Thus there is an elevated RanGTP concentration in the nucleus compared to the cytoplasm .
This gradient arises from the exclusive nuclear localization of RanGEFs , proteins that exchange GDP to GTP on Ran molecules .
Thus there is an elevated Ran concentration in the nucleus compared to the cytoplasm .
This gradient arises from the exclusive nuclear localization of RanGEFs , proteins that exchange GDP to GTP on Ran molecules .