4829
Analysis of the ARSA gene in this patient revealed heterozygosity for two new mutant alleles in one allele , deletion of C 447 in exon 2 leads to a frameshift and to a premature stop codon at amino acid position 105 ; in the second allele , a G - - > A transition in exon 5 causes a Gly309 - - > Ser substitution .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
 None