Inhibiting HDACs would allow for hyperacetylation of the SMN2 gene loci theoretically resulting in an increase in SMN2 expression .
Histone deacetylase ( HDAC ) inhibitors are the main compounds that have been tested to increase SMN2 mRNA expression .
Inhibiting HDAC would allow for hyperacetylation of the SMN2 gene loci theoretically resulting in an increase in SMN2 expression .
Histone deacetylase ( HDAC ) inhibitors are the main compounds that have been tested to increase SMN2 mRNA expression .