since diffusion from the endplate 105 is crucial for maintaining the intervertebral disc , effort is made to re - establish nutrient and waste exchange between the nucleus pulposus and circulation within the vertebral body . guided by anteroposterior and lateral views from fluoroscopes , a trocar 103 enters posteriolaterally , 45 ° from mid - line into the disc 100 , as shown in fig5 . this guiding technique is similar to the one used in diagnostic injection of radiopaque dye for discography or chymopapain injection for nucleus pulposus digestion . a dilator 230 is inserted over the trocar 103 , as shown in fig6 . the trocar 103 is then withdrawn . the dilator 230 remains as a passage leading into the disc 100 , as shown in fig7 . fig8 shows the distal end of the dilator 230 near the nucleus pulposus 128 of the degenerating disc 100 . an elastically curved needle 101 , as shown in fig9 , is resiliently straightened in a rigid sleeve 220 indicated in fig1 . the round cross section of the straightened needle 101 and sleeve 220 is shown in fig1 . the resiliently straightened needle 101 within the rigid sleeve 220 is inserted into the dilator 230 and the disc 100 , as shown in fig1 . a longitudinal view of the needle 101 insertion into the degenerating disc 100 is indicated in fig1 . the elastically curved needle 101 is deployed by holding the rigid sleeve 220 stationary while pushing the needle 101 inward . the needle 101 resumes the curved configuration as it exits the distal opening of the sleeve 220 , puncturing upward as shown in fig1 , through the cartilage 106 and calcified layers 108 into the vertebral body 159 , as indicated in fig1 . multiple endplate 105 punctures 224 can be accomplished to re - establish the exchange of nutrients and waste between the disc 100 and bodily circulation . after retrieving the elastically curved needle 101 into the sleeve 220 , the assembly of needle 101 and sleeve 220 can be further advanced into or slightly withdrawn from the disc 100 to puncture more holes 224 through the calcified cranial endplate 105 . by turning the assembly of needle 101 and sleeve 220 180 °, the caudal endplate 105 can also be punctured , as shown in fig1 , to re - establish the exchange of nutrients , oxygen and waste through the superior and inferior endplates 105 . fig1 indicates restoration of swelling pressure within the nucleus pulposus 128 enabling the disc 100 to sustain compressive loads . with the presence of oxygen within the disc 100 , production of lactic acid may also decrease and ease chemical irritation and pain . endplate 105 puncturing can also be accomplished by electronic devices 134 , such as a laser , cutting or abrading device . fig1 depicts an electronic device 134 powering a cutter 127 to puncture , drill , abrade or cauterize the endplate 105 to re - establish the exchange of nutrients and waste . the electronic device 134 can be a cautery , laser , or drill . re - establishing the exchange of nutrients and waste through the calcified endplate 105 can also be accomplished using a conduit 126 . a conduit 126 can be an elastic tube 125 with a lumen or channel 104 and tissue - holding flanges 113 at both ends , as shown in fig1 . the orientations of the flanges 113 located at both ends of the conduit 126 are counter gripping to anchor onto the endplate 105 . the tube 125 is inserted over the elastically curved needle 101 and abutting a sliding plunger 109 , as shown in fig2 . the needle 101 carrying the elastic tube 125 is resiliently straightened within the rigid sleeve 220 , as depicted in fig2 . the assembly of the straightened needle 101 , tube 125 , sleeve 220 and plunger 109 is inserted into the dilator 230 , as shown in fig2 , and into the disc 100 . as the resilient needle 101 carrying the tube 125 is deployed from the rigid sleeve 220 , the curvature of the needle 101 resumes and punctures through the calcified endplate 105 , as shown in fig2 . the needle 101 is withdrawn while the plunger 109 is held stationary to dislodge the tube 125 from the needle 101 into the endplate 105 , as shown in fig2 . the lumen 104 of the tube 125 acts as a passage for exchanging nutrients , gases and waste between the vertebral body 159 and the inner disc 100 . a portion of the tube 125 is in the nucleus pulposus 128 or inner disc 100 , while the remaining portion is within the vertebral body ( not shown ) in fig2 . the handle 130 of the curved needle 101 and the handle 132 of the rigid sleeve 229 are used to maintain the direction of needle 101 deployment . the square handle 130 of the curved needle 101 is stacked within the handle 132 of the rigid sleeve 220 , as shown in fig2 , to avoid rotation between the needle 101 and sleeve 220 . the handle 130 of the needle 101 can also contain guide rails 131 , as shown in fig2 . the guide rails 131 are sized and configured to fit within the sunken tracks 133 on the handle 132 of the rigid sleeve 220 , as indicated in fig2 . direction of the needle &# 39 ; s curvature is indicated by the orientation lines 153 on the handle 130 of the needle 101 , as shown in fig2 , and on the rigid sleeve 220 as shown in fig2 . to indicate depth of insertion into the body , penetration markers 116 are labeled on the sleeve 220 , as shown in fig2 . the guide rails 131 within the tracks 133 keep the handles 130 , 132 from rotating around each other , as shown in fig2 . as the resiliently straightened needle 101 advances and protrudes from the rigid sleeve 220 , the curvature of the needle 101 resumes , as shown in fig3 . since the handle 130 of the needle 101 and the handle 132 of the sleeve 220 are guided by the rails 131 in tracks 133 , the direction of needle 101 puncturing is established and predictable for the operator or surgeon . non - circular cross - sections of the needle 101 and rigid sleeve 220 can also prevent rotation . fig3 shows a needle 101 and a sleeve 220 with oval cross - section . fig3 indicates a square cross - section . fig3 depicts a rectangular cross - section . fig3 shows a triangular cross - section . conduits 126 can also be made small enough to fit within the lumen of the elastically curved needle 101 . a conduit 126 can be a small tube 125 with a longitudinal channel 104 , as shown in fig3 , for transporting nutrients , oxygen and waste dissolved in fluid . the tubular conduit 126 with a lumen 104 can be braided or weaved with filaments , as shown in fig3 . the fluid can be transported through the lumen 104 as well as permeated through the braided filaments of the tube 125 . the tubular conduit 126 can also be molded or extruded with porous or spongy material , as shown in fig3 , to transport nutrients , oxygen and waste dissolved in fluid through the lumen 104 as well as through the pores . nutrients , oxygen , lactate , metabolites , carbon dioxide and waste can also be transported in fluid through capillary action of multi - filaments or braided filaments 122 , as shown in fig3 . a conduit 126 may not require the longitudinal lumen 104 as mentioned . a strand of braided filaments 122 can be a suture with channels formed among weavings of the filaments , capable of transporting fluid with nutrients , gases and waste . the braided filaments 122 can be coated with a stiffening agent , such as starch , to aid deployment using the plunger 109 . similar to the channels formed by the braided filaments 122 , a conduit 126 made as a spongy thread 124 , as shown in fig3 , can also transport fluid with nutrients , gases and wastes through the pores and channels formed within the porous structure . a conduit 126 is inserted into a longitudinal opening 269 of an elastically curved needle 101 abutting a plunger 109 , as shown in fig4 . to minimize friction between the curved needle 101 and the rigid sleeve 220 , the distal end of the lumen 268 of the sleeve 220 is angled or tapered with a bevel 102 or an indentation , conforming to the concave curvature of the needle 101 , as shown in fig4 . a lubricant or coating to lower friction can also be applied on the surface of the elastically curved needle 101 and / or within the lumen 268 of the rigid sleeve 220 . the elastically curved needle 101 carrying the conduit 126 is resiliently straightened within a rigid sleeve 220 , as shown in fig4 . the assembly is then inserted into a dilator 230 , as indicated in fig4 , which leads into the disc 100 . as the resiliently straightened needle 101 is deployed from the sleeve 220 , the needle 101 carrying the conduit 126 resumes the curved configuration and punctures into the cartilaginous endplate 105 through the calcified layers 108 , as shown in fig4 . the elastically curved needle 101 is then retrieved into the sleeve 220 while the plunger 109 is held stationary to deploy the conduit 126 at the calcified endplate 105 , as shown in fig4 . fig4 depicts insertion of the needle 101 , conduit 126 , plunger 109 , sleeve 220 and dilator 230 into the disc 100 . the resiliently straightened needle 101 carrying the conduit 126 is deployed from the sleeve 220 , resumes the curvature and punctures through the endplate 105 and calcified layers 108 , as shown in fig4 . while the plunger 109 behind the conduit 126 is held stationary , the elastically curved needle 101 is withdrawn from the calcified endplate 105 and retrieved into the sleeve 220 to deploy , expel or dislodge the conduit 126 at the calcified endplate 105 , as shown in fig4 . the conduit 126 acts as a channel or a passage , bridging between the bone marrow of the vertebral body 159 and the disc 100 to re - establish the exchange of fluid , nutrients , gases and wastes . fig4 shows the general location of the conduit 126 between the disc 100 and the vertebral body through the calcified endplate ( both not shown ). multiple conduits 126 can be loaded in series into the curved needle 101 , as shown in fig5 . each conduit 126 is deployed sequentially at the calcified endplate 105 by retrieving the curved needle 101 and holding the plunger 109 stationary . in essence , the plunger 109 is advanced toward the distal end of the needle 101 one conduit - length at a time . after deploying the first conduit 126 at the cranial endplate 105 , the rigid sleeve 220 is rotated 180 ° to deploy the second conduit 126 into the caudal endplate 105 , as shown in fig5 . multiple conduits 126 within the elastically curved needle 101 allow surgeons to implant multiple conduits through calcified endplates 105 without having to withdraw the needle 101 assembly , reload additional conduits 126 and re - insert the assembly into the disc 100 . in the supine position , disc pressure is low . during sleep , fluid is drawn in by the water absorbing glycosaminoglycans within the nucleus pulposus 128 . by bridging the calcified endplate 105 , the glycosaminoglycans draw fluid with sulfate , oxygen and other nutrients through the conduits 126 into the nucleus pulposus 128 during sleep by ( 1 ) capillary action , and ( 2 ) imbibing pull of the water - absorbing glycosaminoglycans . the flow of sulfate , oxygen and nutrients is channeled within the conduit 126 unidirectionally toward the nucleus pulposus 128 , rather than via the dispersion mechanism in diffusion . it is generally accepted that disc 100 degeneration is largely related to nutritional and oxygen deficiency . by re - establishing the exchange , a renewed and sustained supply of sulfate may significantly increase the production of sulfated glycosaminoglycans and restore swelling pressure . restoration of swelling pressure within the nucleus pulposus 128 reinstates the tensile stresses within the collagen fibers of the annulus , thus reducing the inner bulging and shear stresses between the layers of annulus , as shown in fig5 . similar to a re - inflated tire , disc 100 bulging is reduced and nerve impingement is minimized . thus , the load on the facet joints 129 is also reduced to ease pain , the motion segment is stabilized , and disc 100 space narrowing may cease . the progression of spinal stenosis is halted and / or reversed , as shown in fig5 to ease pain . in daily activities , such as walking and lifting , pressure within the disc 100 greatly increases . direction of the convective flow then reverses within the conduit 126 , flowing from high pressure within the disc 100 to low pressure within vertebral bodies 159 . the lactic acid and carbon dioxide dissolved in the fluid within the nucleus pulposus 128 is slowly expelled through the conduit 126 into the vertebral bodies 159 , then to bodily circulation . as a result , the lactic acid concentration decreases , and ph within the disc 100 is normalized . furthermore , due to the abundance of oxygen in the disc 100 supplied through the conduit 126 , lactic acid normally produced under anaerobic conditions may drastically decrease . hence , the pain caused by acidic irritation at tissues , such as the posterior longitudinal ligament 195 , superior 142 and inferior 143 articular processes of the facet joint , shown in fig5 , is anticipated to quickly dissipate . buffering agents , such as bicarbonate , carbonate or others , can be loaded or coated on the conduits 126 to neutralize the lactic acid upon contact and spontaneously ease the pain . the elasticity of the curved needle 101 still can twist within the rigid sleeve 220 during endplate 105 puncturing , as shown in fig5 . the likelihood of twisting increases with the length of the elastic needle 101 . the twisting is depicted in a cross - sectional view of the sleeve 220 , needle 101 and conduit 126 in fig5 . the elastic twisting between the shafts of the needle 101 and sleeve 220 allows directional shift at the tip of the needle 101 during contact with the calcified endplate 105 . as a result , puncturing of the endplate 105 may fail . to avoid twisting , the cross - sections of the needle 101 and sleeve 220 can be made non - round , such as oval in fig5 with a cross - sectional view in fig5 . a square cross - section is shown in fig5 . a rectangular cross - section is shown in fig5 . a triangular cross - section is in fig6 . the elastic property of the curved needle 101 may bend and fail to penetrate through the calcified endplate 105 , as shown in fig6 . the direction of the bend or droop is at the convex side of the curvature of the needle 101 . to minimize the droop , the distal end of the rigid sleeve 220 is cut at an angle , providing an extension to support the convex side of the curved needle 101 during endplate 105 puncturing , as shown in fig6 . the angled cut of the rigid sleeve 220 functions as a rigid needle 220 with a sharp tip supporting the convex side of the curved needle 101 , as shown in fig6 . the supporting structure can be further extended by cutting an indentation near the distal end of the rigid needle 220 , as shown in fig6 , to increase support of the convex side of the curved needle 101 during endplate 105 puncturing . to further support the elastically curved needle 101 , a window 270 may be located near the distal end of the rigid sleeve 220 with an oval cross - section , as shown in fig6 . the distal side of the window 270 is open slanted at an angle . the slant can also be formed with multiple angles into a semi - circular - like pocket , sized and configured to fit the convex side of the elastically curved needle 101 . fig6 shows protrusion of the elastically curved needle 101 from the window 270 of the rigid sleeve 220 . the sharp tip of the curved needle 101 is located on the concave side of the curvature to avoid scraping or snagging on the distal portion of the window 270 during deployment . fig6 shows deployment of the elastically curved needle 101 from the window 270 of the rigid sleeve 220 . the semi - circular pocket of the distal window 270 supports and brackets around the base of the convex curvature to minimize bending , twisting and / or deflection of the curved needle 101 during endplate 105 puncturing . in essence , the slanted portion of the window 270 provides a protruded pocket to direct and support the curved needle 101 . the distal end of the rigid sleeve 220 can be sharpened to function as a rigid needle 220 with the window 270 , as shown in fig6 . when a substantial amount of bone is formed , puncturing through the bony endplate 105 with a small curved needle 101 can be challenging . increasing the size of the needle 101 and creating a large hole 224 at the endplate 105 may cause leakage of nucleus pulposus 128 into the vertebral bodies 159 . to support a small curved needle 101 , a shape memory extension 271 containing a curvature similar to the curved needle 101 is added to strengthen and support the elastically curved needle 101 , as shown in fig6 . the shape memory extension 271 can be indented , as shown in fig6 , or tubular at the distal end . the curved needle 101 and shape memory extension 271 are capable of sliding independently within the rigid sleeve or needle 220 . fig6 shows resiliently straightening of both the curved needle 101 and shape memory extension 271 within the rigid sleeve 220 . both the curved needle 101 and shape memory extension 271 apply stresses on the rigid sleeve 220 . to minimize potential bending of the rigid sleeve 220 , the stresses are distributed over a larger area by positioning the tip of the needle 101 proximal to the curvature of the shape memory extension 271 , as shown in fig6 - 69 . spreading of the stresses also helps to ease the deployment and retrieval of both the needle 101 and shape memory extension 271 . for tissue puncturing , the shape - memory extension 271 is deployed from the rigid sleeve 220 , as shown in fig6 , followed by the curved needle 101 gliding along the curvature of the shape - memory extension 271 and puncturing into the calcified endplate 105 , as shown in fig7 . the shape memory extension 271 provides support to the needle 101 to minimize bending and twisting during puncturing without increasing the size of the puncture . the shape memory extension 271 can also be non - indented and sharpened to facilitate tissue piercing , as shown in fig7 . to dislodge the conduit 126 at the endplate 105 , the plunger 109 behind the conduit 126 is held stationary , while the curved needle 101 is retrieved into the shape memory extension 271 . the shape memory extension 271 is then withdrawn into the rigid sleeve 220 . the outer diameter of the curved needle 101 can be made non - uniform , being small at the distal end for creating a small opening , as shown in fig7 . the adjoining curved portion of the needle 101 contains a thick wall and a larger outer diameter to support and strengthen the process of endplate 105 puncturing . the transition between the small and large outer diameters is gradual , as shown in fig7 , or in steps . the curved needle 101 with varying outer diameters can be made by grinding , machining or injection molding . the lumen 268 of the rigid needle 220 may have a bevel 102 and a double - sided ramp 272 , as shown in fig7 . the bevel 102 or tapering at the distal end of the lumen 268 minimizes friction against the concave side of the curved needle 101 during deployment and retrieval . the double - sided ramp 272 is protruded at the side opposite to the bevel 102 with the distal side in continuation with the sharp tip or extended end of the rigid needle 101 . the proximal side of the ramp 272 or protrusion can be shaped to conform to and support the convex side of the curved needle 101 during endplate 105 puncturing . the ramp 272 can be made with epoxy , solder or other hardened material , then shaped by machining . the ramp 272 can also be created during a molten process to seal the lumen 268 at the distal end . the sealed end is then cut , the ramp 272 and bevel 102 are shaped , and the lumen 268 is re - opened by machining . sections of the conduit 126 are made to optimize the exchange of nutrients and waste . fig7 shows a conduit 126 with braided filaments 122 connected to a porous tube 125 with a lumen 104 . the tubular 125 portion acts as a funnel , collecting nutrients from capillaries within the vertebral body 159 and funneling the nutrients into braided filaments 122 within the nucleus pulposus 128 . especially at the endplate 105 , mineralization within the pores or channels of the conduit 126 may occlude or block the exchange of nutrients and waste between the vertebral body 159 and disc 100 . fig7 shows a tube 125 covering or wrapped around the mid - section of the conduit 126 to prevent ingrowth of minerals or tissue into the pores or channels . the material for making the tube 125 can also have swelling , expanding or sealing characteristics to seal the puncture at the endplate 105 and prevent formation of schmorl &# 39 ; s node . the swelling , expanding or sealing material can be polyethylene glycol , polyurethane , silicon or others . an anti - ingrowth film or coating at the mid - section of the conduit 126 may also discourage mineralization or occlusion within the channels or pores to ensure long lasting exchange of nutrients and waste . especially within the vertebral body 159 or outer annulus , formation of fibrous tissue over the conduit 126 may occur , hindering the exchange of nutrient and waste . a portion of the conduit 126 can be coated , grafted , covalently bonded or ionic bonded with a drug to minimize fibrous formation . the drug can be actinomycin - d , paclitaxel , sirolimus , cell - growth inhibitor or fibrous tissue inhibitor . due to the soft or pliable characteristic , conduits 126 made with braided filaments 122 are difficult to deploy with the retrieving needle 101 and stationary plunger 109 . a conduit 126 made with braided filament can be stiffened with water soluble agents , such as starch , collagen , hyaluronate , chondroitin , keratan or other biocompatible agents . after deployment , the soluble stiffening agent dissolves within the body , exposing the filaments to transport nutrients , oxygen and waste . fig7 shows a monofilament 110 used as a stiff core within the braided conduit 126 to assist deployment . the monofilament 110 can be made with degradable material to maximize transport area after deployment of the conduit 126 . degradable tubes 125 , indicated in the shaded area of fig7 , can also be used to wrap and stiffen the braided filaments 122 . the degradable tube 125 or the degradable monofilament 110 can be made with poly - lactide , poly - glycolide , poly - lactide - co - glycolide or others . since nutrients are relatively abundant within the peripheral 1 cm of the disc 100 , the conduit 126 can also draw nutrients from the outer annulus through capillary action into the nucleus pulposus 128 . a needle 101 carrying the starch - stiffened conduit 126 ( not shown ) and a plunger 109 is punctured into a disc 100 with calcified endplates 105 , as shown in fig7 . the needle 101 guiding technique is similar to the one used in diagnostic injection of radiopaque dye for discography or chymopapain injection for nucleus pulposus 128 digestion to treat herniated discs 100 . guided by anteroposterior & amp ; lateral views from fluoroscopes , the needle 101 enters posteriolaterally , 45 ° from mid - line into the disc 100 . a longitudinal view of the needle 101 carrying the stiffened conduit 126 puncturing through the disc 100 with calcified endplates 108 is shown in fig7 . by holding the plunger 109 stationary while the needle 101 is being withdrawn , the conduit 126 is dislodged from the lumen of the needle 101 and deployed across the disc 100 , as shown in fig7 - 80 . at least one end of the conduit 126 is placed less than 1 cm from the periphery of the disc 100 to draw nutrients and drain lactic acid . to enhance imaging , the section of the needle 101 containing the conduit 126 can be coated with a radiopaque , echogenic or magnetic coating 163 , as shown in fig8 . multiple conduits 126 can be safely and accurately deployed into different areas of a degenerating disc 100 . fig8 shows two conduits 126 deployed across a degenerating disc 100 , exchanging nutrients and waste between the inner and outer disc 100 . in locations lacking any major blood vessel and organ , the tip of the needle 101 can be guided beyond the disc 100 , as shown in fig8 , to deploy the conduit 126 beyond the disc 100 , as shown in fig8 . the extended conduit 126 may draw significantly more nutrients into the disc 100 . in addition , the extended conduit 126 may be more effective in disposing the waste generated within the disc 100 and expediting the repair and / or regeneration of the disc 100 , as shown in fig8 . psoas major muscles 193 are located adjacent to the lumbar segment of the spine . the needle 101 carrying the conduit 126 can puncture beyond the disc 100 into the muscle 193 . as a result , the conduit 126 can draw nutrients from the muscle 193 into the disc 100 , as shown in fig8 . muscles 193 are well supplied with nutrients and oxygen , and muscles 193 dissipate lactic acid well . by extending into the muscles 193 , the conduits 126 can draw an abundant amount of nutrients and safely deposit the waste from the inner disc 100 to repair or regenerate the degenerating disc 100 , as shown in fig8 . the supple and tensionless conduits 126 are expected to be free from interfering with the functions of the disc 100 and muscles 193 . methods and devices for conduit 126 deployments can also be in various combinations . the conduits 126 can be delivered into the endplates 105 , as shown in fig5 , and transverse the annulus , as shown in fig8 or 87 . an accelerated disc degeneration model was developed using rat tails . a tail section involving three discs was twisted or rotated 45 ° and held for 2 weeks . the section was then compressed by coil springs and held for an additional period of time . all discs within the section degenerated . discs that had received additional nucleus pulposus from donor discs by injection experienced a delay in degeneration . furthermore , insertions of the additional nucleus pulposus prior to the destructive loads provided the longest delay against disc degeneration . after lumbar fusion procedures , the intervertebral discs 100 of adjacent free motion segments degenerate quickly . the degenerative process leads to more pain and possibly more surgery ; following each new fusion is a new vulnerable segment adjacent to it . accelerated degeneration of segments adjacent to a lumbar fusion may be the result of additional post - fusion stress and load . in the rat model , the added volume within the nucleus pulposus had a protective function against the destructive load . in conjunction with spinal fusion procedures , implanting conduits 126 within discs 100 adjacent to the fused segment may provide adequate swelling pressure contributed by an abundant supply of sulfate and oxygen to delay and hopefully prevent adjacent disc 100 degeneration . device migration with time is always a concern . the average age of patients undergoing back surgery is 40 - 45 years old . the conduit 126 is expected to remain in place within the patients for fifty or more years . migration of the tensionless conduits 126 may result in loss of effectiveness , but it is not likely to be detrimental to nerves , ligaments , muscles or organs . to minimize migration , knots 161 can be tied on the braided conduit 126 , as shown in fig8 , to anchor within the annulus , endplate 105 and / or muscle 193 . similar to knots 161 , rings 162 or protruded components 162 can be crimped on the conduit 126 , as shown in fig8 . both the knots 161 and the protrusions 162 are small enough to fit within the needle 101 . tissue ingrowth can also limit or prevent device migration . indentations 160 or tissue ingrowth holes 160 can be created on the conduit 126 , as shown in fig9 , to discourage migration with time . the conduit 126 can also be used as a delivery vehicle to introduce healing elements for maintaining or regenerating the disc 100 . the conduit 126 can be coated or seeded with growth factor , stem cells , donor cells , nutrients , buffering agent or minerals . cells sensitive to sterilization can be loaded aseptically . installations of conduits 126 can be in multiple stages , separated by days , weeks , months or even years . initial conduit 126 deployment prepares the biological conditions , including ph , electrolytic balance and nutrients , to favor cell proliferation . subsequent deployments may contain seeded cells within the conduit 126 . since cellularity within the inner disc 100 is low , cell migration from the outer annulus or vertebral bodies 159 can be helpful in regenerating the degenerating disc 100 . cells can be transported along the convective flow within the conduit 126 into the nucleus pulposus 128 . the channels or pores within the conduit 126 need to be sufficiently large , about 50 to 200 microns . for minerals , nutrients , lactic acid and gas exchange alone , the channels or pore size can be much smaller . hence , the useful diameter of the capillary action channel or pore size of the conduit 126 has the range between 200 microns and 10 nanometers . potentially useful coating for the conduit 126 include antibiotic , anti - occlusive coating , lubricant , growth factor , nutrient , sulfate , mineral , buffering agent , sodium carbonate , sodium bicarbonate , alkaline , collagen , hydroxyapatite , analgesic , sealant , humectant , hyaluronate , proteoglycan , chondroitin sulfate , keratan sulfate , glycosamino - glycans , heparin , starch , stiffening agent , radiopaque coating , echogenic coating , cells or stem cells . the tube 125 for preventing occlusion from mineralization or tissue ingrowth can be made with a biocompatible polymer , such as polytetrafluoroethylene , polypropylene , polyethylene , polyamide , polyester , polyurethane , silicon , poly - ether - ether - ketone , acetal resin , polysulfone , polycarbonate or polyethylene glycol . similar material can be used to coat or partially coat the conduit 126 to prevent blockage of nutrient and waste transport . the coating should be able to withstand sterilization by gamma , electron beam , autoclave , eto , plasma or uv light to prevent infection . especially for investigative purposes , a biodegradable conduit 126 may provide evidence within weeks or months . since the conduit 126 degrades within months , any unforeseen adverse outcome would be dissipated . if the investigative - degradable conduit 126 shows promise , a permanent conduit 126 can then be installed to provide continuous benefits . the biodegradable conduit 126 can be made with polylactate , polyglycolic , poly - lactide - co - glycolide , polycaprolactone , trimethylene carbonate , silk , catgut , collagen , poly - p - dioxanone or combinations of these materials . other degradable polymers , such as polydioxanone , polyanhydride , trimethylene carbonate , poly - beta - hydroxybutyrate , polyhydroxyvalerate , poly - gama - ethyl - glutamate , poly - dth - iminocarbonate , poly - bisphenol - a - iminocarbonate , poly - ortho - ester , polycyanoacrylate or polyphosphazene can also be used . similar biodegradable material can be used to make the biodegradable monofilament 110 in fig7 . a wide range of non - degradable materials can be used to fabricate the conduit 126 . biocompatible polymers , such as polytetrafluoroethylene , polypropylene , polyethylene , polyamide , polyester , polyurethane , silicon , poly - ether - ether - ketone , acetal resin , polysulfone , polycarbonate , silk , cotton , or linen are possible candidates . fiberglass can also be a part of the conduit 126 to provide capillarity for transporting nutrients and waste . conduits 126 can also be made with metal , such as nickel - titanium alloy or stainless steel . both non - degradable and degradable conduits 126 can be formed by molding , extruding , braiding , weaving , coiling , spiraling or machining . the conduits 126 can have a longitudinal lumen 104 , pores and / or channels for fluid exchange . the conduit 126 can be a suture with a proven safety record . the conduit 126 can also be called or classified as a shunt , wick , tube , braided suture , braided filaments , thread or sponge . the disc 100 with the conduits 126 installed can be called the shunted disc 100 . the rigid needle 101 , trocar 103 , dilator 230 and plunger 109 can be made with stainless steel or other metal or alloy . the elastically curved needle 101 , shape memory extension 271 and plunger 109 can be formed with nickel - titanium alloy . the needle 101 , rigid needle 220 , dilator 230 , shape memory extension 271 and plunger 109 can be coated with lubricant , tissue sealant , analgesic , antibiotic , radiopaque , magnetic and / or echogenic agents . since nutrients and oxygen are extremely low particularly in degenerating discs 100 , cell death is common , and healthy cells capable of producing glycosaminoglycans are few . healthy cells 277 can be drawn from another disc 100 within the patient to inject with a syringe 276 into the degenerated disc 100 , as shown in fig9 . exchange of nutrients and waste is re - established through the newly installed conduits 126 through the cranial and caudal endplates 105 to nourish both the donor cells 277 and the remaining cells within the degenerating disc 100 . similarly , donor cells 277 can also be injected into the disc 100 with transverse conduits 126 to revitalize the disc 100 , as shown in fig9 . since cellularity within the degenerative disc 100 is low , introduction of donor cells 277 may expedite the process of halting or reversing disc degeneration . the avascular disc 100 is well sealed . even small ions , such as sulfate , and small molecules , such as proline , are greatly limited from diffusing into the nucleus pulposus 128 . the well sealed disc 100 may be able to encapsulate donor cells 277 from a disc 100 of another person , cadaver or animal without triggering an immune response . for disc 100 regeneration , the donor cells 277 can also be stem cells 277 , notochord 277 or chondrocytes 277 . the semi - permeable conduits 126 are permeable to nutrients and waste but impermeable to cells , proteins , glycoproteins and / or cytokines responsible for triggering an immune reaction . the cells of the immune system include giant cells , macrophages , mononuclear phagocyts , t - cells , b - cells , lymphocytes , null cells , k cells , nk cells and / or mask cells . the proteins and glycoproteins of the immune system include immunoglobulins , igm , igd , igg , ige , other antibodies , interleukins , cytokines , lymphokines , monokines and / or interferons . the molecular weights of nutrients and waste are usually much smaller than the immuno - responsive cells , proteins and glycoproteins . the transport selectivity can be regulated or limited by the size of the pores or channels within the semi - permeable conduit 126 . the upper molecular weight cut - off of the conduit 126 can be 3000 or lower to allow the passage of nutrients and waste but exclude the immuno - responsive cells , proteins , immunoglobulins and glycoproteins . the semi - permeable conduit 126 may also contain ionic or affinity surfaces to attract nutrients and waste . the surfaces of the semi - permeable conduit 126 can be selected or modified to repel , exclude or reject immuno - responsive components . in recent years , cell transplants from cadavers or live donors have been successful in providing therapeutic benefits . for example , islet cells from a donor pancreas are injected into a type i diabetic patient &# 39 ; s portal vein , leading into the liver . the islets begin to function as they normally do in the pancreas by producing insulin to regulate blood sugar . however , to keep the donor cells alive , the diabetic patient requires a lifetime supply of anti - rejection medication , such as cyclosporin a . in addition to the cost of anti - rejection medication , the long - term side effects of these immuno - suppressive drugs are uncertain . the benefit of cell transplant may not out weigh the potential side effects . the intervertebral disc 100 with semi - permeable conduits 126 can be used as a semi - permeable capsule to encapsulate therapeutic donor cells 277 or agents , as shown in fig9 and 92 , and evade the immune response ; hence no life - long immuno - suppressive drug would be required . a variety of donor cells 277 or agent can be harvested and / or cultured from the pituitary gland ( anterior , intermediate lobe or posterior ), hypothalamus , adrenal gland , adrenal medulla , fat cells , thyroid , parathyroid , pancreas , testes , ovary , pineal gland , adrenal cortex , liver , renal cortex , kidney , thalamus , parathyroid gland , ovary , corpus luteum , placenta , small intestine , skin cells , stem cells , gene therapy , tissue engineering , cell culture , other gland or tissue . the donor cells 277 are immunoisolated within the discs 100 , the largest avascular organs in the body , maintained by nutrients and waste transport through the semi - permeable conduits 126 . the donor cells 277 can be from human , animal or cell culture . in the supine sleeping position , nutrients and oxygen are supplied through the conduits 126 to the donor cells 277 . during waking hours while the pressure within the disc 100 is high , products biosynthesized by these cells 277 are expelled through the conduit 126 into the vertebral bodies 159 , outer annulus or muscle 193 , then into the veins , bodily circulation and target sites . the product biosynthesized by the cells 277 within the shunted disc 100 can be adrenaline , adrenocorticotropic hormone , aldosterone , androgens , angiotensinogen ( angiotensin i and ii ), antidiuretic hormone , atrial - natriuretic peptide , calcitonin , calciferol , cholecalciferol , calcitriol , cholecystokinin , corticotropin - releasing hormone , cortisol , dehydroepiandrosterone , dopamine , endorphin , enkephalin , ergocalciferol , erythropoietin , follicle stimulating hormone , γ - aminobutyrate , gastrin , ghrelin , glucagon , glucocorticoids , gonadotropin - releasing hormone , growth hormone - releasing hormone , human chorionic gonadotrophin , human growth hormone , insulin , insulin - like growth factor , leptin , lipotropin , luteinizing hormone , melanocyte - stimulating hormone , melatonin , mineralocorticoids , neuropeptide y , neurotransmitter , noradrenaline , oestrogens , oxytocin , parathyroid hormone , peptide , pregnenolone , progesterone , prolactin , pro - opiomelanocortin , pyy - 336 , renin , secretin , somatostatin , testosterone , thrombopoietin , thyroid - stimulating hormone , thyrotropin - releasing hormone , thyroxine , triiodothyronine , trophic hormone , serotonin , vasopressin , or other therapeutic products . the products ( hormones , peptides , neurotransmitter , enzymes , catalysis or substrates ) generated within the shunted disc 100 may be able to regulate bodily functions including blood pressure , energy , neuro - activity , metabolism , activation and suppression of gland activities . some hormones and enzymes govern , influence or control eating habits and utilization of fat or carbohydrates . these hormones or enzymes may provide weight loss or gain benefits . producing neurotransmitters , such as dopamine , adrenaline , noradrenaline , serotonin or γ - aminobutyrate , from the donor cells 277 within the shunted disc 100 can treat depression , parkinson &# 39 ; s disease , learning disability , memory loss , attention deficit , behavior problems , metal or neuro - related disease . release of the products biosynthesized by the donor cells 277 within the shunted disc 100 is synchronized with body activity . during activities of daily living , the pressure within the shunted disc 100 is mostly high to expel the products biosynthesized by the donor cells 277 into circulation to meet the demands of the body . in the supine position , the flow within the shunts 126 is reversed , bringing nutrients and oxygen into the disc 100 to nourish the cells 277 . using islets of langerhans from the donor &# 39 ; s pancreas as an example , production of insulin is induced in the shunted disc 100 during sleeping hours when glucose enters into the disc 100 . during waking hours when disc pressure is high , insulin is expelled through the conduits 126 into circulation to draw sugars into cell membranes for energy production . at night , the insulin released from the shunted disc 100 is minimal to prevent the hypoglycemia . in essence , products biosynthesized by the donor cells 277 are released concurrent with physical activity to meet the demands of the body . some biosynthesized products from the donor cells 277 are appropriately deposited through the vertebral body 159 , as shown in fig9 , then into bodily circulation . other products may be more effectively transported through the outer annulus , as in fig8 , and diffused through the abdomen into bodily circulation . some other products may be far more effective by entering into the muscles 193 , as shown in fig9 . growth factors , buffering agents , hormones , gene therapeutic agents , nutrients , minerals , analgesics , antibiotics or other therapeutic agents can also be injected into the shunted discs 100 , similar to fig9 - 92 . it is to be understood that the present invention is by no means limited to the particular constructions disclosed herein and / or shown in the drawings , but also includes any other modification , changes or equivalents within the scope of the claims . many features have been listed with particular configurations , curvatures , options , and embodiments . any one or more of the features described may be added to or combined with any of the other embodiments or other standard devices to create alternate combinations and embodiments . the conduit 126 can also have a gate to regulate rate and / or flow direction of nutrient , gas and waste exchange . it is also possible to connect a pump to the conduit 126 to assist the exchange between the disc 100 and the bodily fluid . a ph electrode may be exposed near the tip of the rigid needle 220 to detect the acidity within the disc 100 . it should be clear to one skilled in the art that the current embodiments , materials , constructions , methods , tissues or incision sites are not the only uses for which the invention may be used . different materials , constructions , methods or designs for the conduit 126 can be substituted and used . nothing in the preceding description should be taken to limit the scope of the present invention . the full scope of the invention is to be determined by the appended claims . for clarification in claims , sheath is a rigid tubular member . the elastically curved needle 101 can be called the elastic needle .
the intervertebral disc is avascular . with aging , endplates become occluded by calcified layers , and diffusion of nutrients and oxygen into the disc diminishes . the disc degenerates , and pain ensues . conduits are delivered and deployed into the intervertebral disc to re - establish the exchange of nutrients and waste between the disc and bodily circulation to stop or reverse disc degeneration and relieve pain . the intervertebral disc installed with semi - permeable conduits may be used as an immuno - isolated capsule to encapsulate donor cells capable of biosynthesizing therapeutic molecules . the semi - permeable conduits establish the exchange of nutrients and therapeutic molecules between disc and bodily circulation to treat a disease without using immuno - suppressive drugs .