Their development is significantly delayed , and most affected individuals have severe to profound intellectual disability .
Infants with Emanuel syndrome have weak muscle tone ( hypotonia ) and fail to gain weight and grow at the expected rate ( failure to thrive ) .
Infants ' development is significantly delayed , and most affected individuals have severe to profound intellectual disability .
Infants with Emanuel syndrome have weak muscle tone ( hypotonia ) and fail to gain weight and grow at the expected rate ( failure to thrive ) .