De Soto led the largest European expedition of both 15th and 16th centuries through the Southeast and Midwest searching for gold , silver , and other valuables .
This panel depict the burial of Spanish explorer Hernando de Soto in the Mississippi River after his death from a fever .
Hernando de Soto   led the largest European expedition of both 15th and 16th centuries through the Southeast and Midwest searching for gold , silver , and other valuables .
This panel depict the burial of Spanish explorer Hernando de Soto in the Mississippi River after his death from a fever .