Phosphotyrosine ( P. Tyr ) residues on activated RTKs are recognized by a phosphodependent - binding domain , the SH2 domain .
In 1990 receptor tyrosine kinase ( RTK ) initiation of intracellular signaling was detected .
Phosphotyrosine ( P. Tyr ) residues on activated RTK are recognized by a phosphodependent - binding domain , the SH2 domain .
In 1990 receptor tyrosine kinase ( RTK ) initiation of intracellular signaling was detected .