3524
This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure .
 adverse effect: ductal closure, indomethacin; adverse effect: hypoxia, indomethacin
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: ductal closure, indomethacin; adverse effect: hypoxia, indomethacin