However , even the smallest proteins have over 1000 atoms , which makes determining their structure far more complex .
X-ray crystallography had just begun as a discipline in 1911 , and had advanced relatively rapidly from simple salt crystals to crystals of complex molecules such as cholesterol .
Even the smallest proteins have over 1000 atoms , which makes determining their structure far more complex .
X-ray crystallography had just begun as a discipline in 1911 , and had advanced relatively rapidly from simple salt crystals to crystals of complex molecules such as cholesterol .