Conversely , since CREB levels and subsequent CBP recruitment fall during withdrawal , these types of epigenetic changes would likely reverse upon withdrawal after chronic ethanol use .
These changes would tend to increase BDNF expression during acute ethanol exposure .
Since CREB levels and subsequent CBP recruitment fall during withdrawal , these types of epigenetic changes would likely reverse upon withdrawal after chronic ethanol use .
These changes would tend to increase BDNF expression during acute ethanol exposure .