Furthermore , the munc18 - 1 deficient mouse is the first mouse model wherein neurotransmitter secretion is completely absent .
Deletion of munc18 - 1 leads to a defect in secretory vesicle docking .
The munc18 - 1 deficient mouse is the first mouse model wherein neurotransmitter secretion is completely absent .
Deletion of munc18 - 1 leads to a defect in secretory vesicle docking .