 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST]  Read the Patient Information Leaflet if available from your pharmacist before you start taking ivacaftor and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually twice daily (every 12 hours). If you are taking the tablet form of this medication, take this medication with fat-containing foods (such as eggs, butter, peanut butter, cheese). The manufacturer directs to swallow this medication whole. However, many similar drugs (immediate-release tablets) can be split/crushed. Follow your doctor's directions on how to take this medication. If you are taking the granules form of this medication, gently shake the packet before use. Empty the packet into a small cup with 1 teaspoonful (5 milliliters) of soft food (such as yogurt, applesauce) or liquid (such as water, milk, infant formula). The soft food or liquid should be at or below room temperature. Mix the granules with the soft food or liquid and take the entire mixture within 1 hour of mixing. Eat a fat-containing food either right before or just after taking the mixture. The dosage is based on your medical condition, age, weight, response to </s>