5436
A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate .
 adverse effect: brainstem herniation, methotrexate; adverse effect: fatal cerebral edema, methotrexate
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: brainstem herniation, methotrexate; adverse effect: fatal cerebral edema, methotrexate