the characteristics and the advantages of the composition according to the present invention will be illustrated by the following detailed description . by using the process already mentioned previously , and described in the italian patent n o mi 2002a001074 for the preparation of ternary compositions , the applicant has surprisingly found that the addition of a fourth substance , which is usually used as a sweetening agent , leads to an advantage in terms of solubility with respect to the ternary compositions which do not contain it . indeed , this unexpectedly behaves as a second co - grinding auxiliary substance , surprisingly improving the characteristics of the composition itself . in particular the quaternary composition , object of the invention , may have the following characteristics . for the quaternary composition comprising propolis , linear or cross - linked hydrophilic carriers , such as for example cyclodextrin and cyclodextrin derivatives , and aminoacid auxiliary substances , preferentially selected from the group consisting of glycine , glutamic acid , lysine and serine are preferred . the weight ratio between the active substance and the carrier may be between 1 : 1 and 1 : 20 and preferably between 1 : 5 and 1 : 8 . the weight ratio between the active substance and the aminoacid co - grinding auxiliary substance may between 1 : 0 . 1 and 1 : 2 and preferably between 1 : 0 . 2 and 1 : 1 . the ratio between the active substance and the second glycyrrhizate co - grinding auxiliary substance may be between 1 : 0 . 5 and 1 : 2 and preferably 1 : 1 . the co - grinding time for the preparation of the quaternary composition is usually very short and comprised of between 0 . 30 and 2 . 0 hours . the following experimental examples are given as non - exhaustive illustration of the present invention . example 1 a quaternary composition with propolis , ammonium glycyrrhizate , β cyclodextrin and l - glycine 2 kg of a propoflavis , ammonium glycyrrhizate , β cyclodextrin and l - glycine mixture , in the ratio of 1 : 1 : 7 . 5 : 0 . 5 w / w , are homogenised for 10 minutes in a rotating body powder mixer . the mixture is loaded into a vibrational mill equipped with sintered alumina cylindrical milling means and subjected to grinding with a vibrational amplitude comprised of between 6 and 10 mm for 1 hour . the product obtained , with a yield of 98 . 9 %, is sieved and 99 . 8 % of the product recovered in the form of a finely divided , free - flowing powder . example 2 a quaternary composition with propolis , ammonium glycyrrhizate , β cyclodextrin and glutamic acid 2 kg of propoflavis , ammonium glycyrrhizate , β cyclodextrin and glutamic acid mixture in a ratio of 1 : 1 : 7 . 5 : 0 . 5 w / w , are homogenised per 10 minutes in a rotating body powder mixer . the mixture is loaded into a vibrational mill equipped with sintered alumina cylindrical milling means and subjected to grinding with a vibrational amplitude comprised of between 6 and 10 mm for 1 hour . the product obtained , with a yield of 98 . 9 %, is sieved and 99 . 8 % of product recovered in the form of a finely divided free - flowing powder . the quaternary compositions described may be replicated using , as the aminoacid co - grinding auxiliary , substance , other aminoacids amongst which are lysine and serine . with the aim of comparing the quaternary mixture of examples 1 and 2 , ternary compositions have also been prepared without the second ammonium glycyrrhizate co - grinding auxiliary substance , in accordance with the following examples 3 and 4 . example 3 a ternary composition with propolis , β cyclodextrin and l - glycine 1 kg of propoflavis , β cyclodextrin and l - glycine mixture in a ratio of 1 : 7 . 5 : 0 . 5 w / w , are homogenised for 10 minutes in a rotating body powder mixer . the mixture is loaded into a vibrational mill equipped with sintered alumina cylindrical milling means and subjected to grinding with a vibrational amplitude comprised of between 6 and 10 mm for 1 hour . the product obtained , with a yield of 97 . 8 %, is sieved and 99 . 6 % of product recovered in the form of a finely divided free - flowing powder . example 4 a ternary composition with propolis , β cyclodextrin and glutamic acid 1 kg of propoflavis , β cyclodextrin and glutamic acid mixture in a ratio of 1 : 7 . 5 : 0 . 5 w / w , are homogenised for 10 minutes in a rotating body powder mixer . the mixture is loaded into a vibrational mill equipped with sintered alumina cylindrical milling means and subjected to grinding with a vibrational amplitude comprised of between 6 and 10 mm for 1 hour . the product obtained , with a yield of 97 . 8 %, is sieved and 99 . 6 % of product recovered in the form of a finely divided free - flowing powder . the compositions of the examples 1 , 2 , 3 and 4 have then been compared with the starting raw material with regard to their solubilities , obtaining the results reported in the following table 1 . from the results shown above , it is clearly evident that the ternary composition containing an aminoacid co - grinding substance causes a significant improvement in the solubility of the native propolis , but that with the addition of the second co - grinding substance — ammonium glycyrrhizate — the solubility increases further by a range comprised of between 30 and 40 % with respect to the corresponding ternary composition . such results in themselves are very significant in that it is apparent to any expert in the art that an increase in solubility , even by less than that found , may have an important and positive reflection on the bioavailability of the active ingredient ( s ) contained within the active substance . the quaternary compositions obtained in powder form , according to the present invention , may be formulated into products adapted for being used as dietary supplements or as parapharmaceutical , including dermocosmetic , products . for the uses as dietary supplements and parapharmaceutical , the quaternary compositions , forming the object of the present invention , may be formulated in the form of powders , even in single dose sachets , either as such or admixed with dietary or pharmaceutically acceptable excipients and diluents . furthermore , they may also be used in different forms , such as for example capsules , tablets , pastes , gels , solutions or suspensions and sprays , both as such and admixed with dietary or pharmaceutically acceptable excipients adapted to such other forms . furthermore for the dermocosmetic use the quaternary compositions , forming the object of the present invention , may be formulated cosmetic acceptable excipients as lotions , creams , ointments , pastes , gels , stick and other topical forms known for this use . example 5 lip cream 2 % components % purified water 64 . 75 vaseline oil 12 . 0 dermoil hde 5 . 0 arlacel p135 3 . 5 atlas g - 2330 2 . 0 vegetable glycerine 3 . 0 cutin hr 2 . 5 c - proflavis ( example 1 ) 2 . 0 beeswax 1 . 1 polyglyceryl - 3 beeswax 2 . 0 euxil k 300 0 . 8 mg stearate 0 . 5 allantoin 0 . 2 karitè butter 0 . 2 vitamin e acetate 0 . 2 all fruit flavour 0 . 15 bht 0 . 05 edta disodium 0 . 05 example 6 oral cavity spray 3 % water 92 . 91 c - proflavis ( example 1 ) 3 . 0 menthol clathrate 1 . 0 carbopol 934 0 . 30 30 % simethicone emulsion 2 . 0 sodium hydrate 18 % 0 . 69 methyl p - hydroxyibenzoate 0 . 09 propyl p - hydroxyibenzoate 0 . 01 100 example 7 chewable tablets componentis mg biomaltodextrines 529 . 0 destrates 210 . 0 peppermint flavour 72 . 0 c - proflavis ( example 1 ) 50 . 0 technological excipients 27 . 0 mix biovegetable flavours 7 . 0 example 8 chewable tablets biomaltodextrines 536 . 0 destrates 210 . 0 apple flavour 65 . 0 c - proflavis ( example 1 ) 50 . 0 technological excipients 27 . 0 mix biovegetable flavours 7 . 0 example 9 chewable tablets biomaltodextrines 536 . 0 destrates 210 . 0 wood fruit flavour 65 . 0 c - proflavis ( example 1 ) 50 . 0 technological excipients 27 . 0 mix biovegetable flavours 7 . 0 example 10 chewable tablets biomaltodextrines 536 . 0 destrates 210 . 0 milk / honey flavour 55 . 0 c - proflavis ( example 1 ) 50 . 0 technological excipients 27 . 0 mix biovegetable flavours 17 . 0 example 11 chewable tablets biomaltodextrines 370 . 5 destrates 375 . 5 cola flavour 55 . 0 c - proflavis ( example 1 ) 50 . 0 technological excipients 27 . 0 mix biovegetable flavours 17 . 0 example 12 chewable tablets biomaltodextrines 506 . 0 destrates 255 . 0 citrus flavour 40 . 0 c - proflavis ( example 1 ) 50 . 0 technological excipients 37 . 0 mix biovegetable flavours 7 . 0 example 13 effervescent tablets actvive principles mg spirea ulmaria / β cyclodextrin 100 . 0 c - proflavis ( example 1 ) 50 . 0 rosa canina dried extract 50 . 0 excipients mg anhydrous citric acid 2000 . 0 sodium bicarbonate 600 . 0 sodium carbonate 600 . 0 sorbitol 340 . 3 e162 160 . 0 orange flavour 50 . 0 red orange dried extract 10 % 25 . 0 acesulfame k 20 . 0 polisorbate 20 2 . 0 dimethicone emulsion 10 % 2 . 0 vitamin b 2 0 . 7
the present invention describes a quaternary composition consisting of propolis delivered in a hydrophilic carrier and co ground with the aid of two compounds for the preparation thereof in the form of a finely divided powder . the composition exhibits advantageous dissolution characteristics in aqueous environments compared to native propolis , hence resulting in greater bioavailability of the active ingredients contained therein .