Lithium
mania
"For some, lithium is the most effective choice for bipolar mania.  Unfortunately for me, it's not.  My body rebelled against it immediately and without pause for its entire 60-day 'trial'.  My bowels were never solid the entire time.  I'm amazed now that I never recognized any dehydration symptoms over that time.  It worked for my dear departed mother, but not for me, but I gave it a shot."