3400
Although risk factors for MTX - induced pulmonary toxicity are poorly understood , the presence in 3 out of 5 of our patients of pre - existing lung disease , represented by diffuse interstitial changes on chest X - ray , and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis .
 adverse effect: pneumonitis, MTX; adverse effect: pulmonary toxicity, MTX
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: pneumonitis, MTX; adverse effect: pulmonary toxicity, MTX