Eventually , the advent of mass - production techniques and semi-synthetic penicillins resolved the supply issues , so this use of probenecid declined .
When probenecid and penicillin are administered together , probenecid competitively inhibits the excretion of penicillin , increasing penicillin 's concentration and prolonging its activity .
The advent of mass - production techniques and semi-synthetic penicillins resolved the supply issues , so this use of probenecid declined .
When probenecid and penicillin are administered together , probenecid competitively inhibits the excretion of penicillin , increasing penicillin 's concentration and prolonging its activity .