fig1 is a side view of an endofluorescence imaging module 3 attached by friction fit to the distal tip of an endoscope 5 . control lines 7 carrying electrical power and control signals extend from the endofluorescence imaging module 3 back through the working channel 6 of the endoscope 5 . the control lines 7 extend out the working channel spout 9 . fig2 shows an end view of the imaging module 3 attached to the endoscope 5 . an instrumentation mount 11 protrudes into the center of module 3 . the mount 11 is positioned so as to not interfere with an optical channel 13 or working channel 6 of the endoscope 5 . the imaging module 3 also includes a light modulator assembly 17 positioned over the optical channel 13 . the optical channel 13 can be an optical fiber bundle , a television scanning element ( e . g ., a ccd array ), or other imaging system . such systems can include those that transport image information by optical means or are based on electrical or optical scanning systems . the detected image is observed at the proximal end of the endoscope 5 or at a remote location . fig3 is a side view of a control unit 41 for an endofluorescence imaging module mountable on the proximal handle 20 of the endoscope 5 . an eyepiece 25 allows direct optical viewing of the image or is used as an attachment for a television or film camera . a working channel spout 9 provides convenient access to the working channel 6 that extends to the distal end of the endoscope 5 . the control lines 7 extend from the working channel spout 9 and are terminated in a multipin connector 33 . the multipin connector 33 is small enough to extend through the working channel 6 without impediment , thereby allowing the control unit 41 to be electrically connected with the distally mounted endofluorescence imaging module 3 . a cable 44 having a connector 43 extends from the control unit 41 and mates with a connector 33 at the proximal end of the control lines 7 . a flange 45 mates with a bayonet mount 31 for secure attachment of the control unit 41 in a convenient manner . the control unit electronics 49 , which regulate electrical power and signals , is powered by a battery 47 . a switch 51 on the control unit 41 actuates the control electronics 49 . referring to fig4 a , an endofluorescence imaging module 3 includes a housing 100 which can be removably attached to the distal end of an interventional device . a light source 102 and a light modulator 104 are disposed in the housing 100 . the light source 102 illuminates tissue within the body . the light source 102 can include , without limitation , a light emitting diode , a laser , a pulsed light source , a source of ultraviolet energy , or a flashlamp . the light modulator 104 modifies the light emitted by the light source 102 . the light modulator 104 can include a filter providing a range of wavelengths to the optical channel of the interventional device . the filter can include , without limitation , an acousto - optic tunable filter , an interference filter , a grating , a prism , a holographic filter , a birefringent filter , or other component that provides a spectral passband . the light modulator 104 can also include a shutter . the shutter , for example , can comprise a liquid crystal device . referring to fig4 b , a detailed cross - sectional view of an endofluorescence imaging module 3 is shown . the control lines 7 terminate in the instrumentation mount 11 which holds transformer housing 61 . two wire pairs 63 a and 63 b extend from the transformer housing 61 . the first wire pair 63 a is disposed in a recess channel 70 and terminates at a circular xenon flashtube 65 held in place by mounting flange 67 . the transformer ( not shown ) in the transformer housing 61 provides a voltage step up function for operation of the flashtube 65 . the second wire pair 63 b is disposed in a second recess channel 71 and terminates at a light modulator assembly 17 . the light modulator assembly 17 includes a shutter 68 and a filter assembly 69 . endofluorescence imaging module 3 has a rigid distal end section 73 made of a relatively rigid material , such as polystyrene , polycarbonate or polysulfone , and is colored or transparent . a urethane adhesive 75 secures the distal end section 73 to a flexible ring 77 . the flexible ring 77 slides over the end of the endoscope 5 and provides secure attachment materials for this ring include elastomeric materials such as silicone , rubber , latex or polyurethane . other plastics or fabrics can be used as long as the imaging module is securely attached to the endoscope 5 throughout the endoscopic procedure . fig5 shows a detailed light modulator assembly 17 . a liquid crystal shutter 81 and an adjacent acousto - optic tunable filter ( aotf ) 83 are mounted on a surface of the endofluorescent imaging module 3 with an adhesive . a metal mounting block 99 provides a mounting surface for the individual components of the shutter 81 and the aotf 83 . the aotf control leads 101 and shutter control leads 103 extend through the recess channels 71 ( shown in fig4 b ). the liquid crystal shutter 81 includes a liquid crystal 85 located between two electrodes 87 . the electrodes can be metallization layers on glass covers 89 . when an electric field is applied between the electrodes 87 light passing through the liquid crystal 85 becomes polarized . a polarizing filter 91 is aligned for cross - polarization with the liquid crystal 85 in its active state . therefore , when an electrical signal is applied to the electrodes 87 , optical energy is prevented from passing to the optical channel 13 of the endoscope 5 . an electrical signal can be applied for the duration of the optical pulse from the flashtube 65 in order to momentarily shutter the optical channel 13 . an electrical signal applied to both side electrodes 93 of the aotf 83 changes the refractive index of the aotf crystal 95 and polarizes the transmitted optical energy . attenuation or selection of specific wavelengths is achieved when the aotf crystal 95 is used in conjunction with polarizing filters 97 . voltage applied to the electrodes 93 controls the selected wavelength , allowing transmission of specific colors while rejecting other colors . operation of the endofluorescence imaging module 3 occurs after attachment to the interventional device . the flashtube 65 is fired in conjunction with actuation of the shutter 81 and is also be timed with the filter 83 to provide a temporary or repetitive fluorescence algorithm . the shutter 81 is used to temporarily block any white or colored light from entering the optical channel 13 during the firing of the flashtube 65 . the flashtube 65 can have an integral uv filter to attenuate all light outside uv wavelengths . a typical uv wavelength range of interest can include 290 nanometers to 370 nanometers . red fluorescence that can occur can be effectively detected by endoscope 5 by tuning the aotf 83 to a center wavelength of approximately 600 nanometers , thereby blocking all but the fluorescing signal . blue fluorescence or uv fluorescence that may occur can also be detected if the aotf 83 is tuned and timed in sequence with the onset and duration of the optical energy emitted from the flashtube 65 . while the invention has been particularly shown and described with reference to specific preferred embodiments , it should be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims .
an endofluorescence module is utilized with an interventional device insertible in a body to provide at least one fluorescence excitation source . the module can be attached to the distal end of an endoscope , cystoscope or other optical imaging device . one or more filters are utilized to enhance the fluorescence response from the tissue under examination . a light shutter controls the exposure of an optical channel during operation . the adaptability and small size of the module correspond with low cost and disposability .