However , this could create problems with circularizing the DNA fragments since these fragments would be very long , and would also lose the flexibility in choice of end points that one gets in partial digests .
This would significantly reduce the number of clones from millions to thousands .
This could create problems with circularizing the DNA fragments since these fragments would be very long , and would also lose the flexibility in choice of end points that one gets in partial digests .
This would significantly reduce the number of clones from millions to thousands .