A direct link between chromatin function and acetylation was established by the discovery that co-activator complexes were required for transcriptional activation function as histone acetyltransferases , .
Co-repressors containing histone deacetylases confer transcriptional repression .
A direct link between chromatin function and acetylation was established by the discovery that co-activator complexes were required for transcriptional activation function as histone acetyltransferases , whereas co-repressors containing histone deacetylases confer transcriptional repression .