This movie takes place in Japan during the Muromachi period. There was a small village in Ezo. People lived peacefully. Ashitaka lived there. One day the evil god attacked the village and Ashitaka was cursed. The evil god was once a god of the forest, but he was shot by human and died in terrible pain. Ashitaka knew when he would die. He went to the west where the bullet which killed the god was made.