This release leads to a conformational change in 7SK RNA and the ejection of HEXIM .
P - TEFb can be released from the 7SK snRNP by either the HIV transactivator Tat or the bromodomain containing protein BRD4 .
This release leads to a conformational change in 7SK snRNP   and the ejection of HEXIM .
P - TEFb can be released from the 7SK snRNP by either the HIV transactivator Tat or the bromodomain containing protein BRD4 .