 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST]  Read the Medication Guide provided by your pharmacist before you start taking sparsentan and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually once daily before a meal. You may take this medication before your morning or evening meal, but it is important to choose one way and take this medication the same way with every dose. Swallow the tablets whole with water. Do not crush or chew the tablets. The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Antacids can decrease the absorption of sparsentan. If you are taking an antacid, take sparsentan 2 hours before or 2 hours after taking antacids. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets. Tell </s>