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A 53-year - old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once / day to 4 mg twice / day .
 adverse effect: lower leg edema, rosiglitazone
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: lower leg edema, rosiglitazone