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In the late 15th century , he commissioned the Italian painter Bernardino di Betto ( Pinturicchio ) and his studio to decorate them with fresco s. The paintings and frescoes , which were executed between 1492 and 1494 , drew on a complex iconographic program that used themes from medieval encyclopedias , adding an eschatological layer of meaning and celebrating the supposedly divine origins of the Borgias .
 Bernardino di Betto ( Pinturicchio )
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 Bernardino di Betto ( Pinturicchio )