The practice of Inoculation was first used in England after an ambassador's wife witnessed it in Constantinople. Her name was Lady Mary Wortley Montague and she was impressed by the benefits. She had lost her son, and bore scars of the virus herself. When an epidemic of smallpox occurred in England in 1721, she ordered that her daughter be inoculated. Many people visited her daughter, and were impressed at the results of inoculation. Eventually, inoculation was tested in Newgate Prison. This was before the members of the royal family were inoculated. After the success in England, many European countries began to use inoculation against smallpox.