5453
OBJECTIVE : To test the hypothesis that tumor necrosis factor ( TNF ) - alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin - induced lipoatrophies of a diabetic patient who presented extensive lesions .
 adverse effect: lipoatrophies, insulin
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: lipoatrophies, insulin