On December 19, 2010, Flynn made his first NFL start against the New England Patriots because starting quarterback Aaron Rodgers was hurt. Flynn threw three touchdown passes. He threw one each to John Kuhn, James Jones and Greg Jennings against New England. He also threw an interception that was returned for a touchdown by Kyle Arrington. The Packers lost the game 31-27. Flynn completed 23 of 37 passes for 254 yards in the loss, and was praised for his good work