However , short metabolic half - life due to oxidation of the A-ring phenyl group was problematic .
The quinazoline based compounds showed potent inhibition and excellent selectivity over related protease , DPP - 8 .
Short metabolic half - life due to oxidation of the A-ring phenyl group was problematic .
The quinazoline based compounds showed potent inhibition and excellent selectivity over related protease , DPP - 8 .