As of 2018 , endothelins remain under extensive basic and clinical research to define their roles in several organ systems .
Endothelins are implicated in vascular diseases of several organ systems , including the heart , lungs , kidneys , and brain .
As of 2018 , endothelins remain under extensive basic and clinical research to define Endothelins ' roles in several organ systems .
Endothelins are implicated in vascular diseases of several organ systems , including the heart , lungs , kidneys , and brain .