109554
While loop diuretics remain first-line for most people with heart failure , spironolactone has shown to reduce both morbidity and mortality in numerous studies and remains an important agent for treating fluid retention , edema , and symptoms of heart failure .
 heart failure
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: media, plant, vehicle, astronomical object, time, disease, animal, location, person, organization, mythical figure, food, biology, geographical phenomenon, instrument, event 
Text: {0} 
Answer:
 heart failure