2078
Although high - dose methotrexate has been shown to be useful in the treatment of primary osteogenic sarcoma , the tumoricidal effects of therapy appear to have caused a fatal rise in intracranial pressure .
 adverse effect: fatal rise in intracranial pressure, methotrexate
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: fatal rise in intracranial pressure, methotrexate