fig1 is an isometric view of the infusion flow guidewire system 10 wherein the major components are shown separated . fig2 is an isometric view of the components of the infusion flow guidewire system 10 in the engaged form . each figure illustrates readily visible components including : a flexible infusion flow guidewire 12 having a coupling assembly 14 removably attached at the proximal end thereof and a flexible delivery sheath 16 ( also known as a guide catheter ) of braided polyimide preferably having an outside diameter of 0 . 035 inch and an inner diameter of 0 . 017 inch . a proximally located torque handle 18 is shown attached to the proximal end of the delivery sheath 16 . special attention is paid to the connecting structure in the form of a high pressure supply line 20 which enables connection between an angiojet ® pump set ( or another suitable device ) and the infusion flow guidewire 12 where the high pressure supply line 20 does not exceed an infusion flow guidewire 12 having an outer diameter of 0 . 014 inch in order to enable the exchange of 0 . 014 inch compatible devices and does not impinge the inner diameter of 0 . 010 inch at the proximal end infusion flow guidewire 12 in order to provide for a suitable flow therethrough . for reference , the section of high pressure supply line 20 to which the invention can be attached is also shown in alignment with the proximal end of the coupling assembly 14 . the infusion flow guidewire 12 includes a hypotube 22 ( a high pressure tube ), preferably of flexible nitinol , at least one proximally directed jet orifice 32 , 34 ( fig5 ), and a flexible tip 24 , and other components described later in detail . preferably , the greater portion of the hypotube 22 has an outer diameter of 0 . 014 inch and in inner diameter of 0 . 010 inch the hypotube 22 also includes a distally located drawn hypotube section 22 a of reduced diameter for increased flexibility of the distal portion of the infusion flow guidewire 12 . the multiple component shapeable and flexible tip 24 , also shown in fig3 , which is located distally on the drawn hypotube section 22 a , provides a flexibility greater than that of the drawn hypotube section 22 a . with reference to fig3 , 4 and 5 , each figure shows different views in increasing detail exemplifying the generally overlapping and coaxial relationship of components of the flexible tip 24 to each other and to the drawn hypotube section 22 a . the overlapping relationships and structure of such components are now described where fig3 is an assembled view , fig4 is an exploded view of the components of fig3 , and where fig5 shows views along section lines 5 a - 5 a , 5 b - 5 b , 5 c - 5 c , 5 d - 5 d and 5 e - 5 e of fig3 . the complete length of a nitinol reinforcement collar 26 in the form of a tube ( 0 . 014 inch od by 0 . 010 inch id for purpose of example and illustration ) is aligned over and about a distal region of the drawn hypotube section 22 a at the distal end of the hypotube 22 and is secured thereto by laser welds 28 and 30 as shown in fig5 . as shown in section line 5 b - 5 b of fig5 , a unitary rearwardly directed jet orifice 32 is provided by a hole 32 a in the reinforcement collar 26 in close alignment with a hole 32 b in the distal region of the drawn hypotube section 22 a and , correspondingly , another unitary rearwardly directed jet orifice 34 is provided by a hole 34 a in the reinforcement collar 26 in close alignment with a hole 34 b in the distal region of the drawn hypotube section 22 a . the reinforcement collar 26 provides a structural support along and about the drawn hypotube section 22 a in the region of the jet orifices 32 and 34 . the rearwardly directed jet orifices 32 and 34 are used to direct high pressure fluid jet streams proximally , as later described in detail . one or more such rearwardly directed jet orifices , such as jet orifices 32 and 34 , may be formed by electrical discharge machining or by other suitable processes . although symmetric rearwardly directed orifices 32 and 34 are shown , other symmetric or asymmetric jet orifice configurations can be used including one or more orifices which can be rearwardly , forwardly , perpendicularly directed in one or more directions or combinations of directions . at the distal region of the infusion flow guidewire 12 , the proximal end of a flexible coil 36 ( preferably of , but not limited to , platinum ) is aligned over and about the distal end of the drawn hypotube section 22 a and can be soldered , welded or otherwise suitably secured thereto . the proximal terminus of the flexible coil 36 is aligned with the distal terminus end of the reinforcement collar 26 and can be soldered , welded , or otherwise suitably secured thereto . a flexible core wire 38 of gold - plated steel consists of a core wire round section 38 a with a contiguous core wire flat section 38 b of the same material . the core wire 38 is attached to the distal end of the drawn hypotube section 22 a and extends distally therefrom and is in coaxial alignment with the flexible coil 36 along the inner length thereof . more specifically , the proximal end of the core wire round section 38 a is aligned within the lumen 40 of the drawn hypotube section 22 a . at the distal end of the drawn hypotube section 22 a , the core wire round section 38 a is in direct coaxial alignment within the inner and distal portion of the drawn hypotube section 22 a and in indirect coaxial alignment with the proximal portion of the flexible coil 36 . the proximal end of the gold - plated core wire round section 38 a is secured to the inner wall of the drawn hypotube section 22 a by laser swages 43 a , 43 b and 43 c by the process referred to in related patent application ser . no . 11 / 702 , 990 filed feb . 6 , 2007 , entitled “ miniature flexible thrombectomy catheter ,” and to patent application ser . no . 11 / 702 , 995 filed feb . 6 , 2007 , also entitled “ miniature flexible thrombectomy catheter ,” describing the process and use of laser swaging of gold - plated components to nitinol components . such laser swaging of components , as described therein , provides for superior attachment and connection of the proximal end of the gold - plated core wire round section 38 a to the drawn hypotube section 22 a without degrading or weakening the swaged components . preferably , the diameter of the core wire round section 38 a is reduced in a distal direction transitioning to the flattened profile of the core wire flat section 38 b . the core wire flat section 38 b extends along the inner and distal portion of the flexible coil 36 , thus providing an increased flexibility along the length of the flexible core wire 38 . the distal terminus of the core wire flat section 38 b is secured to the distal terminus of the flexible coil 36 , such as by a weld 41 . with reference to fig6 , 7 and 8 , each figure shows the relationships of components of the torque handle 18 to each other , to the hypotube section 22 and to the delivery sheath 16 . the relationships and the structure of such components are now described where fig6 is an exploded isometric view of the torque handle , fig7 is an exploded vertical cross section view of the components of fig6 , and fig8 is a view of the components shown in cross section in fig7 arranged as an assembly . the torque handle 18 includes a torque body 42 , a collet 44 , a collet nut 46 , and a strain relief 48 having a passage 49 , the assembly of which provides for the coaxial accommodation of the delivery sheath 16 and the hypotube 22 . the torque body 42 is generally cylindrical in shape and includes a centrally located bore 50 , proximally located external threads 52 , and a proximally located annular tapered actuating surface 54 located between the proximal end of the bore 50 and the proximal end of the threads 52 . the centrally located bore 50 accommodates portions of one or more components including the hypotube 22 , the delivery sheath 16 , and one end of the strain relief 48 in coaxial fashion . an annular positioning ring 56 is also located about the exterior of the torque body 42 . the collet 44 , as generally known in the art , includes at least a plurality of like spaced slots 58 extending longitudinally along a portion of such a collet 44 defining , in part , a plurality of like spaced flexible jaws 60 , each having a distally located tapered and arcuate surface 62 for collective simultaneous forced interaction with the annular tapered actuating surface 54 of the torque body 42 . each of the like spaced flexible jaws 60 of the collet 44 has a proximally located tapered and arcuate surface 64 for collective simultaneous forced interaction with features of the collet nut 46 , such features being later described in detail . each of the like spaced flexible jaws 60 includes a centrally located tapered arcuate surface 66 , preferably an inward taper , to accommodate the loading of the hypotube 22 from a proximal location . the tapered arcuate surfaces 66 of the collet 44 adjoin a passageway 68 located between the innermost portions of the flexible jaws 60 and which passageway 68 adjoins a larger bore 70 . the passageway 68 accommodates the hypotube 22 in coaxial fashion and the bore 70 accommodates the hypotube 22 and the proximal end of the delivery sheath 16 in coaxial fashion . the proximal end of the delivery sheath 16 secures centrally within the bore 70 in alignment with the passageway 68 , such as by adhesive 71 or other suitable method . the strain relief 48 secures in the bore 50 of the torque body 42 . the collet nut 46 includes a centrally located bore 72 aligned with internal threads 74 which accommodate the external threads 52 and the adjacent unthreaded proximal end of the torque body 42 , respectively . an internal annular tapered surface 76 extends in a proximal direction from the internal threads 74 . a passageway 78 adjoins the annular tapered surface 76 . an outwardly opening annular tapered passageway 80 adjoins the passageway 78 . the tapered wall of the annular tapered passageway 80 accommodates the insertion of the hypotube 22 . in order to frictionally engage the hypotube 22 , the wall of the annular tapered surface 76 maintains a forced intimate contact with the tapered and arcuate surfaces 64 of the collet 44 in order to flex and force the collet jaws 60 against the hypotube 22 in the passageway 68 in frictional engagement when the collet nut 46 and the torque body 42 . either the collet nut 46 or the torque body 42 is rotated with respect to each other to draw the torque body 42 and the collet nut 46 together about the collet 44 . thus , the torque handle 18 is engaged in frictional engagement with and about the hypotube 22 in order that a unitary longitudinal and / or torque movement of the infusion flow guidewire 12 and the delivery sheath 16 can be accomplished within the vasculature . independent movement of the infusion flow guidewire 12 or of the delivery sheath 16 with respect to each other or within the vasculature can be accomplished by loosening the collet nut 46 in order to release the frictional engagement of the torque handle 18 with the hypotube 22 . longitudinal and / or torque movement of the delivery sheath 16 can be accomplished by grasping and actuating the torque body 42 . longitudinal and / or torque movement of the infusion flow guidewire 12 can be accomplished without interference with the torque handle 18 by grasping and actuating the torque coupling assembly 14 which can be in frictional engagement with the proximal end of the hypotube 22 , as later described in detail . with reference to fig9 , 10 and 11 , each figure shows different relationships of components of the coupling assembly 14 to each other , to the high pressure supply line 20 and to the hypotube section 22 . such relationships and the structure of the components are now described where fig9 is an exploded isometric view of the torque coupling assembly 14 , fig1 is an exploded vertical cross section view of the components shown in fig9 , and fig1 is a view of the components shown in cross section in fig1 arranged as an assembly . the coupling assembly 14 , which is removably attached to the hypotube 22 of the infusion flow guidewire 12 , is provided for rapid connection of the proximal end of the hypotube 22 of the infusion flow guidewire 12 to a high pressure supply device , such as the angiojet ® pump set or other suitable device . the angiojet ® pump set is described in detail in patent application ser . no . 11 / 237 , 558 filed sep . 28 , 2005 , entitled “ thrombectomy catheter deployment system ”. in particular , the coupling assembly 14 provides for communication and connection between the proximal end of the hypotube 22 to the distal end of the high pressure supply line 20 which is connected to a high pressure supply device . the coupling assembly 14 includes a proximal knob 82 which generally is stationary with reference to an opposing distal knob 84 . the distal knob 84 is rotatable with reference to the proximal knob 82 . the proximal knob 82 is indirectly connected to the distal end of the high pressure supply line 20 , as later described in detail . the distal knob 84 is used for removable attachment of the proximal end of the hypotube 22 to provide communication of the hypotube 22 with the proximal end of the high pressure supply line 20 , the latter being secured indirectly to the proximal knob 82 . a plurality of components , which components are substantially stationary , is connected to and associated with the generally stationary proximal knob 82 and include a threaded insert 85 , set screws 86 , a threaded body 88 , an o - ring 90 , and a compression fixture 92 . the stationary proximal knob 82 includes a longitudinally oriented central bore 94 and opposed body holes 96 and 98 aligned perpendicular to and intersecting the bore 94 for accessing of the set screws 86 . the threaded insert 85 is aligned in and is suitably secured within the central bore 94 of the proximal knob 82 , such as by , but not limited to , the use of adhesives or frictional engagement . the threaded insert 85 includes internal threads 100 and threaded holes 102 and 104 aligned perpendicular to and intersecting the internal threads 100 in order to facilitate threaded engagement of the set screws 86 with the proximal end of the threaded body 88 to ensure secure fastening of the threaded body 88 within the internal threads 100 of the threaded insert 85 . the threaded body 88 includes external threads 106 with the proximal portion of the threads 106 threadingly engaging the threads 100 of the threaded insert 85 . the threaded body 88 also includes a partial bore 108 having an internal annular end surface 109 , a centrally located proximally extending tubular flange 110 , and a passageway 112 ( fig1 ), being part of the tubular flange 110 extending through the tubular flange 110 and connecting to the bore 108 . the distal end of the high pressure supply line 20 is suitably secured to the tubular flange 110 within the proximal portion of the passageway 112 of the tubular flange 110 , as shown in fig1 . the compression fixture 92 has a generally cylindrical shape and includes a passageway 114 extending along the longitudinal axis thereof . the compression fixture 92 terminates proximally at an annular recess 116 and distally at an annular tapered actuating surface 118 . the annular recess 116 of the compression fixture 92 accommodates the o - ring 90 . the compression fixture 92 aligns closely within the bore 108 of the threaded body 88 and is longitudinally positionable therewithin . a plurality of components , which can be unitarily actuated in rotary fashion , is connected to and associated with the distal knob 84 including a threaded insert 120 and a tubular collet 122 . the distal knob 84 includes a bore 124 terminating at an annular end surface 126 and a passageway 128 having a taper 129 extending from the annular end surface 126 through the distal wall of the distal knob 84 for accommodation of the hypotube 22 . the threaded insert 120 includes a partial bore 130 terminating at one end by an annular end surface 132 and at the other end by adjacent threads 134 . the threads 134 progressively engage the distal portion of the external threads 106 of the threaded body 88 . a passageway 136 extends from the bore 130 through a distal wall 138 of the threaded insert 120 . the tubular collet 122 includes a plurality of like spaced flexible jaws 140 each having a tapered and arcuate surface 142 surrounding a centrally located multiple radius passageway 144 . the threaded insert 120 is suitably secured within the bore 124 of the distal knob 84 , such as , but not limited to , by the use of adhesives or frictional engagement . the tubular collet 122 aligns to the annular end surface 132 of the threaded insert 120 , whereby the passageway 144 of the tubular collet 122 and the passageway 136 of the threaded insert 120 are in coaxial alignment . the coupling assembly 14 , which is removably attached to the hypotube 22 of the infusion flow guidewire 12 and which is provided for rapid connection to the proximal end of the hypotube 22 of the infusion flow guidewire 12 , uses previously described structure to effect suitable connection and coupling thereof and therewith . more specifically , the components of the coupling assembly 14 are assembled , as shown in fig1 , where the hypotube 22 is positioned , sealed and secured within the coupling assembly 14 . the hypotube 22 is shown in coaxial direct alignment within the passageway 128 and taper 129 of the distal knob 84 , the passageway 136 of the threaded insert 120 , the passageway 144 of the tubular collet 122 , the annular tapered actuating surface 118 of the compression fixture 92 , the passageway 114 of the compression fixture 92 , the center of the o - ring 90 , and finally , within and in communication with the passageway 112 of the threaded body 88 resulting in a suitable communication with the high pressure supply line 20 . as the distal knob 84 is rotated and advanced proximally along the threads 106 of the threaded body 88 , the tube collet 122 is forcefully positioned against the annular tapered actuating surface 118 of the compression fixture 92 , thereby urging and advancing the compression fixture 92 proximally . during such urging and advancement , sealing and securing of the hypotube 22 within the coupling assembly 14 are accomplished . sealing is provided by the resultant advancement of the compression fixture 92 to cause the o - ring 90 , which is located in the annular recess 116 of the compression fixture 92 , to bear against the annular end surface 109 of the threaded body 88 to deform the o - ring 90 thereby effecting a seal about the hypotube 22 , as well as perfecting a seal with the passageway 112 of the threaded body 88 . a seal is also perfected between the bore 108 of the threaded body 88 and the passageway 112 of the threaded body 88 . securing of the hypotube 22 within the coupling assembly 14 is provided by the interaction of the advancing tapered and arcuate surfaces 142 of the tubular collet jaws 140 with the annular tapered actuating surface 118 of the compression fixture 92 , whereby the collet jaws 140 are forcibly urged inwardly about the longitudinal axis of the tubular collet 122 to frictionally engage the hypotube 22 . the engagement of the o - ring 90 about the hypotube 22 also provides for additional securement by frictional engagement . fig1 illustrates a stainless steel extension wire 139 for use with the preferred all nitinol wire infusion flow guidewire 12 , including a constant size body 141 and an irregular shaped distal end 143 . the irregular shaped distal end 143 can be inserted into the inner diameter of the nitinol infusion flow guidewire 12 to be engaged therein in light frictional engagement to easily and quickly convert a rapid exchange length wire into an exchange length wire ( for over - the - wire devices ). as shown in fig1 a , another shape could be substituted for the irregular shaped distal end 143 including a tapered section 145 and a constant size extension 147 which can frictionally engage the inner diameter of the infusion flow guidewire 12 . alternatively , other configurations of the present invention can be advantageous . first , an infusion flow guidewire can be fashioned where a proximal section of the nitinol hypotube 22 is replaced by a proximally located section of stainless steel hypotube joined to a shortened length of the nitinol tube , such as is used for the hypotube 22 , instead of the full length nitinol hypotube 22 . the drawn hypotube section 22 a and components located distally thereto remain unchanged . in this construction , the proximal section of stainless steel structure provides a more pushable and torqueable proximal infusion flow guidewire end , thereby eliminating the need for and the use of the delivery sheath 16 , as previously described . this approach requires a connection between the stainless steel hypotube section and the reduced length nitinol hypotube section , such as those seen in the 0 . 014 inch guard dog device ( application ser . no . 11 / 581 , 613 ) or 3 fr swage proximal swage joint ( application ser . nos . 11 / 702 , 990 and 11 / 702 , 995 ). the proximal end of the nitinol section could be drawn down and inserted in the distal inner diameter of the stainless steel section and then swaging the stainless steel section over the drawn nitinol . another configuration could be accomplished by drawing the distal end of the stainless steel , gold plating it , and then laser swaging the proximal end of the nitinol onto the distal stainless steel section . such designs are more economically feasible due to the reduction in the use of nitinol . a second alternative construction involves the jet orifices . the greatest difficulty is achieving a high velocity and significant flow rate for the jet orifices . however , if one were to produce a series of orifices , 8 - 10 orifices for example , along the distal end of the infusion flow guidewire 12 , preferably on the collar 26 , one could produce a weeping style infusion catheter similar to the prostream guidewire . the orifices could be proximally , distally or perpendicularly directed in multiple combinations or arrangement thereof . in this case , the device would still have the advantage of a 0 . 014 inch profile versus the 0 . 035 inch profile for the prostream , but would be incapable of conducting power pulse as previously described . thirdly , the connection for the pump to the infusion flow guidewire could be of an alternative arrangement . rather than using a screw mechanism to squeeze the o - rings about the flow wire , one could use a hinged handle on a cam to advance a pusher plate to squeeze the o - rings . this invention describes a 0 . 014 inch infusion flow guidewire system which can infuse fibrinolytics and which can also macerate and propel fluid or debris in a proximal direction . the guidewire system can be operated with devices using an angiojet ® system in various forms of implementation for treatment of thrombus in small vessels , such as in distal peripheral vessels , e . g ., foot or other neurovascular sites . delivery of the infusion flow guidewire 12 , preferably of 0 . 014 inch diameter , is facilitated by inserting the delivery sheath 16 into and along the vasculature to position the distal end of the delivery sheath 16 at a location in close proximity to a thrombus site . such positioning is facilitated by grasping the torque handle 18 and urging the delivery sheath 16 distally . then , the flexible tip 24 of the infusion flow guidewire 12 can be inserted into and engage the proximal end of the torque handle 18 , and thence , gain entry into the delivery sheath 16 , whereby the hypotube 22 and the flexible tip 24 can be positioned distally therein by the use of the attached coupling assembly 14 . in the alternative , the infusion flow guidewire 12 can be prepackaged in the delivery sheath 16 for unitary delivery . when delivery is accomplished , fibrinolytics can be introduced or maceration of thrombus can take place in conjunction with an angiojet ® system , such as disclosed in patent application ser . no . 11 / 237 , 558 filed sep . 28 , 2005 , entitled “ thrombectomy catheter deployment system ,” or with other angiojet ® systems . as previously described , the torque handle 18 can be tightened over and about the hypotube 22 and unitary longitudinal and rotary positioning of the infusion flow guidewire 12 including the hypotube 22 can be accomplished . the clamping action of the torque handle 18 can be terminated by loosening the collet nut 46 , whereby the infusion flow guidewire 12 can be longitudinally and rotatingly positioned independently of the delivery sheath 16 by use of the attached coupling assembly 14 to achieve the desired position . when the infusion flow guidewire 12 is in the desired position , the coupling assembly 14 can be rotationally actuated to release the proximal end of hypotube 22 at the proximal end of the infusion flow guidewire 12 to allow separation of the hypotube 22 and the coupling assembly 14 , thereby allowing access over and about the infusion flow guidewire 12 by other devices , as necessary . fig1 , 14 and 15 show various locations of the jet orifices 32 and 34 with respect to the thrombus 148 located in a vessel 150 , such locations being used for various operating modes . fig1 shows the location of the jet orifices 32 and 34 in close proximity to and proximal to the thrombus 148 , fig1 shows the location of the jet orifices 32 and 34 in close proximity to and distal to the thrombus 148 , and fig1 shows the location of the jet orifices 32 and 34 aligned within the thrombus 148 . preferably , the invention is used with and is connected to an angiojet ® system . the invention may be used either to inject fibrinolytics , to macerate and propel fluid or debris in a proximal direction , or to accomplish all or other such functions . a hypothetical procedure , such as for use in the foot , for example , may be to advance the infusion flow guidewire to this very distal anatomy , farther than currently possible with available thrombectomy catheters . as shown in fig1 , fibrinolytics 146 can be delivered at a nominal rate , such as by use of an angiojet ® system , in close proximity to the proximal portion of a buildup of thrombus 148 located in the vessel 150 for the treatment and softening of the thrombus prior to thrombus removal . as shown in fig1 , the jet orifices 32 and 34 can be positioned in close proximity and distal to the thrombus 148 where an angiojet ® system can deliver fibrinolytic at a nominal rate or in the power pulse mode , the latter mode of which proximally directs and infuses a fibrinolytic to the thrombus 152 of the thrombosed vessel segment in a direction as shown by arrows 152 . this will ensure that the fibrinolytic is driven into the organized thrombus debris for effective loosening of the thrombus 148 . following a period of time , the physician would operate the same infusion flow guidewire 12 to macerate the organized debris by high pressure jet streams emanating proximally from the jet orifices 32 and 34 in a direction shown by arrows 152 the net effect of the procedure is that any thrombus 148 that would have been removed by a long duration drip is removed in the catheterization laboratory with the power pulse technique . this avoids the need to keep patients on a long term drip of fibrinolytics which is undesirable from a bleeding complication perspective . the flow rate and the jet orifice 32 and 34 arrangement of the infusion flow guidewire 12 result in a power direct infusion of fluid sufficient to disrupt and macerate the thrombus or push debris in the direction of the jet flow subsequent to breaking through the thrombus 148 . preferably , the infusion flow guidewire 12 is actuated in a to and fro motion , as well as a rotary motion . as shown in fig1 , the jet orifices 32 and 34 are positioned in the midst of the thrombus 148 . again , an angiojet ® system can be used to deliver fibrinolytics under nominal pressure or under power pulse pressures . such a location of the jet orifices 32 and 34 can be advantageous in treatment at the center of the thrombus 148 from the inside to the outside thereof . after a suitable length of time , high pressure jet streams emanating from the jet orifices 32 and 34 in a direction as shown by arrows 152 macerate the thrombus 148 . preferably , the infusion flow guidewire 12 is actuated in a to and fro motion , as well as a rotary motion . an aspiration catheter or an angiojet ® catheter , such as one with a proximal balloon , could be delivered over the infusion flow guidewire 12 and connected an angiojet ® system roller pump . thus , the infusion flow guidewire system 10 could conduct thrombus maceration coupled with aspiration . although the infusion flow guidewire system 10 may not be truly isovolumetric , there would be some aspiration of the material . furthermore , the high velocity fluid jet stream from the infusion flow guidewire 12 is generally effective in macerating debris . finally , once the debris is removed , there may need for other treatments . for example , a stent could be delivered over the same wire following the thrombectomy / lysis procedure . other techniques for use of the infusion flow guidewire 12 would be to first treat the thrombus segment with the “ power pulse ” technique . following this procedure , a pressurized bag of saline / lytic could be attached to the infusion flow guidewire 12 and the patient moved out of the catheterization laboratory . alternatively , the physician may elect to only conduct a drip type procedure with the infusion flow guidewire 12 or a nominal pressure slow infusion could be accomplished with an angiojet ® system . there are many potential treatment modalities . the angiojet ® system along with its capability of delivering fluid at pressures up to 20 kpsi , can enable the 0 . 014 inch infusion flow guidewire 12 to deliver a powerful stream of fluid sufficient to the treatment site , if required . the entire infusion flow guidewire 12 is fashioned of nitinol to eliminate any flow restrictions between nitinol tubing and previously used stainless steel tube components and associated joint restrictions , as well as wall thickness strength constraints . the use of nitinol tubing also makes the infusion flow guidewire 12 kink resistant . the goal of the infusion flow guidewire system 10 is to enable delivery of as much a flow rate as possible to the jet orifices 32 and 34 . the resulting flow rate , divided by the jet hole area , will yield the jet velocity . vessel safety tests have shown that jet velocity higher than the angiojet ® catheter side exhaust holes ( 15 m / s ) are safe , but that the velocities must be less than the angiojet ® internal jets ( 150 m / s ). however , there may be occasions where destructive velocities in excess of 150 m / s may be required in treatment of calcific plaque , tissue destruction or disruption . hence , the jet hole diameter and the entire flow resistance of the device is engineered to yield jet velocities in the range of 15 to 100 m / s . aside from connections between stainless steel and nitinol , there may be other major restrictions that require attention . first , the infusion flow guidewire 12 should preferably be a rapid exchange length of 190 cm in order to achieve the least resistance as possible . secondly , the id of the nitinol infusion flow guidewire 12 should be as large as practical preferably 0 . 010 inch diameter dimension . third , the drawn hypotube section 22 a at the distal end of the infusion flow guidewire 12 is designed as short as possible in order to achieve an acceptably deliverable infusion flow guidewire . importantly , an infusion flow guidewire 12 device of 0 . 014 inch can deliver a significant flow rate (& gt ; 5 cc / min ) to the jet orifices 32 and 34 using a typical angiojet ® pressure range of 0 . 25 kpsi to 12 kpsi . various modifications can be made to the present invention without departing from the apparent scope thereof .
an infusion flow guidewire system including a delivery sheath and an infusion flow guidewire . the minimal cross section flexible infusion flow guidewire includes a nitinol hypotube , a flexible tip and distally located rearwardly directed orifices for infusion of fibrinolytics and for introduction of high pressure fluids for maceration and rearwardly directed flow of thrombus debris located in tortuous small sized vessels . apparatus , some of which is removably attachable , is provided for grasping members of the invention for rotational torquing and for longitudinal actuation along and within the vasculature .