Spironolactone
acne
"I have tried everything, even asked my dermatologist for Accutane after reading the horrible reviews, that's how  desperate I was. She prescribed Spironolactone & after 3 months, MY SKIN IS CLEAR! I did gain about 15 lbs, but hey, I can lose weight, whereas I  couldn't clear up my skin on my own! I noticed a slight feeling of depression in the first little while. But that's gone. Also, I started out with 50 mg & went up too 100. I think if I would have waited a bit longer I wouldn't have needed to & that may have helped the weight gain. But I'd do it all over again!"