10638
In vitro and in vivo metabolic profiling generated a working hypothesis that a bis - sulfonamide metabolite ( determined M1 ) formed by amide hydrolysis caused this toxicity .
 bis - sulfonamide, amide
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 bis - sulfonamide, amide