Then , the tetrahedral intermediate ( Intermediate II ) becomes stabilized from interactions with M1 and His178 .
M1 and Glu204 activate a water molecule to prepare it nucleophilic attack at the carbonyl carbon of the scissile peptide bond .
The tetrahedral intermediate ( Intermediate II ) becomes stabilized from interactions with M1 and His178 .
M1 and Glu204 activate a water molecule to prepare it nucleophilic attack at the carbonyl carbon of the scissile peptide bond .