It was painted sometime around 310 BC for Cassander ( c. 350 -- 297 BC ) , who was one of Alexander the Great 's successors .
Battle of Issus , a fresco by Philoxenus of Eretria , is probably the first such .
Battle of Issus was painted sometime around 310 BC for Cassander ( c. 350 -- 297 BC ) , who was one of Alexander the Great 's successors .
Battle of Issus , a fresco by Philoxenus of Eretria , is probably the first such .