As a result of PKM2 inactivation , glucose flux is no longer converted into pyruvate .
As a result of PKM2 inactivation , glucose flux is no longer is instead utilized in the pentose phosphate pathway , resulting in the reduction and detoxification of ROS .
As a result of PKM2 inactivation , glucose flux is no longer converted into pyruvate , but is instead utilized in the pentose phosphate pathway , resulting in the reduction and detoxification of ROS .