2366
We describe a 57-year - old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy ( bleomycin and methotrexate ) used to treat a metastatic squamous cell carcinoma of the hypopharynx .
 adverse effect: acute digital ischemia, bleomycin; adverse effect: acute digital ischemia, methotrexate; adverse effect: gangrene, bleomycin; adverse effect: gangrene, methotrexate
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: acute digital ischemia, bleomycin; adverse effect: acute digital ischemia, methotrexate; adverse effect: gangrene, bleomycin; adverse effect: gangrene, methotrexate