a container according to the invention is shown in fig1 . this container is a glass bottle , for example with a filling volume of 4 ml . the right hand side of fig1 shows a cross - sectional view of the bottle . a detailed cross - sectional view of the bottom of the bottle is shown in fig1 a . the glass bottle is preferably made from borosilicate glass tubing by state of the art methods . manufacture from tubular glass in the present case has the advantage that a comparatively large number of bottom configurations may be formed in a comparatively easy manner in contrast to manufacture from blow - molded glass . the bottle has a cylindrical casing section 1 , whose wall is comparatively uniformly thin in order to fulfill the requirements for a lightweight container . the 4 ml bottle in the present embodiment has a wall thickness of only 1 mm . an upwardly tapered neck or outlet section 2 is connected to the cylindrical casing section 1 . the neck or outlet section 2 has a standard thread , so that a standard screw cap can be used to provide the customary closure . the height of the neck or outlet section 2 amounts to about 9 mm in the present example and the length of the cylindrical casing section 1 amounts to about 23 mm so that the entire length of the bottle is about 35 mm . about 2 mm remains for the transition region between the cylindrical casing section 1 and the neck section 2 . the interior diameter of the neck section 2 amounts to about 9 mm , while the outer diameter of the cylindrical casing section 1 is about 18 mm . the massive bottom portion 3 and the geometrically inhomogeneous shape and nonuniform thickness of the container bottom portion 3 are characteristic for the bottles according to the invention . the bottom portion is clearly thicker than the wall of the cylindrical casing section 1 . a reinforced section 3 a of glass whose thickness is approximately three times the wall thickness of the cylindrical casing section 1 extends circumferentially around the container edge of bottom portion 3 in the embodiment according to fig1 a . the container bottom portion 3 also has a central interior depression 3 b and an outer bottom surface indentation 3 c in a central region that is as small as possible , i . e . the distance of the center point of the container bottom portion 3 from the supporting surface for the container is as small as possible . in this example the indentation amounts to about 0 . 7 mm . the weight of the container is thus only slightly greater than that of a comparable known container of the same filling volume , since only the bottom portion weight is increased . the required stability is attained by providing this center point indentation and as large a base contacting surface as possible . the interior depression 3 b in the container bottom portion allows the emptying of the container almost completely , since the liquid found in the container collects in the interior depression , i . e . the glass container according to the invention has only a residual volume of less than 1 % of the filling volume in regard to container contents , and moreover can be emptied automatically . freeze - drying experiments have shown an additional surprising effect of the described nonuniform bottom shape : a very uniform crystalline freeze - dried product ( lyophilizate ) is formed , without callapsed amorphous regions . a rotationally symmetric lyophilizate structure can be obtained . the freeze - drying process was not measurably retarded in spite of the on - the - average greater bottom portion mass in comparison to the standard containers . furthermore the specially formed bottom portion considerably reduces the number of broken bottles during lyophilization . the number of broken bottles during freeze - drying of 3 % mannitol solutions with a filling height of 24 mm ( filling volume about 10 ml ) is only 10 % of the number of broken standard bottles for the same conditions . the experimental conditions correspond to the known parameters . different embodiments of the bottle bottom portion shown in fig1 a are possible , in which the limiting factor is always the ratio of the glass diameter of the starting glass tubing to the wall thickness . five different embodiments are shown in fig2 a to 2 e . in the embodiment of fig2 a the reinforced section 3 a is an annular bead that is thicker than the pan - like central interior depression 3 b . furthermore the bottom portion 3 has a flat outer bottom surface 3 o . also the bottom portion 3 in the embodiment of fig2 b has a flat bottom . the embodiment of fig2 b differs from that of fig2 a by a considerably reduced reinforced section 3 a and a flatter interior depression 3 b . a central reinforced section 3 a ′, a concentric annular bead 3 a and a circumferential interior depression 3 b in connection with a gentle outer bottom surface indentation 3 c of the bottom center than shown in fig1 a in the present case are provided in the embodiment shown in fig2 c . the embodiment of fig2 d has a flat bottom surface on its bottom portion , single pedestal - shaped reinforced section 3 a and a gutter - like peripheral depression 3 b at its edge . the embodiment according to fig2 e is in principal like that of fig2 d , however the central glass reinforced section 3 a is less pronounced . also a peripheral reinforcing bead 3 a 1 is formed on the flat outer bottom surface 3 o of the bottom portion 3 at the lower bottom edge . in the embodiments of the invention described up to now the container according to the invention is made of glass with a circular cross section . however it can also be made of plastic material . the plastic container according to the invention can be made in a simple way with known plastics technology methods , such as injection molding , injection die - casting , immersion blowing . the desired geometric nonuniform interior base shape can be made by insertion of a die that has the corresponding opposite shape . the container is preferably made from a plastic material , which is translucent or transparent , so that e . g . the freeze - dried substance is accessible on dissolving it immediately prior to use by a professional , e . g . by a medical professional . preferably the translucent plastic material used should have a light transmission degree of greater than 90 % according to astm 1003 at a wall thickness of 2 mm . when the plastic material used is not sufficiently transparent , one skilled in the art can increase the transparency by addition of known additives according to the state of the art . the plastic material for the container for lyophilization and storage of slightly acid sensitive substances is selected with a density of & lt ; 1 . 1 g / cm 3 , a water vapor permeability according to din 53122 at a thickness of 1 mm of & lt ; 0 . 1 g / m 2 d and / or a water absorption of & lt ; 0 . 05 % according to astm d 570 . plastic materials with these specifications include cycloolefin polymers or cycloolefin copolymers , such those marketed under the trade names topas ® ( all types ) of ticona ; zeonex ® of nippon zeon ( all types , preferably zeonex ® 250 and zeonex ® 280 ) or apel ® of misui . cycloolefin polymers or copolymer with a water vapor permeability according to din 53122 of & lt ; 0 . 03 g / m 2 d and a thermal shape stability temperature ( hdtb / b ( 0 . 45 n / mm 2 ) according to iso 75 parts i and ii in the range between 50 ° c . and 90 ° c ., such as topas ® 08007 with a glass transition temperature in a range of 60 ° c . to 100 ° c . the plastic materials for the container for lyophilization and storage of very acid sensitive substances are selected from the group with a density of not less than 1 . 4 g / cm 3 and an acid permeability of & lt ; 50 cm 3 / m 2 d bar at a layer thickness of 100 μm . plastic materials with these specification are for example made of polymers based on polyethylene terephthalate ( pet ), glycol - modified polyethylene terephthalate ( petg ), oriented pet ( o - pet ) or polyethylene naphthalate ( pen ). the use of plastic material for the container according to the invention allows containers to be made with cross sections that are non - circular in a comparatively simple manner . to improve the thermal behavior in the lyophilization process it is advantageous when the container 10 according to the invention has planar side surfaces 11 , which are in a position to be in a planar contact with the side surfaces 11 of neighboring containers 10 . the transverse cross - section of this sort of container body can be preferably triangular , quadrangular or six - sided . typical examples are shown in fig3 a , 3b , 3 c and 3 d . if the cross section is triangular , then at least two of the three sides are preferably equal . the preferred triangular cross section is equilateral . in the case of the quadrangular cross section at least two sides opposite each other are parallel to each other . the quadrangular cross section can be shaped like a trapezoid , a parallelogram , a rhombus , a rectangle and especially a square . a six - sided cross section in which two sides opposite each other are of equal length ( fig3 c ) is however the preferred cross section . in the most preferred six - sided cross section all the sides are of equal length ( fig3 d ). when the side surfaces of the containers are planar and the containers have the cross - sections as described in fig3 a to 3 d , especially fig3 d , the containers for lyophilization can be arranged according to a batch process in a lyophilizaiton chamber , so that the available space is used in an optimum manner . the planar form of the side surfaces of the container casings together with the triangular , quadrangular or six - sided cross - sectional form allows each container of a batch to be arranged so that its side surfaces come into contact with the side surfaces on neighboring containers , unless of course it is in a position on the outer edge of the group of containers . besides the optimum use of space in the chamber this has the result that heat transfer and balancing occurs during the lypophilization process in spite of the usual reduced thermal conductivity of the plastic in comparison to glass , so that a more or less uniform temperature distribution arises in all the containers of a batch . the dead space between the containers occurring unavoidably with circular cross sectioned containers , which results in a thermal isolation of the individual containers , does not occur with the containers having corners . also increased heat exchange between the bottom plate of the lyophilizator ( cooling plate ) and the material to be lyophilized in the containers can occur in comparison to glass bottles in addition to the uniform heat exchange between the individual containers . since the bottom surface has an indentation of less than 0 . 5 mm heat exchange is improved in comparison with the more or less indented bases of conventional containers made of glass . with a predetermined amount of material to be lyophilized and a predetermined available surface area in the lyophilizator less time is required for the lyophilization when the containers with corners are used instead of the conventional round bottles . since the material to be lyophilized in a predetermined volume can be distributed over a larger surface region ( they make dead space occur with circular or round bottles available ), a smaller filling height can be used than with the round container bodies for the same volume , whereby the ratio of ‘ active surface area ’ to filling height in the container and thus the efficiency of the sublimation of the ice from the active surface is increased . one then requires a smaller available surface area and thus reduced freeze - drying unit than with the round glass bottles when the cornered containers are used . the containers with the cornered casing cross section according to that shown in fig3 a to 3 d have a geometrically nonuniform base portion analogous to that shown in fig2 . however preferably the reinforcing sections and the depressions are not rotationally symmetric , but are formed according to the geometric shape of the cross section . the disclosure in german patent application 198 31 112 . 5 - 43 of jul . 11 , 1998 is incorporated here by reference . this german patent application describes the invention described hereinabove and claimed in the claims appended hereinbelow and provides the basis for a claim of priority for the instant invention under 35 u . s . c . 119 . while the invention has been illustrated and described as embodied in a universal container for medicinal purposes , it is not intended to be limited to the details shown , since various modifications and changes may be made without departing in any way from the spirit of the present invention . without further analysis , the foregoing will so fully reveal the gist of the present invention that others can , by applying current knowledge , readily adapt it for various applications without omitting features that , from the standpoint of prior art , fairly constitute essential characteristics of the generic or specific aspects of this invention . what is claimed is new and is set forth in the following appended claims .
the improved container for liquid and solid medicinal preparations , especially freeze - dried products , includes a casing section with a bottom portion and an outlet portion . the casing section is thin - walled in comparison to the bottom portion and the outlet portion is formed so as to be closable by a closure device . the bottom portion has a nonuniform geometry and is provided with at least one interior depression , a reinforced section and an outer bottom surface that is completely planar or planar with a comparatively slight central indentation . the container is lightweight and stable which guarantees a uniform lyophilizate structure . in the case of a glass container the container of the invention has a very low breakage rate and can be nearly completely emptied .