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Four years after the beginning of IFN therapy , he acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody , and then 28 units / day of insulin injection was started .
 adverse effect: moderate hyperglycemia, IFN; adverse effect: severe ketonuria, IFN
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: moderate hyperglycemia, IFN; adverse effect: severe ketonuria, IFN