He was married to Dorothy Harvey from 1925 until they divorced in 1926. Then he married Lesley Black from 1937 until they divorced in 1945. Thirdly he married Enrica Soma from 1950 until her death in 1969. Lastly he married Celeste Shane from 1972 until they divorced in 1977. He was partners with Zoe Sallis. Huston had 5 children (one is adopted), including Anjelica Huston.