Nevertheless , mouse ME - CRCs grown in a three - dimensional extracellular matrix gave rise to mammary acinar structures .
However , the expression of certain mammary progenitor subpopulations , such as CD49f+ ESA+ CD44+ , drops significantly in later passages .
Mouse ME - CRCs grown in a three - dimensional extracellular matrix gave rise to mammary acinar structures .
However , the expression of certain mammary progenitor subpopulations , such as CD49f+ ESA+ CD44+ , drops significantly in later passages .