 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST] every 8 hours). Swallow the medication whole. Do not crush or chew the tablets or use a tablet that is damaged or broken. Doing so can release all of the drug at once, increasing the risk of side effects. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Use this medication regularly to get the most benefit from it. Remember to take it at the same times each day. Do not stop taking this medication without consulting your doctor. Your condition may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased. Your doctor may direct you to use other medications in addition to treprostinil to treat your condition and to prevent problems. Use all prescribed medications exactly as directed. Tell your doctor if your condition does not improve or if it worsens.The side effects of Orenitram Oral: Headache, nausea, diarrhea, jaw pain, flushing </s>