an apparatus 10 for treatment of an aneurysm and in accord with the present invention is schematically shown in fig1 and 2 . apparatus 10 comprises a laser 12 , a steerable guide wire 14 , and a catheter 16 . catheter 16 will be appropriately sized depending upon where in the patient &# 39 ; s body a treatment will occur . for treatment of a cerebral aneurysm , which may require navigation through very small blood vessels in the brain , catheter 16 will be a microtube in the form of an elongated tube and may include a substantially centrally disposed tubular passage 18 defined by a wall 20 for receiving guide wire 14 . catheter 16 may , as shown in fig1 also include an expandable balloon 21 , which is used for occluding an artery during an interventional surgical procedure . catheter 16 may also include a channel 22 disposed in the catheter wall 24 that is in fluid communication balloon 21 . guide wire 14 has a tubular configuration and thus defines a tubular passage 30 receiving an optical fiber 32 . the rigid proximal end ( not shown ) of the guide wire 14 is connectable to a fiber optic connector 34 , which couples the output of the uv laser 12 to the fiber 32 . fiber 32 is secured substantially coaxially at the center of guide wire 14 . the optical fiber 32 terminates an optical tip 36 disposed at the distal end thereof . the proximal end of the catheter 16 has two hermetic fluid ports 40 and 42 for receiving a fluid from external fluid sources , typically saline . port 40 communicates with balloon 21 through the channel 22 in the wall 24 of catheter 16 and serves for inflation of the balloon through the flow of saline from an external source ( not shown ) through the port 40 , into the channel 22 and from there into balloon 21 . the space between the external surface of guide wire 14 and the wall 20 of catheter passage 18 define a second channel for fluid flow . this second channel communicates with port 42 , which may also be fluidly connected to an external fluid source such as saline to provide a clear fluid distally of balloon 21 through the holes 26 . referring to fig1 it will be observed that an aneurysm 60 has formed at the branch of a parent artery 62 into a pair of daughter arteries 64 . the aneurysm 60 includes a neck 66 , a sac 68 defining a cavity 70 lined with endothelial cells , which form the inner wall or surface 72 of an artery ( and hence the sac ), and a dome 74 . the catheter is placed in the blood vessel over the guide wire 14 ( 0 . 009 ″ to 0 . 014 ″ in diameter ). the guide wire 14 has a hollow tubular configuration and according to the present invention is made of a metallic material , though it will be understood that other materials now known or hereafter developed could also find use as a guide wire . to provide the desired flexibility , fiber 32 has diameter of about fifty ( 50 ) micrometers or less and preferably in a range of about twenty - five ( 25 ) to about fifty ( 50 ) micrometers . fiber 32 is preferably a multimode fiber made of fused silica adapted for the efficient transmission of uv radiation . the optical tip 36 is transparent ( or translucent ) for the uv radiation and is made , for example , of sapphire or fused silica . the surface of the optical tip 36 is mated to the fiber 32 and configured so as to diffuse uv light in the forward and side directions to better illuminate the inner surface 72 of the aneurysm 60 . the uv radiation propagates in the optical fiber 32 from its proximal end to the distal end which is terminated with the optical tip 36 . the optical tip 36 scatters the radiation in different directions to the aneurysm &# 39 ; s wall 72 . the optical tip 36 is desirably positioned inside the aneurysm 60 at different distances from the aneurysm wall 72 . during irradiation of the dome 74 the distance between the optical tip 36 and the inner surface 7 is short , ranging from about one down to zero mm while during irradiation of the neck 66 the optical tip 36 is placed therewithin . the laser can be pulsed or continues wave ( cw ), with the preferred form being a cw ion argon laser generating uv radiation with wavelength 257 nm , which is strongly absorbed by the dna of the endothelial cells . preferably , the energy source , regardless of its particular embodiment , should generate ultraviolet radiation in the range of about 240 to about 280 nanometers , corresponding to maximum uv absorption in dna . [ 0033 ] fig3 represents enlarged view of the distal end of the catheter . guide wire 14 is illustrated as a low profile metal tube 80 with fiber 32 disposed thereinside with a spiral , thin wire 82 around it , brazed at both ends to the metal tube 80 . the optical tip 36 can be secured to the end of the tube 80 and fiber 32 with an epoxy or other glue 84 . wash fluid flow through the holes 26 and out of the open end 86 of the catheter 16 is illustrated by arrows 88 . [ 0034 ] fig4 and 5 show another implementation of the present invention . in the embodiment shown in the figure , a catheter 100 is used to deliver the necrotizing uv radiation to the aneurysm 60 . catheter 100 does not include an expandable balloon to occlude the artery 62 and thus can have a simpler construction than the catheter shown in fig1 - 3 . catheter 100 comprises a single elongate tubular member including a central passage 102 defined by an inner wall 104 . passage 102 receives a guide wire 106 . because there is no need to inflate a balloon , there is no need for a separate port and interwall fluid channel such as channel 22 as shown in fig2 . thus , catheter 100 includes a single hermetic fluid port 110 that receives a wash fluid such as saline from an external source as indicated by arrow 112 . port 110 is in fluid communication with passage 102 , thus providing a flow path from the external fluid source through the port 110 , through the passage 102 and out of the open end 114 of the distal end of the catheter 100 . catheter 100 further includes one or more optical fibers 32 disposed within the catheter wall 116 . each fiber will include an optical tip 36 at its distal end attached in any known manner . the uv radiation will be delivered to the inner surface 72 of the aneurysm by the tips 36 , each of which will radiate in a substantially semispherical direction in the same manner as the embodiment shown in fig1 . uv radiation will be delivered to the fibers 32 by laser 12 through the optical coupler 34 . a method of treatment of cerebral aneurysms comprises the steps of : a ) inserting a fiber optic guide wire into an artery feeding an aneurysm , with the distal optical tip of the guide wire being placed inside the aneurysm ; b ) placing a balloon over the wire proximally to the optical tip of the guide wire ; c ) occluding the artery by inflating the balloon ; d ) clearing the optical field inside the artery and the aneurysm by delivering steady flow of fluid transparent or substantially transparent to uv radiation ; e ) activating a uv laser and delivering uv energy on the inside surface of the aneurysm in quantity sufficient for killing 99 . 9 % or more of the endothelial cells on the irradiated surface of the aneurysm . [ 0037 ] fig6 a , 6b , and 6 c illustrate generally the treatment of an aneurysm . fig6 b shows an artery 150 with an aneurysm 152 . the aneurysm dome 154 reveals a thinner vessel wall 156 as a result of the distention of the vessel 150 at that location . blood flow is indicated generally by arrow 158 . [ 0038 ] fig6 b illustrates the aneurysm following treatment with the present invention . it will be observed that a necrotized layer 160 of endothelial cells has been formed following treatment with uv radiation on the inside surface of the aneurysm . [ 0039 ] fig6 c illustrates the aneurysm 152 after the formation of a “ real arterial thrombus ” 164 . at the dome the thickness of the aneurysm &# 39 ; s wall is the lowest and the probability of rupture is the highest ( about 90 % of all cerebral aneurysms are ruptured at the dome ). narrowing the neck of the aneurysm causes a decrease in the blood pressure within the aneurysm sac and thus assists in its stabilization . a “ real arterial thrombus ” significantly differs from a blood clot , as that term is usually used in the described methods of stabilization of aneurysms . the underlying core of the arterial thrombus consists of fibrin and aggregated platelets , which strongly adhere to each other and to the arterial wall . the color of the core is white , so an arterial thrombus is sometimes referred to as a “ white thrombus ”. the margin or exterior layer of the arterial thrombus consists of coagulated blood and is red . arterial thrombi form at the site of an injury to the endothelium , which exposes the highly thrombogenic connective tissue underlying the endothelial layer to the blood flow . this connective tissue , primarily collagen , causes activation of platelets , leading to the formation of a thrombus . necrotic endothelial cells are not able to produce tissue plasmogen activator t - pa , major function of which is preventing thrombus formation on the vessel walls , and cannot stay attached to the the vessel wall surface . as they are flaked off and carried away by the blood flow , the highly thrombogenic underlying layer consisting of collagen is exposed . platelets from blood , activated at the denuded from endothelium surface of the aneurysm , start aggregation and the whole sequence of arterial thrombus formation on the irradiated surface of the aneurysm is launched . in several days after intervention the thrombus , contracted in volume and ingrown by capilaries and fibroblasts , becomes organized . the fully organized thrombus on the inside surface of the aneurysm leaves a thick layer of fibrotic tissue , covered with a newly restored endothelial layer , thereby stabilizing the aneurysm against rupture and futher thrombosis . the energy fluence , required for causing necrosis of the endothelial cells , falls in the range of several units to several hundreds of mj / cm2 , that is , within a range of about 5 to about 1000 mj / cm2 . the time required for achieving full necrosis of endothelial cells with a milliwatt uv laser , falls in the range of about 10 seconds to several minutes . it will be understood that the time period over which irradiating of the aneurysm with uv energy occurs is inversely dependent upon the applied energy . as the power of the applied radiation decreases , the duration of time over which the energy must be applied to cause the desired cell death increases and vice versa . an argon ion laser , generating uv radiation with wavelength 257 nanometers or a nd - yag laser generating radiation with a wavelength 256 nanometers ( the fourth harmonic of the infrared wavelength 1 . 06 microns ) is just two examples of uv radiation sources that can be used in accord with the present invention . without functioning endothelial cells the aneurysm &# 39 ; s inner wall becomes highly thrombogenic , triggering formation of thrombus on it and coagulation of the blood in the sac of the aneurysm . after organization of the thrombus the inner wall of the aneurysm will be covered with a thick layer ( several hundred microns ) of a collagen rich fibrous tissue . for a normal artery the thickening of its wall is a negative event . it results in a loss of patency and flexibility of the vessel . but for an aneurysm the thickening of the wall decreases actual tensile stresses in it and arrests the growth of the aneurysm . it follows from a well - known fact that circumferential stress , responsible for the aneurysm rupture , is inversely proportional to the aneurysm wall thickness : a several time increase in wall thickness causes a several time drop in the stresses . the formula is taken from “ the physics of cerebrovascular disease ” by george j . hademenos and tarik f . massoud , springer — verlag , 1998 , isbn 1 - 56396 - 558 - 5 . the critical thickness of a saccular aneurysm , at which a rupture occurs , is around 40 - 50 microns . the thickness of a fibrous layer after full organization of thrombus reaches several hundred microns , thus warranting stabilization of the aneurysm after treatment with uv radiation . [ 0050 ] fig7 schematically illustrates treatment of an arterial venous malformation ( avm ) 120 in accord with the present invention . avms are massive blood formations wherein one or more feeding arteries provide blood to the mass , which is then drained by one or more draining arteries without the blood ever being supplied to the tissue , typically cerebral tissue . the formation of the avm , then , results in starvation of the surrounding tissues because of the diversion of the fresh arterial blood from the tissue by the avm . as shown in the figure , guide wire 14 with an optical fiber 32 inside is advanced through a feeding artery 122 to avm 120 . the optical tip 36 of the fiber 32 is placed into a shunting arteriole 124 of the avm 120 . the balloon 21 inflates and occludes the artery 122 . saline flow distally to the balloon 21 clears the feeder 122 and proximal part of avm 120 from blood . the uv laser 12 is turned on and the feeder &# 39 ; s wall and adjacent vessels of the avm are irradiated by uv radiation emitted by the optical tip 36 . this procedure is repeated with all feeding arteries of the avm . after blood flow is restored , arterial thrombi are formed in the avm and adjacent feeders . the thrombus after organization causes stenosis or closing of the feeders , significantly decreasing blood flow through the avm and out through the draining vessels 126 it will be understood that the present invention can also be used to treat arterial fistulas in the same manner as previously described with reference to aneurysms and avms . it will be obvious to those skilled in the art that many modifications may be made within the scope of the present invention without departing from the spirit of thereof , and the invention includes all such modifications . for example , it will be understood that other sources of ultraviolet radiation now available or hereafter developed could provide the necessary ultraviolet radiation and that the use of a laser is not required by the present invention , though with current technology it is preferred .
an apparatus and method for stabilization of aneurysm is disclosed . the apparatus comprises an ultraviolet radiation generator for generating uv radiation having a wavelength , strongly absorbed by the dna and a catheter including means for delivering the ultraviolet radiation to the aneurysm . the distal end of the catheter is placed inside the aneurysm . stabilization of the aneurysm is achieved by forming a mural arterial thrombus inside the aneurysm . to make irradiation possible , the blood is displaced from the aneurysm by a steady stream of uv radiation transparent fluid . the injury to the endothelium that triggers the thrombus formation is caused by uv radiation delivered to the aneurysm . in several days after intervention the thrombus becomes fully organized , leaving on the inside surface of the aneurysm a thick layer of fibrotic tissue that stabilizes the aneurysm .