The loss of traditional jobs in manufacturing , rapid suburbanization and high labor costs have led to economic decline .
The loss of traditional jobs in manufacturing , rapid suburbanization and high labor costs made Buffalo one of the poorest U.S. cities with populations of more than 250,000 people .
The loss of traditional jobs in manufacturing , rapid suburbanization and high labor costs have led to economic decline and made Buffalo one of the poorest U.S. cities with populations of more than 250,000 people .