It easily ionizes to a cation and binds to the anionic sites of the epithelial cells of the proximal tubule as part of receptor - mediated pinocytosis .
Amikacin causes nephrotoxicity ( damage to the kidneys ) , by acting on the proximal renal tubules .
Amikacin easily ionizes to a cation and binds to the anionic sites of the epithelial cells of the proximal tubule as part of receptor - mediated pinocytosis .
Amikacin causes nephrotoxicity ( damage to the kidneys ) , by acting on the proximal renal tubules .