 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST] . Rifampin interacts with many medications. While you are using rifampin, it is very important to tell your doctor or pharmacist of any changes in medications that you are taking. Rifampin can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include atovaquone, certain anti-cancer drugs (such as irinotecan), certain azole antifungals (such as itraconazole), certain calcium channel blockers (such as nifedipine), certain products used to treat chronic hepatitis C (such as sofosbuvir), cobicistat, lurasidone, HIV NNRTIs (such as etravirine, nevirapine), praziquantel, HIV protease inhibitors (such as atazanavir, darunavir), among others. This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use reliable backup birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth </s>