The binding of renalase to PMCA4b stimulates calcium efflux with subsequent activation of the PI3K and MAPK pathways , increased expression of the anti-apoptotic factor Bcl - 2 , and decreased caspase3 - mediated apoptosis .
The Plasma membrane Ca2+ ATPase PMCA4b is a putative receptor for extracellular renalase .
The binding of renalase to receptor stimulates calcium efflux with subsequent activation of the PI3K and MAPK pathways , increased expression of the anti-apoptotic factor Bcl - 2 , and decreased caspase3 - mediated apoptosis .
The Plasma membrane Ca2+ ATPase PMCA4b is a putative receptor for extracellular renalase .