Even back in the 17th century, people disagreed about animal testing. In 1655, Edmund O'Meara said that "the miserable torture of vivisection places the body in an unnatural state." O'Meara and others said that animals could be affected by pain during vivisection, making results unreliable. Others also disliked animal testing because they felt that animals should not be hurt for humans. Others opposed animal testing for different reasons: many believed that animals were not as good as humans and that they were so different that results of animal testing would not work on humans.