Naringenin has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2 even resulting in carcinogens of otherwise harmless substances .
CYP1A2 can change pharmacokinetics in a human ( or orthologous ) host of several popular drugs in an adverse manner .
Naringenin has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2 , which can change pharmacokinetics in a human ( or orthologous ) host of several popular drugs in an adverse manner , even resulting in carcinogens of otherwise harmless substances .