Thus , depending on the dose , the ratio of fat and liver tissue concentrations may vary considerably in rodents .
In rat liver , however , high doses cause induction of CYP1A2 enzyme , and this binds dioxins .
Depending on the dose , the ratio of fat and liver tissue concentrations may vary considerably in rodents .
In rat liver , however , high doses cause induction of CYP1A2 enzyme , and this binds dioxins .