The mathematical methods , developed initially with Jay Berzofsky , were subsequently extended .
The mathematical methods , developed initially with Jay Berzofsky , were subsequently modified by many others , presaging the now widely used bioinformatic approaches to guide the design of peptide vaccines .
The mathematical methods , developed initially with Jay Berzofsky , were subsequently extended and modified by many others , presaging the now widely used bioinformatic approaches to guide the design of peptide vaccines .