Furthermore , HDAC inhibitors are known to prevent SOD1 protein aggregates in vitro .
In experiments with mice , HDAC inhibtors counteract this hypoacetylation , reactivate aberrantly down - regulated genes , and counteract apoptosis initiation .
HDAC inhibitors are known to prevent SOD1 protein aggregates in vitro .
In experiments with mice , HDAC inhibtors counteract this hypoacetylation , reactivate aberrantly down - regulated genes , and counteract apoptosis initiation .