 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST]  any serious side effects, including: mental/mood changes (such as confusion, anxiety, depression, trouble paying attention, memory problems), numbness/tingling, vision changes (such as blurred/double vision, decreased vision), eyes being sensitive to light, signs of heart failure (such as shortness of breath, swelling ankles/feet, unusual/sudden weight gain), signs of liver problems (such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine). Get medical help right away if you have any very serious side effects, including: fast/irregular heartbeat, severe dizziness, fainting. This medication may increase your risk for bone fractures. Fractures may happen with or without a fall or injury. Tell your health care provider right away if you have bone pain or changes in movement. This medication may cause your blood uric acid levels to increase. Your doctor will check uric acid levels regularly during treatment, and may adjust your dose of entrectinib. You may also be prescribed other medication to treat high uric acid levels. This medication may lower your ability to fight infections. This may make you more likely to get a serious (ra </s>