considering the drawings , wherein like reference numerals denote like parts throughout the various drawing figures , reference numeral 10 as shown in fig1 is directed to the loading station according to the present invention . in its essence , the loading station 10 includes a support 2 , to which the following are mounted : a thrombin processing unit 4 , a clotting and adhesive proteins processing unit 6 , and a dispensing manifold 8 . each unit 4 , 6 has a separate dispensing line 16 a , 16 b to the dispensing manifold 8 as shown in fig1 , to maintain sequestration of each component of the biological glue . the outlet 12 connected to the thrombin processing unit 4 leads into a reserve vessel 14 , whereby pressure from a thrombin syringe 7 causes thrombin to enter the reserve vessel 14 . rods 1 suspend support 2 . hooks 3 support the thrombin processing unit 4 , the clotting and adhesive proteins processing unit 6 , and reserve vessel 14 . clips 5 support the dispensing manifold 8 . the dispensing manifold 8 is preferably oriented to load a plurality of syringe pair assemblies 20 ( fig1 b ) with components of the biological glue . fig2 depicts four such syringe pair assemblies 20 , but it is also observed from fig2 that additional assemblies 20 may be present . the syringe pair assembly 20 is pictured in fig1 a , 13 b . the assembly 20 includes two syringes ( dispensing means ) 22 a , 22 b ; a barrel - holding frame 24 ; and a plunger connector 26 . a fitting 18 is also present , the fitting 18 adapted to frictionally hold the syringe pair assembly 20 together and link to the dispensing manifold 8 via tubing 9 . the barrel - holding frame 24 includes a spring - based plastic retaining member 28 ; in fig1 b , the retaining member 28 secures the barrel - holding frame 24 to the fitting 18 . the spring 27 is shown as a resilient leaf ( fig1 b ) integral with frame 24 and leading to the retainer 28 . the assembly 20 is housed inside a membrane 30 , particularly during loading . the membrane 30 is preferably flexible plastic , formed with a gathered ( doubled - over ) portion 32 about the assembly 20 . the gathered portion 32 is formed by creating pleats 36 using “ accordion ”- type folds in the membrane 30 , with a first layer 30 a ( fig1 ) of the membrane 30 proximate the syringe pair assembly 20 ( fig4 , 12 ) and an outer layer 30 b which moves from an overlying position ( relative to the first layer 30 a ) to a coextensive position after loading a syringe pair assembly 20 , one with clotting proteins and the other with thrombin . one end of the membrane 30 is sealed over the tubing 9 that connects to the dispensing line 16 a , 16 b via dispensing manifold 8 . the other end of the membrane 30 is also closed and is deployed about the syringe plungers 38 a , 38 b , to allow an operator to grasp and extend the plunger end during filling of the syringe pair assembly 20 without exposure to ambient conditions . downward force , shown by the arrow a in fig6 , while grasping the plunger end and the membrane 30 allows the pleats 36 of the gathered portion 32 to expand while always encasing the now - fully extended assembly 20 ( fig5 , 14 ). the plunger end of the membrane 30 will be opened ( fig1 ) in an operatory to allow access to the filled syringe pair assembly 20 during a surgical procedure . as shown in fig1 , a free end 37 of the membrane 30 shows the membrane as formed from the parts 37 a , 37 b , sealed together but separable ( by peeling apart ) to expose plunger connector 26 of the loaded syringe pair . thus , the loaded syringe pair is maintained sterile until actual use in surgery . the procedure for loading the assemblies 20 with thrombin and adhesive and clotting proteins is shown in fig6 – 11 . before loading , all assemblies 20 are encased in membranes 30 and attached to the dispensing manifold 8 using the fittings 18 . the assembly 20 located furthest from the end of the dispensing manifold 8 is preferably drawing on the dispensing lines 16 a , 16 b by extending the syringe plungers ( fig6 ) to fill the dispensing lines 16 a , 16 b and dispensing manifold 8 . it is then preferably returned to its original contracted position ( fig7 ) after having expelled excess air . beginning from the opposite end , each assembly 20 is successively extended to fill the syringe barrels 34 a , 34 b with the appropriate amounts of thrombin and clotting and adhesive proteins ( fig8 – 11 ). after all assemblies 20 are loaded , each assembly 20 and its associated membrane 30 may then be removed from the dispensing manifold 8 by heat sealing or crimping tubing 9 and severing at the crimp or heat seal , or upstream at the juncture 11 of the tubing 9 with the manifold 8 . to remove assembly 20 from membrane 30 , spring 27 is depressed toward syringes 22 a , 22 b to release retaining member 28 from mating catch on fitting 18 . syringes 22 a , 22 b are twisted and pulled away from fitting 18 , allowing assembly 20 to reside loose within membrane 30 . membrane 30 is then peeled apart , as described earlier , to remove assembly 20 . once filled and removed , the assembly 20 may be fitted with an outlet coupling 40 , shown in fig2 a . the retaining member 28 latches to a catch 42 on coupling 40 ( fig2 ). as shown in fig2 b and 22c , the outlet coupling 40 equips each syringe 22 a , 22 b with a separate exit path 44 a , 44 b , such that the thrombin and the adhesive and clotting proteins may exit separately as lines or dots from ports 46 a , 46 b in the outlet coupling 40 , thereby preventing clogging of the outlet coupling 40 . a recessed threaded area 48 is located proximate the ports 46 a , 46 b of the outlet coupling 40 to support a dispensing attachment . the recessed female threaded area 48 of the outlet coupling 40 may receive any of a variety of dispensing attachments having a threaded end 49 ; examples of attachments are shown in fig1 – 21 , 23 – 27 . the spray nozzle 50 shown in fig2 , 24 may be combined with lengthening attachments , shown in fig2 – 27 . these lengthening attachments are preferably constructed with an external cylindrical shroud 63 which overlies intermediate sleeves 65 that support a central internal helical path 54 to enhance admixture of the thrombin and the adhesive clotting proteins . mixing of the thrombin with the adhesive and clotting proteins occurs within the chosen attachment and is dispensed out the spray end 52 of the spray nozzle 50 for precise placement . the spray nozzle 50 is comprised of a barrel 51 having tactile enhancing , longitudinally extending peripheral ribs 53 . the end 52 includes a flow diverter 55 and a restrictor orifice body 57 having an orifice 59 . the body 57 is press - fit into bore 61 of nozzle 50 or attached by other means . fig1 depicts a dispensing apparatus 60 adapted to receive the syringe pair assembly 20 . in this embodiment , the outlet coupling 40 connects to the dispensing apparatus 60 by registering a clasp 42 present on the underside of the outlet coupling 40 with a pivot 62 ( fig1 ). the syringe pair assembly 20 is inserted into the outlet coupling 40 and the frame 24 is removed . fig2 , 29 depict a heating apparatus 70 , which includes a plurality of elongated arctuate indentations 72 , each shaped with projecting saddles 73 to receive a syringe pair assembly 20 and to ensconce a large portion of each syringe &# 39 ; s barrel . the heating apparatus 70 contains resistive heating elements 74 to maintain the assemblies 20 at a constant temperature for heat transfer through indentations 72 and saddles 73 . the power cord 76 is connected to a power supply 78 , which in turn plugs into an electrical supply outlet . a sensor and microcontroller 76 optimize temperature . compatible dispensing assemblies include , but are not limited to , the spraying apparatus 60 of fig1 and the basic syringe setup depicted in fig2 , 21 . thus , the prepared biological glue is readily available for use during the medical procedure . moreover , having thus described the invention , it should be apparent that numerous structural modifications and adaptations may be resorted to without departing from the scope and fair meaning of the instant invention as set forth hereinabove and as described hereinbelow by the claims .
a loading station having a dispensing manifold for loading syringe pairs with thrombin and adhesive and clotting proteins for use as a biological adhesive . the resulting loaded syringe pairs are compatible with a variety of biological adhesive dispensers and may be used in a surgical setting .