Benzodiazepines can become less effective over time .
Patients can develop increasing physical and psychological adverse effects , e.g. , agorophobia , gastrointestinal complaints , and peripheral nerve abnormalities such as burning and tingling sensations .
Benzodiazepines can become less effective over time , and patients can develop increasing physical and psychological adverse effects , e.g. , agorophobia , gastrointestinal complaints , and peripheral nerve abnormalities such as burning and tingling sensations .