For example , soft substrates promote neuroepithelial conversion while inhibiting neural crest differentiation of hESCs in a BMP4 - dependent manner .
Substrate rigidity is an important biophysical cue influencing neural induction and subtype specification .
Soft substrates promote neuroepithelial conversion while inhibiting neural crest differentiation of hESCs in a BMP4 - dependent manner .
Substrate rigidity is an important biophysical cue influencing neural induction and subtype specification .