8085
OBSERVATIONS : We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll - like receptor ( TLR ) 7 agonist imiquimod .
 adverse effect: aggravation and spreading of a psoriatic plaque, imiquimod
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: aggravation and spreading of a psoriatic plaque, imiquimod