8413
There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea .
 adverse effect: CML, hydroxyurea
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: CML, hydroxyurea