When antibiotics are introduced to the medium , they bind to the transpeptidation domain .
When antibiotics are introduced to the medium , they inhibit the ability of PBPs to cross-link muropeptides , therefore preventing the formation of stable cell wall .
When antibiotics are introduced to the medium , they bind to the transpeptidation domain and inhibit the ability of PBPs to cross-link muropeptides , therefore preventing the formation of stable cell wall .