Although these experiments were conducted using genotype 1a and 1b HCV RNA and miR - 122 is also required for replication of infectious type 2a HCV .
Genotype 1a and 1b HCV RNA is the miR - 122 binding sites are highly conserved across different genotypes .
Although these experiments were conducted using genotype 1a and 1b HCV RNA , the miR - 122 binding sites are highly conserved across different genotypes , and miR - 122 is also required for replication of infectious type 2a HCV .