Spironolactone
acne
"I've been on this medicine off and on for almost a year now. After I am on it for a few weeks, my joints start to hurt really bad. I think it is because of the diuretic nature of the drug. It doesn't stop the black heads. It also makes me get up in the night to pee. My Dermatologist says he has never heard of the joint pain being a problem and refused to believe its the spironolactone causing it. But after starting and stopping the medicine three times, I am sure it's the cause."