For the 2004–05 fiscal year, the university spent $561.3 million on research. Of Cornell's units, the largest amount of this funding went to the colleges of Medicine ($164.2 million), Agriculture and Life Sciences ($114.5 million), Arts and Sciences ($80.3 million), and Engineering ($64.8 million). The money comes largely from federal sources, with federal investment of $381.0 million. The federal agencies that invest the most money are the Department of Health and Human Services and the National Science Foundation that make up, respectively, 51.4% and 30.7% of all federal investment in the university. Cornell was on the top-ten list of U.S. universities receiving the most patents in 2003, and was one of the nation's top five institutions in forming start-up companies. In 2004–05, Cornell received 200 invention disclosures, filed 203 U.S. patent applications, completed 77 commercial license agreements, and distributed royalties of more than $4.1 million to Cornell units and inventors.