The Argonaute proteins ( Ago1 - 4 ) , which are essential for miRNA - directed repression , appear to be necessary for miR - 122 to regulate HCV .
MiR - 122 overexpression may overcome this requirement .
The Argonaute proteins ( Ago1 - 4 ) , which are essential for miRNA - directed repression , appear to be necessary for miR - 122 to regulate HCV , although miR - 122 overexpression may overcome this requirement .