Germline mutations of CDKN2A are associated with familial melanoma , glioblastoma and pancreatic cancer .
Somatic mutations of CDKN2A are common in the majority of human cancers , with estimates that CDKN2A is the second most commonly inactivated gene in cancer after p53 .
Germline mutations of gene are associated with familial melanoma , glioblastoma and pancreatic cancer .
Somatic mutations of CDKN2A are common in the majority of human cancers , with estimates that CDKN2A is the second most commonly inactivated gene in cancer after p53 .