Leflunomide
rheumatoid arthritis
"I've been using Leflunomide since July 2007.  It took 3 months for it to become effective, but I have been pain free since then!  Wonderful!  BUT, I have developed chronic urinary tract infections -- 12 in the last two years.  My urologist is exasperated and has about exhausted his bag of tricks; daily Macrodantin (antibiotic) for over a year helped for a few months at a time, but I'm now resistant to that.  I only take 10 mg leflunomide and really hate to think of doing without it, but my bladder is important too.  I'm going to ask the rheumatologist this week about cutting the dosage in half."