2262
However , there remain questions concerning whether these drugs , especially methimazole ( MMI ) , may be associated with aplasia cutis congenita ( ACC ) and how best to avoid impairment of fetal thyroid function during their use .
 adverse effect: ACC, methimazole; adverse effect: ACC, MMI; adverse effect: aplasia cutis congenita, methimazole; adverse effect: aplasia cutis congenita, MMI
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: ACC, methimazole; adverse effect: ACC, MMI; adverse effect: aplasia cutis congenita, methimazole; adverse effect: aplasia cutis congenita, MMI