 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST]  of this product come with a Medication Guide. If available, read the Medication Guide provided by your pharmacist before you start using methadone and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth on a regular schedule as directed by your doctor, not as needed for sudden (breakthrough) pain. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible). Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If your medication comes in an oral dosing syringe, use the syringe to measure the dose. Do not inject the medication. Before taking, mix the dose in at least 1 ounce (30 milliliters) of water or other liquid as directed. Drink all of the mixture right away. Do not prepare a supply in advance. The dosage is based on your medical condition and response to treatment. Suddenly stopping this medication may cause withdrawal, especially if you have used it </s>