Mona Lisa (also known as La Gioconda or La Joconde) is a 16th-century portrait painted in oil by Leonardo da Vinci during the Renaissance in Florence, Italy. Many people think Mona Lisa's smile is mysterious. It is so often studied, recognized, and copied that it is the most famous painting . The Louvre says that about 80 percent of its visitors come to see the painting of Mona Lisa.