Only 2 infectious diseases have been eradicated: smallpox has been eradicated in humans and rinderpest has been eradicated in ruminants. smallpox is the only human disease that ha been eradicated. Former President of the United States of America Carter wants to make Guinea Worm the 2nd eradicated human disease. The Carter Center's International Task Force for Disease Eradication (ITFDE) works to achieve this goal.