M1 and Glu204 activate a water molecule to prepare it nucleophilic attack at the carbonyl carbon of the scissile peptide bond .
The carbonyl and amide groups of the scissile peptide bond interact with the first metal ion , M1 , in addition to His178 and His79 , respectively .
M1 and Glu204 activate a water molecule to prepare M1 nucleophilic attack at the carbonyl carbon of the scissile peptide bond .
The carbonyl and amide groups of the scissile peptide bond interact with the first metal ion , M1 , in addition to His178 and His79 , respectively .