Withdrawal following chronic exposure decreases levels of CRE - DNA binding and p - CREB .
Furthermore , acute ethanol use increases while chronic exposure stabilizes p - CREB levels in rat cerebellum and striatum .
Withdrawal following chronic exposure decreases levels of CRE - DNA binding and CREB     .
Furthermore , acute ethanol use increases while chronic exposure stabilizes p - CREB levels in rat cerebellum and striatum .