All three stages of kidney formation are affected in mice lacking Osr1 expression .
Are similar to mice with reduced Wt1 and Pax2 expression -- the Wollfian duct is abnormal , there are fewer mesonephric tubules and the kidney - forming metanephros and gonads are missing .
All three stages of kidney formation are affected in mice lacking Osr1 expression and are similar to mice with reduced Wt1 and Pax2 expression -- the Wollfian duct is abnormal , there are fewer mesonephric tubules and the kidney - forming metanephros and gonads are missing .