4288
Animal studies and mechanistic studies indicate that nicotine could play a role in accelerating atherosclerosis , but evidence among humans is too inadequate to be definitive about such an effect .
 nicotine, atherosclerosis
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease, Chemical 
Text: {0} 
Answer:
 nicotine, atherosclerosis