It is thought that cleavage of C2 by C1s , while bound to C4b , results in a conformational rotation of C2b .
The released C2a fragment may retain most of C2 's original structure .
It is thought that cleavage of C2 by C1s , while bound to C4b , results in a conformational rotation of C2b whereas the released C2a fragment may retain most of its original structure .