 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST] mar-plantar erythrodysesthesia). Tell your doctor right away if you experience swelling, pain, redness, peeling, blisters, or tingling/burning of the hands/feet. The symptoms can be made worse by heat/pressure on your hands/feet. Limit your time in the sun. Avoid tanning booths and sunlamps, as well as unnecessary exposure to heat (for example, hot dishwater, long hot baths). Use a sunscreen and wear protective clothing when outdoors. Avoid pressure on elbows, knees, and soles of feet (such as leaning on elbows, kneeling, taking long walks). Wear loose clothing and comfortable shoes. Depending on how severe your hand-foot reaction is, your doctor may give you an additional medication to reduce the symptoms, or stop or delay your medication treatment. This medication may rarely cause new skin cancers. Your doctor should do regular skin exams before and during treatment. Check your skin and tell your doctor right away if you notice skin changes such as a new wart, skin sore/bump that bleeds or does not heal, change in size or color of a mole. This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. This </s>