The first area of the brain to be affected by Alzheimer's is the "transentorhinal region" which is part of the "medial temporal lobe" located deep within the brain. Neurons start dying in this area first. It then spreads into the adjacent entorhinal cortex (EC) which acts as a central hub, for a widespread network that handles signals for memory and movement(like a main train station with train tracks going to different areas). 