FXR does not directly bind to the CYP7A1 promoter .
One of the primary functions of FXR activation is the suppression of cholesterol 7 alpha - hydroxylase ( CYP7A1 ) , the rate - limiting enzyme in bile acid synthesis from cholesterol .
FXR does not directly bind to the CYP7A1 promoter .
One of the primary functions of FXR activation is the suppression of cholesterol 7 alpha - hydroxylase ( CYP7A1 ) , the rate - limiting enzyme in bile acid synthesis from cholesterol .