12226
A 66-year - old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D - penicillamine ( D - Pen ) treatment , although the leukopenia was not markedly severe .
 adverse effect: anemia, D - Pen; adverse effect: anemia, D - penicillamine; adverse effect: thrombocytopenia, D - Pen; adverse effect: thrombocytopenia, D - penicillamine
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: anemia, D - Pen; adverse effect: anemia, D - penicillamine; adverse effect: thrombocytopenia, D - Pen; adverse effect: thrombocytopenia, D - penicillamine