U.S. Route 250 (US 250) is a route of the United States Numbered Highway System. It is a spur of U.S. Route 50. It runs for from Sandusky, Ohio to Richmond, Virginia. It passes through the states of Virginia, West Virginia, and Ohio. The road goes through the cities of Richmond, Virginia, Charlottesville, Virginia, Staunton, Virginia, and Wheeling, West Virginia. US 250 intersects and forms a short overlap with its parent US 50 west of Pruntytown, West Virginia. In West Virginia, the route is signed north–south. In Ohio and Virginia, the route is signed east–west.