Baclofen
muscle spasm
"I don't notice it working.  I notice when it stops.  Example.  I had a physical therapy pool session.  I overslept and took my 10mg dose 30 minutes before pool time.  I started my session shuffling my feet along the pool floor.  30 minutes in to my pool time I could pick my knees up like a drum majorette.  I convinced my PT about the value of Baclofen.  

Like other antispasmodics and pain pills, Baclofen starts working in one hour.  It's helpful to set your alarm an hour early and take it before you get out of bed.

I take it for a mitochondrial myopathy.  I always have a low level of spasms that become like charley horses with activity."