3252
The mechanism of caffeine seems to involve the inhibition of the extracellular signal - regulated kinase 1 / 2 ( ERK1 / 2 ) , p38 , and Akt , leading to a marked decrease in adenosine - induced HIF - 1alpha accumulation , VEGF transcriptional activation , and VEGF and IL - 8 protein accumulation .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Anatomy 
Text: {0} 
Answer:
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