Issam Jad'aan Zahreddine (Arabic: عصام جدعان زهر الدين‎‎; 1961 – 18 October 2017) sometimes called as Issam Zaher Eldin or Issam Zaher al-Deen, was a Major General of the Syrian Republican Guard. He played a major role in the Syrian Civil War, leading Syrian government forces on several fronts. His most prominent role was the leadership of the surrounded Syrian forces during the over three-year long Siege of Deir ez-Zor.