PTEN works by dephosphorylating PIP3 to PIP2 which limits AKTs ability to bind to the membrane , decreasing its activity .
Knocking out PTEN has been shown to increase the mass of the brain because of the unregulated proliferation that occurs .
PTEN works by dephosphorylating PIP3 to PIP2 which limits AKTs ability to bind to the membrane , decreasing PTEN 's activity .
Knocking out PTEN has been shown to increase the mass of the brain because of the unregulated proliferation that occurs .