Barrymore was born on February 15, 1882 in Philadelphia, Pennsylvania. He was married to Katherine Corri Harris from 1910 until they divorced in 1917. Then he was married to Blanche Oelrichs from 1920 until they divorced in 1925. Then he was married to Dolores Costello from 1928 until they divorced in 1934. Then he was last married to Elaine Barrie from 1936 until they divorced in 1940. Barrymore had three children. Barrymore died on May 29, 1942 in Los Angeles, California from cirrhosis, aged 60.