This came to a head after a disastrous harvest in 1539 , which drove up prices in Perugia and its rural hinterland .
Beginning in the late 15th century , successive popes attempted to rein in Perugian autonomy , despite resistance by the Perugians .
This came to a head after a disastrous harvest in 1539 , which drove up prices in Perugian and Perugian 's rural hinterland .
Beginning in the late 15th century , successive popes attempted to rein in Perugian autonomy , despite resistance by the Perugians .