Tress MacNeille (born June 20, 1951) is an American voice actress best known for doing voices on the animated television series "The Simpsons", "Futurama", and "Animaniacs", The Powerpuff Girls". Her most famous characters on "The Simpsons" include Agnes Skinner, Brandine Spuckler and Lindsey Naegle, while her performance as Mom is her most notable "Futurama" role.