Francisco Guillermo Flores (October 17, 1959 – January 30, 2016) was a Salvadoran politician. He served as President of El Salvador serving from 1999 to 2004 as a member of the conservative Nationalist Republican Alliance (ARENA) replacing Armando Calderón Sol. He was born in Santa Ana, El Salvador. At the time of his death, Flores was being investigated for corruption charges.