Soon after the discovery of the mechanism of action of NSAIDs , strong indications emerged for alternative forms of COX , but little supporting evidence was found .
The impetus for development of selective COX - 2 inhibitors was the adverse gastrointestinal side - effects of NSAIDs .
Soon after the discovery of the mechanism of action of NSAIDs , strong indications emerged for alternative forms of COX - 2 , but little supporting evidence was found .
The impetus for development of selective COX - 2 inhibitors was the adverse gastrointestinal side - effects of NSAIDs .