Thus , CD47 antagonists enable cell self - renewal and reprogramming by overcoming negative regulation of c - Myc and other stem cell transcription factors .
Thrombospondin - 1 is a key environmental signal that inhibits stem cell self - renewal via CD47 .
CD47 antagonists enable cell self - renewal and reprogramming by overcoming negative regulation of c - Myc and other stem cell transcription factors .
Thrombospondin - 1 is a key environmental signal that inhibits stem cell self - renewal via CD47 .