3889
Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin - D ( NSC-3053 ) and mithramycin ( NSC-24559 ) .
 adverse effect: Exacerbations of the heart failure, actinomycin - D; adverse effect: Exacerbations of the heart failure, mithramycin; adverse effect: Exacerbations of the heart failure, NSC-24559; adverse effect: Exacerbations of the heart failure, NSC-3053
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: Exacerbations of the heart failure, actinomycin - D; adverse effect: Exacerbations of the heart failure, mithramycin; adverse effect: Exacerbations of the heart failure, NSC-24559; adverse effect: Exacerbations of the heart failure, NSC-3053