the specific antenna embodiment 10 used for comparative testing purposes described below constituted a 0 . 095 cm od semi - rigid coaxial cable sized to slip within plastic catheter 16 ( fig1 ). the outer diameters of inner conductor 11 , insulator 12 and outer conductor 13 were 0 . 02 cm , 0 . 061 cm and 0 . 095 cm , respectively . gap g , between the distal end of outer conductor 13 and the proximal end of helical coil 14 , was 0 . 1 cm whereas length l of the helical coil was 1 . 0 cm . the distal end of the helical coil was soldered to the distal end of the inner conductor at 15 . the inner and outer conductors were composed of a standard copper based alloy having high electromagnetic wave energy transmission properties whereas insulator 12 was composed of a standard teflon ( polytetraflouroethylene ) material . helical coil 14 was also composed of a metallic conductor having high microwave energy transmission properties . for example , antennas constructed with 0 . 032 cm nichrome , 0 . 032 cm varnish insulated copper , and 0 . 0203 cm silver - plated copper wire all have been used successfully . the outside diameter of the helical coil closely approximated 0 . 12 cm to facilitate insertion of antenna 10 into standard 16 - gauge plastic catheter 16 . helical coil 14 was formed by wrapping a wire tightly around a stainless steel wire form , dimensioned to provide the desired diameter , length and turn density of helical coil 14 . after extracting the wire form from the formed helical coil , the helical coil was installed carefully over the bare dielectric insulator portion of insulator 12 , as shown in fig1 and soldered at 15 . gap g was set at 0 . 1 cm . in the preferred embodiments of this invention , axial length l and the turn density of helical coil 14 provide an impedance match of a microwave generator to an organic subject ( e . g ., tissue to be treated ) at a microwave frequency ranging from approximately 0 . 1 to 3 . 0 ghz . helical coil 14 preferably has a length l selected from the approximate range of from 1 . 0 - 10 . 0 cm and has equally spaced turns in the approximate range of 7 to 16 turns per cm . more sophisticated applications of this invention are anticipated with variable turn density along the coil to customize the heating field shape . the following discussion briefly summarizes a typical surgical procedure using the above - described helical coil microwave antenna 10 for improving the localization of interstitial hyperthermia . an appropriate length antenna is first chosen to provide the desired heating pattern in accordance with the above discussions . for 915 mhz operation , a nichrome or copper wire coil with axial length l in the range of 1 . 0 - 10 . 0 cm may be selected for proper heat localization to the coil tip . depending on target size , multiple - antenna array operation is possible to expand the effective heating volume . a parallel array of 16 - gauge plastic catheters 16 are inserted into the target region of a patient with the aid of a ≦ 1 . 0 cm grid template or stereotactic surgical frame . metal needles or stainless steel stylets are normally used to guide the catheters in place . a standard ct scan or simple x - ray will verify proper location of the catheters relative to the tumor or other tissue to be treated . antennas 10 are inserted into the desired catheters 16 and extended to the appropriate insertion depth . standard temperature sensing probes are inserted into other plastic catheters to monitor and control the temperature distribution . if it is found that one or more of the antennas are not well matched electrically to the tissue load , minor adjustments can be made to the helical coil turn spacing or a double stub tuner can be used to obtain the best match of antenna to generator . each antenna is connected to a microwave generator via a flexible coaxial cable in a conventional manner . microwave power can be controlled either manually or automatically by a computer feedback system to maintain the desired minimum tissue temperature ( typically 43 ° c . for one hour , or equivalent ). the temperature probes are manually translated inside the respective plastic catheters to monitor temperatures at approximately 1 cm increments within the heated tissue volume several times during the treatment to provide information on the internal temperature distribution of the tumor volume . at the end of treatment , microwave power is terminated and all antennas and sensors are removed from the catheters . interstitial hyperthermia therapy induced via the implanted antennas can be repeated before and after radioactive seed brachyradiotherapy without additional surgery , using the same implanted plastic catheters 16 . standard dipole antenna 17 of fig3 was constructed from a 0 . 095 cm semi - rigid coaxial cable having an inner conductor 18 covered by an insulator 19 . an outer conductor 20 was cut circumferentially at 21 to form an axial separation gap of 0 . 1 cm between the cut portions of the outer insulator . a metallic connector 22 was soldered between the distal ends of the inner and outer conductors . previous tests have shown this simple &# 34 ; dipole &# 34 ; type structure operates identically to other dipole styles having a soldered connection ( not shown in fig3 ) of inner conductor 18 to outer conductor 20 , adjacent to gap 21 . the specific polarization pattern of hcs style antennas is highly dependent on the source frequency , length of helix , spacing and diameter of coil turns 14 . antenna 10 with a coil turn density of 10 turns / cm , a gap g of 0 . 1 cm , a coil diameter of 0 . 12 cm and a coil length of λ / 4 of 1 . 0 cm ( 3 . 5 cm ) was found to generate apparently circularly polarized electromagnetic waves which effectively localized the heating to the region surrounding the coil when driven at 2450 mhz ( 915 mhz ). other similar helical coil antennas with lengths l ranging from 1 - 5 cm , turn densities of 7 - 16 turns / cm and gap g from 0 . 1 - 5 cm also have been tested successfully at the two frequencies . for comparative dosimetry study purposes and to match heating efficiencies of the antennas , each antenna was tuned to the coaxial feedline with a double stub tuner . the tuners were capable of precisely matching the antennas to the source frequency and feedline characteristics . this procedure enabled a direct comparison of antenna performance under optimum matched conditions , regardless of tissue properties or antenna insertion depth . in order to study the antenna heating characteristics in a reproducible , homogenous tissue medium , soft tissue phantom was used initially to obtain the relative heating profiles of the different antenna configurations as a function of insertion depth . the phantom was composed of a mixture of distilled water ( 75 . 2 %, base ), tx - 150 ( 15 . 4 %, gelling agent ), sodium chloride ( 1 . 0 %, to adjust electrical conductivity ), and polyethylene powder ( 8 . 4 %, to lower dielectric constant ). the mixture is known to have approximately the same electrical properties as those of human soft tissue at 915 mhz . a similarly appropriate phantom mixture was used for studies at 2450 mhz . the material was contained in an 8 × 8 × 11 cm plexiglass box transversed by a 0 . 5 cm array of 16 - gauge teflon catheters for holding the antennas and multi - sensor temperature probes . five phantom models were constructed during the course of the experiments and the reproducibility of thermal profiles in each phantom was verified , using both antennas 10 and 17 . to evaluate the difference in axial thermal profiles ( fig2 vs . fig4 ) produced by each antenna type , single antennas were inserted into a catheter which was immersed in the phantom so that gap g ( fig1 ) or gap 21 ( fig3 ) was located 1 . 0 cm below the phantom surface . the total insertion depth of 2 . 1 cm ( approximately λ / 2 in tissue ) was considered near optimum for the standard dipole antenna 17 . axial power deposition profiles of antennas 10 and 17 were compared for total insertion depths of 1 . 35 cm , 2 . 1 cm and 3 . 1 cm in phantom , as illustrated by each of the three curves in fig2 and 4 . these tests were intended to model the three clinically relevant conditions of antenna use : too shallow , optimum implant depth , and too deep . radial power deposition profiles in several planes perpendicular to the antennas were obtained for a single insertion depth of 2 . 1 cm . these profiles were then compared to the radial temperature fall - off obtained using a heated water circuit of similar dimensions as a control for strictly thermal conduction heating . the antennas were both driven at either 915 mhz or 2450 mhz using a continuous wave microwave power source ( model ca 2450 , manufactured by cheung laboratory , inc ., lanham - seabrook , md . power fed to each antenna was tuned with a double stub tuner ( model 1729 , maury microwave , cucamonga , calif .) for optimum impedance match to the generator , since no attempt was made to trim each antenna to exactly 50 ohms . since the phantom material had no cooling effect from circulating blood , all experiments consisted of short 30 sec . heat trials during which the rate of change of temperature was determined at all internally monitored points to represent the power deposition characteristics of the antennas . the thermal profile information was obtained using a multiple - sensor optical fiber probe with four sensors spaced 0 . 25 cm apart with each inserted in a catheter parallel to and 0 . 5 cm away from the antenna axis . using a separate stationary single sensor probe located mid - depth in a second parallel catheter as control between trials , longer axial heating profiles were measured by moving the multi - sensor probe 1 cm and repeating the heat trial after cool - down of the phantom to initial conditions . all temperatures were recorded every 10 seconds by a computerized fiber optic thermometry system and displayed in tabular and graphic forms on a color monitor . the increase in temperature above baseline [ δt was calculated for each point and the measure of power deposition ( specific absorption rate or sar ) was determined from the time rate of change of temperature following power on as sar = c · dδt / dt , wherein c = specific heat of phantom tissue ]. the axial thermal power deposition profile of each antenna was determined independently at four different sites within the phantom box for each experiment . the antennas were tested in more than one phantom to minimize erroneous conclusions that might arise from slight catheter placement variations at depth in the phantom or other systematic test errors . axial profiles from corresponding trials were averaged together by first selecting the maximum sar of each linear distribution as 100 % sar and normalizing the profile to a percentage of the peak ( relative sar ). fig2 and 4 compare the effects of varying insertion depth on the axial power deposition profiles of antennas 10 and 17 . as noted in fig4 the thermal profile of standard antenna 17 varied significantly , depending on insertion depth . with a 3 . 1 cm total insertion depth , the thermal profile was almost symmetrical with the peak located 1 . 5 cm below the surface and a 50 % hl and dead length of 2 . 04 and 0 . 68 cm , respectively . with a shorter insertion of 1 . 35 cm ( gap 21 depth of 0 . 25 cm ), the 50 % hl and dead lengths were both drastically reduced to 1 . 21 cm and 0 . 17 cm , respectively , but the antenna entrance point was overheated with 78 % of the peak sar obtained near the surface . in contrast , the power deposition profiles induced by antenna 10 were essentially identical regardless of insertion depth . the heat peak moved correspondingly deeper with increasing insertion , remaining 0 . 5 cm proximal to the antenna tip midway along the axis of helical coil 14 ( fig1 ). the 50 % hl for 1 . 35 , 2 . 1 , and 3 . 1 cm insertion depths was a constant 1 . 2 cm and the dead length remained essentially 0 . 0 . studies on the reproducibility of profiles for antennas 10 and 17 tested identically in five different phantoms disclosed no significant variation in the location of peak depth , 50 % hl , or dead length . relative radial power deposition profiles perpendicular to the axes of antennas 10 and 17 were also obtained and compared with the radial temperature fall - off from a heated water circuit of similar dimensions . the corresponding comparative radial temperature distributions for l = 3 . 5 cm antennas 10 and 17 driven at 915 mhz in dog thigh muscle tissue in vivo are shown in fig5 . fig6 gives the absolute temperature distributions in dog thigh muscle along the axial length of antenna 10 ( at r = 0 . 5 cm distance ) for three different clinically relevant antenna insertion depths . note the very similar 50 % hl &# 39 ; s and slopes of the individual temperature distributions for the three different implant conditions .
an implantable helical coil microwave antenna , particularly adapted for interstitial hyperthermia therapy of cancer , comprises a coaxial cable having a distal end of its outer conductor removed and a helical coil mounted on the exposed inner conductor insulator . a proximal end of the helical coil is separated axially from the distal end of the outer conductor and the distal end of the helical coil is connected to the inner conductor of the coaxial cable feed line . the antenna functions to confine heat to the area immediately surrounding the coil and thus induces substantially identical thermal profiles at varying antenna insertion depths in tissue when the antenna is energized with microwave energy .