6769
In contrast , when the isoform containing the C epsilon4 domain joined directly to the M2 exon ( IgE grande ) is expressed in the J558L cell line , it is degraded intracellularly , suggesting a cell line - dependent regulation of secretion .
 IgE grande
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: GENE 
Text: {0} 
Answer:
 IgE grande