6939
Conversely , activation of this signaling pathway by expression of a constitutively active MKK1 mutant dramatically increased cyclin D1 promoter activity and cyclin D1 protein expression , in a growth factor - independent manner .
 MKK1 mutant, cyclin D1, cyclin D1 protein
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: GENE 
Text: {0} 
Answer:
 MKK1 mutant, cyclin D1, cyclin D1 protein