Wistert, still being a minor league baseball player, played for a short while in Major League Baseball, playing in three games for the Cincinnati Reds between September 11, 1934 and September 25, 1934. In two times he pitched, Wistert let only one run in eight innings, for a career earned run average of 1.13. Though, in the three times he batted, he went did not hit the ball, so he struck out twice. Although he only played for a short while in Major League Baseball, Wistert played five years of professional baseball. Fellow 1933 Michigan Wolverines football All-American, Ted Petoskey also debuted for the Reds in September 1934.