The ATPase domain also contains regions responsible for protein - protein interactions with host cell proteins , most notably topoisomerase 1 and the cell cycle regulator p53 .
Energy from ATP hydrolysis is required for helicase activity .
The ATP domain also contains regions responsible for protein - protein interactions with host cell proteins , most notably topoisomerase 1 and the cell cycle regulator p53 .
Energy from ATP hydrolysis is required for helicase activity .