Santiago de Cuba Province is the second most populated province in the island of Cuba. It has a population of about 1.2 million people. The largest city Santiago de Cuba (554,000) is its main administrative center. Other large cities include Palma Soriano (125,000), Contramaestre (88,000), Mayarí Arriba (80,000), San Luis (65,000) and Songo-la Maya (50,000).