the present invention provides aqueous compositions of matter suitable for oral administration to mammalian subjects , including without limitation humans , which compositions comprise theacrine species in solid or in liquid vehicles ( carriers ) that have been synthesized in commercial quantities by vital pharmaceuticals , inc ., d / b / a vpx / redline of davie , fla . ; theacrine itself has the general structure : the material described by structure i above , and the corresponding text in the description , including any and all of their derivative chemical forms , are all theacrine species and are , as such , the subject of the present disclosure . aqueous compositions of matter suitable for oral administration to mammalian subjects according to this disclosure may be caused to have any ph in the range of between about 1 . 5 and about 8 . 5 as desired , by adjusting such compositions using additions of appropriate amounts of strong or weak acids or bases including without limitation aqueous mineral acids including hcl , h3po4 , and bases including sodium hydroxide , ethanolamines , etc . to prepare a composition according to one embodiment of the present invention , one may simply add a desired amount of theacrine to a selected volume of water , and sufficient stirring is affected to cause dissolution of the theacrine to afford an aqueous composition . furthermore , according to one embodiment , the solution may be buffered before the addition of theacrine or the solution may be may be made more acidic or alkaline prior to the addition of theacrine . according to another embodiment , the total concentration of theacrine species in an aqueous solution provided hereby may be any amount between about 0 . 01 % and about 20 % ( or more ) by weight based on the total weight of the aqueous solution , including all percentages and ranges of percentages therebetween . according to another embodiment , the total concentration of theacrine in an aqueous solution provided hereby may be any amount between about 0 . 1 % and about 20 % by weight based on the total weight of the aqueous solution , including all percentages and ranges of percentages therebetween . according to another embodiment , the total concentration of theacrine species in an aqueous solution provided hereby may be any amount between about 0 . 1 % and about 25 % by weight based on the total weight of the aqueous solution , including all percentages and ranges of percentages therebetween . according to another embodiment , the total concentration of theacrine species in an aqueous solution provided hereby may be any amount between about 0 . 1 % and about 30 % by weight based on the total weight of the aqueous solution , including all percentages and ranges of percentages therebetween . in an alternate embodiment , theacrine ( or any one or more theacrine species ) may be added to a natural beverage in any amount provided that an aqueous solution or suspension results . in addition , a composition according to the present invention also includes nutritional adjuvant materials including flavoring agents , colorants , viscosity modifiers , preservatives , chelating agents , antioxidants , surface modifiers and other nutritional adjuvant materials . other nutritional adjuvant materials include any substance which is generally recognized as promoting the health or function of a mammalian organism , including humans , or benefiting a composition useful thereof in terms of its efficacy , appearance , stability , consistency , aroma , or viscosity . such substances include , but are not limited to , other amino acids and their salts , vitamins , minerals , essential fatty acids , enzymes , mono - glycerides , di - glycerides , tri - glyceride ester oils ( including , for example vegetable oils and animal fats ) emulsifiers , hydrolyzed proteins , whey protein , stabilizers , flow modifiers , viscosity improvers , chelating agents , enzymes , surfactants , whether anionic , cationic or nonionic , and combinations thereof . the total amount of the one or more nutritional adjuvant materials above present in a composition according to this disclosure is present in any amount between about 0 . 01 % and about 50 % by weight based on the total weight of said composition , including all percentages and ranges of percentages therebetween . in addition to ingredients containing adjuvant materials , a composition according to one embodiment of the present invention also comprises one or more natural beverages . a natural beverage , as used herein , is a beverage suitable for human or animal consumption which contains the pulp , juice or any other constituent of a naturally - occurring fruit , vegetable , or animal product whether from the wild , cultured , cultivated on a farm or otherwise domesticated by man . natural beverages include without limitation materials including , but not limited to as milk products , soy products , ice cream , yoghurt , citrus fruit juices , non - citrus fruit juices , and vegetable juices , or components of any of the foregoing , wherein said natural beverages are present in any effective amount to impart flavor to the compositions , which are any amount between about 0 . 1 % and about 99 % by weight based on the total weight of said composition , including all percentages and ranges of percentages there between . in addition to ingredients containing adjuvant materials , a composition according to one embodiment of the present invention comprises one or more synthetic beverages . a synthetic beverage is any beverage that is not a natural beverage . in general , a composition according to one embodiment of the present invention is provided by combining and mixing the ingredients selected , including theacrine and any desired quantity of any one or more other ingredients specified herein . one advantage of compositions according to this disclosure is that they may be packaged at ph levels as low as about ph 2 , in the cold or at about room temperature ( alternative embodiment ) or only slightly elevated temperature ( alternative embodiment ), as opposed to many prior art compositions which typically require hot packaging methods that utilize specialized and expensive equipment and packaging materials . thus , it is evident that a composition according to one embodiment of the present invention is made quite palatable by a mammalian subject , including human subjects desiring to administer theacrine orally in an aqueous mixture . typical serving sizes may be any serving size in the range of about 1 milligram to about 50 grams , in an aqueous solution that is from about 20 ml to about 2500 ml in volume . the composition of theacrine in an aqueous composition according to this disclosure is limited only by the solubility limit of the theacrine and which may exceed 50 grams per liter and concentrations at or near the solubility limit are herein provided by contacting excess amounts of the theacrine in contact with water or an aqueous solution to provide a solution saturated with theacrine . such saturated solutions may then be diluted slightly , to afford a concentrate from which other theacrine containing compositions may be conveniently provided . the following compositions are illustrative and not meant to limit the scope of the present invention . 1 . an oral liquid composition ( ready - to - drink ) comprising theacrine , said composition with a ph of about 2 to 8 . 5 being substantially stable at room temperature for normal warehouse storage conditions , stable at 104 ° f . ( 40 c . degrees ) for shipping in hot weather trucks and / or overseas containers , and stable at 39 ° f . ( 4 c . degrees ) in coolers so that it can be stored under refrigeration conditions . the composition comprising a suitable aqueous solvent or vehicle , a non - aqueous vehicle , a preservative , a physical stabilizing ingredient , one or more surfactants , and one or more buffer salts that can render the composition ph stable . the composition , in one embodiment contains psychostimulants , nucleotides , oligonucleotides , the monophosphates , diphosphates , triphosphates and cyclic derivatives of these nucleotides , and amino acids , vitamins and vitamin - like isoprenoids , peptides and one or more additional components selected from the group consisting of : lipids , starches , carbohydrates , polyols , minerals , electrolytes , amino trace elements , colorings , flavors , artificial sweeteners , and anti - oxidants . 2 . an oral liquid composition for buccal sublingual administration comprising theacrine , said composition with a ph of about 2 to 8 . 5 being substantially stable at room temperature for normal warehouse storage conditions , stable at 104 ° f . ( 40 c . degrees ) for shipping in hot weather trucks and / or overseas containers , and stable at 39 ° f . ( 4 c . degrees ) in coolers so that it can be stored under refrigeration conditions . the composition comprising a suitable aqueous solvent or vehicle , a non - aqueous vehicle , a preservative , a physical stabilizing ingredient , one or more surfactants , and one or more buffer salts that can render the composition ph stable . the composition , in one embodiment , contains psychostimulants , nucleotides , oligonucleotides , the monophosphates , diphosphates , triphosphates and cyclic derivatives of these nucleotides , and amino acids , vitamins and vitamin - like isoprenoids , peptides and one or more additional components selected from the group consisting of : lipids , starches , carbohydrates , polyols , minerals , electrolytes , amino trace elements , colorings , flavors , artificial sweeteners , and anti - oxidants . 3 . an oral solid composition in the form of a capsule ( licap ®) with a liquid composition as fill material , said liquid fill material being substantially stable at room temperature for normal warehouse storage conditions , stable at 104 ° f . ( 40 c . degrees ) for shipping in hot weather trucks and / or overseas containers , and stable at 39 ° f . ( 4 c . degrees ) in coolers so that it can be stored under refrigeration conditions . the composition comprising a suitable lipophilic solvent or vehicle , a physical stabilizing ingredient , one or more surfactants , and one or more buffer salts that can render the composition ph stable . the composition in one embodiment , contains psychostimulants , nucleotides , oligonucleotides , the monophosphates , diphosphates , triphosphates and cyclic derivatives of these nucleotides , and amino acids , vitamins and vitamin - like isoprenoids , peptides and one or more additional components selected from the group consisting of : lipids , medium and short chain triglycerides , starches , polyols , carbohydrates , minerals , electrolytes , amino trace elements , colorings , and anti - oxidants . 4 . an oral liquid composition containing from 1 gram to 100 grams of protein and from 1 g ram to 100 g of carbohydrates per serving comprising theacrine , said liquid being substantially stable at room temperature for normal warehouse storage conditions , stable at 104 ° f . ( 40 c . degrees ) for shipping in hot weather trucks and / or overseas containers , and stable at 39 ° f . ( 4 c . degrees ) in coolers so that it can be stored under refrigeration conditions . the composition comprising an acid stable protein isolates , or a combination or blend of protein isolates , concentrates and hydrolyzates and caseins in micellar forms , a suitable aqueous solvent or vehicle , a non - aqueous vehicle , a preservative , a physical stabilizing ingredient , one or more surfactants , and one or more buffer salts that can render the composition ph stable . the composition , in one embodiment , contains psychostimulants , nucleotides , oligonucleotides , the monophosphates , diphosphates , triphosphates and cyclic derivatives of these nucleotides , and amino acids , vitamins and vitamin - like isoprenoids , peptides and one or more additional components selected from the group consisting of : lipids , starches , carbohydrates , polyols , minerals , electrolytes , amino trace elements , colorings , flavors , artificial sweeteners , and anti - oxidants . 5 . an aqueous injectable composition for human consumption said composition being isotonic and sterile in nature comprising theacrine , said injectable preparation with a ph of about 2 , being substantially stable at room temperature for normal warehouse storage conditions , stable at 104 ° f . ( 40 c . degrees ) for shipping in hot weather trucks and / or overseas containers , and stable at 39 ° f . ( 4 c . degrees ) in coolers so that it can be stored under refrigeration conditions . the composition comprising a suitable aqueous solvent , a preservative , a physical stabilizing ingredient and one or more buffer salts that can render the composition ph stable . the composition , in one embodiment , contains psychostimulants , nucleotides , oligonucleotides , the monophosphates , diphosphates , triphosphates and cyclic derivatives of these nucleotides , and amino acids , peptides , proteins and carbohydrates . 6 . an emulsion injectable composition for human consumption said composition being isotonic and sterile in nature comprising theacrine , said injectable preparation with a ph of about 2 , being substantially stable at room temperature for normal warehouse storage conditions , stable at 104 ° f . ( 40 c . degrees ) for shipping in hot weather trucks and / or overseas containers , and stable at 39 ° f . ( 4 c . degrees in coolers so that it can be stored under refrigeration conditions . the composition comprising a suitable aqueous solvent , pharmaceutically acceptable oil ( sesame , olive , castor , peanut , cotton seed , etc . ), a natural emulsifier such as lecithin or any other synthetic emulsifier , be it of the polysorbate or ethoxylated glyceride type , a preservative , a physical stabilizing ingredient and one or more buffer salts that can render the composition ph stable . the composition , in one embodiment , contains psychostimulants , nucleotides , oligonucleotides , the monophosphates , diphosphates , triphosphates and cyclic derivatives of these nucleotides , and amino acids , peptides , proteins and carbohydrates . ingredients % w / w theacrine 2 . 10 peptides 3 . 00 amp 12 . 50 utp 0 . 10 ubiquinone 3 . 30 peg - 400 45 . 0 peg esters and monoglycerides 9 . 00 polysorbate 80 20 . 0 buffer salt ( s ) qs to adjust ph purified water qs to 100 ingredient % w / w per 16 oz serving theacrine 1 . 00 2 . 10 whey protein isolate 6 . 000 30 . 00 whey protein concentrate 0 . 640 3 . 20 whey hydrolysate 0 . 320 1 . 60 micellar casein 0 . 320 1 . 60 casein protein hydrolysate 0 . 000 0 . 00 potassium chloride 0 . 076 0 . 38 ascorbic acid 0 . 012 0 . 06 vitamin e tpgs 0 . 052 0 . 26 riboflavin 100 0 . 000 0 . 00000010 niacin 0 . 000 0 . 0020 pyrodoxine hcl 0 . 000 0 . 000007 calcium panthothenate 0 . 000 0 . 0011 magnesium maleate 0 . 020 0 . 1000 d - ribose 0 . 040 0 . 2000 centromix e 0 . 600 3 . 00 saflower oil 1 . 200 6 . 00 sunflower oil 1 . 200 6 . 00 medium chain triglycerides 0 . 800 4 . 00 l - glutamine 0 . 025 0 . 13 glucose polymers ( rice trin ) 0 . 800 4 . 00 waxy maize starch 1 . 000 5 . 00 high amylose starch ( amylose adp11p ) 0 . 100 0 . 50 magnesium citrate 0 . 124 0 . 62 microcrystalline cellulose 0 . 100 0 . 50 malic acid 0 . 140 0 . 70 citric acid to ph 6 . 5 0 . 566 2 . 83 sodium citrate to ph 6 . 5 0 . 140 0 . 70 sucralose 0 . 011 0 . 06 glycerin 3 . 000 15 . 00 na 2 edta 0 . 050 0 . 25 sodium benzoate 0 . 090 0 . 45 potassium sorbate 0 . 190 0 . 95 water qs qs per 16 oz serving % w / w theacrine 2 . 10 0 . 25 whey protein isolate acid stable 44 . 44 9 . 26 sucralose 0 . 12 0 . 025 sodium edta 0 . 24 0 . 050 potassium sorbate 0 . 96 0 . 200 sodium benzoate 0 . 48 0 . 100 citric acid to ph 3 . 0 qs qs malic acid to ph 3 . 0 qs qs water 433 . 8 90 . 37 480 100 a composition as provided herein may be administered chronically . as used herein , “ chronically ” has its normal meaning , which generally means repeated ingestion over a period of several days , several weeks or even several months . “ chronic ” is generally not acute . consideration must be given to the fact that although this disclosure has been described and disclosed in relation to certain preferred embodiments , obvious equivalent modifications and alterations thereof will become apparent to one of ordinary skill in this art upon reading and understanding this specification and the claims appended hereto . this includes subject matter defined by any combination of any one of the various claims appended hereto with any one or more of the remaining claims , including the incorporation of the features and / or limitations of any dependent claim , singly or in combination with features and / or limitations of any one or more of the other dependent claims , with features and / or limitations of any one or more of the independent claims , with the remaining dependent claims in their original text being read and applied to any independent claims so modified . this also includes combination of the features and / or limitations of one or more of the independent claims with features and / or limitations of another independent claim to arrive at a modified independent claim , with the remaining dependent claims in their original text being read and applied to any independent claim so modified . accordingly , the present disclosure is intended to cover all such modifications and alterations and is not intended to be necessarily limited by any one or more particular strict interpretations of the claims that now follow .
the invention provides nutritional supplements , in powder , tablet or capsule dosage forms and aqueous formulations , containing one or more of the purine bioactive compounds described including theacrine and theacrine species .