in the following description , identical numbers indicate identical elements . where an element has been described in one figure , and is unaltered in detail or relation in any other figure , said element description applies to all figures . a detailed explication of a general procedure common to many of the approaches employed by various embodiments of the present invention will generally involve establishing stratification of at least one risk of a cardiac adversity by : a ) accessing at least one 24 hour ( generally ) period of a patient &# 39 ; s electrocardiograph recordings ; b ) ascertaining both an rr and a qt acrophase ( time of peak value ≡− φ r and − φ q , respectively ) from that patient &# 39 ; s 24 hour electrocardiograph record utilizing regression analysis ; c ) determining a phase difference φ equal to the difference between the rr and qt acrophases ; d ) discerning 24 hour records of the qt and rr values from the patient &# 39 ; s electrocardiograph recordings ; e ) ( optionally ) partitioning each of these 24 hour rr and qt value records into bins that encompass a selected period of time , such as 30 minutes apiece , and finding an average rr or qt value , respectively , for each of the bins ; f ) fitting ( with regression analysis ) the 24 hour rr and qt ( raw or partitioned ) records to the formulas : rr fit = rr mean + cr cos [( 2π / 24 )( t + φ r )] and qt fit = qt mean + cq cos [( 2π / 24 )( t + φ q )], wherein rr mean is the mean rr value and qt mean is the mean qt value for the 24 hour period , and further wherein “ t ” is a variable indicating the time of the respective rr or qt values , while cr and cq are defined as the rr and qt circadian amplitude coefficients , respectively ; g ) determining the cr and cq values that result from the above fitting of the formulas to the 24 hour rr and qt records , and ( optionally ) determining a : lissajous slope ≡( cq / cr ) cos [( 2π / 24 )( φ r − φ q )]; h ) ( optionally ) plotting rr fit vs . qt fit to produce a rr - qt lissajous curve representation of the 24 hour electrocardiograph record , and optionally further determining at least one feature , such as the area encompassed by the rr - qt lissajous curve , of the plotted representation ; and i ) realizing at least one stratification of risk of at least one cardiac adversity by identifying at least one correlation between said stratification of risk and at least one of said lissajous slope , said plotted representation feature , at least one of said rr fit and said qt fit , and combinations thereof . in the above description of a general procedure common to many of the approaches employed by various embodiments of the present invention , it should be understood that the detailed aspects of the description are focused on certain specific attributes of a particular application of the procedure , for purposes of clarity of illustration only . included among the aspects of the procedure that can be varied , and still fall within the scope of the present invention , are that the specific quantities being measured and analyzed can differ from the rr and qt intervals specified herein , as well as the period of periodic rhythm differing from 24 hours , in which case the factor of 24 in the equations of f ) and g ) will need to be replaced with the period of the periodic rhythm being studied . additional utilities of the present invention include , but are not limited to , employing at least one of said rr or qt acrophases , φ , rr fit , qt fit , cr , cq , lissajous slope , rr - qt lissajous curve , plotted representation feature , and combinations thereof to effect at least one of risk stratification for at least one cardiac adversity , risk stratification for at least one non - cardiac health issue , risk stratification for at least one condition that can affect a cardiac adversity , and indications of at least one collateral issue that can influence biologically related research investigations . an example of such a collateral issue would be , due to the influence of the patient &# 39 ; s autonomic tone on the phase difference φ , an indication that when a particular determined φ is found that that may suggest a potentially deleterious condition which affects that patient &# 39 ; s autonomic tone , so that the collateral issue would be the condition of that patient &# 39 ; s systems which influence their autonomic tone . as shown in fig1 , a patient 110 is wearing a typical holter monitor arrangement involving a base electrocardiograph 112 that receives , processes , and plots the heart function information of the patient 110 that is sensed by the electrodes 114 . fig2 shows an illustrative representation 210 of a pair of heartbeat recordings such as would be registered by an electrocardiograph 112 . the dominant characteristic features of the heartbeat plots are termed p , q , r , s , and t . the intervals and sections of the electrocardiograph heartbeat plots shown in the illustrative representation 210 are the rr interval 212 , the qt interval 214 , the pr interval 216 , the pr segment 218 , the qrs complex 220 , and the st segment 222 . fig3 illustrates the “ noisiness ” of the raw data from an electrocardiograph by depicting a plot 310 of qt vs . rr interval for an hour &# 39 ; s worth of canine ecg data . the numerals on the axes denote milliseconds , and though , of course , canines are not humans there are sufficient similarities for the studies of canines to be substantially useful as an animal model for investigating humans , particularly in situations such as cardiac health issues wherein the consequences can be dire , and because some of the best information available in autonomic tone studies also involves canine study subjects , it is clear that data garnered from studies of canines is revelatory of performance in humans . in any case , fig3 is presented herein purely for purposes of contrast to demonstrate the issues that are still not yet satisfactorily handled by the current approaches , i . e . to show the lack of clarity available hereto now , due probably in large part to hysteresis var , which is unmistakably apparent in fig3 . fig4 shows a plot 410 of a pair of lissajous curves according to the present invention , with each of the curves being formed from 24 hourly points ( the curves are hypothetical , not measured because each individual patient &# 39 ; s plot will not produce an illustration of the overall phenomena and its variations with sufficient clarity ). the curve 412 is produced by a φ of 6 hours , while the curve 414 is produced by a φ of 3 hours . as φ is varied larger in magnitude past 6 hours the ellipse will change further in shape so that it will appear more and more like a mirror image of curve 412 . for a φ of 0 or 12 hours , the resulting lissajous curve plot would be a line , with the slope being positive for a φ of 0 and negative for a φ of 12 hours . in clinical application , φ , the rr fit &# 39 ; s and qt fit &# 39 ; s , cr and cq , and the various other factors will be at least partially indicative of patient specific parameters , and hence will vary individually . the factors that induce the individual variations are hence indicative of individually variable attributes of the patient &# 39 ; s condition , which in turn provides the present invention with the individually variable results from the present invention &# 39 ; s novel approaches that will produce the more accurately individually responsive risk assessments . the method embodiments of the present invention employ a variety of the various steps described previously , as well as certain well known to those of skill in the art ( heart condition diagnosis , treatment , and research ) auxiliary steps which would be expected to be generally concomitant procedures when at least one of the embodiments of the present invention are being utilized . these concomitant procedures can include , but are not limited to , drug treatment protocols , health and wellness actions and ingestibles and injectibles , and related treatments that are intended to more clearly enable the present invention &# 39 ; s resolution of the patient &# 39 ; s degree of risk . as a system , the various aspects will fulfill the functions explicated in a ) through i ) with various parts such as a discerner that will effect d ) detailed previously . it is well known to many in the art of medical equipment design and production , as well as those versed in the fields of electrical engineering and software design , that carrying out the steps and functions explicated herein are relatively easily accomplished with presently available equipment and software ( such as a modern laptop with standard operating system and average relevant software ), much less the also easily understood and executed procedures and approaches implementable to design and / or develop specialized hardware and / or software . the actual development and design of this equipment is not the focus of the present invention , and hence is not explicate in exhaustive depth herein . in a representative diagnosis and treatment procedure , once a patient has undergone the extended period of electrocardiograph recording of their heart function , and the various factors and determinations needed to assess their cardiac adversity risk with the above described procedures have been executed , the present invention &# 39 ; s risk stratification can be effected . at least one of the lissajous slope by itself , and the lissajous slope in combination with other independent risk stratifiers , such as left ventricular ejection fraction , are combined to construct a risk score . the score , for example , can be constructed from weighted points for each abnormal parameter , such as + 2 for ejection fraction & lt ; 30 %, + 1 for ejection fraction 30 - 50 %, and 0 for ejection fraction & gt ; 50 %; along with + 1 for lissajous slope & gt ; threshold criteria , 0 for lissajous slope & lt ; threshold criteria ; + 1 for positive t wave altemans test , 0 for negative ; and + 2 for qrs duration & gt ; 0 . 14 sec , + 1 for qrs duration 0 . 12 - 0 . 14 sec , 0 for normal qrs duration . the scores are summed for each patient , and when the sum score is greater than a specified value , say 3 , the patient is then deemed at high risk for a cardiac adversity and will receive a defibrillator , or other aggressive medical treatment , such as constant telemetric monitoring . in view of the above , it will be seen that the various objects and features of the invention are achieved and other advantageous results obtained . the examples contained herein are merely illustrative and are not intended in a limiting sense .
systems and methods for stratifying relative risks of adverse cardiac events by processing a duration of electrocardiograph recordings generally recorded by a holter type of device . the duration of electrocardiograph recordings are processed to resolve rr interval related data , qt interval related data , and are fitted to formulas to at least partially establish fitting related measures . the fitting formulas incorporate circadian related periodic factors , and can further incorporate additional processing including utilizing lissajous analysis techniques , among others .