the present invention provides a kit , the use of which may provide a method for enhancing muscle performance under conditions of acute anaerobic resistance training . the use of the kit may further provide a method which provides for the synergistic functioning of three independent compositions for the purposes of one or more of enhancing muscle performance , building muscle , increasing muscle strength , increasing muscle size and reducing muscle fatigue . a first composition of the kit may comprise , for example , glycine , l - arginine and alpha - ketoisocaproic acid . the first composition may be used to enhance muscle performance , and recovery from fatigue in an individual , e . g . a human or an animal . for example , u . s . pat . no . 6 , 100 , 287 , the disclosure of which is fully incorporated by reference herein , describes a method for enhancing muscle performance and recovery from fatigue wherein the method includes administering a composition of a cationic or dibasic amino acid and a ketoacid . a specific embodiment disclosed therein comprises glycine , and the l - arginine monohydrochloride salt of alphaketoisocaproic acid calcium . the aforementioned formulation , e . g ., glycine , and the l - arginine monohydrochloride salt of alphaketoisocaproic acid calcium , has benefits which may include the following : 1 ) a more rapid and complete recovery from intense acute athletic training and greater muscle power ; 2 ) it provides a safe way to enhance athletic performance since the composition of glycine , and the l - arginine monohydrochloride salt of alphaketoisocaproic acid calcium is devoid of the detrimental side effects of anabolic steroids ; and 3 ) the composition of glycine , and the l - arginine monohydrochloride salt of alphaketoisocaproic acid calcium can improve exercise tolerance and recovery during rehabilitation . a second composition of the kit may comprise , for example , leucine or monobasic branched — chain amino acids and ketoisocaproic acid . the second composition of the kit may be used to stimulate and optimize protein synthesis , potently signal muscle building and increase muscle size in an individual , e . g ., a human or an animal . for example , applicant &# 39 ; s co - pending provisional patent application no . 60 / 1735 , 057 , discloses compositions and methods to directly activate protein synthesis for the purposes of muscle growth and development which may be employed in the second composition of the kit . leucine and other branched - chain amino acids are able to directly modify critical points ( fingar d c , richardson c j , tee a r , cheatham l , tsou c , blenis j . mtor controls cell cycle progression through its cell growth effectors s6k1 and 4e - bp1 / eukaryotic translation initiation factor 4e . mol cell biol . 2004 jan ; 24 ( 1 ): 200 - 16 .) in muscle development to activate the protein kinase mtor ( mammalian target of rapamycin ); a site of integration of the signals that stimulate muscle protein synthesis , cell growth and size as well as progression into the cell cycle . the second composition of the kit , e . g ., leucine and ketoisocaproic acid , may be designed to influence the genetic control system for muscle protein synthesis to stimulate muscle growth , increase muscle mass , decrease catabolic , decrease recovery time and treat muscle wasting . a third composition of the kit may comprise , for example , creatine , alpha lipoic acid and ketoisocaproic acid . the third composition may be used to neutralize reactive oxygen species and improve creatine uptake into muscle tissue . alpha lipoic acid is an insulin modulator and an antioxidant that serves as protection against oxidative injury in non - neuronal and neuronal tissue ( bloch - damti a , bashan n . proposed mechanisms for the induction of insulin resistance by oxidative stress . antioxid redox signal . 2005 nov - dec ; 7 ( 11 - 12 ): 1553 - 67 . review .) alpha lipoic acid is a nutrient that the human body makes in minute quantities and may be obtained from yeast and liver ( wollin s d , jones p j . alpha - lipoic acid and cardiovascular disease . j nutr . 2003 nov ; 133 ( 11 ): 3327 - 30 . review .) studies have shown that alpha lipoic acid can significantly increase the body &# 39 ; s utilization of blood sugar in type ii diabetics and that lipoic acid may increase the metabolic clearance rate of glucose . moreover , alpha lipoic acid may improve creatine uptake in the body by a similar mechanism . creatine is a naturally occurring amino acid derived from the amino acids glycine , arginine , and methionine . it is readily found in meat and fish and is also synthesized by humans . the main role of creatine is as a fuel renewal source in muscle . about 65 % of creatine is stored in muscle as phosphocreatine ( creatine bound to a phosphate molecule ) ( casey a , constantin - teodosiu d , howell s , hultman e , greenhaff p l . metabolic response of type i and ii muscle fibers during repeated bouts of maximal exercise in humans . am j physiol . 1996 jul ; 271 ( 1 pt 1 ): e38 - 43 ). phosphocreatine serves as a major source of phosphate wherein adp is able to bind said phosphate to re - generate to form atp which can be used in subsequent contractions . after 6 seconds of exercise , muscle concentrations of phosphocreatine drop by almost 50 % ( gaitanos g c , williams c , boobis l h , brooks s . human muscle metabolism during intermittent maximal exercise . j appl physiol . 1993 aug ; 75 ( 2 ): 712 - 9 .) as it is used to regenerate atp . creatine supplementation has been shown to increase the concentration of creatine in the muscle ( harris r c , soderlund k , hultman e . elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation . clin sci ( lond ). 1992 sep ; 83 ( 3 ): 367 - 74 .) and increase the resynthesis of phosphocreatine within 2 minutes of recovery following exercise ( greenhaff p l , bodin k , soderlund k , hultman e . effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis . am j physiol . 1994 may ; 266 ( 5 pt 1 ): e725 - 30 .). advantageously , each of the three aforementioned compositions of the kit may perform different functions . by providing the three compositions in the form of a kit , a daily regimen of the compositions can advantageously and conveniently be administered in an effective sequence so as to enhance muscle performance , build muscle , increase muscle strength and increase muscle size at a time wherein each of the said compositions may be optimally effective . the method of using the kit involves the administration to an individual , e . g ., a human or an animal , of each one of the compositions of the kit at different times of the day as well as in relation to an individual &# 39 ; s workout schedule . the first independent composition of the kit , comprised of glycine , and the l - arginine monohydrochloride salt of alphaketoisocaproic acid calcium , may be administered to an individual , by having the individual ingest the composition . on days when the individual participates in exercise , the first composition may be administered up to 45 minutes , e . g ., 30 minutes , prior to exercise . furthermore , said second independent component of the kit , comprised of , e . g ., leucine and ketoisocaproic acid , may be administered to an individual , by having the individual ingest the composition on a daily basis . on days when exercise will take place , the daily serving of said second component of the kit is administered prior to exercise . on days where exercise will not take place , the serving is administered in the morning . additionally , said third independent component of the kit , comprised of , e . g ., creatine , alpha lipoic acid and ketoisocaproic acid may be administered to an individual , by having the individual ingest the composition on a twice daily basis . the servings of said third independent component of the kit may be administered twice daily , wherein the first serving is administered in the morning on both exercise and non - exercise days , followed by a second serving which may be administered post - exercise . on days where exercise will not take place , the second serving is to be administered in the afternoon . although the following example illustrates the practice of the present invention in one of its embodiments , the example should not be construed as limiting the scope of the invention . other embodiments will be apparent to one skilled in the art from consideration of the specification of the following example . as an example , a 15 - day regimen is used to illustrate the dosing protocol of the 3 independent compositions of said kit of the present invention . it should be noted that a regimen of any length may be used . an exercise training program may be followed on certain days of the regimen . on these days , the composition of the kit may be administered according to following regimen : 1 serving of a composition comprising creatine , alpha lipoic acid and ketoisocaproic acid in morning , 1 serving of a composition comprising glycine , and the l - arginine monohydrochloride salt of alphaketoisocaproic acid calcium up to 45 minutes , e . g ., 30 minutes , prior to exercise , 1 serving of a composition comprising leucine and ketoisocaproic acid post - exercise and 1 serving of a composition comprising creatine , alpha lipoic acid and ketoisocaproic acid post - exercise . on other days the individual may refrain from undertaking the exercise training program . on these days , wherein an exercise training program is not undertaken , the components of the kit may be administered according to the following regimen : 1 serving of a composition comprising creatine , alpha lipoic acid and ketoisocaproic acid in the morning , 1 serving of a composition comprising leucine and ketoisocaproic acid in the morning , 1 serving of a composition comprising creatine , alpha lipoic acid and ketoisocaproic acid in the afternoon .
a kit , and a method of using same , that comprises first , second and third components wherein the first , second and third components collectively comprise glycine , arginine , leucine , creatine , alpha lipoic acid , and earth metal salts of ketoisocaproic acid . use of the kit may enhance muscle performance , build muscle , increase muscle strength , increase muscle size and reduce muscle fatigue . the three compositions may be used in synergy so as to promote muscle anabolism , neutralize reactive oxygen species , and improve creatine uptake in muscle tissue . the method may also include a schedule for administering each composition to the user for optimal results .