The microcirculatory problems in the retina of people with diabetes can cause retinal ischaemia and a switch in the balance of pro-angiogenic VEGF isoforms over the normally expressed VEGF b isoforms .
Retinal ischaemia results in the release of VEGF - A .
The microcirculatory problems in the retina of people with diabetes can cause retinal ischaemia , which results in the release of VEGF - A , and a switch in the balance of pro-angiogenic VEGF isoforms over the normally expressed VEGF b isoforms .