It has been shown that SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells .
SIRT4 is a mitochondrial ADP - ribosyltransferase that inhibits mitochondrial glutamate dehydrogenase 1 activity , thereby downregulating insulin secretion in response to amino acids .
SIRT4 has been shown that SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells .
SIRT4 is a mitochondrial ADP - ribosyltransferase that inhibits mitochondrial glutamate dehydrogenase 1 activity , thereby downregulating insulin secretion in response to amino acids .