Normal SOD protein is also implicated in other cases of ALS due to potentially cellular stress .
Most of the SOD1 mutations associated with ALS are gain - of - function mutations in which the protein retains its enzymatic activity , but aggregate in motor neurons causing toxicity .
Normal SOD1 protein is also implicated in other cases of ALS due to potentially cellular stress .
Most of the SOD1 mutations associated with ALS are gain - of - function mutations in which the protein retains its enzymatic activity , but aggregate in motor neurons causing toxicity .