Fundamental question on marginal utility I was just thinking back to some introductory economics courses, but now I'm extremely confused on a fundamental concept. How is marginal utility interpreted as the additional &quot;happiness&quot; gained from consuming one more unit of some good? If marginal utility is the derivative of utility, then isn't it only measuring how the gains from an incredibly small consumption of some good? And then I started thinking about indifference curves and the MRS. I'm not sure how the MRS tells you the slope at which you are willing to exchange 1 unit of good x for however many units of good y? Take this simple indifference for instance where y = 100/x:

The MRS at (20,5) is -1/4 which should mean that at (20,5) this person will be ok with trading in 4 units of good x for 1 unit of good y correct? But this agent is only indifferent at (16,6.25) so I'm not really sure what the interpretation of the slope MRS here could be and how that differs from the indifference curve.
How is marginal utility interpreted as the additional &quot;happiness&quot; gained from consuming one more unit of some good?

Not sure what you mean. Utility is not interpreted as some biological measure of happiness. A bundle of goods with high utility is prefered by the consumer to bundles with lower utilities. This is all that utility describes; it is a modelling/storytelling tool.

If marginal utility is the derivative of utility, then isn't it only measuring how the gains from an incredibly small consumption of some good?

Yes, it is.
On your graph: kudos for using Desmos!

The MRS at (20,5) is -1/4 which should mean that at (20,5) this person will be ok with trading in 4 units of good x for 1 unit of good y correct?

Strictly speeking this is only true for marginal quantities (infinitesimally small quantities). Basically you are approximating the indifference curve with a linear curve (a line) at the (20,5) point. This line only coincides with the indifference curve at (20,5), and as you move farther away from this point, the line becomes a more and more imprecise approximation of the curve. (Note that 6.25 instead of 6 is not too bad as an approximation.)  
The line about MRS representing the ratio at which a consumer is willing to trade is just to get the intuition across, it is not an exact definition.