As medifoxamine is metabolized extensively in the liver during first - pass metabolism .
As these metabolites have as much as 3-fold greater activity relative to medifoxamine , it is likely that they contribute significantly to the pharmacology of the parent drug .
As medifoxamine is metabolized extensively in the liver during first - pass metabolism , and as these metabolites have as much as 3-fold greater activity relative to medifoxamine , it is likely that they contribute significantly to the pharmacology of the parent drug .