12435
Retrospectively , bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D - penicillamine , which was the subject of an abundance of reports of mammary hyperplasia .
 adverse effect: giant hypertrophy, bucillamine; adverse effect: mammary hyperplasia, D - penicillamine
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: giant hypertrophy, bucillamine; adverse effect: mammary hyperplasia, D - penicillamine