He explores Central America , and discovers St. Lucia ( possibly ) , the Isthmus of Panama , Honduras , and Costa Rica .
May 11 -- Christopher Columbus leaves Cadiz , Spain for his fourth and final trip to the New World .
Christopher Columbus explores Central America , and discovers St. Lucia ( possibly ) , the Isthmus of Panama , Honduras , and Costa Rica .
May 11 -- Christopher Columbus leaves Cadiz , Spain for his fourth and final trip to the New World .