At that time , the land along the river was inhabited by the St. Lawrence Iroquoians ; at the time of Cartier 's second voyage in 1535 .
The first European explorer known to have sailed up the Saint Lawrence River itself was Jacques Cartier .
At that time , the land along the river was inhabited by the St. Lawrence Iroquoians ; at the time of Jacques Cartier 's second voyage in 1535 .
The first European explorer known to have sailed up the Saint Lawrence River itself was Jacques Cartier .