From 1721 - 1735 , Spanish landowners waged a struggle to overthrow the Jesuit monopoly of Indian trade and labor .
For the next 150 years , Jesuits developed their own autonomous area of control within Paraguay which led to conflict with the Spanish administration of the colony .
From 1721 - 1735 , Spanish landowners waged a struggle to overthrow the Jesuits monopoly of Indian trade and labor .
For the next 150 years , Jesuits developed their own autonomous area of control within Paraguay which led to conflict with the Spanish administration of the colony .