In contrast , other studies have rebutted any association between Frank 's sign and coronary artery disease in diabetics .
Some studies have described Frank 's sign as a marker of cardiovascular disease but not linked to the severity of the condition .
Other studies have rebutted any association between Frank 's sign and coronary artery disease in diabetics .
Some studies have described Frank 's sign as a marker of cardiovascular disease but not linked to the severity of the condition .