the preferred embodiment ( s ) of the present invention is illustrated in fig1 - 4 . the present invention teaches a prefilled , unifying dispensing container containing at least two different dosage units for the treatment of rhinitis , and containing indicia for distinguishing the dosage units and signifying their use together , and coordinated instructions for their use together . it is to be understood that either single or multiple doses of each dosage units are contained . the dosage units may be in the form of tablet , pill , capsule , caplet , powders , liquids , gels , some of which may require reconstituting , or any generally recognized oral form of medication . referring to the drawings , it will be understood that while preferred embodiments of the invention have been illustrated and described , the invention is not limited to such embodiments . changes and additions may be made therein and thereto without departing from the spirit of the invention . embodiments of the unifying container of the preferred invention are depicted in fig1 - 4 . fig1 depicts a support package 10 containing multiple dosages of two different dosage units 12 , 14 in tablet form 50 in blister packaging 52 . fig2 depicts a support package 20 which houses two modules in the form of bottles 22 , 24 containing different dosage units , which can be either in liquid form or in solid form . fig3 depicts a support package 30 with a single dosage unit 32 for morning and a single different dosage unit 34 for night . fig4 depicts a support package 40 which is manufactured to house a multiplicity of daytime modules in the form of pouches 42 and a multiplicity of nighttime modules in the form of pouches 44 . in each of the four depicted configurations , the support package has specific provision for supporting said dosage units in physical accord with indicia 16 , 26 , 36 , 46 of fig1 - 4 , respectively . the indicia manufactured with the support package distinguishes between the dosage units by means of wording , color , shape symbol , or other means known in the art . the indicia , by their presence , also indicate the suitability of said dosage units for use with each other . the support package also incorporates coordinated administration instructions 18 , 28 , 38 , 48 of fig1 - 4 , respectively , which also indicate the suitability of the dosage units for use with each other , and instruct coordination of the dosage units as a regimen . although the embodiments specifically described herein have two medicament housings , packaging containing other numbers of housings is also within the scope of this invention . the packaging may be adapted by widening the packaging and increasing the number of housings and indicia . additionally , the packaging may be in any geometric configuration . the packaging contains combinations of medications , which include nasal decongestants and antihistamines that comprise a regimen for treating rhinitis . specifically , the packaged medication is comprised of at least two dosage units , a non - sedating dosage unit for administration during the day , and a dosage unit , which is non - stimulatory in accord with the susceptibility of the user , for use at night . the package also contains instructions for taking the dosage units as a regimen . it is to be understood that the nighttime dosage unit , at least , contains a lesser amount of decongestant as compared to the aforementioned conventional decongestant - antihistamine dosage units . it is considered that in the case of a package intended for over - the - counter sales , a comparison between the amount of decongestant to conventional dosing is provided by the instructions , indicia , or both in a manner which would allow a user to estimate the degree of stimulation which might be expected . in the case of a package intended for prescription , however , the prescribing provider would be expected to be able to assess the stimulatory qualities of such regimens on behalf of the user , and the inclusion of such a comparison within the package is optional . the daytime dosage unit may be formulated to contain non - sedating antihistamine , and / or decongestant , but not sedating antihistamine . the decongestant may be in conventional or attenuated quantity . the nighttime dosage unit may be formulated to contain sedating or nonsedating antihistamine , and , if containing decongestant , contains an attenuated quantity in comparison to conventional dosing . the terms “ daytime ” is intended to be synonymous with a time when sedation is considered undesirable , such as time of awakening , and the term “ nighttime ” to be synonymous with times when stimulation would be undesired , such as times of sleeping , as well as daytime and nighttime literally , in that such times vary in accordance with the schedule of individuals . the regimen is devised using dosage units , which are favorable for use with each other , especially with regard to their pharmacokinetic and therapeutic characteristics . the following are examples of regimens according to the present invention : the following regimen is suggested for an individual who is considered to be moderately susceptible to the stimulating side - effects of decongestants : daytime dosage : 90 mg pseudoephedrine hydrochloride in 12 hour time - release formulation , and 5 mg loratidine ( to be taken in the morning ), and bedtime dosage : 60 mg pseudoephedrine hydrochloride in 12 hour time - release formulation , and 5 mg loratidine ( to be taken at bedtime ). this regimen employs the stimulating decongestant pseudoephedrine hydrochloride and the non - sedating antihistamine loratidine . the conventional 12 - hour dosing of 120 mg of pseudoephedrine has been illustrated by the aforementioned examples of single dosage unit antihistamine - decongestant combinations . as noted , stimulatory side effects are known to occur with conventional dosing , and some individuals are more susceptible to side effects than others . this regimen utilizes a morning dosing to 90 mg of pseudoephedrine , instead of the conventional 120 mg , and a bedtime dosing to 60 mg , one - half of the conventional 120 mg , to achieve therapeutic effects to address side effects in an individual considered to have a moderate degree of susceptibility . consideration of susceptibility and therefore appropriateness of this regimen may be based upon self - assessment of prior experience , or assessment by a caregiver . methods for time - release formulation of pseudoephedrine are well known in the art . avoidance of daytime sedation is considered important in regimens of the present invention , and is avoided by the employment of the non - sedating antihistamine , loratidine . half of the daily loratidine dose is given at bedtime to assure significant receptor binding in the morning . the following regimen is considered appropriate for an individual who is moderately susceptible to the stimulating side - effects of decongestants , and particularly susceptible to insomnia from decongestants at night : daytime dosage : 90 mg pseudoephedrine hydrochloride in 12 hour time - release formulation ( to be taken in the morning ), and nighttime dosage : 30 mg pseudoephedrine hydrochloride in 12 hour time - release formulation , and 4 mg of chlorpheniramine ( to be taken at bedtime ). in this example , the total 24 hour dose of 120 mg of pseudoephedrine is one - half that of conventional dosing . by reducing the morning dose of pseudoephedrine to 90 mg , instead of the conventional 120 mg , and the bedtime dose to 30 mg , instead of the conventional 120 mg , a balance between therapeutic and side effects might be achieved in an individual susceptible to stimulatory side - effects , particularly insomnia . the potential for nighttime stimulation from pseudoephedrine is further diminished by the inclusion of the sedating antihistamine , chlorpheniramine in the nighttime formulation . dosing of antihistamine at bedtime favors binding by histamine receptors in the morning , when such binding is typically most desired . 60 mg pseudoephedrine sulfate in a 12 - hour time release formulation , and 60 mg of fexofenadine ( to be taken in the morning ), and 60 mg of fexofenadine ( to be taken in the evening ). for an individual known to be prone to insomnia with decongestants , limitation of pseudophedrine dosing to the day , in this example , avoids stimulation and insomnia at night . dosing of one half of the conventional daytime dosage of 120 mg of pseudoephedrine might suit an individual who is susceptible to its side effects but able to tolerate a decreased dosage in order to gain therapeutic benefit . use of the non - sedating antihistamine fexofenadine avoids daytime sedation compared to sedating antihistamine . the 12 - hour duration of antihistaminic activity of fexofenadine requires daytime dosing to achieve an effective daytime combination of antihistamine and decongestant . binding of fexofenadine to the histamine receptors in the morning is expected with its bedtime dosing . in addition to antihistamines and decongestants , additional therapeutic ingredients for the treatment of rhinitis may be formulated if desired . for example , analgesics , anticholinergic agents , and inhibitors of allergic mediators other than histamine , such as those generated by the arachadonic acid pathways , may be considered for inclusion in such formulations and are within the scope of this invention . these examples do not constitute an exhaustive list of potential combinations , and variations and modifications may be made by those of ordinary skill in the art . those of skill in the art may also recognize modifications to these presently disclosed embodiments . these variations and modifications are meant to be covered by the spirit and scope of the present claims .
a prepackaged , therapeutic regimen includes a non - sedating first dosage unit that includes a nasal decongestant , a second dosage unit that includes an antihistamine and an attenuated dosage of nasal decongestant , indicia for distinguishing between the first and second dosage units , administration instructions that teach the coordinated use of the first and second dosage units , and a pharmaceutical dispensing container containing the first and second dosage units and incorporating the indicia and coordinating instructions .