As senescent cells accumulate with aging , expression of CDKN2A increases exponentially with aging in all mammalian species tested to date .
As senescent cells has been argued to serve as a biomarker of physiological age .
As senescent cells accumulate with aging , expression of CDKN2A increases exponentially with aging in all mammalian species tested to date , and has been argued to serve as a biomarker of physiological age .