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Our studies demonstrate for the first time that CD3 antigen-derived signals and CD2 antigen -derived signals are synergistic in inducing the emergence of transcription factors that bind to the NF-AT1 , AP-1 , and NF-kB sites located in the promoter/enhancer region of the IL-2 gene.
 IL-2, CD2 antigen, promoter/enhancer region, transcription factors, CD3
Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: cell line, protein, RNA, DNA, cell type 
Text: {0} 
Answer:
 IL-2, CD2 antigen, promoter/enhancer region, transcription factors, CD3