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The full HBV genome or individual HBV open - reading frame ( ORF ) was introduced into HepG2 cells to examine the effect on host genomic stability , DNA repair efficacy in response to double - strand DNA damage , and DNA damage - induced cell death .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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