 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST]  away. Your doctor may need to adjust your diabetes medications. Canagliflozin may rarely increase the risk of losing a lower limb. This risk may be greater in people who have a history of heart disease, blood circulation disease (peripheral vascular disease), nerve problems (neuropathy), foot ulcers, or previous loss of limbs. Talk to your doctor for more details. Tell your doctor right away if you have any pain/tenderness/redness/swelling/sores on your legs and feet. This medication may cause you to become dehydrated. This can lead to serious kidney damage. Drink plenty of fluids to prevent dehydration. Tell your doctor or pharmacist right away if you are not able to drink fluids as usual, or losing fluid (such as due to vomiting, diarrhea, or heavy sweating). Also, tell your doctor right away if you have any signs of dehydration, such as urinating less than usual, unusual dry mouth/thirst, fast heartbeat, or dizziness/lightheadedness/fainting. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Canagliflozin may cause some bone loss, or even a broken bone. Lifestyle habits </s>