Nitric Oxide is thought to migrate back to the presynaptic membrane to enhance the expression of the voltage - gated N - calcium channels resulting in a pain wind - up phenomenon .
NMDA receptor activation ( by glutamate ) enhances postsynaptic Nitric Oxide Synthase .
Nitric Oxide Synthase   is thought to migrate back to the presynaptic membrane to enhance the expression of the voltage - gated N - calcium channels resulting in a pain wind - up phenomenon .
NMDA receptor activation ( by glutamate ) enhances postsynaptic Nitric Oxide Synthase .