Thus , when this is mutated , patients may suffer mild haemophiliac symptoms due to increased turnover .
It has been shown that the sulfation of Tyr1680 in Factor VIII is essential for effective binding to vWF .
When this is mutated , patients may suffer mild haemophiliac symptoms due to increased turnover .
It has been shown that the sulfation of Tyr1680 in Factor VIII is essential for effective binding to vWF .