4823
One mutation , detected by the abnormal pattern of migration of an amplified fragment , is a C to T transition in the splice acceptor site of intron 10 , which resulted in the skipping of exon 11 with the premature termination of RNA translation downstream from exon 12 ( - 3 IVS10 ) .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Disease 
Text: {0} 
Answer:
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