fig1 is a schematic diagram that illustrates a two - dimensional front view of one of the embodiments with a spherical tapered textile structure . it has three components in one of the embodiments : a shape - set textile structure , a bonding zone at the region of the proximal marker band , and a delivery system or hypotube . the shape - set tapered textile structure in several embodiments has a distal tip , that in the expanded configuration has an outer diameter of less than e . g ., 0 . 017 inches ( 0 . 43 mm ) and in the collapsed configuration has an outer diameter of less than e . g ., 0 . 0125 inches ( 0 . 317 mm ) in several embodiments , the expanded configuration of the tip has a diameter in the range of about 0 . 35 - 0 . 65 mm ( e . g ., 0 . 40 - 0 . 45 mm ) in several embodiments , the collapsed configuration has a diameter in the range of about 0 . 1 - 0 . 34 mm ( e . g ., 0 . 25 - 0 . 33 mm ) in some embodiments , for larger vessels , the expanded configuration has a diameter in the range of about 1 - 40 mm and a diameter in the range of about 0 . 5 - 10 mm in a collapsed configuration . in some embodiments , the ratio of the expanded configuration to the collapsed configuration is 1 . 2 : 1 - 10 : 1 . in several embodiments , the distal neck is narrow and has similar outer diameter in the expanded and collapsed configuration as the distal tip . the distal neck has a length that ranges from about 1 - 5 mm in one of the embodiments . in several embodiments , there are a total of 10 spherical bulbs in one of the embodiments with varying diameters in the expanded configuration and in the collapsed configuration has an outer diameter of less than e . g ., 0 . 0125 inches ( 0 . 317 mm ) in several embodiments , the expanded configuration of the bulbs has a diameter in the range of about 1 - 6 mm ( e . g ., 3 - 4 . 5 mm ) in several embodiments , the collapsed configuration has a diameter in the range of about 0 . 1 - 0 . 9 mm ( e . g ., 0 . 25 - 0 . 5 mm ) in some embodiments , for larger vessels , the expanded configuration has a diameter in the range of about 5 - 40 mm and a diameter in the range of about 0 . 5 - 5 mm in a collapsed configuration . in some embodiments , the ratio of the expanded configuration to the collapsed configuration is 1 . 2 : 1 - 10 : 1 . in some embodiments , the varying outer diameters of the 10 spherical bulbs in the expanded configuration are as follows in one of the embodiments : the distal three extra - small spherical bulbs have an outer diameter ( e . g ., d = 3 mm ) in the expanded configuration and corresponds to the extra - small vessel segments such as the m2 segments of the middle cerebral artery , the next three small spherical bulbs have an outer diameter ( e . g ., d = 3 . 5 mm ) in the expanded configuration and corresponds to the smaller vessel segments such as the distal m1 segment of the middle cerebral artery , the next two medium spherical bulbs have an outer diameter ( e . g ., d = 4 mm ) in the expanded configuration and corresponds to the medium vessel segments such as the proximal m1 segment of the middle cerebral artery , and the proximal two large spherical bulbs have an outer diameter ( d = 4 . 5 mm ) in the expanded configuration that corresponds to the large vessel segments such as the distal supra - clinoid segment of the internal carotid artery . this tapered configuration of the shape - set textile structure allows for adequate and safe deployment of the device across blood vessels with multiple diameters . although specific diameter numbers are provided in this paragraph , other embodiments include diameters that are +/− 5 , 10 , 15 , or 20 %. in some embodiments , 10 bulbs are used . however , in other embodiments , 1 - 9 bulbs or 11 - 30 ( or more ) bulbs may be used . in some embodiments , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 or 20 bulbs are used . in some conditions , for example in the leg , where clots can be up 20 - 40 cm , 40 - 60 bulbs may be used . in some embodiments , 1 bulb is used for every 0 . 2 - 5 cm ( e . g ., about 0 . 5 - 2 cm ). in several embodiments , bulbs of various sizes and / or shapes are provided on a single elongate support structure ( such as a neck , tube , spindle , spine , rod , backbone , etc .). the elongate support structure may be hollow , filled or partially hollow . the elongate support structure may have a length in the range of about 1 - 20 cm ( e . g ., about 4 - 8 cm , 5 - 10 cm , etc ). in larger vessels ( e . g ., outside the brain ) the length can be about 20 - 50 cm . the diameter or width of the elongate support structure is in the range of about 0 . 35 - 0 . 65 mm ( e . g ., 0 . 40 - 0 . 45 mm ) in an expanded configuration and in the range of about 0 . 1 - 0 . 34 mm ( e . g ., 0 . 25 - 0 . 33 mm ) in the collapsed configuration . in some embodiments , for larger vessels , the expanded configuration of the elongate support structure has a diameter in the range of about 1 - 40 mm ( e . g ., 5 - 20 mm ) and a diameter in the range of about 0 . 5 - 10 mm ( e . g ., 1 - 2 mm ) in a collapsed configuration . wall thickness of the elongate support structure are , in some embodiments , ranges from about 0 . 01 - 4 mm ( e . g ., about 0 . 02 - 1 mm 0 . 02 - 0 . 05 mm , e . g ., 0 . 025 mm ) the elongate support structure may be braided , knitted or weaved with two or more strands ( e . g ., about 12 - 120 strands , 12 - 96 strands , 48 strands ) in some embodiments . the pattern , in some embodiments , is one - over - one - under - two , one - over - one - under - one , two - over - two - under - two , etc . in some embodiments , the braid angle is in the range of about 45 - 179 degrees ( e . g ., about 130 - 160 degrees , 151 degrees ). the picks ( or pixels ) per inch ( ppi ) range from about 50 - 300 ppi ( e . g ., about 150 - 190 ppi , e . g ., 171 ppi ). in some embodiments , increased outward expansile force and / or compression resistance is provided by a higher braid angle and / or higher ppi . in some embodiments , the force / resistance ( e . g ., radial force ) is in a range sufficient to expand a target vessel in the range of about 0 %- 30 %. in some embodiments , the total diameter size of the treatment device is 0 . 5 mm - 1 . 5 mm greater than the target vessel diameter . in some embodiments , the total diameter size of the treatment device is oversized by 10 - 50 % with respect to the target vessel diameter . the elongate support structure may be made of shape memory alloys ( e . g ., nickel titanium ). in some embodiments , the elongate support structure is about 50 - 95 % ( e . g ., 75 %) nickel titanium and about 5 - 50 % ( e . g ., 25 %) platinum iridium or platinum tungsten or combinations thereof . the radio - opaque portions can be spaced or clustered to increase visibility under x - ray . for example , a thick band pattern may be used which can include 1 - 12 radio - opaque strands ( e . g ., filaments , wires , etc .) that are wound adjacently with one another . in several embodiments , the bulbs are integral with the elongate support structure . in other embodiments , the bulbs are coupled ( fixably or reversibly coupled ) to the elongate support structure . for example , bulbs size ( with respect to the outer diameter in an expanded configuration ) is about 0 . 5 - 3 mm ( e . g ., 3 mm ), about 3 . 1 - 3 . 9 mm ( e . g ., 3 . 5 mm ), about 4 - 4 . 4 mm ( e . g ., 4 mm ), and about 4 . 5 - 7 . 5 mm ( e . g ., 4 . 5 mm ) are provided . in some embodiments , the bulbs are sized in the range of about 1 mm - 80 mm ( e . g ., 2 mm - 12 mm ) bulbs in range of 4 - 10 mm may be particular beneficial for larger clots and / or vessels ( e . g ., in the leg ). the sizes above are reduced by 1 . 3 - 10 times in the collapsed configuration . in some embodiments , the collapsed configuration of the bulbs is about 50 - 80 % of the inner diameter of the delivery catheter ( e . g ., microcatheter ). in some embodiments , each consecutive bulb is larger than the other . in other embodiments , two sizes are used in an alternate pattern . in yet other embodiments , three or more sizes are used in a series , and each series is repeated two , three , four , five , six , seven , or more times . as an example , if a series of three sizes is alternated , twenty - one bulbs are used . in some embodiments , larger bulbs may be used at the ends , while smaller bulbs are used in the middle . bulbs may be smaller at the ends and larger in the middle . various bulb shapes may be used according to several embodiments , including spherical , oblong , egg , and elliptical ( e . g ., with respect to top view , side - view and / or cross - section ). square , rectangular and diamond - shapes ( e . g ., with respect to top view , side - view and / or cross - section ) are used in some embodiments . spiral , twisted , or helical bulbs are provided in some embodiments . for example , sphere - like bulbs and oblong bulbs may be used in a single strand . in some embodiments , shapes are alternated . in yet other embodiments , three or more shapes are used in a series , and each series is repeated two , three , four , five , six , seven , or more times . in some embodiments , bulbs of a first shape may be used at the ends , while bulbs of a second shape are used in the middle . bulbs may be a first shape at the ends and a second shape in the middle , or vice versa . the positioning of the bulbs may be beneficial for certain vessel sizes and / or clot locations , material , and / or sizes . bulbs may be touching ( e . g ., contiguous ) or non - touching . a single strand may include bulbs that are both touching and non - touching . in several embodiments , a strand includes bulbs that are all non - touching and / or are spaced apart by one or more spacers . these spacers may be of the same or different material than the bulbs . the spacers may also be shaped differently than the bulbs . the spacers may comprise , be embedded with or coated by markers or other visualization aids ( such as radio - opaque portions ). the bulbs may be separated by distances of about 0 . 1 to 50 mm , including , but not limited to , about 0 . 5 - 1 , 1 - 2 , 2 - 3 , 3 - 4 , 4 - 5 , 5 - 8 , 8 - 10 , 10 - 12 , 12 - 15 , 15 - 25 , 25 - 35 , and 35 - 50 mm apart , including overlapping ranges thereof . the spaces between all the bulbs in one strand may be constant . alternatively , the spacing between two or more ( or all ) of the bulbs may be different . in some embodiments , some bulbs are spaced the same distance from one another , while other bulbs have different spacing . fig2 is a schematic diagram illustrating the 3d perspective view of one of the embodiments with a spherical tapered textile structure . fig3 is a schematic diagram illustrating the 2d view of one of the embodiments with an oblong tapered textile structure . fig4 is a schematic diagram illustrating the 3d perspective view of one of the embodiments with an oblong tapered textile structure . fig5 is a schematic diagram illustrating the 2d view of one of the embodiments with a spherical and oblong interspersed tapered textile structure . fig6 is a schematic diagram illustrating the 2d view of one of the embodiments with a spherical non - tapered textile structure . fig7 is a schematic diagram illustrating the 2d view of one of the embodiments with an oblong non - tapered textile structure . fig8 is a schematic diagram illustrating the 2d view of one of the embodiments with a spherical and oblong interspersed non - tapered textile structure . fig9 is a schematic diagram illustrating the 2d view of one of the embodiments with cylindrical wide - mouthed distal tip textile structure . fig1 is a schematic diagram illustrating the 2d view of one of the embodiments with a cylindrical narrow - mouthed distal tip textile structure . fig1 is a schematic diagram illustrating the 2d view of one of the embodiments with a cylindrical narrow - mouthed distal tip with a spherical or oblong distal filter textile structure . fig1 is a schematic diagram illustrating the 2d view of one of the embodiments with a cylindrical narrow - mouthed distal tip with a spherical distal and proximal filter textile structure . fig1 is a schematic diagram illustrating the 2d view of one of the embodiments with a cylindrical narrow - mouthed distal tip with an oblong distal and proximal filter textile structure . fig1 a is a schematic diagram illustrating the wires positioned on the yarn to develop a biomedical textile structure in one of the embodiments . fig1 b is a schematic diagram illustrating the braid carrier set up mechanism for the position of the wires on the yarn to develop a biomedical textile structure in one of the embodiments . fig1 a is a photograph illustrating the wires being braided into a biomedical textile structure on the yarn in one of the embodiments . fig1 b is a photograph illustrating the wires being knitted into a biomedical textile structure in one of the embodiments . fig1 c is a photograph illustrating the wires being woven into a biomedical textile structure in one of the embodiments . fig1 is a photograph illustrating the primary tubular shape set textile structure in one of the embodiments . fig1 is a schematic diagram illustrating the primary shape setting into the necessary geometries needed to develop the shape - set textile structures in one of the embodiments . fig1 is a photograph illustrating the mandrel used for braiding on the yarn that is then used for primary shape setting into the necessary geometries needed in one of the embodiments . fig1 is a photograph illustrating secondary shape setting into the necessary geometries needed to develop the shape - set textile structure in one of the embodiments . fig2 is an x - ray photograph illustrating one of the embodiments where there is grouping of multiple radio - opaque filaments or wires together to form an inter - twining thick band for maximal radio - opacity during fluoroscopy . radio - opaque materials , metals or alloys , including but not limited to iridium , platinum , tantalum , gold , palladium , tungsten , tin , silver , titanium , nickel , zirconium , rhenium , bismuth , molybdenum , or combinations of the above etc . to enable visibility during interventional procedures . fig2 is an x - ray photograph illustrating single filaments inter - twined to provide radio - opacity during fluoroscopy in one of the embodiments . fig2 is an x - ray photograph illustrating double filaments inter - twined to provide radio - opacity during fluoroscopy in one of the embodiments . fig2 is a photograph illustrating the need for post - processing of the free end of the textile structure to keep the filaments or wires from fraying in one of the embodiments . post - processing of the free end of the textile structure ( e . g ., the elongate support structure and the bulbs ) in some of the embodiments includes dip coating , spray coating , sandwich welding the free end using radio - opaque marker bands . radio - opaque marker band materials , metals or alloys , including but not limited to iridium , platinum , tantalum , gold , palladium , tungsten , tin , silver , titanium , nickel , zirconium , rhenium , bismuth , molybdenum , or combinations of the above etc . to enable visibility during interventional procedures . in some of the embodiments , radio - opaque marker bands can be sandwich welded to the free end of the textile structure ( e . g ., the elongate support structure and the bulbs ), butt welded to the distal end of the delivery system / hypotube , bonded or soldered to the delivery system or hypotube at regular intervals or laser welded into the kerfs created in the laser cut pattern at regular intervals to help measure a clot length , such radio - opaque markers at regular intervals may be separated by distances of about 0 . 1 to 50 mm , including , but not limited to , about 0 . 5 - 1 , 1 - 2 , 2 - 3 , 3 - 4 , 4 - 5 , 5 - 8 , 8 - 10 , 10 - 12 , 12 - 15 , 15 - 25 , 25 - 35 , and 35 - 50 mm apart , including overlapping ranges thereof . the dip coating or spray coating may comprise a biomedical polymer , e . g ., silicone , polyurethane , polyethylene ( rexell ™ made by huntsman ), polypropylene , polyester ( hytril ™ made by dupont ), poly tetra fluoro - ethylene ( ptfe ), polyvinyl chloride ( pvc ), polyamides ( durethan ™ made by bayer ), polycarbonate ( corethane ™ made by corvita corp ), or polyethylene - terephthalate . the dip coating or spray coating may further comprise a radio - opaque material , e . g ., particles of tantalum , particles of gold , other radio - opaque agents , e . g ., barium sulfate , tungsten powder , bismuth subcarbonate , bismuth oxychloride , iodine containing agents such as iohexol ( omnipaque ™ amersham health ). fig2 is a schematic diagram illustrating the appearance of the free end of the textile structure ( e . g ., the elongate support structure and the bulbs ) after laser cutting the free end to keep the filaments or wires from fraying in one of the embodiments . fig2 is a schematic diagram illustrating the inlay bonding approach between the shape - set textile structure ( e . g ., the elongate support structure and the bulbs ) and the delivery system ( e . g ., a hypotube , wire or multi - filament hybrid ) using solder in one of the embodiments . the solder may be a silver - based lead free solder in some embodiments . the shape - set textile structure may be substantially or fully oxide free when bonding the shape - set textile structure to the delivery system when using such solder . fig2 is a schematic diagram illustrating the overall ratio of the cross - sectional area between the filaments or wires of the textile structure ( e . g ., the elongate support structure and the bulbs ) and the bonding agent in one of the embodiments . fig2 a is a schematic diagram illustrating the inlay bonding approach between the shape - set textile structure and delivery system using epoxy agents in one of the embodiments . fig2 b is a photograph illustrating the inlay bonding approach between the shape - set textile structure and delivery system using epoxy agents in one of the embodiments . fig2 is a schematic diagram illustrating the inlay bonding approach between the shape - set textile structure ( e . g ., the elongate support structure and the bulbs ) and delivery system using a pinched ring as well as a bonding agent in one of the embodiments . fig2 is a schematic diagram illustrating the inlay bonding approach between the shape - set textile structure ( e . g ., the elongate support structure and the bulbs ) and delivery system ( e . g ., a hypotube , wire or multi - filament hybrid ) using a pinched tube as well as a bonding agent in one of the embodiments . in some of the embodiments , inlay bonding approach includes laser welding , laser butt welding , laser rivet welding , and mechanical crimping of a flared distal end of the hypotube on the inlayed proximal neck of the textile structure ( e . g ., the elongate support structure and the bulbs ). fig3 is a schematic diagram illustrating the overlay bonding approach between the proximal neck of the shape - set textile structure ( e . g ., the elongate support structure and the bulbs ) and the distal end of the delivery system ( e . g ., a hypotube , wire or multi - filament hybrid ) using solder in one of the embodiments . fig3 is a schematic diagram illustrating the overlay bonding approach between the proximal neck of the shape - set textile structure ( e . g ., the elongate support structure and the bulbs ) and the distal end of the delivery system ( e . g ., a hypotube , wire or multi - filament hybrid ) using epoxy in one of the embodiments . fig3 is a schematic diagram illustrating the overlay bonding approach between the proximal neck of the shape - set textile structure ( e . g ., the elongate support structure and the bulbs ) and the non - laser cut distal tip of the delivery system ( e . g ., a hypotube , wire or multi - filament hybrid ) using epoxy in one of the embodiments . fig3 is a schematic diagram illustrating the overlay bonding approach between the proximal neck of the shape - set textile structure ( e . g ., the elongate support structure and the bulbs ) and the distal end of the delivery system ( e . g ., a hypotube , wire or multi - filament hybrid ) using epoxy and heat shrink tubing in one of the embodiments . fig3 is a schematic diagram illustrating the overlay bonding approach between the distal neck of the shape - set textile structure ( e . g ., the elongate support structure and the bulbs ) and the distal end of the delivery system ( e . g ., a hypotube , wire or multi - filament hybrid ) using bonding agent in one of the embodiments . in some of the embodiments , overlay bonding approach includes laser welding , laser butt welding , laser rivet welding , and mechanical crimping of a flared distal end of the hypotube on the inlayed proximal neck of the textile structure ( e . g ., the elongate support structure and the bulbs ). fig3 is a photography illustrating the angled flexible laser - cut hypotube delivery system in one of the embodiments . various components ( e . g ., the elongate support structure , the bulbs , the sheath or the delivery system such as the hypotube ) may be made up of materials that are biocompatible or surface treated to produce biocompatibility . suitable materials include e . g ., platinum , titanium , nickel , chromium , cobalt , tantalum , tungsten , iron , manganese , molybdenum , and alloys thereof including nitinol , chromium cobalt , stainless steel , etc . suitable materials also include combinations of metals and alloys . suitable materials also include polymers such as polylactic acid ( pla ), polyglycolic acid ( pga ), polyclycoloc - lactic acid ( plga ), polycaprolactone ( pcl ), polyorthoesters , polyanhydrides , and copolymers thereof . in some embodiments , the thrombectomy device is made of nitinol and platinum tungsten . fig3 is a schematic diagram illustrating dimensions for laser - cut pattern a in one of the embodiments . fig3 is a schematic diagram illustrating dimensions for laser - cut pattern b in one of the embodiments . fig3 is a schematic diagram illustrating the directional stagger of laser - cut pattern a and pattern b in one of the embodiments . fig3 is a schematic diagram illustrating the interspersed laser - cut pattern a and b in one of the embodiments . fig4 is a schematic diagram illustrating the interspersed laser - cut pattern a and b with the inter - pattern stagger in one of the embodiments . fig4 is a schematic diagram illustrating the edges of the kerf in the angled laser - cut delivery system or hypotube are rounded or sharp in one of the embodiments . fig4 is a schematic diagram illustrating the flexible transition points in the laser - cut pattern of the hypotube in one of the embodiments . fig4 is a photograph illustrating the degree of angled laser - cut and the degree of uncut in the angled laser - cut delivery system or hypotube in one of the embodiments . fig4 is a schematic diagram illustrating the horizontal laser - cut delivery system in one of the embodiments . fig4 is a schematic diagram illustrating the edges of the kerf in the horizontal laser - cut delivery system or hypotube are rounded or sharp in one of the embodiments . fig4 is a photograph illustrating the degree of horizontal laser - cut and the degree of uncut in the horizontal laser - cut delivery system or hypotube in one of the embodiments . fig4 is a schematic diagram illustrating a hybrid delivery system with the filaments or wires that are braided together like a hypotube in one of the embodiments . fig4 is a schematic diagram illustrating a thrombus or blood clot in the right middle cerebral artery causing an acute ischemic stroke noted during angiography with a guide catheter or a shuttle or a balloon guide catheter positioned in the right internal carotid artery in one of the embodiments . fig4 is a schematic diagram illustrating a catheter ( e . g ., microcatheter ) being advanced across the thrombus or blood clot in the right middle cerebral artery over a microwire in one of the embodiments . the microwire is then removed and the mechanical thrombectomy device is advanced through the hub of the microcatheter via an introducer sheath that is protective encasing for the flexible delivery system . in several embodiments , the catheter ( e . g ., microcatheter ) is reinforced with the laser cut hypotube so as to , in one embodiment , inherit the maneuverability advantages of the hypotube ( e . g ., to facilitate proximal support and distal flexibility ). in some embodiments , a catheter with varying pitches is used . for example , the pitch from the distal end to the proximal end varies as follows : about 0 . 005 inch , 0 . 01 inch , 0 . 02 inch , 0 . 04 inch , 0 . 08 inch and 0 . 16 inch . in some embodiments , the pitch from the distal end to the proximal end varies as follows : about 0 . 005 inch for the distal most 20 %, 0 . 01 inch for the next 15 %, 0 . 02 inch for the next 15 %, 0 . 04 inch for the next 15 %, 0 . 08 inch for the next 15 %, and 0 . 16 inch for the next ( or proximal - most ) 20 %. the introducer sheath may comprise a biomedical polymer , e . g ., silicone , polyurethane , polyethylene ( rexell ™ made by huntsman ), polypropylene , polyester ( hytril ™ made by dupont ), poly tetra fluoro - ethylene ( ptfe ), polyvinyl chloride ( pvc ), polyamides ( durethan ™ made by bayer ), polycarbonate ( corethane ™ made by corvita corp ), or polyethylene - terephthalate . combinations of two or more of these materials may also be used . the microcatheter may comprise a biomedical polymer , e . g ., silicone , polyurethane , polyethylene ( rexell ™ made by huntsman ), polypropylene , polyester ( hytril ™ made by dupont ), poly tetra fluoro - ethylene ( ptfe ), polyvinyl chloride ( pvc ), polyamides ( durethan ™ made by bayer ), polycarbonate ( corethane ™ made by corvita corp ), or polyethylene - terephthalate . combinations of two or more of these materials may also be used . fig5 is a photograph illustrating the shape - set textile structure based mechanical thrombectomy device in one of the embodiments . in several embodiments , the devices described herein can be used in the brain . in some embodiments , vasculature in the periphery can be treated . in some embodiments , coronary vessels are treated . abdominal aorta and branches are treated in several embodiments . in some embodiments , a subject having a clot is identified . an access catheter is advanced over a guidewire to a vessel proximate or containing the clot . the guidewire may be removed at this stage . a microcatheter is advanced over a microwire , but stop before or at the clot . the microwire then crosses the clot by 0 . 5 - 5 mm ( e . g ., slices through the center of the clot ). the microcatheter is then advanced over the microwire to cross the clot . the microwire is then removed or retracted . the thrombectomy device ( the elongate support structure with the bulbs bonded to a delivery system , such as a hypotube , wire or multi - filament wire / hypotube device ), as disclosed in several embodiments herein is positioned within an introducer sheath , and together are advanced through the hub of the microcatheter . the thrombectomy device is then advanced through the microcatheter , and the introducer sheath is removed . the thrombectomy device is advanced until it is at the tip of the microcatheter ( which is beyond the clot ). the thrombectomy device is kept in position , and the microcatheter is retracted ( e . g ., unsleeved , unsheathed ) until the thrombectomy device is expanded . the length of retraction is related to length of the clot in one embodiment ( e . g ., the microcatheter is retracted to or before the proximal end of the clot ). the thrombectomy device is torqued ( e . g ., in a counterclockwise motion ) to facilitate torsional rasping ( e . g ., rotationally scraping ), thereby allowing the bulb ( s ) to entrap the clot , and collect any debris ( emboli ). the sticky portions of the clot , which can be attached to the endothelium wall , can be removed by the torqueing motion . the non - laser cut braided nature of the bulbs facilaite gentle entrapment of the clot without perforating the blood vessel . in one embodiment , a 360 degree rotation on the proximal end results in a distal rotation that is less than 360 degrees ( e . g ., 90 - 180 degrees ). in several embodiments , the rotational force from the proximal end to the distal is not 1 : 1 . instead the ratio is 1 : 0 . 75 , 1 : 0 . 5 or 1 : 0 . 25 . this non - 1 : 1 ratio , in some embodiments , is beneficial because it provides a gentle rotation that reduces the risk that the blood vessel is rotated , displaced , disrupted or perforated . in several embodiments , if one bulb cannot fully entrap the clot , another bulb ( whether it is the same or different in size and / or shape ) will be able to further entrap the clot . in some embodiments , the undulations ( e . g ., the hills and valleys created by the bulbs and support structure ) facilitate clot entrapment . undulation is also provided at a micro level by the braiding pattern . this dual - undulating pattern enhances scraping and entrapment in several embodiments . the clot , once entrapped or captured by the bulbs , can then be removed as the thrombectomy device is removed from the subject . the thrombectomy device is removed as follows in some embodiments : the microcatheter and the delivery system ( e . g ., hypotube ) are retracted into the tip of the guide catheter while negative suction is applied ( e . g ., with a syringe ) at the level of the guide catheter and also while the microcatheter is retracted at a similar rate such that the microcatheter does not generally recapture any expanded portion of the thrombectomy device or expand ( or expose ) additional portions of the thrombectomy device . in other words , unexpanded bulbs remain unexpanded and expanded bulbs remain expanded until they are retracted into the guide catheter . suction can be applied for about 5 - 30 seconds using a 30 - 90 cc syringe . the steps above need not be performed in the order recited . the following references are herein incorporated by reference : ( 1 ) sarti c , rastenyte d , cepaitis z , tuomilehto j . international trends in mortality from stroke , 1968 to 1994 . stroke . 2000 ; 31 : 1588 - 1601 ; ( 2 ) wolf p a , d &# 39 ; agostino r b . epidemiology of stroke . in : barnett h j m , mohr j p , stein b m , yatsu f , eds . stroke : pathophysiology , diagnosis , and management . 3rd ed . new york , n . y . : churchill livingstone ; 1998 : 6 - 7 ; ( 3 ) adams h p , jr ., adams r j , brott t , del zoppo g j , furlan a , goldstein l b , grubb r l , higashida r , kidwell c , kwiatkowski t g , marler j r , hademenos g j . guidelines for the early management of patients with ischemic stroke : a scientific statement from the stroke council of the american stroke association . stroke . 2003 ; 34 : 1056 - 1083 ; ( 4 ) rymer m m , thrutchley d e . organizing regional networks to increase acute stroke intervention . neurol res . 2005 ; 27 : 59 - 16 ; and ( 5 ) furlan a , higashida r , wechsler l , gent m , rowley h , kase c , pessin m , ahuja a , callahan f , clark w m , silver f , rivera f . intra - arterial prourokinase for acute ischemic stroke . the proact ii study : a randomized controlled trial . prolyse in acute cerebral thromboembolism . jama . 1999 ; 282 : 2003 - 2011 . while the invention is susceptible to various modifications , and alternative forms , specific examples thereof have been shown in the drawings and are herein described in detail . it should be understood , however , that the invention is not to be limited to the particular forms or methods disclosed , but to the contrary , the invention is to cover all modifications , equivalents and alternatives falling within the spirit and scope of the various embodiments described and the appended claims . the ranges disclosed herein also encompass any and all overlap , sub - ranges , and combinations thereof . language such as “ up to ,” “ at least ,” “ greater than ,” “ less than ,” “ between ,” and the like includes the number recited . numbers preceded by a term such as “ about ” or “ approximately ” include the recited numbers . for example , “ about 3 mm ” includes “ 3 mm .”
a biomedical shape - set textile structure based mechanical thrombectomy systems and methods are described . in one of the embodiments , the mechanical thrombectomy device can be customized to the length of the clot in each patient . in one of the embodiments , the mechanical thrombectomy device because of the textile structure has a very low overall profile or thickness that is less than 0 . 0125 inches and therefore can be deployed within microcatheters with inner lumen diameter as small as 0 . 014 inches .