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Alkaptonuria ( AKU ) , the prototypic inborn error of metabolism , has recently been shown to be caused by loss of function mutations in the homogentisate - 1 , 2 - dioxygenase gene ( HGO ) .
 Alkaptonuria, AKU, inborn error of metabolism
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 Alkaptonuria, AKU, inborn error of metabolism