8472
In this report , two newborns with congenital heart anomalies demonstrated the harlequin color change , one whose skin findings showed a course related to the dose of systemic prostaglandin E1 , suggesting a possible association .
 adverse effect: harlequin color change, prostaglandin E1
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: harlequin color change, prostaglandin E1