In 2013, Khan joined Pakistani news channel News One. In 2014, following a brief stint at PTV, she joined Dawn News presenting the current affairs show "In Focus". In May 2015, she began to host "The Reham Khan Show", a programme celebrating Pakistani heroes. In December 2015, she started a new talk show by the name of "Tabdeeli" on Neo TV. "Tabdeeli" (change) is also a political slogan of Imran Khan, her former husband.