Nevertheless , the allo isomer was 10-fold more toxic .
In animal studies , they found that both isomers had similar affinity for DPP - 4 , similar in vivo efficacy , similar pharmacokinetic and metabolic profiles .
The allo isomer was 10-fold more toxic .
In animal studies , they found that both isomers had similar affinity for DPP - 4 , similar in vivo efficacy , similar pharmacokinetic and metabolic profiles .