Neosho (; originally is the most populous city in Newton County, Missouri, United States, which it serves as the county seat. With a population of 11,835 as of the 2010 census, the city is part of the Joplin, Missouri Metropolitan Statistical Area, a region with an estimated 176,849 (2011) residents. Neosho lies on the western edge of the Ozarks. The cost of living in Neosho is low at about 9.9% less than the Missouri average and 17.9% less than the national average.