A lot of people in the real world think that Sheldon has Asperger syndrome but some people think he doesn’t. Bill Prady and Chuck Lore have said he doesn’t. Jim Parsons said that he didn’t think Sheldon was Autistic when he started playing him but after reading John Elder Robison’s book about having Asperger’s, Parsons thinks Sheldon is Autistic. When Dr. Neil deGrasse Tyson asked Dr. Mayim Bialik if Sheldon were Autistic she said “the show doesn’t pathologize its characters”. 