11439
Current evidence for this type of DNA supercoiling - dependent transcriptional coupling , based largely on the in vivo activities of promoters contained in engineered DNA constructs , suggests that the transcription complex must be physically hindered to generate DNA supercoils and to prevent their diffusion throughout the DNA duplex .
 None
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: GENE 
Text: {0} 
Answer:
 None