 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST]  urine, pink/bloody urine), mental/mood changes (such as depression, thoughts of suicide). Rarely, this medication can cause a severe (sometimes fatal) blood problem (lactic acidosis). Tell your doctor right away if you develop symptoms of lactic acidosis (such as deep/rapid breathing, drowsiness, nausea/vomiting, unusual weakness). Changes in body fat may occur while you are taking this medication (such as increased fat in the upper back and stomach areas, decreased fat in the arms and legs). The cause and long-term effects of these changes are unknown. Discuss the risks and benefits of treatment with your doctor, as well as the possible use of exercise to reduce this side effect. Tenofovir may increase the risk of bone loss. Discuss the risks and benefits of treatment with your doctor, as well as the possible use of calcium and vitamin D to reduce this side effect. If you are at risk for bone loss, your doctor may monitor your bone mineral density. Tell your doctor right away if any of the following serious side effects occur: bone pain, easily broken bones. This medication can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a </s>