Patients with chronic renal insufficiency appear to have 43 % lower plasma concentration compared to healthy individuals , with a 47 % increase in apparent clearance .
Plasma concentration can be expected that patients with mild to moderate hepatic impairment have increased steady - state AUC .
Patients with chronic renal insufficiency appear to have 43 % lower plasma concentration compared to healthy individuals , with a 47 % increase in apparent clearance , and it can be expected that patients with mild to moderate hepatic impairment have increased steady - state AUC .