On 21 June 2019, RB Leipzig announced that Nagelsmann would be their coach from the 2019–20 season and signed a four-year contract which would expire in 2023. Nagelsmann won his first Bundesliga match as RB Leipzig coach against FC Union Berlin 4–0, he also led Leipzig to a 1–1 draw against FC Bayern Munich. On match-day 10 Leipzig won against Mainz 8–0. Nagelsmann faced his former club Hoffenheim on match-day 14 and won 3–1 against them.