Second , it can cause the target protein to become incompatible with other proteins that it usually binds with .
First , neddylation can cause a conformational change in the substrate which may restrict molecular movement and the positioning of different binding partners .
It can cause the target protein to become incompatible with other proteins that it usually binds with .
First , neddylation can cause a conformational change in the substrate which may restrict molecular movement and the positioning of different binding partners .