23906
Symptomatic hypoglycemia occurred in 6 , 13 , and 1 patient for lixisenatide morning , evening , and placebo , respectively , with no severe episodes . CONCLUSIONSIn patients with type 2 diabetes inadequately controlled on metformin , lixisenatide 20 mu g once daily administered in the morning or evening significantly improved glycemic control , with a pronounced postprandial effect , and was well tolerated .
 metformin
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 metformin