reference is now made to fig1 and 2 , which illustrate apparatus 10 for administering a substance ( e . g ., insulin ) to a subject , in accordance with a non - limiting embodiment of the present invention . typically , apparatus 10 includes a cartridge 12 ( fig2 ) that contains the substance to be administered to a subject . fig2 illustrates a door 14 of a cartridge insertion assembly in the open position and cartridge 12 poised for insertion into a pathway 15 in apparatus 10 . as seen in fig2 , cartridge 12 includes a cartridge coupling element 16 ( e . g ., a gear ) for coupling ( e . g ., meshing ) with an activation mechanism 18 ( seen in fig4 , which typically includes a motor , a battery and a control unit ) that causes the substance contained in cartridge 12 to be metered out of cartridge 12 for eventual administration to the patient . ( in some embodiments , cartridge coupling element 16 is assembled to an end of a driving screw .) the way in which the activation mechanism works to meter the substance out of cartridge 12 is not pertinent to this invention . by way of example , the activation mechanism may work as in an external drug pump of the type described in us patent applications 20090093792 and 20090093793 or pct patent application pct / il2008 / 001312 ( published as wo 2009 / 044401 ), the disclosures of which are incorporated herein by reference . however , the invention is not limited to such a drug pump , and may be used for any kind of suitable administration of substances , not just by needle puncture into the patient , but also transdermally ( wherein the substance is metered by apparatus 10 to a transdermal patch ), by spray ( wherein the substance is metered by apparatus 10 to a spray nozzle ), micro needles array and others . it is noted that although cartridge 12 is typically a one - use item , the electronics , batteries and motor and other elements of the system can be used more than once if desired . as seen in fig3 , in accordance with a non - limiting embodiment of the present invention , door 14 includes a door coupling element 20 ( e . g ., a gear , but could also be any other coupling element for transmitting rotary motion , such as a friction wheel ) for effecting coupling ( e . g ., meshing ) between the cartridge coupling element 16 and a coupling element 22 ( fig2 ) of the activation mechanism 18 , as will be described more in detail below . reference is now made to fig4 , which illustrates the cartridge 12 partially inserted into apparatus 10 , showing components of the cartridge insertion assembly . cartridge 12 has a septum 24 at an end opposite to cartridge coupling element 16 . the septum 24 is pierced by a hollow needle 26 so that contents of cartridge 12 flow out of cartridge 12 into needle 26 and from needle 26 to an exit port ( not shown ) for eventual administration to the patient . a cartridge stopper 28 , which may be made of a rigid material ( e . g ., plastic ) or more preferably a resilient material ( e . g ., an elastomer or silicone ), is provided for arresting movement of cartridge 12 during insertion into apparatus 10 and preventing over - insertion of cartridge 12 . cartridge stopper 28 also prevents the torque , which is generated by the activation mechanism 18 to rotate the driving screw of the cartridge , from rotating cartridge 12 . the cartridge stopper 28 abuts against a shoulder 30 of cartridge 12 . fig5 shows cartridge 12 fully inserted into apparatus 10 up to cartridge stopper 28 with door 14 still open . reference is now made to fig6 and 7 . the cartridge insertion assembly of apparatus 10 includes a locking latch 32 which is cantilevered from a base 33 ( fig7 ) of the apparatus 10 . while inserting cartridge 12 into apparatus 10 , a rim 34 near cartridge coupling element 16 depresses and slides over locking latch 32 . when cartridge 12 is fully inserted into apparatus 10 , rim 34 moves past locking latch 32 and locking latch 32 springs back and abuts against rim 34 , thereby locking cartridge 12 in place . the user cannot remove cartridge 12 from apparatus 10 . reference is now made to fig8 , which illustrates the inside of door 14 . the door coupling element 20 mentioned above is in the middle of the inside of door 14 . on one side of element 20 is a hinge member 36 that pivotally connects ( e . g ., by snap fit ) into a corresponding socket 38 ( seen in fig1 ) in the body of apparatus 10 . on the other side of element 20 is a closure member 40 , which is formed with a central hub 42 and one or more ramp members 44 ( in the illustrated embodiment , two inclined ramp members 44 extend on either side of hub 42 ). even if the user has not fully inserted cartridge 12 into apparatus 10 , the act of closing door 14 ( see fig9 ) causes the ramp members 44 to slide and swipe against cartridge coupling element 16 . the inclined surfaces of ramp members 44 gently push and wedge cartridge coupling element 16 to seat fully into apparatus 10 so that septum 24 is pierced by hollow needle 26 as described above with reference to fig4 and 5 . after the cartridge 12 is locked in place , ramp members 44 keep pushing against the driving screw to create priming of the drug pump , wherein contents of the cartridge 12 overflow and pressurize into the needle 26 and drip out therefrom . this priming process reduces the breaking force ( the initial force to remove the plunger after a long storage time ) and removes air bubbles from the fluid path . the inside of door 14 is formed with one or more ribs 46 , which when door 14 is fully closed , are received in one or more corresponding grooves 38 ( fig1 ) formed at the end of the housing of apparatus 10 . ribs 46 seated in grooves 48 provide resistance to axial pull - out forces that may be acting on cartridge 12 and door 14 during operation of apparatus 10 . fig1 illustrates door 14 fully closed . door coupling element 20 couples between cartridge coupling element 16 of the cartridge and coupling element 22 of the activation mechanism , so that the activation mechanism can now cause the substance contained in the cartridge to be metered out of the cartridge for eventual administration to the patient . reference is now made to fig1 . when door 14 is fully closed , hub 42 of closure member 40 snaps and is fixedly received in a snap member 50 ( curved snap member ) so that door 14 is properly secured to the body of apparatus 10 . it will be appreciated by persons skilled in the art that the present invention is not limited by what has been particularly shown and described hereinabove . rather the scope of the present invention includes both combinations and subcombinations of the features described hereinabove as well as modifications and variations thereof which would occur to a person of skill in the art upon reading the foregoing description and which are not in the prior art .
a cartridge insertion assembly including apparatus with a pathway formed therein , a cartridge including a cartridge coupling element connectable to an activation mechanism disposed in the apparatus operative to cause a substance contained in the cartridge to be metered out of the cartridge , and a door pivoted to the apparatus that includes a door coupling element arranged with respect to the cartridge such that when the door is in a fully closed position , the door coupling element couples the cartridge coupling element with a coupling element of the activation mechanism .