And efforts on further improvement of the structure , based on the structure modification in the stomach due to the acid dissociation constant of the compound , led to the development of metiamide .
The potency of burimamide was still too low for oral administration .
Efforts on further improvement of the structure , based on the structure modification in the stomach due to the acid dissociation constant of the compound , led to the development of metiamide .
The potency of burimamide was still too low for oral administration .