The Sox opened the season against the Cleveland Indians at home on April 5 and closed the season also against the Indians at home on October 3 .
The 2010 Chicago White Sox season was the organization 's 111th season in Chicago and 110th in the American League .
The Chicago White Sox opened the season against the Cleveland Indians at home on April 5 and closed the season also against the Indians at home on October 3 .
The 2010 Chicago White Sox season was the organization 's 111th season in Chicago and 110th in the American League .