Wu 's hypothesis was also advanced independently in 1936 by Mirsky and Linus Pauling .
In 1929 , Hsien Wu hypothesized correctly that denaturation corresponded to protein unfolding , a purely conformational change that resulted in the exposure of amino - acid side chains to the solvent .
Hsien Wu 's hypothesis was also advanced independently in 1936 by Mirsky and Linus Pauling .
In 1929 , Hsien Wu hypothesized correctly that denaturation corresponded to protein unfolding , a purely conformational change that resulted in the exposure of amino - acid side chains to the solvent .