 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST]  can affect your night vision. Do not drive, use machinery, or do any activity that requires clear vision after dark until you are sure you can perform such activities safely. If you wear contact lenses, you may not tolerate them as well as usual while using this medication. Contact your doctor for more information. Do not have cosmetic procedures to smooth your skin (such as waxing, laser, dermabrasion) during and for 6 months after isotretinoin therapy. Skin scarring may occur. Avoid the use of alcohol while taking this medication because it may increase the risk of certain side effects (such as pancreatitis). Limited information suggests isotretinoin may cause some bone loss effects. Playing contact or repetitive impact sports (such as football, basketball, soccer, tennis) may result in bone problems, including an increased risk of broken bones. Limited information also suggests isotretinoin may stop normal growth in some children (epiphyseal plate closure). Consult your doctor for more details. Older adults may be more sensitive to the side effects of this drug, especially the effects on bones. Children may be more sensitive to the side effects of this drug, especially back/joint/muscle pain. This drug must not be used during pregnancy or by </s>