3641
Well - known signs of methotrexate toxicity include bone marrow suppression and oral and gastrointestinal ulceration .
 adverse effect: bone marrow suppression, methotrexate; adverse effect: methotrexate toxicity, methotrexate; adverse effect: oral and gastrointestinal ulceration, methotrexate
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: bone marrow suppression, methotrexate; adverse effect: methotrexate toxicity, methotrexate; adverse effect: oral and gastrointestinal ulceration, methotrexate