You need an awful lot of persuading to get doctors to start to use a new medicine and a classic example was of the treatment of depression, where the pharmaceutical manufacturers started to produce tablets which were very effective in stopping depression, not just feeling a bit blue but actual serious clinical depression where the person's sat in the corner and stared at the wall and did nothing — I mean really serious depression — doctors took a long time to realize that there was an effective treatment for that and to start to prescribe it, and in fact actually doctors in Britain are rather good in that we prescribe many more effective treatments for depression, we diagnose it more often, and this  we believe in our office that this is one of the reasons why the suicide rate has gone down in Britain quite dramatically in the last few years, because depression, which is obviously one of the main causes of suicide, is being effectively treated.