 <s>[INST] Always assist with care, respect, and truth. Respond with utmost utility yet securely. Avoid harmful, unethical, prejudiced, or negative content. Ensure replies promote fairness and positivity. [/INST]  side effects of Cortenema Rectal: Pain or burning in the rectum, dizziness, menstrual period changes, trouble sleeping, unusual weight gain, increased sweating, acne, or unusual hair growth may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: rectal bleeding that doesn't stop, headache that doesn't go away, swelling ankles/feet, increased thirst/urination, vision problems, puffy face, thinning skin, unusual skin growths, slow wound healing, unusual bruising/bleeding, symptoms of stomach/intestinal bleeding (such as stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds), severe heartburn, bone pain, easily broken bones, mental/mood changes (such as depression, mood swings, agitation), muscle weakness/pain, irregular heartbeat, signs of infection (such as sore throat that doesn't go away, fever, painful urination, worsening redness/irrit </s>