Specifically , the covalent binding of either the ovalicin or fumagillin epoxide moiety to the active site histidine residue of MetAP2 has been shown to inactivate the enzyme , thereby inhibiting angiogenesis .
Numerous studies implicate MetAP2 in angiogenesis .
The covalent binding of either the ovalicin or fumagillin epoxide moiety to the active site histidine residue of MetAP2 has been shown to inactivate the enzyme , thereby inhibiting angiogenesis .
Numerous studies implicate MetAP2 in angiogenesis .