an exemplary embodiment of a dry powder inhaler 100 is illustrated in fig3 a and 3b . according to various aspects of the disclosure , the dry powder inhaler 100 may comprise a casing 102 having an outer wall 104 and two inner walls 106 , 108 . the inner walls 106 , 108 may extend in a first direction from a first inner surface 112 of the outer wall 104 toward a second inner surface 114 of the outer wall 104 . the inner walls 106 , 108 may also extend in a second direction from a proximal end 116 of the casing 102 to a distal end 118 of the casing 102 . thus , according to various aspects , the outer wall 104 and inner walls 106 , 108 may cooperate to define three chambers in the casing 102 . according to some aspects , the three chambers may include a middle chamber 122 and two side chambers 124 , 126 located on opposite sides of the middle chamber 122 relative to one another . the side chambers may comprise a first side chamber 124 located to a first side of the middle chamber 122 and a second side chamber 126 located to a second side of the middle chamber 122 . in accordance with various aspects , the distal end 118 of the casing 102 may include one or more airflow inlets 128 providing fluid communication between the middle chamber 122 and ambient air outside the casing 102 . the proximal end 116 of the casing 102 may include a mouthpiece 130 . the mouthpiece 130 may a separate structure affixed to the outer wall 104 of the casing 102 , or the mouthpiece 130 and casing 102 may comprise a single piece of unitary construction . the mouthpiece 130 may include an opening 132 providing fluid communication between the middle chamber 122 and the outside of the casing 102 . the opening 132 may be shaped as an oval , a circle , a triangle , or any other desired shape . the mouthpiece 130 may have a shape that facilitates pursing of a patient &# 39 ; s lips over the mouthpiece 130 and creating a seal between the lips and the mouthpiece 130 . the inhaler 100 may include a nozzle 134 between the middle chamber 122 and the opening 132 . according to various aspects , the nozzle 134 may extend from the opening 132 , through the mouthpiece 130 , and into the middle chamber 122 . in some aspects , the nozzle 134 may comprise at least one helical tube 136 through which air and powder can be inhaled . the tube 136 can be configured to increase the turbulence in the air that flows through the nozzle 134 . an aeroelastic element 140 may extend across a center region 142 of the middle chamber 122 between the inner walls 106 , 108 . the aeroelastic element 140 may include one or more doses of a medicament 141 , for example , doses of powdered medicament , and the center region 142 may comprise a region for dispensing a dose of medicament into airflow through the inhaler 100 . according to some aspects , the aeroeslastic element 140 may comprise a membrane 144 , for example , a thin elastic membrane , wound between two spools 146 , 148 . an unused end of the membrane 144 may be wound on a first spool 146 , and a used end of the membrane 144 may be wound on a second spool 148 . the first spool 146 may be disposed about a first axle 147 , and the second spool 148 may be disposed about a second axle 149 . the first spool 146 may be in the first side chamber 124 , and the second spool 148 may be in the second side chamber 126 . in such an embodiment , the membrane 144 extends through a slot 150 in the inner wall 106 , across the center region 142 , and through a slot 152 in the inner wall 108 . in accordance with some aspects , the aeroelastic element 140 may comprise a membrane , a film , a reed , a sheet , a panel , or a blade . the aeroelastic element may be manufactured of materials comprising polymers , thin metals , polymer - coated metals , and / or metal - coated polymers . according to various aspects , the inhaler 100 may include two base clamps 154 , 156 fixedly attached to a first inner surface 112 of the casing 102 . according to some aspects , the base clamps 154 , 156 may be in the middle chamber 122 . a first of the base clamps 154 may be between the center region 142 and the first inner wall 106 , and the second of the base clamps 156 may be between the center region 142 and the second inner wall 108 . the aeroelastic element 140 may rest on the base clamps 154 , 156 . the inhaler 100 may include two upper clamps 158 , 160 in the middle chamber 122 associated with the two base clamps 154 , 156 . for example , a first upper clamp 158 may be on an opposite side of the aeroelastic element 140 relative to the first base clamp 154 and configured to descend atop the first base clamp 154 to sandwich the aeroelastic element therebetween . similarly , the second upper clamp 160 may be on an opposite side of the aeroelastic element 140 relative to the second base clamp 156 and configured to descend atop the second base clamp 156 to sandwich the aeroelastic element therebetween . the upper clamps 158 , 160 and base clamps 154 , 156 may hold the aeroelastic element 140 in place across the center region 142 with a desired amount of tension . the desired amount of tension may be determined based on a user &# 39 ; s inhalation strength . it should be appreciated that in some aspects , the upper clamps may be fixedly attached to the second inner surface 114 of the casing 102 , and the base clamps may be configured to ascend toward the upper clamps to sandwich the aeroelastic element therebetween . in an alternative embodiment ( not shown ), a first of the base clamps 154 may be in the first side chamber 124 between the first spool 146 and the first wall 106 , and the second of the base clamps 156 may be in the second side chamber 126 between the second spool 148 and the second wall 108 . the inhaler 100 may include an advancement member 162 extending outward of the casing 102 . the advancement member 162 may comprise , for example , a lever , a dial , or the like . the advancement member 162 may be mechanically coupled to the first and second upper clamps 158 , 160 via , for example , a crank 164 or other known linkage . the advancement member 162 and crank 164 are structured and arranged such that when the advancement member 162 is actuated by a user , the crank 164 is caused to move the upper clamps 158 , 160 in a direction away from the base clamps 154 , 156 . actuation of the advancement member 162 may also cause the second axle 149 to turn in a manner that increases the used end of the aeroelastic element 140 wound thereon . according to some exemplary aspects , as shown in fig7 a - 7c , the inhaler 100 may include one or more tensioning rods 166 , 168 configured to increase the tension of the aeroelastic element 140 beyond the tension applied by the base clamps 154 , 156 and upper clamps 158 , 160 . the tensioning rods 166 , 168 are between the first and second upper clamps 158 , 160 . the tensioning rods 166 , 168 may be mechanically coupled to the crank 164 such that actuation of the advancement member 162 causes the tensioning rods 166 , 168 to move in a direction away from the aeroelastic element 140 . when the advancement member 162 is released or unactuated , the tensioning rods 166 , 168 return to a position that applies a desired amount of tension to the aeroelastic element 140 . it should be appreciated that in some aspects , one or more tension controllers 157 , 159 ( fig4 ) may be attached to one or both of the spool axles 147 , 149 , thus allowing the tension of the aeroelastic element 140 to be manually fixed and maintained across the spool axles 147 , 149 and obviating the need for tensioning rods . in any design , the amount tension applied by the clamps , tensioning rods , and / or tension controllers can be determined based on inhalation strength of a user . referring again to fig3 b , in various aspects , the second axle 149 associated with the second spool 148 may comprise a concentric spring 170 , which is mechanically coupled to the advancement member 162 so that actuation of the advancement member 162 results in the aeroelastic element 140 being transferred from the first spool 138 to the second spool 148 as the spring - loaded axle 149 is activated . the inhaler 100 may include a roller 172 ( fig5 ) adjacent to the first spool 146 and engaging the aeroelastic element 140 , thereby resulting in additional tension in the aeroelastic element . according to some aspects , for example , inhalers having an aeroelastic element with multiple doses of medicament , a dose counter 174 may be mechanically coupled to the advancement member 162 in such a way that the dose counter 174 changes numbers by one each time the advancement member 162 is actuated . in some aspects , the dose counter 174 may be at an exterior surface of the casing 102 so as to be visible to a user . in some aspects , the dose counter 174 may be inside the casing 102 , but visible to a user via a transparent or translucent window ( not shown ), as would be understood by persons skilled in the art . according to various aspects , as shown in fig5 , the inhaler 100 may include a powder dose applicator 176 located between the first spool 146 and the first base clamp 154 . in some aspects , the powder dose applicator 176 may include a dispensing chute 178 filled with at least one dose of powder 180 . the dispensing chute 178 may include a top end 182 and a bottom end 184 . a wheel 186 may be at the bottom end of the dispensing chute 178 . the wheel 186 may be rotatable about an axle 188 . the axle 188 may be mechanically coupled to the advancement member 162 such that the wheel 186 rotates an amount sufficient to dispense one dose of powdered medicament to the aeroelastic element . for example , the wheel 186 may include one or more notches 190 in its periphery , with the volume of each notch being sized for one dose of powdered medicament . according to some aspects , the wheel shown in fig5 may be replaced with a dispensing disk 686 , as shown in fig6 . for example , the dispensing chute 178 above the aeroelastic element 140 is filled with at least one dose of powdered medicament . the dispensing disk 686 may be located between the aeroelastic element 140 and the dispensing chute 178 and may be in contact with the bottom end 184 of the chute 178 . the disk 686 may further include multiple dispensing openings 690 clustered in one section of the disk 686 , for example , a periphery of the disk 686 . the dispensing openings 690 correspond to an accurate amount of powdered medicament to be dispensed as a dose . the dispensing disk 686 rotates about an axle 688 as the advancement member 162 is actuated , thereby resulting in an accurate amount of powdered medicament falling through the dispensing openings 690 and to the aeroelastic element 140 . for example , the disk 686 may make one complete 360 ° rotation each time the advancement member 162 is actuated . in various aspects , the inhaler 100 may include blister strip packaging attached to the two spools in place of the powder dose applicators discussed above . for example , as shown in fig8 , the blister strip packaging 801 may include at least one individual dosing cup 803 . each cup 803 may be filled with a dose of powdered medicament and covered by a peelable top layer . the dosing cups 803 may be arranged serially along the length of the packaging strip 801 . an aeroelastic element 840 may be streteched across the center region 142 and fixedly coupled to , for example , the inner walls or any other structure capable of maintaining the element 840 fixedly stretched across the center region 142 . the strip 801 may be in proximity to the aeroelastic element 840 in the center region 142 such that the aeroelastic element 840 may act as an actuator , making contact with the blister packaging and dispersing the powder dose when the aeroelastic element begins to vibrate during inhalation by a patient . a powder dose opener 805 may be configured to remove the top peelable layer from the blister strip packaging 801 for one dose when the blister strip 801 is advanced from the first spool to the second spool . the powder dose opener may alternatively be a simple puncturing device , such as a needle , that inserts small holes in the blister strip blister cavity , making the dose ready for inhalation . in some embodiments , as shown in fig9 , blister strip packaging 901 may include clusters 905 of multiple small dosing cups 903 for simultaneous multiple drug dosing , the clusters 905 may be arranged serially along the length of the blister strip 901 . the large arrows depict the direction of airflow across the blister strip and aeroelastic element . the small vertical arrows depict the vibrational motion of the aeroelastic element . in various embodiments , as shown in fig1 , the inhaler may include an aeroelastic element 1040 that may comprise , for example , an aeroelastic and deformable membrane . the element 1040 may include at least one individual dosing cup 1003 filled with a dose of powdered medicament in the form of blister strip packaging 1001 . the dosing cup 1003 may be configured to deform and raise the powder dose to the level of the surrounding element 1040 . it should be appreciated that the inhaler may comprise a single powder dose such that the inhaler may be disposed of after a single use . referring again to fig5 , in some aspects , the inhaler 100 may include two rollers 192 , one above and one below the aeroelastic element 140 . the rollers 192 may be between the powder dose applicator 176 and the first base clamp 154 or between the powder dose applicator 176 and the inner wall 106 . the rollers 192 turn as the aeroelastic element 140 moves from the first spool 146 to the second spool 148 due to the frictional force applied by the aeroelastic element 140 as it is urged past the pinching rollers 192 . the rollers 192 fully engage the aeroelastic element 140 and flatten the powder deposited onto the aeroelastic element 140 and break up clumps in the powder . thus , the advancement member 162 may be capable of turning the crank to release the upper clamps and tensioner rods , advancing the dose counter , turning the wheel in the dispensing chute , advancing the spring - loaded axle in the second spool by one position to advance the aeroelastic element a predetermined distance from the first spool to the second spool , and / or moving a dose of powder medicament into the center region 142 . referring again to fig3 a and 3b , according to various aspects , the inhaler 100 may include one or more airflow modifiers 198 proximal of the one or more airflow inlets 128 and at a distal end of the center region 142 . it should be appreciated that the one or more airflow modifiers 198 may be distal of the center region 142 and / or at a distal portion within the center region 142 . in some aspects , the one or more airflow modifiers 198 may comprise multiple triangular rods extending from the first inner wall 106 to the second inner wall 108 . as air flows through the one or more airflow inlets 128 and toward the center region 142 , the one or more airflow modifiers 198 may cause vortices that allow air to pass above and below the modifiers . referring now to fig1 , airflow at velocity v over an aeroelastic element under tension is illustrated . as shown , the airflow may result in flutter or vibration of the aeroelastic element 140 . the vibration is represented by vertical arrows , and the airflow is represented by horizontal arrows . fig2 illustrates the airflow at velocity v past an airflow modifier prior to encountering an aeroelastic element 140 . as shown , the airflow modifier introduces turbulence into the airflow , thus increasing the vibration or flutter of the aeroelastic element for a given inhalation strength . in operation , a method for dispensing powder by inhalation using any of the aforementioned exemplary dry powder inhaler apparatuses may begin with a patient actuating the advancement member . the patient may purse his / her lips around the mouthpiece and inhales . as the patient inhales , air is sucked into the inhaler through one or more airflow inlets at the distal end of the inhaler . the inhaled air flows over the airflow modifiers . the airflow then encounters the aeroelastic element , causing the element to vibrate or flutter and disperse a dose of powdered medicament from the element into the airflow . the combined flow of air and powder then flow into the distal end of the airflow nozzle and the mouthpiece . the combined flow of air and powder leave the mouthpiece and enter the patient &# 39 ; s mouth and respiratory tract . the airflow modifiers and / or the helical shape of the nozzle may increase the turbulence of the airflow to better aerosolize and break up the powdered dose of medicament into smaller particles , thus maximizing the dose received by the patient and allowing the smaller particles to pass further into the respiratory tract . it will be apparent to those skilled in the art that various modifications and variations can be made in the inhalers and methods of the present disclosure without departing from the scope of the invention . other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein . it is intended that the specification and examples be considered as exemplary only .
a dry powder inhaler for delivering medicament to a patient includes a housing defining a chamber for receiving a dose of powdered medicament , an inhalation port in fluid communication with the chamber , at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing , and an aeroelastic element in the chamber and associated with a dose of powdered medicament . a tensioning assembly is configured to apply a first amount of tension to the aeroelastic element such that the aeroelastic element is capable of vibrating in response to airflow through the chamber so as to aerosolize the dose of powdered medicament .