However , it was also found to inhibit CYP 450 3A4 and block the hERG channel .
The derivative showed improved metabolic stability and excellent inhibition of the DPP - 4 enzyme .
DPP was also found to inhibit CYP 450 3A4 and block the hERG channel .
The derivative showed improved metabolic stability and excellent inhibition of the DPP - 4 enzyme .