 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST]  as local anesthetics. It works by numbing the skin to block the feelings of pain and itching. This product may also contain other ingredients including skin protectants (such as calamine, zinc acetate, zinc oxide). Read the product package for more information.Do not use pramoxine for skin irritation in children younger than 2 years or use pramoxine for hemorrhoids or other genital/anal conditions in children younger than 12 years unless directed by the doctor.If you are self-treating with this medication, it is important to read the package instructions carefully before you start using this product to be sure it is right for you. (See also Precautions section. How to use Pramoxine-Calamine Lotion This medication is for use only on the skin as directed by your doctor. Do not apply on severely broken skin areas such as open wounds, deep cuts, or serious burns. If you are self-treating, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist. Gently clean and dry the affected area. If you are using a lotion, spray, or foam product, shake the container well before using as directed on the label. For skin irritation, apply </s>