Significant work with artemisinin suppositories in severe malaria was conducted in Viet Nam in the early 1990s .
Clinical trials of rectal artesunate followed by mefloquine treatment in moderately severe malaria were conducted in the mid-1990s in Thailand .
Significant work with artemisinin suppositories in severe malaria was conducted in Viet Nam in the early 1990s , and clinical trials of rectal artesunate followed by mefloquine treatment in moderately severe malaria were conducted in the mid-1990s in Thailand .