For example , ADAM10 can cut off part of the HER2 receptor , thereby activating it .
Those ADAMs which are active proteases are classified as sheddases because they cut off or shed extracellular portions of transmembrane proteins .
ADAM10 can cut off part of the HER2 receptor , thereby activating it .
Those ADAMs which are active proteases are classified as sheddases because they cut off or shed extracellular portions of transmembrane proteins .