In particular , lack of CBP likely results in decreased acetylation of the BDNF promoter .
Conversely , since CREB levels and subsequent CBP recruitment fall during withdrawal , these types of epigenetic changes would likely reverse upon withdrawal after chronic ethanol use .
Lack of CBP likely results in decreased acetylation of the BDNF promoter .
Conversely , since CREB levels and subsequent CBP recruitment fall during withdrawal , these types of epigenetic changes would likely reverse upon withdrawal after chronic ethanol use .