It was found that when replacing the quinazolinone with a pyrimidinedione , the metabolic stability was increased .
The result was a potent , selective , bioavailable DPP - 4 inhibitor named alogliptin .
It was found that when replacing the quinazolinone with a pyrimidinedione , the metabolic stability was increased and the result was a potent , selective , bioavailable DPP - 4 inhibitor named alogliptin .