9050
We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature , emphasizing the risk factors associated with this manifestation .
 adverse effect: methotrexate toxicity, methotrexate; adverse effect: painful erosions of their psoriasis, methotrexate
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: methotrexate toxicity, methotrexate; adverse effect: painful erosions of their psoriasis, methotrexate