I am trying to design a pie, but I'm not sure what to take into consideration I think a blueberry salmon pie with goat cheese would be delicious, but I am not a professional baker - just an amateur with a decent amount of experience and a good pie crust recipe.

So here are my questions: 


Am I insane, or would that actually be tasty? 
What things do I need to consider? 
Chemistry.


Basically, if you were trying to make such a pie, what considerations would you take into account?
We can't answer #1, because it is simply a matter of opinion.  You need to consider two things: crust and filling.  Since you already have a good pie crust, this is just about filling.  Flavor aside (as that is personal preference), you are going to want to consider consistency, that is, how the filling will behave when you cut the pie.  You are probably going to need to experiment a bit.  Traditional thickeners are flour, tapioca, and corn starch. Other considerations include visual appeal and flavor, but again, that is a matter of opinion.