Entacapone
parkinson's disease
"Pros: Greatly reduces tremors and lasts up to the next scheduled dose, which is the point of taking the medicine. However.....
Cons: Immediately after taking the drug, there is temporary nausea, drowsiness, sleepiness & disorientation, dizziness. It makes me sleep more than desired. I can no longer drive, cook,  or do much of anything because of the dizziness. I prefer tremor relief, so the medicine wins. We don't have much choice with this disease.
It's very expensive, but what is your quality of life (what little there is)  worth to you? If I have to exist, I would rather sleep than suffer tremors most of my waking hours."