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A 10-year - old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high - dose methotrexate ( MTX ) ( 12 g / m2 ) , and went on to develop acute renal failure with life - threatening hyperkalemia 29 hours later .
 adverse effect: acute renal failure, methotrexate; adverse effect: acute renal failure, MTX; adverse effect: elevation of aspartate aminotrasferase, methotrexate; adverse effect: elevation of aspartate aminotrasferase, MTX; adverse effect: renal toxicity, methotrexate; adverse effect: renal toxicity, MTX
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: acute renal failure, methotrexate; adverse effect: acute renal failure, MTX; adverse effect: elevation of aspartate aminotrasferase, methotrexate; adverse effect: elevation of aspartate aminotrasferase, MTX; adverse effect: renal toxicity, methotrexate; adverse effect: renal toxicity, MTX