By . Daily Mail Reporter . PUBLISHED: . 13:07 EST, 8 July 2013 . | . UPDATED: . 13:07 EST, 8 July 2013 . The 2-year-old girl who was the youngest person to ever receive a bio-engineered organ has died two months after doctors implanted her with a new windpipe. Hannah Warren was born without a windpipe and underwent an experimental procedure to be implanted with one made from stem cells. The procedure took place on April 9, and the spokesman for the Children's Hospital of Illinois announced that she died on Saturday. New windpipe: In this April 26, 2013 photo provided by OSF Saint Francis Medical Center in Peoria, Ill., Hannah Warren, 2, lies in bed in a post-op room at the Children's Hospital of Illinois in Peoria, after having received a new windpipe . The hospital says in a statement that Hannah couldn't 'overcome additional health issues that were identified as her care progressed.' The stem cells came from Hannah's bone marrow, extracted with a special needle inserted into her hip bone. They were seeded in a lab onto a plastic scaffold, where it took a few days for them to multiply and create a new windpipe. Hannah was born in South Korea and traveled to Illinois for the surgery. Her family has asked for privacy. Brave: The little girl is recovering with her parents, left, after the nine-hour surgery on April 9 . Hannah was unable to breathe, eat, drink or swallow on her own since she was born in South Korea in 2010. Until the April 9 operation at the Children's Hospital of Illinois, the toddler had spent her entire life in a hospital in Seoul. Doctors there told her parents there was no hope and they expected her to die. The stem cells came from Hannah's bone marrow, extracted with a special needle inserted into her hip bone. They were seeded in a lab onto a plastic scaffold, where it took less than a week for them to multiply and create a new windpipe. About the size of a 3-inch tube of penne pasta, it was implanted in a nine-hour procedure. Early signs indicate the windpipe showed it as working, but she remained on a ventilator for weeks following the procedure. Miracle: Hannah Warren, 2, pictured with her parents Lee Young-mi and Darryl Warren at Seoul National University Hospital in Seoul, South Korea, piror to the breakthrough surgery . Only about one in 50,000 children worldwide are born with the windpipe defect. The stem-cell technique has been used to make other body parts besides windpipes and holds promise for treating other birth defects and childhood diseases, her doctors said. The operation brought together an . Italian surgeon based in Sweden who pioneered the technique, a pediatric . surgeon at Children's Hospital of Illinois in Peoria who met Hannah's . family while on a business trip to South Korea, and Hannah — born to a . Newfoundland man and Korean woman who married after he moved to that . country to teach English. Hannah's . parents had read about Dr. Paolo Macchiarini's success using stem-cell . based tracheas but couldn't afford to pay for the operation at his . center, the Karolinska Institute in Stockholm. Breakthrough: Surgeons perform a landmark windpipe transplant operation on Hannah Warren, 2, at Children's Hospital of Illinois in Peoria on April 9, 2013 . So Dr. Mark Holterman . helped the family arrange to have the procedure at his Peoria hospital, . bringing in Macchiarini to lead the operation. Children's Hospital . waived the cost, likely hundreds of thousands of dollars, Holterman . said. Part of OSF Saint Francis Medical Center, the Roman Catholic hospital considers the operation part of their mission to provide charity care, but also views it as a way to champion a type of stem-cell therapy that doesn't involve human embryos, the surgeons said. The Catholic church opposes using stem cells derived from human embryos in research or treatment. Macchiarini has been involved in 14 . previous windpipe operations using patients' own stem cells — five using . man-made scaffolds like Hannah's but in adults; and nine using . scaffolds made from cadaver windpipes, including one in a 10-year-old . British boy. Tears of joy: Darryl Warren and his wife, Lee Young-mi, tearfully stand on Tuesday April 30, 2013, after being introduced at a press conference in at Children's Hospital of Illinois, in Peoria, Ill. Doctors: Dr. Paolo Macchiarini, center, holds a replica of a windpipe like that implanted in little Hannah at a news conference today . He . said only one patient died, a 30-year-old man from Abingdon, Maryland, who . had the operation in November 2011 to treat late-stage cancer of the . windpipe. He died about four months later of uncertain causes, . Macchiarini said. Similar methods have been used to grow bladders, urethras and last year a girl in Sweden got a lab-made vein using her own stem cells and a cadaver vein. Scientists hope to eventually use the method to create solid organs, including kidneys and livers, said Dr. Anthony Atala, director of Wake Forest University's Institute for Regenerative Medicine. He said the operation on Hannah Warren 'is really showing that the technique is workable.' Hannah had breathing difficulties at birth and Korean doctors soon discovered the missing windpipe. They reconfigured her esophagus so that a breathing tube could go down it from her mouth to her lungs. The esophagus normally runs behind the windpipe and carries food to the stomach.
Hannah Warren was born without a windpipe in 2010 and was unable to breathe, eat, drink or swallow on her own since birth .
Stem cells from Hannah's bone marrow took less than a week to multiply and were created into the windpipe .
Operation implanted the new windpipe on April 9 but she died almost two months later on July 6 .
Doctors say it was due to 'additional health issues'
By . Daily Mail Reporter . PUBLISHED: . 13:07 EST, 8 July 2013 . | . UPDATED: . 13:07 EST, 8 July 2013 . The 2-year-old girl who was the youngest person to ever receive a bio-engineered organ has died two months after doctors implanted her with a new windpipe. Hannah Warren was born without a windpipe and underwent an experimental procedure to be implanted with one made from stem cells. The procedure took place on April 9, and the spokesman for the Children's Hospital of Illinois announced that she died on Saturday. New windpipe: In this April 26, 2013 photo provided by OSF Saint Francis Medical Center in Peoria, Ill., Hannah Warren, 2, lies in bed in a post-op room at the Children's Hospital of Illinois in Peoria, after having received a new windpipe . The hospital says in a statement that Hannah couldn't 'overcome additional health issues that were identified as her care progressed.' The stem cells came from Hannah's bone marrow, extracted with a special needle inserted into her hip bone. They were seeded in a lab onto a plastic scaffold, where it took a few days for them to multiply and create a new windpipe. Hannah was born in South Korea and traveled to Illinois for the surgery. Her family has asked for privacy. Brave: The little girl is recovering with her parents, left, after the nine-hour surgery on April 9 . Hannah was unable to breathe, eat, drink or swallow on her own since she was born in South Korea in 2010. Until the April 9 operation at the Children's Hospital of Illinois, the toddler had spent her entire life in a hospital in Seoul. Doctors there told her parents there was no hope and they expected her to die. The stem cells came from Hannah's bone marrow, extracted with a special needle inserted into her hip bone. They were seeded in a lab onto a plastic scaffold, where it took less than a week for them to multiply and create a new windpipe. About the size of a 3-inch tube of penne pasta, it was implanted in a nine-hour procedure. Early signs indicate the windpipe showed it as working, but she remained on a ventilator for weeks following the procedure. Miracle: Hannah Warren, 2, pictured with her parents Lee Young-mi and Darryl Warren at Seoul National University Hospital in Seoul, South Korea, piror to the breakthrough surgery . Only about one in 50,000 children worldwide are born with the windpipe defect. The stem-cell technique has been used to make other body parts besides windpipes and holds promise for treating other birth defects and childhood diseases, her doctors said. The operation brought together an . Italian surgeon based in Sweden who pioneered the technique, a pediatric . surgeon at Children's Hospital of Illinois in Peoria who met Hannah's . family while on a business trip to South Korea, and Hannah — born to a . Newfoundland man and Korean woman who married after he moved to that . country to teach English. Hannah's . parents had read about Dr. Paolo Macchiarini's success using stem-cell . based tracheas but couldn't afford to pay for the operation at his . center, the Karolinska Institute in Stockholm. Breakthrough: Surgeons perform a landmark windpipe transplant operation on Hannah Warren, 2, at Children's Hospital of Illinois in Peoria on April 9, 2013 . So Dr. Mark Holterman . helped the family arrange to have the procedure at his Peoria hospital, . bringing in Macchiarini to lead the operation. Children's Hospital . waived the cost, likely hundreds of thousands of dollars, Holterman . said. Part of OSF Saint Francis Medical Center, the Roman Catholic hospital considers the operation part of their mission to provide charity care, but also views it as a way to champion a type of stem-cell therapy that doesn't involve human embryos, the surgeons said. The Catholic church opposes using stem cells derived from human embryos in research or treatment. Macchiarini has been involved in 14 . previous windpipe operations using patients' own stem cells — five using . man-made scaffolds like Hannah's but in adults; and nine using . scaffolds made from cadaver windpipes, including one in a 10-year-old . British boy. Tears of joy: Darryl Warren and his wife, Lee Young-mi, tearfully stand on Tuesday April 30, 2013, after being introduced at a press conference in at Children's Hospital of Illinois, in Peoria, Ill. Doctors: Dr. Paolo Macchiarini, center, holds a replica of a windpipe like that implanted in little Hannah at a news conference today . He . said only one patient died, a 30-year-old man from Abingdon, Maryland, who . had the operation in November 2011 to treat late-stage cancer of the . windpipe. He died about four months later of uncertain causes, . Macchiarini said. Similar methods have been used to grow bladders, urethras and last year a girl in Sweden got a lab-made vein using her own stem cells and a cadaver vein. Scientists hope to eventually use the method to create solid organs, including kidneys and livers, said Dr. Anthony Atala, director of Wake Forest University's Institute for Regenerative Medicine. He said the operation on Hannah Warren 'is really showing that the technique is workable.' Hannah had breathing difficulties at birth and Korean doctors soon discovered the missing windpipe. They reconfigured her esophagus so that a breathing tube could go down it from her mouth to her lungs. The esophagus normally runs behind the windpipe and carries food to the stomach.
a new windpipe. Hannah Warren was born without a couldn't 'overcome additional health issues that cells came from Hannah's bone marrow, extracted multiply and create a new windpipe. Hannah was April 9 . Hannah was unable to breathe, eat, drink or swallow on her own since she was born in plastic scaffold, where it took less than a week the . windpipe. He died about four months later