Topiramate
bipolar disorde
"After taking 300mgs (100mg AM/200mg PM) for three years, it's no longer working.  When I first went on it, it worked great for both mood stabilization and weight control.  I lost all the weight that I gained after being on Zyprexa and Depakote, and my moods were controlled well for about two and a half years.  I had minimal negative side effects that seemed to fade after a few months' use.  For the last six months I've been struggling with dosage adjustments and adding new drugs to my cocktail while trying to keep Topamax.  Finally I'm giving up and going off Topamax because it's not doing anything anymore.  "