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Exposure of the fetus to indomethacin by administration of the drug to the mother may cause many side effects , including premature closure of the ductus arteriosus .
 adverse effect: premature closure of the ductus arteriosus, indomethacin
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: premature closure of the ductus arteriosus, indomethacin