the disclosure provides for a cocrystal comprising , consisting of , or consisting essentially of prothioconazole and metalaxyl . in another aspect , the disclosure provides for a composition comprising , consisting of , or consisting essentially of a cocrystal of prothioconazole and metalaxyl . the disclosure also provides for a cocrystal comprising , consisting of , or consisting essentially of prothioconazole and metalaxyl , wherein the cocrystal has a melting point of about 100 . 8 ° c . when measured with a differential scanning calorimeter . the melting point of a material is dependent on the purity of the material . for example , the more pure the substance , the higher the expected melting point . fig5 and fig8 exhibit a relatively high purity of material based on the upward slope of the heatflows in the respective scans . the higher purity material also has a melting point ( heat of fusion ) temperature of about 100 . 8 ° c .- 100 . 9 ° c . fig6 has a lower purity cocrystal material with a 98 . 4 ° c . melting point and exhibit a more shallow slop on the heat flow scan . in an aspect , the disclosure also provides for a cocrystal comprising , consisting of , or consisting essentially of prothioconazole and metalaxyl , wherein the cocrystal has a melting point of about 95 ° c . to about 105 ° c ., about 98 ° c . to about 102 ° c ., or about 100 ° c . to about 101 ° c . when measured with a differential scanning calorimeter . in another aspect , the disclosure provides for a cocrystal comprising , consisting of , or consisting essentially of prothioconazole and metalaxyl with the crystal structure as set forth in fig1 , 2 , or 3 . in yet another aspect , the disclosure provides for a cocrystal comprising , consisting of , or consisting essentially of prothioconazole and metalaxyl with the differential scanning calorimeter parameters of fig5 , 6 , or 8 . the disclosure also provides for a cocrystal composition comprising , consisting of , or consisting essentially of prothioconazole and metalaxyl wherein the water solubility of the crystal composition is less than that of metalaxyl ( about 8 . 4 g / 1 at 22 ° c . ), prothioconazole ( 610 μg / 1 at 25 ° c . ), or a combination of metalaxyl and prothioconazole . in an aspect , the water solubility measurements are at ph 7 . 0 . in another aspect , the prothioconazole and metalaxyl crystal composition has a reduced water solubility that is reduced by about 5 %, about 10 %, about 20 %, about 30 %, about 50 %, about 60 %, about 70 %, about 80 %, about 90 %, about 95 %, or about 99 % or more relative to the water solubility of metalaxyl alone . in yet another aspect , the prothioconazole and metalaxyl crystal composition has a reduced water solubility that is reduced by about five times , about ten times , about fifteen times , about twenty times , about twenty - five times , about thirty times , or about forty times or more relative to the water solubility of metalaxyl alone . such relatively low water solubility reduces runoff and active agent mobility from treated areas . such relatively low water solubility reduces runoff and active agent mobility from treated areas . in another aspect , the prothioconazole and metalaxyl crystal composition has an increased water solubility that is increased by about 5 %, about 10 %, about 20 %, about 30 %, about 50 %, about 60 %, about 70 %, about 80 %, about 90 %, about 95 %, or about 99 % or more relative to the water solubility of prothioconazole alone . in yet another aspect , the prothioconazole and metalaxyl crystal composition has an increased water solubility that is increased by about five times , about ten times , about twelve times , about thirteen times , about fifteen times , or about twenty times or more relative to the water solubility of prothioconazole alone . examples 5 and 6 and fig9 ( a ) , fig1 ( a ) and ( b ), and fig1 ( a ), ( b ), and ( c ) provide support for the increased prothioconazole solubility and decreased metalaxyl solubility of the crystal compositions described herein . such an increased solubility of prothioconazole is unexpected and can result in a composition where the metalaxyl exhibits a decreased solubility and the prothioconazole exhibits an increased solubility . in an aspect , the prothioconazole and metalaxyl crystal composition will have increased bioavailability of prothioconazole together with a decreased bioavailability of metalaxyl . in another aspect , the prothioconazole and metalaxyl crystal composition exhibits decreased metalaxyl solubility wherein the metalaxyl has the ability to stay with the plant longer while reducing metalaxyl seepage into groundwater . in an aspect , the cocrystal structures described herein comprise metalaxyl and prothioconazole in about a 44 : 52 ratio or about a 1 : 1 molar basis . in another aspect , the cocrystal structures described herein comprise metalaxyl and prothioconazole in about a 1 : 1 molar basis . in an aspect , the disclosure provides for a method of making a metalaxyl and prothioconazole cocrystal by dissolving metalaxyl and prothioconazole in a solvent . in another aspect , the disclosure provides for a method of making a metalaxyl and prothioconazole cocrystal composition by the disclosure also provides for a method of making a metalaxyl and prothioconazole cocrystal by ( a ) dissolving metalaxyl and prothioconazole in one or more solvents ; and ( b ) adding a solvent that is less soluble than the dissolved metalaxyl and prothioconazole solution to the dissolved metalaxyl and prothioconazole in an amount sufficient to induce crystallization . the disclosure also provides for a method of making a metalaxyl and prothioconazole cocrystal by ( a ) dissolving metalaxyl and prothioconazole in one or more solvents ; and ( b ) adding water to the dissolved metalaxyl and prothioconazole in an amount sufficient to induce crystallization . in an another aspect , the disclosure provides for a method of making a metalaxyl and prothioconazole cocrystal by ( a ) dissolving metalaxyl and prothioconazole in one or more solvents ; ( b ) adding water to the dissolved metalaxyl and prothioconazole in an amount sufficient to form crystals ; and ( c ) adding an additional amount of water to the crystallized material . in another aspect , the disclosure provides for a method of making a metalaxyl and prothioconazole cocrystal by ( a ) dissolving metalaxyl and prothioconazole in one or more solvents ; and ( b ) altering the temperature of the dissolved metalaxyl and prothioconazole composition in a manner that produces a metalaxyl and prothioconazole cocrystal composition . in an aspect , the compounds described herein can be crystallized by any known crystallization method , for example , crystallization by altering temperature , increasing temperature , decreasing temperature , a combination of increasing and decreasing temperature , freezing , or by initiating solvent - induced crystallization . the disclosure also provides for a method of crystallizing compounds described herein by seeding by any known technique . in another aspect , the compounds described herein can be crystallized by adding a preformed cocrystal to a saturated solution thereby seeding the solution . in another aspect , about 1 % or less , about 2 % or less , about 5 % or less , or about 10 % or less of the preformed cocrystal is used to seed the solution and facilitate cocrystal formation . in an aspect , the crystallization solvent used with the methods described herein include one or more organic or polar solvents . in another aspect , the solvent used with the methods described herein is selected from the group consisting of butyrolactone and acetone . other solvents that may be used with the methods described herein , for example , include aliphatic hydrocarbons , aromatic hydrocarbons , halogenated hydrocarbons such as toluene , xylene , mineral oils such as white spirit , petroleum , alkylbenzenes and spindle oil , tetrachloromethane , chloroform , methylene chloride and dichloromethane , esters such as ethyl acetate , lactates , lactones , lactams such as n - methylpyrrolidone , n - octylpyrrolidone , n - dodecylpyrrolidone , n - octylcaprolactam and n - methylcaprolactam , gamma - butyrolactone , dimethylformamide , tributyl phosphate , acetonitrile , dichloromethane , dimethylsulfoxide , ethyl acetate , n - heptane , 1 - octanol , polyethylene glycol , or 2 - propanol . in an aspect , the solvent is added in an amount that is sufficient to crystallize the active agent , for example , metalaxyl and prothioconazole . in another aspect , the cocrystals described herein exhibit a diameter of about 0 . 01 μm to about 100 μm , about 0 . 1 μm to about 50 μm , about 1 μm to about 20 μm , or about 2 μm to about 10 μm . further compounds or actives capable of being crystallized in the compositions or methods described herein include triazolyl derivatives such as those described in u . s . pat . no . 5 , 789 , 430 , and compounds described in u . s . pat . no . 4 , 742 , 079 , the contents of each of these applications is herein incorporated by reference in their entirety . in an aspect , the disclosure provides for a method of treating a crop , plant , seed , or plant part with a cocrystal or composition described herein . in yet another aspect , the disclosure provides for a method of reducing phytotoxicity to a crop , plant , seed , or plant part by the application of a cocrystal or composition described herein . in another aspect , the disclosure provides for a method of reducing damage or infestation caused by weeds , fungi , or pests by applying a cocrystal or composition described herein to a to a crop , plant , seed , or plant part thereof . in yet another aspect , the disclosure provides for a method of improving crop yield by the application of a cocrystal or composition described herein . in yet another aspect , a cocrystal or composition described herein is a time released or delayed release composition . in an aspect , pests include , for example , insects , mites , phytopathogenic fungi , or bacteria . in an aspect , a cocrystal or composition described herein is applied to a crop , plant , seed , or plant part thereof in a single application step . in another aspect , a cocrystal or composition described herein is applied in multiple application steps to a crop , plant , seed , or plant part thereof . in yet another aspect , a cocrystal or composition described herein is applied in one , two , three or more application steps to a crop , plant , seed , or plant part thereof . the cocrystals or compositions described herein can be used in an amount effective to increase plant or crop yield , reduce phytotoxicity to a crop , plant , seed , or plant part , or reduce damage or infestation caused by weeds , fungi , or pests . in an aspect , a cocrystal or composition described herein is applied at about 0 . 5 fluid ounces / acre to about 10 . 0 fluid ounces / acre , about 1 . 0 fluid ounces / acre to about 8 . 0 fluid ounces / acre , about 2 . 0 fluid ounces / acre to about 6 . 0 fluid ounces / acre , or about 3 . 0 fluid ounces / acre to about 5 . 0 fluid ounces / acre . in another aspect , a cocrystal or composition described herein is applied at about 0 . 1 , about 1 . 0 , about 2 . 0 , about 3 . 0 , about 4 . 0 , about 5 . 0 , about 6 . 0 , about 7 . 0 , about 8 . 0 , about 9 . 0 , about 10 . 0 , or about 20 . 0 or more fluid ounces / acre . in yet another aspect , a cocrystal or composition described herein is applied at about 0 . 1 , about 1 . 0 , about 2 . 0 , about 3 . 0 , about 4 . 0 , about 5 . 0 , about 6 . 0 , about 7 . 0 , about 8 . 0 , about 9 . 0 , about 10 . 0 , or about 20 . 0 fluid ounces / acre . in another aspect , a cocrystal or composition described herein is applied to a crop , plant , seed , or plant part at planting . in another aspect , a cocrystal or composition described herein is applied to a crop , plant , seed , or plant part at about 5 to about 10 , about 5 to about 15 , about 7 to about 14 , about 5 to about 20 , about 10 to about 30 days , about 10 to about 40 days , about 15 to about 25 days , or about 20 to about 40 days after planting . in another aspect , a cocrystal or composition described herein is applied to a crop , plant , seed , or plant part described herein at about 5 , about 10 , about 15 , about 20 , about 25 , about 30 , or about 50 or more days after planting . in yet another aspect , a composition described herein is applied to a crop , plant , seed , or plant part described herein at least 5 , at least 10 , at least 15 , at least 20 , at least 25 , at least 30 , or at least 50 after planting . in an aspect , the methods disclosed herein reduce damage caused by a weed , fungi , or pest by about 10 % to about 20 %, about 10 % to about 30 %, about 10 % to about 40 %, about 10 % to about 90 %, about 20 % to about 80 %, about 30 % to about 70 %, about 40 % to about 60 %, or about 5 % or more , about 10 % or more , about 20 % or more , about 30 % or more , about 40 % or more , about 50 % or more , about 60 % or more , about 70 % or more , about 80 % or more , or about 90 % or more , about 5 % or less , about 10 % or less , about 20 % or less , about 30 % or less , about 40 % or less , about 50 % or less , about 60 % or less , about 70 % or less , about 80 % or less , or about 90 %. in yet another aspect , the methods , compounds , and compositions disclosed herein reduce damage caused by a weed , fungi , or pest described herein by about 5 %, about 10 %, about 20 %, about 30 %, about 40 %, about 50 %, about 60 % about 70 %, about 80 %, or about 90 %. in another aspect , the above percentages are relative to an untreated plant . in an aspect , binders , coating agents , wetting agents , or buffering agents can be added to a composition described herein . in another aspect , at least one agriculturally acceptable carrier can be added to the formulation such as water , solids , or dry powders . the dry powders can be derived from a variety of materials such as wood barks , calcium carbonate , gypsum , vermiculite , talc , humus , activated charcoal , and various phosphorous compounds . in an aspect , a composition described herein can include a spray or tank mix adjuvant . in another aspect , a composition described herein can include additional components , such as an insecticide , fungicide , herbicides , fertilizer , or foliar - applied fertilizers . in another aspect , compositions described herein can include methylated seed oil (“ mso ”), for example mso at 0 . 5 % v / v to 1 . 0 % v / v . in yet another aspect , compositions described herein can contain high surfactant oil concentrates (“ hsoc ”) or crop oil concentration (“ coc ”). in another aspect , mso is a tank mix adjuvant capable of being used with a composition described herein . compositions described herein may also be combined with additional fungicides , pesticides , herbicides , or insecticides . in an another aspect , compositions described herein may be combined with , for example , chlorothalonil ; clothianidin ; copper hydroxide ; copper oxide ; copper oxychloride ; furathiocarb ; imazalil ; imidacloprid ; ipconazole ; mancozeb ; metconazole ; myclobutanil ; pcnb ; prothioconazole ; pyraclostrobin ; tcmtb ; tebuconazole ; thiabendazole ; thiram ; triadimefon ; triadimenol ; trifloxystrobin ; or triticonazole . in an aspect , the compositions described herein can include about 0 . 1 % to about 2 %, about 5 % to about 10 %, about 10 % to about 30 %, about 20 % to about 50 %, or about 50 % to about 90 % percent , or about 0 . 1 % to about 90 % percent by weight of a binder , coating agent , wetting agent , solvent , carrier , or buffering agent described herein . in an another aspect , the compositions described herein can include about 0 . 1 % to about 2 %, about 10 % to about 30 %, about 20 % to about 50 %, or about 0 . 1 % to about 90 % percent by weight of an additional fungicide , pesticide , herbicide , or insecticide described herein . in yet another aspect , the compositions described herein can include about 0 . 01 % to about 0 . 5 %, about 1 % to about 2 %, about 2 % to about 4 %, about 5 % to about 10 %, about 20 % to about 50 % percent by weight of a cocrystal described herein . in yet another aspect , the compositions described herein can include about 0 . 01 % to about 0 . 5 %, about 1 % to about 2 %, about 2 % to about 4 %, about 5 % to about 10 %, about 20 % to about 50 % percent , or about 0 . 1 % to about 90 % percent by weight by weight of a cocrystal described herein . in another aspect , the compositions described herein can include about 1 %, about 2 %, about 5 %, about 10 %, about 20 %, about 50 %, about 75 %, or about 0 . 1 % to about 90 % percent by weight of more by weight of a cocrystal described herein . in an aspect , components of compositions described herein can be converted into customary formulations , such as , emulsions , wettable powders , suspensions , suspension concentrate , powders , dusts , pastes , soluble powders , granules , suspoemulsion concentrates , natural and synthetic materials impregnated with active compound , and ultrafine encapsulations in polymeric materials . in the case of the use of water as an extender , organic solvents can , for example , also be used as cosolvents in compositions described herein . liquid solvents which are suitable include : aromatics , such as xylene , toluene or alkylnaphthalenes , chlorinated aromatics or chlorinated aliphatic hydrocarbons , such as chlorobenzenes , chloroethylenes or methylene chloride , aliphatic hydrocarbons , such as cyclohexane or paraffins , for example mineral oil fractions , mineral oils and vegetable oils , alcohols , such as butanol or glycol as well as their ethers and esters , ketones , such as acetone , methyl ethyl ketone , methyl isobutyl ketone or cyclohexanone , strongly polar solvents , such as dimethylformamide and dimethyl sulphoxide , and water . solid carriers which are suitable are for example , ammonium salts and ground natural minerals , such as kaolins , clays , talc , chalk , quartz , attapulgite , montmorillonite or diatomaceous earth , and ground synthetic minerals , such as highly - disperse silica , alumina and silicates ; suitable solid carriers for granules are : for example crushed and fractionated natural rocks such as calcite , marble , pumice , sepiolite and dolomite , and synthetic granules of inorganic and organic meals , and granules of organic material such as sawdust , coconut shells , maize cobs and tobacco stalks ; suitable emulsifiers and / or foam formers are : for example non - ionic and anionic emulsifiers , such as polyoxyethylene fatty acid esters , polyoxyethylene fatty alcohol ethers , for example alkylaryl polyglycol ethers , alkylsulphonates , alkyl sulphates , arylsulphonates as well as protein hydrolysates ; suitable dispersants are : for example lignin - sulphite waste liquors and methylcellulose . in one embodiment , plant species and plant varieties which are found in the wild or which are obtained by traditional biological breeding methods , such as hybridization or protoplast fusion , and parts of these species and varieties are treated . in a further preferred embodiment , transgenic plants and plant varieties which were obtained by recombinant methods , if appropriate in combination with traditional methods ( genetically modified organisms ) and their parts can be treated . crops , plants , seeds , or plant parts thereof which can be treated by the compositions or methods described herein include , for example , any plant capable of being effectively treated by a cocrystal comprising prothioconazole or metalaxyl individually or together . examples of crops , plants , seeds , or plant parts which can be treated by the compositions or methods described herein include , for example , cereals , barley , wheat , winter wheat , triticale winter rye , ground nut , peanuts , rape , bulb onions , oilseed rape , canola , rice , pulses , soybeans , sugar beet , vegetables , and corn . in an aspect , the seeds or plants described herein can be treated in an amount effective to confer the desired solubility property . in another aspect , the seeds or plants described herein can be treated in an amount described herein . in another aspect , the disclosure provides for a method of treating a seed , for example a plant seed , with a composition described herein . in yet another aspect , the seed is a soybean or corn seed . the plants and their parts may be treated with the described compositions by applying the compositions directly to the plants or plant parts . in another embodiment , the plant and plant parts may be treated indirectly , for example by treating the environment or habitat in which the plant parts are exposed to . conventional treatment methods may be used to treat the environment or habitat including dipping , spraying , fumigating , chemigating , fogging , scattering , brushing on , shanking or injecting . in another aspect , the disclosure provides for a kit comprising , consisting essentially of , or consisting of any of the cocrystal or compositions disclosed herein . in an aspect , the kit includes any of the combination of the cocrystals or compositions described in examples 1 - 7 or fig1 - 11 . in another aspect , the kit provides for the cocrystals compositions described in examples 1 - 7 and fig1 - 11 applied in a manner that is consistent with the methodology of these examples and figures . in another aspect , the kit provides instructions or guidance regarding the use of the cocrystals , compositions , or methods described herein . in an aspect , the kit includes instructions describing the methodology described herein . in another aspect , the kit includes instructions describing the methodology set forth in any of examples 1 - 7 and fig1 - 11 . in an aspect , the instructions are included with the kit , separate from the kit , in the kit , or are included on the kit packaging . the following examples serve to illustrate certain aspects of the disclosure and are not intended to limit the disclosure . example 1 sets forth the co - crystallization of prothioconazole and metalaxyl crystallized from a butyrolactone solution . 0 . 5 g prothioconazole ( 98 . 4 % pure ) and 0 . 5 g metalaxyl ( 98 . 2 % pure ) were placed into a 0 . 5 oz . bottle . butyrolactone ( aldrich bio , 360 - 8 ) was added in an amount sufficient to dissolve the prothioconazole and metalaxyl (˜ 3 ml ). water ( di ) was added dropwise to the mixture and tan to off - white crystals appeared . about 10 ml of additional water was added to the mixture . the crystals were filtered from the liquid using a porous glass filter and washed water . the crystals were dried in a 60 ° vacuum oven at about 23 ″ hg vacuum . the yield was found to be 0 . 9 g . the prothioconazole and metalaxyl sample in butyrolactone was weighed into a 40 μl aluminum crucible and closed with a pierced cap . the melting point of the prothioconazole is approximately 140 ° c . and the melting point of the metalaxyl is approximately 70 ° c . the sample was heated from 30 ° c . to 180 ° c . at 5 ° c ./ minute . as set forth in fig5 , a differential scanning calorimetry scan shows a sharp exotherm from the melt at 89 - 109 ° c . ( temperature of fusion at about 100 . 8 ° c .). example 2 sets forth the co - crystallization of prothioconazole and metalaxyl crystallized from an acetone solution . 0 . 5 g prothioconazole ( 98 . 4 % pure ) and 0 . 5 g metalaxyl ( 98 . 2 % pure ) were placed into a 0 . 5 oz . bottle . acetone was added in an amount sufficient to dissolve the prothioconazole and metalaxyl (˜ 3 ml ). water ( di ) was added dropwise to the mixture and dark tan to off - white crystals appeared . compared to the crystals of example 1 , the crystals identified in example 2 were stickier and exhibited an increased variation in color . about 10 ml of additional water was added to the mixture . the crystals were filtered from the liquid using a porous glass filter and washed water . the crystals were dried in a 60 ° c . vacuum oven at about 23 ″ hg vacuum . once dry , the crystals were no longer sticky and were easily dispersed into a powder form . the prothioconazole and metalaxyl in acetone sample was weighed into a 40 μl aluminum crucible and closed with a pierced cap . the sample was heated from 30 ° c . to 180 ° c . at 5 ° c ./ minute . a small endotherm was observed at 58 ° c . to 68 ° c . and a larger endotherm from 70 ° c . to 104 ° c . as set forth in fig6 , a peak is present at about 63 . 10 ° c . this peak is expected to be in the range of a metalaxyl melt . so we have some metalaxyl not in the cocrystal lattice in this dsc scan . the dsc scan of fig6 also includes cocrystal at 98 . 4 ° c . example 3 sets forth a differential scanning calorimetry scan of metalaxyl and prothioconazole . metalaxyl and prothioconazole were combined into a single crucible without crystallization . a differential scanning calorimetry scan was run on the metalaxyl and prothioconazole as a control . the prothioconazole and metalaxyl sample heated from 30 ° c . to 150 ° c . at 5 ° c ./ minute . an endotherm was observed at 55 ° c . to 78 ° c . and a small double endotherm at 124 ° c . and 132 ° c . ( fig7 ). fig7 exhibits a peak at the melting point of metalaxyl and another at the melting point of prothioconazole . the particulate matter retained on the sieves from example 1 was microphotographed and is illustrated in fig1 a and b and fig2 . an additional microphotograph of the crystals along with a 1 - mm glass sphere is found in fig3 . the crystals of fig3 corresponds to the dsc of fig8 . a saturated solution of metalaxyl and prothioconazole as separate compounds was prepared by the following procedure : 0 . 2 grams each of metalaxyl and prothioconazole were weighed and placed into a 0 . 5 oz bottle . 10 ml of ph 7 . 0 ( fisher # sb107 - 500 ) was added to the bottle . a magnetic stir bar was added to the bottle and the bottle was capped and shaken . the bottle was placed on a magnetic stirrer for about 12 hours at a temperature of 20 ° c .± 1 ° c . stirring on low . after the above procedure , the solubility of metalaxyl at ph 7 . 0 was measured as 0 . 62 % and the solubility of prothioconazole at ph 7 . 0 was measured as 0 . 0002 %. fig1 ( a ) and fig1 ( b ) provide for hplc scans of the metalaxyl and prothioconazole compositions of example 5 . example 6 provides for metalaxyl and prothioconazole cocrystallized water solubility measurements . a saturated solution of metalaxyl and prothioconazole was prepared by the following procedure : 0 . 3 g of laboratory prepared metalaxyl - prothioconazole cocrystallized material was weighed in a 0 . 5 oz bottle . 10 ml of ph 7 . 0 ( fisher # sb107 - 500 ) was added to the bottle . a magnetic stir bar was added to the bottle and the bottle was capped and shaken . the bottle was placed on a magnetic stirrer for about 12 hours in a room at 20 ° c .± 1 ° c ., stirring on low . after the above procedure , the solubility of metalaxyl at ph 7 . 0 was measured as 0 . 02 % and the solubility of prothioconazole at ph 7 . 0 was measured as 0 . 003 %. fig1 ( b ) and fig1 ( c ) provide for hplc scans of the metalaxyl and prothioconazole cocrystalized compositions of example 6 . approximately 3 ml of the solutions of example 5 and 6 were filtered through a 0 . 45 μm polytetrafluoroethylene (“ ptfe ”) filter . 2 . 0 ml of these solutions were pipetted into separate 10 ml volumetric flasks . 3 ml of acetonitrile (“ acn ”) was added to each flask and diluted to volume with water . the analytical standard material of metalaxyl and prothioconazole were used as follows for the analysis of examples 5 and 6 as follows : metalaxyl — 0 . 1010 g / 100 ml ( 30 ml acn then h 2 o ); purity of 98 . 2 % prothioconazole — 0 . 1008 g / 100 ml ( 30 ml acn then h 2 o ); purity of 98 . 4 % example 7 provides for metalaxyl and prothioconazole water solubility measurements as measured by hplc . the solutions of examples 5 and 6 were diluted 2 / 10 into acetonitrile were injected using the following instrument conditions : the cocrystallized material exhibited about a 30 fold decrease in metalaxyl solubility and about a 13 fold increase in prothioconazole solubility at ph 7 . 0 as compared to metalaxyl and prothioconazole compounds alone .
the invention relates to co - crystals of metalaxyl and prothioconazole , to methods of making them , to compositions containing them and to the methods of using said co - crystals and said compositions to treat crops and plants .