Arg513 is thought to be a key residue for diaryl heterocycle inhibitors such as the coxibs .
This side - pocket allows for interactions with Arg513 , which is a replacement for His513 of COX - 1 .
replacement is thought to be a key residue for diaryl heterocycle inhibitors such as the coxibs .
This side - pocket allows for interactions with Arg513 , which is a replacement for His513 of COX - 1 .