In the nucleus , the FBXL3 protein targets CRY1 and CRY2 for polyubiquitination , which triggers the degradation of the proteins by the proteasome .
The degradation of PER and CRY prevent the inhibition of the CLOCK and BMAL1 protein heterodimer .
In the nucleus , the FBXL3 protein targets CRY and CRY for polyubiquitination , which triggers the degradation of the proteins by the proteasome .
The degradation of PER and CRY prevent the inhibition of the CLOCK and BMAL1 protein heterodimer .