Ayden-Grifton High School is a high school in Pitt County, North Carolina, United States. It is located along NC 11 South in between the towns of Ayden and Grifton. Ayden-Grifton High School is one of the six public high schools in the Pitt County School System. Ayden-Grifton High School is classified as a 2-A school with 650 students.