Can I substitute a beef round rump roast for brisket? I am making a slow cooker recipe that calls for beef brisket. Unfortunately, my grocery store only had obnoxiously large cuts of brisket so I just grabbed a reasonably sized beef round rump roast. In the back of my head I thought I remembered that the two could be substituted for the other, but in trying to confirm that I'm coming up short.

Can I substitute a beef round rump roast for brisket? Do I need to adjust cooking time for the differing cut?
Pretty much no, they are totally non-alike. The beauty of brisket is that it is full of connective tissue and other odd stuff that translates to succulence when cooked low and slow. Round is pretty much the opposite, it has very little in the way of interest.