1885
Prolonged responses were achieved with low doses of HU ( 3 - 10 mg / kg / day ) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb .
 adverse effect: hepatic toxicity, HU; adverse effect: mild reversible hematologic, HU
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: hepatic toxicity, HU; adverse effect: mild reversible hematologic, HU