Samira Khalil () is an activist from the Homs region of Syria. She was in prison for four years, from 1987–1991, because she opposed the Bashar al-Assad government in Syria. She disappeared in the city of Douma on December 9, 2013, with activists Razan Zeitouneh, Wael Hamada, and Nazem Hammadi. They are called the "Douma 4".