The gameplay of 1 player "Dr. Mario" is to make sure vitamins of the same color are lined-up together to defeat viruses. There are three colors of vitamins (red, blue, yellow). The goal is to clear all the capsules without going to the top. The player can pick any default level from 0-20, with a set number of viruses to clear depending what level the player is on. The virus count goes as high as 84, and does not increase after you pass level 20. There are over 40 levels in the game.