In the 2010 Kansas Republican primary for the 4th District Congressional seat, Pompeo defeated State Senator Jean Schodorf (who received 24%), Wichita businessman Wink Hartman (who received 23%), and small business owner Jim Anderson (who received 13%). In the general election, Pompeo defeated Democratic nominee State Representative Raj Goyle. Pompeo received 59% of the vote (117,171 votes), to 36% for Goyle (71,866).