Sir John Byron MP (1386–1450) was an English nobleman, landowner, politician, and knight. He had estates in Clayton near Manchester and at South Stoke (now Stoke Rochford) in Lincolnshire. He was Member of Parliament for Lancashire in 1421 and 1429, and for Lincolnshire in 1447. He was the son and heir of Sir Richard Byron (1354-1415), He married Margery Booth, daughter of John Booth. His son Sir Nicolas Byron inherited his estates.