Upon dissociation each protomer can assume a relaxed state .
This concerted response of each protomer accounts for the nonlinearity of enzyme activity : a ligand molecule that stabilizes the relaxed state of one of the monomers prevents the others from returning to the associated state .
Upon dissociation each protomer can assume a relaxed state and this concerted response of each protomer accounts for the nonlinearity of enzyme activity : a ligand molecule that stabilizes the relaxed state of one of the monomers prevents the others from returning to the associated state .