A United States Department of Defense official has announced that Mansour was killed in a U.S. drone strike in Ahmad Wal, Pakistan while driving his car to visit his family get medical treatment for some of his injuries on 21 May 2016, at the age of 62. He was succeeded by his first deputy, Hibatullah Akhundzada, who successfully retook power over Afghanistan following the Fall of Kabul on 15 August 2021.