the present invention involves a process for the production of the hydrochloride salt form of creatine . the process uses creatine monohydrate and acetyl chloride as the reactants and ethanol as the preferred solvent . the product of this reaction is a granular precipitate consisting of the creatine hydrochloride salt in high purity and yield . the invention also involves an application or use of the creatine hydrochloride salt as a nutritional supplement for enhancing muscle performance and muscle mass in both humans and livestock . what sets this creatine hydrochloride salt apart from the other forms of creatine is its high aqueous solubility . studies in the inventors &# 39 ; laboratory indicate that the aqueous solubility of the creatine hydrochloride is 150 mg / ml or greater , while that of creatine monohydrate and creatine citrate salt is at least an order of magnitude lower ( approximately 10 - 15 mg / ml ). as the low oral absorption of creatine supplements are believed to be attributable in part to reduced solubility , the creatine hydrochloride would be expected to have better oral absorption properties . an alternate embodiment of the process uses anhydrous creatine . an alternate embodiment of the process uses other short chain alcohols selected from methanol , propanol , butanol , isopropanol , among others to replace the ethanol solvent . various other applications for use with this type of a salt , other than in the sports beverage area , may include its application as a feed additive in livestock . certainly , based upon what is now known about the product , it would have immediate applications in the solid oral dosage supplementation area , as an additive or a feed supplement in livestock feed . or , it may be added into a liquid , or any water , that is fed to the livestock , during there consumption of liquids and solids . this is contemplated within the essence of this invention that the formulation for the oral supplementation of this invention could be provided in a solid oral dosage form , such as in a capsule form , or tablets , for treatment requirements when taken by the human , animal , and the like . this is known in the art . the formulation for the creatine oral supplementation , using the creatine hydrochloride salt , is crhcl . the formulation could be added into a beverage in addition the crhcl may be provided as an ingredient to a sports drink , liquid meal replacement , or the like , and as can be understood . furthermore , the concept of this invention for use of this formulation within a supplementation can be used and applied for nutritional and energy purposes . furthermore , the composition could be added as a fortification to other foods . finally , it is likely that this composition could be added as a feed supplement , to further enhance the energy requirements of the horses , and other animals , as may be desired and required . the product of this reaction of creatine monohydrate and acetyl chloride dissolved in ethanol is a granular precipitate consisting of the creatine hydrochloride salt in high purity and yield . yield is measured by 1h - nmr analysis used for organic chemicals . 1h - nmr uses spectroscopy and nuclear magnetic resonance technology to ascertain the structure of chemical compounds . the reactants are measured as mole equivalents while the solvent is measured as milliliters per gram of creatine hydrochloride salt . the preferred process uses 1 . 4 mole equivalents of acetyl chloride . above 1 . 5 and including 2 . 0 mole equivalents acetyl chloride , the process produces less desirable creatine ethyl ester hydrochloride at a sacrifice of yield for creatine hydrochloride . above 2 . 0 mole equivalents acetyl chloride , the process forms creatinine hydrochloride . the preferred process dissolves the reactants in 10 ml of ethanol . alternatively , the process has ethanol ranging from about 6 to about 10 ml . the preferred process operates in a temperature range of 25 deg . c to 35 deg . c . at temperatures above the preferred range including 50 deg . c , the process produces the less desirable creatine ethyl ester hydrochloride . in excess of 50 deg . c , the process produces creatinine hydrochloride . however , even in the preferred embodiment minor fractions of creatine ethyl ester hydrochloride and creatinine hydrochloride are produced . to form creatine hydrochloride salt , a manufacturer blends creatine monohydrate with acetyl chloride in a vessel . then ethanol is added to the vessel as a solvent . the temperature of the solution is raised to between about 24 deg . c to about 50 deg . c , preferably to 25 deg . c . in that condition , the solution precipitates a hydrochloride salt of creatine in granular form in the vessel . after reducing the temperature and pressure to ambient atmospheric temperature and pressure , the manufacturer collects the granules of creatine hydrochloride salt then packages the granules for consumption by humans or livestock . as an alternative method , a manufacture produces creatine hydrochloride by bubbling gaseous hydrochloric acid into diethyl ether solvent . then , creatine monohydrate is stirred into the solvent . from the reaction , creatine hydrochloride precipitates . the manufacturer then filters and washes the precipitate . lastly , the precipitate dries at room temperature to a crystalline form , white in color and then is packaged for human or livestock consumption . in using the alternative method , the hydrochloric acid may have a range of concentrations so long as the hydrochloric acid exceeds the molar equivalent of creatine monohydrate . next , the alternative method stirred from about 0 grams to about 5 grams of creatine monohydrate into the solution at 25 deg . c for two hours . filtering and washing were performed with 50 milliliters of fresh diethyl ether . variations or modifications to the subject matter may occur to those skilled in the art upon review of the invention as described herein . such variations , if within the spirit of this development , are intended to be encompassed within the scope of the invention as defined herein . the description of the preferred embodiment , as provided , is set forth for illustrative purposes only .
creatine oral supplementation using creatine hydrochloride salt , that may be added to a liquid or other beverage , or may be also used as an additive to solid oral dosages , or as a supplement , and which may be consumed by the athlete , or other party looking for immediate supplementation of strength , and may be added as a supplement within feed to livestock , in the veterinary area .