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Dualism is closely associated with the thought of René Descartes ( 1641 ) , which holds that the mind is a nonphysical - and therefore , non-spatial - substance .
 René Descartes
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: media, plant, vehicle, astronomical object, time, disease, animal, location, person, organization, mythical figure, food, biology, geographical phenomenon, instrument, event 
Text: {0} 
Answer:
 René Descartes