It is known that a SO NHCOCH moiety as in parecoxib is 10 -- 10 more reactive acetylating agent of enzyme serine hydroxyl groups than simple amides .
Parecoxib is a prodrug for valdecoxib .
It is known that a SO NHCOCH moiety as in parecoxib , which is a prodrug for valdecoxib , is 10 -- 10 more reactive acetylating agent of enzyme serine hydroxyl groups than simple amides .