Mel Burke (Melissa Joan Hart) lives in Toledo, Ohio. She is a politician there. Her sister and brother-in-law ran a Ponzi scheme. The sister is in prison and the brother-in-law is on the run. This leaves her niece Lennox and her nephew Ryder without their parents to take care of them. Mel takes them into her home. However, Joe Longo (Joey Lawrence) used to work for Mel's brother-in-law and lost everything he had including his car, money, house and his wife who left him. He tries to find a job. Mel finds it hard to handle her own life including parenting her niece and nephew. She hires Joe to become the family's new male nanny, or "manny".