Regarding the free - energy penalty for the cyclol reaction , Wrinch disagreed with Pauling 's calculations .
Regarding the free - energy penalty for the cyclol reaction , Wrinch stated that too little was known of intramolecular energies to rule out the cyclol model on that basis alone .
Regarding the free - energy penalty for the cyclol reaction , Wrinch disagreed with Pauling 's calculations and stated that too little was known of intramolecular energies to rule out the cyclol model on that basis alone .