} 
Answer:
 malignancies, premalignant lesions