From the passage of the ODA in 1983 until May 2010 , the FDA approved 353 orphan drugs .
From the passage of the ODA in 1983 until May 2010 , the FDA granted orphan designations to 2,116 compounds .
From the passage of the ODA in 1983 until May 2010 , the FDA approved 353 orphan drugs and granted orphan designations to 2,116 compounds .