On 6 October 2020 Struber became head coach of Major League Soccer team New York Red Bulls. The Red Bulls paid an unknown sum to Barnsley in order to sign him. Struber made his coaching debut for the club in a 3–2 MLS Cup Playoffs loss against the Columbus Crew on 21 November. At the end of the season they were in the play-offs but lost the first round after a 0:0 with 0:1 in extra time versus Philadelphia Union.