6945
Their inhibitory effects on high - mobility group box 1 ( HMGB1 ) were evaluated using a cell - based lipopolysaccharide ( LPS ) induced tumor necrosis factor alpha ( TNF - alpha ) release study .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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