 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST]  and Instructions for Use provided by your pharmacist before you start using inotersen and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Before use, take inotersen out of the refrigerator. Let it warm up to room temperature for at least 30 minutes. Do not heat this medication any other way, such as by heating in the microwave or placing in hot water. Do not shake this medication. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Inject this medication under the skin of the thigh, abdomen, or upper arm as directed by your doctor, usually once weekly. The dosage is based on your medical condition and response to treatment. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. Do not inject into scars or areas of skin that are bruised, tender, red, hard, or tattooed. Use this medication regularly to get the most benefit from it. To help you remember, inject this medication on the same day each week. Learn how to store and discard medical supplies safely.The side effects of Inotersen Subcutaneous: See also Warning section </s>