The plot focuses on a world where alchemy is a main form of science. Edward Elric and his brother Alphonse, fail to resurrect their mother. When Alphonse's body is destroyed, Edward sacrifices his arm and leg during the alchemy in order for Alphonse's soul to be transferred in a suit of armour. Their friend, Winry Rockbell, makes prosthetic parts for Edward's limbs. As the series progresses, the brothers solve the case about the Philosopher's Stone, a forbidden material breaking the law of Equivalent Exchange.