Methylnaltrexone
constipation, drug induced
"Opioids since 2000,  Chronic Pain from Post-Polio Syndrome.  I've been fighting this big problem since 2001 &  I've tried everything.  For the last two years I used "irrigation",  a slow and messy solution.  Recently I tried  Movantik,  but found it to be significantly harsher on the GI tract.  As soon as I got over the "Yikes!  I'm about to stick a needle in my stomach!",  everything went swimmingly.  Yes,  moderate gas cramping,  but far gentler than what I'd suffered in the past.  It was incredibly fast in my case.  First "urge"  in under 15 minutes and major evac in just a few minutes.  I  figured I was done for the day 1,  so I  headed back to bed.  Fifteen minutes later my 2nd evac was twice as big as the first.  5 Stars"