1666
Patient 1 was homozygous for a complex mutant allele containing two alterations , including a 194C > T transition ( P65L ) and 739A > C transversion ( K247Q ) ; in the case of P65L , the amino acid change does not reduce enzyme activity .
 None
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 None