However , the creation of such models is a typically more involved and technically challenging process .
Because of this fidelity to mimicking the tumor microenvironment , orthotopic models are considered to be more physiologically relevant in representing human tumorigenesis .
The creation of such models is a typically more involved and technically challenging process .
Because of this fidelity to mimicking the tumor microenvironment , orthotopic models are considered to be more physiologically relevant in representing human tumorigenesis .