11757
In the simulated hypothetical trials , the impact of different dosing strategies ( i . e . , the fixed dose versus the weight - based per kilogram dose ) , sample size , and scenarios governing the drug exposure - response relationship ( e . g . , E max , ED 50 , and SD ) was also evaluated .
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Please list all entity words in the text that fit the category. Output format is "word1, word2". 
Option: Chemical 
Text: {0} 
Answer:
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