10163
Methotrexate - associated nephropathy is a rare complication in pediatric oncology , and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development .
 adverse effect: nephropathy, Methotrexate
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: nephropathy, Methotrexate