From Oklahoma to Little Rock , Interstate 40 generally follows U.S. Route 64 through the Ozark Mountains .
For the majority of its routing through Arkansas , I - 40 follows the historic alignment of two separate United States highways .
From Oklahoma to Little Rock , I - 40   generally follows U.S. Route 64 through the Ozark Mountains .
For the majority of its routing through Arkansas , I - 40 follows the historic alignment of two separate United States highways .