September 22 -- Pope Pius III ( Francesco Todeschini Piccolomini ) succeeds Alexander VI as the 215th pope .
September 22 -- Pope Pius III ( Francesco Todeschini Piccolomini ) dies on October 18 .
September 22 -- Pope Pius III ( Francesco Todeschini Piccolomini ) succeeds Alexander VI as the 215th pope , but dies on October 18 .