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To evaluate the fine solvation structure near the solute by incorporating the long - range solute - solvent Coulombic interaction with low computational cost , we introduced the dual solvent box protocol ; one small box with the fine spacing is employed for the first and the second solvation shells and the other large box with the normal spacing is employed for long - range solute - solvent interaction .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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