Prasugrel , like its precursors is a pro-drug .
Pro-drug 's 's metabolism starts in the pro-drug Prasugrel it is metabolized by esterase into a thiolactone , this inactive intermediate then undergoes CYP - mediated ring opening , mainly by CYP3A4 and CYP2B6 to the active metabolite .
Prasugrel , like its precursors is a pro-drug but its metabolism starts in the intestines where it is metabolized by esterase into a thiolactone , this inactive intermediate then undergoes CYP - mediated ring opening , mainly by CYP3A4 and CYP2B6 to the active metabolite .