In 1991 the existence of the COX - 2 enzyme was confirmed by being cloned by Dr. Dan Simmons at Brigham Young University .
COX enzyme proved to be difficult to purify and was not sequenced until 1988 .
In 1991 the existence of the COX     enzyme was confirmed by being cloned by Dr. Dan Simmons at Brigham Young University .
COX enzyme proved to be difficult to purify and was not sequenced until 1988 .