Still , the major concern with these methods above are increased risk of bleeding .
Clinical approaches on how to overcome clopidogrel resistance include higher doses of clopidogrel , concomitant use with the phosphodiesterase inhibitor cilostazol or switching to a new antiplatelet agent such as prasugrel and ticagrelor .
The major concern with these methods above are increased risk of bleeding .
Clinical approaches on how to overcome clopidogrel resistance include higher doses of clopidogrel , concomitant use with the phosphodiesterase inhibitor cilostazol or switching to a new antiplatelet agent such as prasugrel and ticagrelor .