"The liquid generally sticks at the end of the vial, so you have to "flick" at it to push it towards the tip before twisting off the cap.  Xiidra leaves a bitter taste in my mouth for a good 30 mins. It causes watery eyes for about the same time too.  2 times every 12 hours can be a pain. Some days I forget and end up doing it once every 24 hours. It's been 4 months now and it's help a little bit. Won't know for sure if my dry eyes are "cured" after 12 months of use. We'll see when I get off it."