747
The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis , and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities , the combination use of these drugs should be avoided .
 adverse effect: fatal toxicities, itraconazole; adverse effect: fatal toxicities, vincristine
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: fatal toxicities, itraconazole; adverse effect: fatal toxicities, vincristine