further scope of applicability of the present invention will become apparent from the detailed description given hereinafter . however , it should be understood that the detailed description and specific examples , while indicating preferred embodiments of the invention , are given by way of illustration only , since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description . in accordance with a preferred embodiment of the present invention , the heparin syringe 10 visible from fig1 , which is prefilled with a heparin concentration fixed ex works , is connected to the tube system during the equipping of the blood hose system 20 for the carrying out of the therapy process / dialysis process and is inserted into the provided delivery unit , namely the syringe pump 30 . during the flushing phase of the blood hose system 20 with physiological fluid , preferably with physiological saline , the syringe pump 30 is filled with the physiological fluid shortly before the end of the flushing until a defined heparin concentration in the syringe 10 is reached . for this purpose , the heparin concentration which is fixed ex works and is present in the syringe is communicated to the therapy device made as a dialyzer in accordance with this embodiment . the therapy device then calculates the required volume of the diluting agent with reference to the individually prescribed prescription for the patient and carries out a corresponding actuation of the syringe 10 in an automated manner such that the latter takes up the computed volume of physiological fluid from the extracorporeal blood circuit ( i . e ., blood hose system ) 20 via the connection line 40 . the prescribed concentration of the diluted heparin solution is then located in the syringe 10 . furthermore , provision can be made for the therapy device to automatically calculate the delivery rate of the heparin pump with reference to an individually prescribed prescription for the patient and to add it to the blood to be therapied during the treatment in accordance with a defined profile . in the following , a possible process routine for the carrying out of the method in accordance with the invention is presented : the heparin dose is usually given in “ units ”. typical doses of heparin in dialysis treatments are around 500 - 1 , 000 units per hour . one - time initial does are 1 , 000 to 3 , 000 units . heparin is provided in glass bottles of 5 ml with 25 , 000 units . a 30 ml large heparin syringe prefilled ex works could accordingly be filled with a selected dose of 10 , 000 units . this would correspond to a volume of 10 , 000 / 25 , 000 * 5 ml = 2 ml . these heparin syringes can be prefilled ex works or in a fairly large number at the dialysis center . the 30 ml heparin syringe 10 prefilled with 2 ml heparin is connected to the extracorporeal blood hose system 20 during preparation and is filled with fresh physiological flushing solution , e . g . dialysate , before the end of the flushing procedure . for example , the heparin syringe can be filled with 18 ml flushing solution so that a heparin concentration arises of 20 , 000 units / 20 ml = 1 , 000 units / ml . the filling of the 30 ml syringe on the machine side should not exceed the volume of 25 ml . if the prescription requires an initial dose of 2 , 500 units at the start of the treatment and a continuous dosage of 500 units per hour , the heparin pump 30 will add a bolus of 2 . 5 ml to the blood immediately after the start of the treatment . the heparin syringe will continuously supply a delivery rate of 0 . 5 ml per hour up to the desired stop time . as can furthermore be seen from fig1 , a pressure sensor 50 is connected to the extracorporeal blood hose system , said pressure sensor being able to be the pressure sensor anyway present in the arterial blood hose line . the sensor 50 serves for the monitoring of the filling of the syringe 10 within the framework of the method in accordance with the invention . during the drawing up of the syringe 10 for the reception of the diluting agent from the blood hose system 20 , the pressure is monitored by means of the sensor 50 . if an inconsistency is found between the pressure drop and the filling of the syringe 10 , this can be communicated accordingly to the user . in this manner , the tightness can be checked and leaks at the connection point 60 between the connection hose 40 and the extracorporeal blood hose system 20 can be pressure - monitored . the filling can be taken from a saline bag or from a dialysate prepared online in accordance with the flushing procedure . as shown in fig1 , the invention also includes an input device 80 with which the concentration of the agent to be metered can be input individually for a specific patient , and a control unit 70 which ( i ) determines the required volume of the diluting agent in an automated manner on the basis of the data received from the input device 80 and ( ii ) controls the metering apparatus , i . e ., the syringe 10 , such that the syringe takes up the determined volume of the diluting agent . instead of the blood hose system 20 , the heparin syringe 10 can also be connected to a cassette system 90 as shown in fig1 . the term of the extracorporeal circuit within the framework of the present invention comprises , for example , the blood hose system , the cassette system , etc . or any other constituents and components of the extracorporeal circuit . fig2 shows the time procedure of the volume located in the syringe 10 ( upper illustration ) and the time procedure of the heparin concentration of the heparin solution located in the syringe 10 ( lower illustration ). the time zones in detail designate the equipping phase 1 , the filling of the syringe 2 , connection of the patient 3 , adding of the heparin bolus 4 and continuous heparin dosing during the treatment 5 . in accordance with the prescription of the physician , the initial dose is communicated to the therapy device in heparin “ units ”, the continuous dosage in “ units per hour ” and the profile and the stop time by input or patient card . the input of the concentration in the heparin syringe filled ex works is only necessary on a change in the filling of the prefilled syringes , but not before every treatment . the concentration of heparin is determined in accordance with the filling of the heparin syringe ex works and the initial volume and the delivery rate are determined in accordance with the specifications of the physician via simple relationships . the following computation steps are carried out , by way of example , on the device side : continuous delivery rate with a dosage of 500 units per hour : in accordance with the embodiment shown here by way of example , the advantage is achieved that a conversion of a dosage of heparin prescribed for a specific patient from “ units ” into “ ml per hour ” is omitted . the required computation steps can be carried out on the device side . computation errors can thereby be reliably avoided . the delivery rate of the heparin pump is then irrelevant for the staff and their attention can be reduced solely to the prescribed dosage in the “ units ”. as was stated above , the advantage results due to the use of heparin prefilled ex works or at the dialysis center that the filling with an individualized amount of heparin matched to the patient and the use of additional consumable materials are omitted . the process procedure is substantially simplified with respect to the solutions known from the prior art due to the filling of the metering apparatus or syringe from the extracorporeal blood circuit during the preparation phase . a further advantage results from the fact that connection points and inlet lines can simultaneously be checked for tightness and passage on the device side , for which purpose the aforesaid pressure sensor can be used . a saving in consumable material and so a cost advantage result from the standardized preparation of heparin syringes . the method in accordance with the invention is preferably carried out automatically . this means an intervention of the user is preferably not necessary . the invention being thus described , it will be apparent that the same may be varied in many ways . such variations are not to be regarded as a departure from the spirit and scope of the invention , and all such modifications as would be recognized by one skilled in the art are intended to be included within the scope of the following claims .
a method is provided for the filling of a metering apparatus of a therapy device having an extracorporeal circuit with which the metering apparatus is in communication such that an agent can be infused into the extracorporeal circuit during the operation of the therapy device by means of the metering device . the method includes a step of diluting a concentrate located in the metering apparatus by taking up a diluting agent from the extracorporeal circuit .