5347
Two explanations for hyporesponsiveness of the human iNOS promoter to LPS +/- IFN-gamma were found: (1) multiple inactivating nucleotide substitutions in the human counterpart of the enhancer element that has been shown to regulate LPS / IFN-gamma induced expression of the mouse iNOS gene ; and (2) and absence of one or more nuclear factors in human macrophages (e.g., an LPS -inducible nuclear factor-kappa B/ Rel complex ), that is (are) required for maximal expression of the gene.
 iNOS, LPS -inducible nuclear factor-kappa B/ Rel complex, nuclear factors, IFN-gamma, IFN-gamma, human iNOS promoter, iNOS, human macrophages, Rel, mouse iNOS gene, enhancer element
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: cell line, protein, RNA, DNA, cell type 
Text: {0} 
Answer:
 iNOS, LPS -inducible nuclear factor-kappa B/ Rel complex, nuclear factors, IFN-gamma, IFN-gamma, human iNOS promoter, iNOS, human macrophages, Rel, mouse iNOS gene, enhancer element