Lindsay (played by Ashley C. Williams) and Jenny (played by Ashlynn Yennie) are two American girls who are on holiday in Germany. They are kidnapped by a mad doctor called Dr. Heiter (played by Dieter Laser) after their car breaks down and they go to his house to look for help. The doctor Heiter then kidnaps a Japanese man named Katsuro (played by Akihiro Kitamura). The doctor tells the three that he is world-famous for separating conjoined twins, but wants to join people together so they share a single digestive system. He tells the three how he will connect his three victims together mouth-to-anus. Lindsay tries to escape, but is captured before she can get away. The doctor then sews the three together; he sews Lindsays's mouth to Katsuro's anus, and Jenny's mouth to Lindsay's anus. This means that when he feeds Katsuro food, Katsuro defecates into Lindsay's mouth, and Lindsay defecates her feces into Jenny's mouth.