referring now to fig1 through 4 , a multiple sample bioptome 10 according to the invention includes a proximal handle 12 and a distal end effector 14 . a long flexible coil 16 having an axially displaceable control wire 18 extending therethrough couples the handle 12 and the end effector 14 . the coil 16 is preferably covered with a ptfe , fep or polyolefin sheath 15 along substantially all of its length and a strain relief sleeve 17 covering a portion of the coil which extends from the handle 12 . the control wire 18 is preferably flexible but longitudinally inelastic and is ideally formed from 304 steel and provided with and outer diameter of approximately 0 . 018 inch . the proximal handle 12 includes a central shaft 20 and a displaceable spool 22 . the proximal end of the shaft 20 is provided with a thumb ring 24 and a longitudinal bore 26 is provided at the distal end of the shaft 20 . a longitudinal slot 28 extends from the proximal end of bore 26 to a point distal of the thumb ring 24 . the displaceable spool 22 is provided with a cross member 30 which passes through the slot 28 in the central shaft 20 . the cross member 30 is provided with a central through hole 32 and a radially engaging set screw 34 . a short bore 36 and a radially engaging set screw 38 are provided in the shaft 20 distal of the thumb ring 24 with the bore 36 communicating with the longitudinal slot 28 . the proximal end of the coil 16 extends into the central through hole 32 in the cross member 30 and is fixed there by the set screw 34 . the proximal end of the control wire 18 , passes through slot 28 , is inserted into the short bore 36 , and held there by the set screw 38 . from the foregoing , those skilled in the art will appreciate that relative movement of the shaft 20 and spool 22 results in movement of the control wire 18 relative to the coil 16 . such action results in actuation of the end effector 14 as described in detail below . turning now to fig2 through 4 , according to a first embodiment of the invention , the end effector 14 includes a cylinder 40 having a distal edge 42 and a jaw assembly 44 . the jaw assembly 44 includes a pair of end effectors 44 a , 44 b , a screw 102 , and a washer or retaining sleeve 104 . each end effector 44 a , 44 b includes a jaw cup 46 a , 46 b preferably having a rim 48 a , 48 b with radially arranged teeth , and a resilient , preferably narrow , arm 50 a , 50 b which extends proximally from the jaw cup 46 a , 46 b . the proximal end 51 a , 51 b of the narrow arm 50 a , 50 b preferably includes a sharply descending angled portion 52 a , 52 b . the approximate center of the arm 50 a , 50 b is bent at 53 a , 53 b so that the arms diverge as seen in fig2 . the arms 50 a , 50 b are formed from super - elastic memory metal such as nitinol ( nickel - titanium alloy ), and are biased apart from each other due to bends 53 a , 53 b , thereby urging the jaw cups 46 a , 46 b apart as seen in fig2 . in addition , as the arms 50 a , 50 b and the jaws 46 a , 46 b are preferably integral with each other , the jaws are preferably formed from a super - elastic or shape memory metal . the proximal end 51 a , 51 b of each arm 50 a , 50 b is coupled to the distal end 16 a of the coil 16 by crimping / locking with a hollow threaded screw 102 and a washer 104 . the threaded screw 102 is substantially cylindrical , and generally includes a head portion 106 , a threaded portion 108 , and a cylindrical throughbore 110 along its central axis . the throughbore 110 is dimensioned to receive and allow movement of the control wire 18 . the distal end 112 of the head portion 106 has a diameter substantially equal to that of the outer diameter of the coil 16 , and is provided with two opposing grooves 114 a , 114 b on the outer perimeter of the distal end 112 of the head portion 106 . grooves 114 a , 114 b are dimensioned to receive the angled portion 52 a , 52 b at the proximal end 51 a , 51 b of each of the narrow arms 50 a , 50 b . the proximal end of the head portion 106 is frustroconical with a smaller diameter at the threaded portion 108 . the threaded portion 108 has a diameter slightly larger than the inner diameter of the coil 16 and the proximal end of the threaded portion 108 includes threads 124 for lockingly engaging the interior of the distal end 16 a of the coil 16 . the washer 104 is substantially cylindrical , and generally includes a throughbore 126 . the distal portion of the throughbore 126 is frustroconical . it will be appreciated that the throughbore 126 of the washer 104 has substantially the same configuration as the proximal end of the head portion 106 of the screw 102 . it will therefore be understood that the throughbore 126 of the washer 104 is dimensioned for engaging the proximal end of the head portion 106 of the screw 102 and distal end 16 a of the coil 16 with the stepped 52 a , 52 b proximal ends 51 a , 51 b of the narrow arms 50 a , 50 b positioned in the grooves 114 a - b of the threaded screw 102 when the screw is threaded into the interior of the distal end 16 a of the coil 16 . the stepped 52 a , 52 b proximal ends 51 a , 51 b of the narrow arms 50 a , 50 b are thus fastened between the washer 104 and the threaded screw 102 . as shown in fig2 through 4 , the control wire 18 is provided with a bent end 18 a which is welded to a hole 45 in the side of the cylinder 40 . however , as described in detail in the related applications , other methods of coupling the control wire to the cylinder are possible . the cylinder 40 is slidably mounted over the cylindrical washer 104 and head portion 106 of the threaded screw 102 , and is axially movable over the resilient arms 50 a , 50 b , thereby bending the arms and closing the jaws 46 a , 46 b as shown in fig4 . as the resilient arms 50 a , 50 b are made of superelastic metal , they will immediately return to their original open position ( fig2 ) once the cylinder 40 is retracted . as seen best in fig3 and 4 , each jaw 46 a , 46 b has a widest part or apex 47 a , 47 b which is denoted by the line 47 a in fig3 . when the distal end 42 of the cylinder 40 reaches the apex 47 a , 47 b of the jaws ( or some definite point proximal of the apex ), the jaws are completely closed . from the foregoing description and with reference to fig1 through 4 , those skilled in the art will appreciate that when the spool 22 and the shaft 20 are axially displaced relative to each other , the cylindrical sleeve 40 and the end effectors 44 a , 44 b are similarly axially displaced relative to each other , from the positions shown in fig2 to the positions shown in fig5 and vice versa . when the spool 22 and shaft 20 are in the approximate position shown in fig1 the cylindrical sleeve 40 and the end effectors 44 a , 44 b will be in the approximate position shown in fig2 ; i . e ., with the jaws open . thus , when the spool 22 is moved towards the thumb ring 24 , or vice - versa , the cylindrical sleeve 40 and the end effectors 44 a , 44 b will be brought into the approximate position shown in fig4 ; i . e ., with the jaws closed . moreover , it will also be appreciated that it is preferable to move the thumb ring 24 relative to the spool 22 , rather than vice versa since that will move the cylindrical sleeve 40 relative to the end effectors 44 a , 44 b rather than vice versa . this is desirable so that the end effectors are not moved away from a tissue sample while the jaws are being closed . according to the first embodiment of the invention , a crimped stopping band or welded stopping sleeve 19 is provided on the control wire 18 . the stopping band 19 has an outer diameter which is larger than the diameter of the throughbore 110 of the screw 102 . the stopping band 19 is specifically located on the control wire 18 so that the distance between the stopping band 19 and the screw 102 is substantially equal to the distance between the distal edge 42 of the cylinder 40 and the apices 47 a , 47 b ( or desired closing point ) of the jaws 46 a , 46 b . therefore , when the jaws are moved to the closed position as shown in fig4 the control wire 18 and the coil 16 are stopped from further displacement by the stopping band 19 and the screw 102 . the hard stop provided by the stopping band 19 abutting the screw 102 prevents the cylinder 40 from pushing harder on the end effectors . turning now to fig5 and 6 , and with reference to fig1 a second embodiment of a bioptome 100 according to the invention may utilize substantially the same proximal handle 12 as the bioptome 10 described above . the difference in this second embodiment lies primarily in the end effector assembly 114 and in how that assembly is coupled to a coil 116 and control wire 118 . the coil 116 may be substantially the same as the coil 16 described above , having a sheath 115 , and the control wire 118 may be substantially the same as the control wire 18 described above , having a bent end 118 a . according to this second embodiment of the invention , the end effector 114 includes a cylinder 140 having a distal edge 142 , and a jaw assembly 144 . the jaw assembly 144 includes a pair of opposed jaw cups 146 a , 146 b each preferably having a plurality of sharp teeth 148 a , 148 b . a resilient , preferably narrow , arm l 50 a , 150 b extends proximally from each jaw cup 146 a , 146 b . a cylindrical base member 152 joins the proximal ends of the arms 150 a , 150 b . the narrow resilient arms 150 a , 150 b are biased apart from each other , thereby urging the jaw cups 146 a , 146 b apart . the cylindrical base member 152 of the jaw assembly 144 is coupled to the distal end 118 a of the control wire 118 by providing the base member 152 with a lateral hole 153 and providing the distal end 118 a of the control wire with a substantially right angle bend . the distal end 118 a of the control wire 118 is soldered or otherwise attached in the hole 153 in the base member 152 . the cylinder 140 is coupled to the distal end 116 a of the coil 116 by crimping and / or soldering . from the foregoing description , and with reference to fig1 , and 6 , those skilled in the art will appreciate that when the spool and the shaft ( 22 , 20 in fig1 ) are axially displaced relative to each other , the cylindrical sleeve 140 and the jaw assembly 144 are similarly axially displaced relative to each other , from the positions shown in fig5 to the positions shown in fig6 and vice versa . it will also be appreciated that when the spool and shaft are in the approximate position shown in fig1 the cylinder 140 and the jaw assembly 144 will be in the approximate position shown in fig5 ; i . e ., with the jaws open . thus , those skilled in the art will further appreciate that when the spool is moved towards the thumb ring ( 24 in fig1 ), or vice versa , the cylinder 140 and the jaw assembly 144 will be brought into the approximate position shown in fig6 by movement of the jaw assembly into the cylinder , thereby closing the jaws . in accord with the second embodiment of the invention , the cylinder 140 is provided with an annular stopping crimp 141 at a point distal of the distal end 116 a of the coil 116 , but proximal of the distal edge 142 of the cylinder 140 . the distance between the stopping crimp 141 and the proximal end 152 a of the jaw assembly is preferably approximately equal to the distance between the distal edge 142 of the cylinder 140 and the points 147 a , 147 b on the jaw cups where the distal edge of the cylinder lies when the jaws are closed . it will therefore be appreciated that when the jaws are brought into the closed position as shown in fig6 the base member 152 of the jaw assembly 144 abuts the stopping crimp 141 in the cylinder 140 as soon as the jaws are closed . this prevents further movement of the cylinder 140 and jaw assembly 144 relative to each other and thereby limits the cutting force applied to the jaws . referring now to fig7 and 8 , according to a third embodiment of the invention , the end effector 214 includes a cylinder 240 having a distal edge 242 and a jaw assembly 244 . the jaw assembly 244 includes a pair of jaws 244 a , 244 b , a screw 302 , and a washer or retaining sleeve 304 . the jaw assembly is substantially the same the jaw assembly 44 described above with reference to fig2 - 4 and is coupled to the distal end of the coil 216 in substantially the same manner as described above . according to this embodiment , a portion 216 a of the coil 216 which is proximally adjacent to the washer 304 is ground to a reduced external diameter . the length of the reduced diameter portion 216 a is preferably approximately equal to the distance between the distal edge 242 of the cylinder 240 ( when the jaws are open ) and the points 247 a , 247 b on the jaw cups where the distal edge of the cylinder lies when the jaws are closed . in addition , the proximal end of the cylinder 240 is provided with a radially inward directed flange 243 which defines a proximal opening having a diameter slightly larger than the reduced diameter of the ground portion 216 a . the cylinder 240 is coupled to the control wire 218 in substantially the same manner as the cylinder 40 of the first embodiment is coupled to the control wire 18 , described above with reference to fig1 - 4 . it will therefore be appreciated that when the jaws are brought into the closed position as shown in fig8 the flange 243 of the cylinder 240 abuts the washer 304 as soon as the jaws are closed . this prevents further movement of the cylinder 240 and jaw assembly 244 relative to each other and thereby limits the cutting force applied to the jaws . referring now to fig9 and 10 , according to a fourth embodiment of the invention , the end effector 314 includes a cylinder 340 having a distal edge 342 and a jaw assembly 344 . the cylinder 340 is substantially the same as the cylinder 40 described above and is coupled to the control wire 318 in substantially the same manner as the cylinder 40 is coupled to the wire 18 . the jaw assembly 344 includes a pair of jaws 344 a , 344 b , a screw 402 , and a washer or retaining sleeve 404 . the jaw assembly is similar to the jaw assembly 44 described above with reference to fig2 - 4 and is coupled to the distal end of the coil 316 in substantially the same manner as described above . according to this fourth embodiment , each jaw 344 a , 344 b is provided with a outer surface step 345 a , 345 b which is located approximately at the points on the jaw cups where the distal edge of the cylinder lies when the jaws are closed . it will therefore be appreciated that when the jaws are brought into the closed position as shown in fig1 , the distal edge 342 of the cylinder 340 abuts the steps 345 a , 345 b on the outer surfaces of the jaws 344 a , 344 b . this prevents further movement of the cylinder 340 and jaw assembly 344 relative to each other and thereby limits the cutting force applied to the jaws . there have been described and illustrated herein several embodiments of an endoscopic multiple sample bioptome . while particular embodiments of the invention have been described , it is not intended that the invention be limited thereto , as it is intended that the invention be as broad in scope as the art will allow and that the specification be read likewise . thus , while particular configurations of the cutting edges of the jaws , it will be appreciated that other types of cutting edges could be utilized . in particular , the cutting edges may have teeth or a toothless sharp edge , or a combination of both . the teeth may be radially arranged or arranged in another manner . in addition , while the jaws have been shown as coupled to the coil with a screw and washer in several embodiments , other coupling means could be provided . moreover , while the cylinder has been described as having a stopping crimp in the second embodiment , other types of radial occlusions may be used to limit movement of the jaw assembly and the cylinder relative to each other . in fact , if the base member of the jaw assembly and / or the cylinder is properly dimensioned and located , the coil itself can be used as the stopping device . it will therefore be appreciated that in the third embodiment of the invention , the proximal flange on the cylinder could be replaced with a stopping crimp . also , it will be appreciated that while the invention was described as advantageously permitting the obtaining of multiple biopsies without removal from the surgical site , the apparatus of the invention , if desired , could still be used for obtaining single biopsies at a time . it will therefore be appreciated by those skilled in the art that yet other modifications could be made to the provided invention without deviating from its spirit and scope as so claimed .
an endoscopic bioptome includes a flexible coil having a lumen with an axially displaceable wire extending therethrough . the proximal ends of coil and wire couple to a manual actuator for axially displacing one of the coil and wire relative to the other . the distal end of the coil couples to either a jaw assembly or a cylinder . the jaw assembly includes a pair of jaws each having a distal jaw cup having a proximal neck and a relatively narrow bent resilient arm . the distal end of the wire couples to the other of the cylinder or the jaw assembly . the cylinder is slidable over the jaw assembly . axial movement of either the wire relative to the coil or vice versa moves the cylinder over the arms of the jaws and over the necks of the jaw cups , thereby forcing the jaw cups together in a biting action .