3714
In patients with cirrhosis , the metabolism of meperidine is decreased , leading to accumulation of the parent drug and possible CNS depressive effects similar to hepatic encephalopathy .
 adverse effect: accumulation of the parent drug, meperidine; adverse effect: CNS depressive effects, meperidine
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: accumulation of the parent drug, meperidine; adverse effect: CNS depressive effects, meperidine