Sané signed a 3-year professional contract with Schalke 04 in 2014. He made his Bundesliga debut against VfB Stuttgart on April 20, 2014. He was subbed on in the 77th minute, replacing Max Meyer in a 3-1 loss. He scored his first goal on December 13, 2014 in a 2-1 loss against 1. FC Köln. He scored his first UEFA Champions League goal in a 4-3 win against Real Madrid on March 11, 2015.