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We highlight two instances of systemic allergic reaction , and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use .
 adverse effect: systemic allergic reaction, aprotinin
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: systemic allergic reaction, aprotinin