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Based upon the observed fall of the filtration fraction , the rise in the relative clearance of 99Tc - dimercaptosuccinic acid and the increase in proteinuria , we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity .
 adverse effect: fall of the filtration fraction, cyclosporine A; adverse effect: increase in proteinuria, cyclosporine A; adverse effect: nephrotoxicity, cyclosporine A; adverse effect: rise in the relative clearance of 99Tc - dimercaptosuccinic acid, cyclosporine A
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: fall of the filtration fraction, cyclosporine A; adverse effect: increase in proteinuria, cyclosporine A; adverse effect: nephrotoxicity, cyclosporine A; adverse effect: rise in the relative clearance of 99Tc - dimercaptosuccinic acid, cyclosporine A