Sané signed a 5-year contract with Premier League club Manchester City on August 2, 2016. The transfer fee was £37 million. It included add-ons based on performance. The deal could be worth as much as £46.5 million. He made his debut with the club on September 10, 2016. The team played against Manchester United in the Manchester derby. On December 18, 2016, he scored his first goal for the club. It was during the Premier League match against Arsenal. He did not play in the 2017 FIFA Confederations Cup because he had to have surgery for a nasal congestion problem.