In the absence of insulin , PI3K is inactive .
The FOXO homolog daf - 16 is able to translocate to the nucleus and turn on many genetic pathways associated with longevity in the roundworm Caenorhabditis elegans .
In the absence of insulin , PI3K is inactive , so the FOXO homolog daf - 16 is able to translocate to the nucleus and turn on many genetic pathways associated with longevity in the roundworm Caenorhabditis elegans .