Later it passed into the hands of the Alexander the Great , the Hellenistic Seleucid Empire , the Greco - Bactrians , and the Kushan Empire .
Bukhara entered history in 500 BCE as a vassal state or satrapy in the Persian Empire .
Later Bukhara passed into the hands of the Alexander the Great , the Hellenistic Seleucid Empire , the Greco - Bactrians , and the Kushan Empire .
Bukhara entered history in 500 BCE as a vassal state or satrapy in the Persian Empire .