The first USFDA NDA failed to gain approval .
The first USFDA NDA was followed by a pair of NDAs ( one for alogliptin and a second for a combination of alogliptin and pioglitazone ) in July 2011 .
The first USFDA NDA failed to gain approval and was followed by a pair of NDAs ( one for alogliptin and a second for a combination of alogliptin and pioglitazone ) in July 2011 .