Some cancer cells that lack the tumor suppressor PTEN may be sensitive to PARP inhibitors because of downregulation of Rad51 although other data suggest PTEN may not regulate Rad51 .
Downregulation of Rad51 is a critical homologous recombination component .
Some cancer cells that lack the tumor suppressor PTEN may be sensitive to PARP inhibitors because of downregulation of Rad51 , a critical homologous recombination component , although other data suggest PTEN may not regulate Rad51 .