4123
To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy , we conducted a retrospective survey of 25 additional patients with Wilson 's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine .
 adverse effect: neurologic disease, penicillamine; adverse effect: neurologic worsening, penicillamine
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: neurologic disease, penicillamine; adverse effect: neurologic worsening, penicillamine