Amitriptyline
interstitial cystitis
"For my IC/PBS, I get bladder infections every two weeks, try as hard as I can to watch my diet (though it's difficult not to cheat), get pelvic floor physical therapy, take Uribel and Klonapin as needed, and take 25 mg of amitriptyline each night.  When I first started taking it, after about a couple of weeks, I felt completely normal for the first time in months.  No symptoms at all for about 4 weeks.  Now I have some creeping back.  I'm going to try upping my dose to 50 mg each night and see how I tolerate it.  It does make you dopey in the morning at first, but that goes away eventually."