At the age of thirteen, she went to North Bend, Ohio to live with her father and the stepmother. After few years, she met William Harrison, a young army officer. She married him on 25th November 1795. The couple had six sons and four daughters: Elizabeth Bassett "Betsy" (1796 - 1846), John Cleves Symmes (1798 - 1830), Lucy Singleton (1800 - 1826), William Henry, Jr. (1802 - 1838), John Scott (1804 - 1878), Benjamin (1806 - 1840), Mary Symmes (1809 - 1842), Carter Bassett (1811 - 1839), Anna Tuthill (1813 - 1845), and James Findlay (1814 - 1817).