The Princess Alice (Alice Maud Mary: Princess Louis and Grand Duchess of Hesse and by Rhine by marriage; April 25, 1843 – December 14, 1878) was the second daughter of Queen Victoria and Prince Albert. In 1861, she acted as the nurse to her dying father, and became interested in nursing. In 1862, she married Prince Louis of Hesse and moved to Hesse, where she had several children including Princess Elisabeth of Hesse, Alice Romanov Chaytow and Alexandra, future Russian Empress and wife of Tsar Nicholas II. After an unhappy marriage and a number of family deaths, the royal family of Hesse caught diphtheria. Alice's younger son died, and after kissing the elder one, she caught the disease and died on the anniversary of her father's death, 14 December 1878. She is buried in Hesse.