29058
By replacing naphthyl with quinoline moieties , we prepared active analogs with up to a 1400 - fold increase in solubility from 1 .
 naphthyl, quinoline
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
 naphthyl, quinoline