the systems and methods of the present disclosure address the needs of the art by providing tomosynthesis apparatus and techniques for imaging breast specimens that overcome the shortfall of the data received from two - dimensional imaging systems . the aspects of the present disclosure enable the use of tomosynthesis to efficiently provide accurate three - dimensional imaging of a specimen in which overlapping images having differing attenuation characteristics by applying a three - dimensional reconstruction algorithm , all in an x - ray cabinet . as used herein , the term “ computer ,” “ computer system ” or “ processor ” refers to any suitable device operable to accept input , process the input according to predefined rules , and produce output , including , for example , a server , workstation , personal computer , network computer , wireless telephone , personal digital assistant , one or more microprocessors within these or other devices , or any other suitable processing device with accessible memory . the term “ computer program ” or “ software ” refers to any non - transitory machine readable instructions , program or library of routines capable of executing on a computer or computer system including computer readable program code . specimen tomography is a three - dimensional specimen imaging system . it involves acquiring images of a sample at multiple viewpoints , typically over an arc or linear path . the three - dimensional ( 3 - d ) image is constructed by the reconstruction of the multiple image data set . one embodiment of a system 100 incorporating aspects of the present disclosure is illustrated in fig1 the system 100 is totally enclosed or housed in an x - ray cabinet 22 . in accordance with the aspects of the disclosed embodiments , the x - ray source 10 moves around the stationary sample 18 , typically , but not necessarily , in an arc . references 12 , 14 and 16 of fig1 illustrate exemplary positions of the x - ray source 10 within the cabinet 22 . the reference “ c ” at each of the positions 12 , 14 , 16 of the source 10 in fig1 refers to the point source of the x - ray beam . the reference “ m ” refers to the spread or fan of the x - ray beam . while the detector 20 may move or rotate , in accordance with one aspect of the present disclosure , the detector 20 remains stationary relative to the sample 18 and source 10 to maintain an equidistant center point . the x - ray data taken at each of a number of exemplary positions 12 , 14 , 16 of the source 10 relative to the sample 18 within the cabinet 22 is processed to form images , where two or more of the differing imaging positions are utilized to form a digital tomosynthesis image . in one embodiment , the aspects of the present disclosure limit the arc or linear travel of the x - ray source 10 over about a 20 ° to about a 50 ° arc , preferably about 30 °, more preferably about 20 °. the movement can be clockwise or counter clockwise along a path , which includes for example , one or more , or a combination thereof , of the following exemplary ranges : between approximately 350 ° ( reference position 12 ), to 0 ° ( reference position 14 ) to 10 ° ( reference position 16 ), or between approximately 340 ° ( reference position 12 ) to 0 ° ( reference position 14 ) to 20 ° ( reference position 16 ) and or between approximately 335 ° ( reference position 12 ) to 0 ° ( reference position 14 ) to 25 ° ( reference position 16 ). the ranges recited herein are intended to be approximate and inclusive of start and endpoints . in the example of fig1 the detector 20 is stationary as is the sample 18 . the sample 18 , also referred to as the “ object ” or “ imaging object ” is disposed on or rests on the protective cover 19 or other surface of the detector 20 . in operation , source 10 is energized to emit an x - ray beam , generally throughout its travel along one or more of the paths or positions described above . the x - ray beam travels through the sample 18 to the detector 20 and the multiple images collected at varying angles are stored and then utilized for the tomosynthesis reconstruction . the x - ray source 10 may range from about 0 kvp to about 90 kvp , preferably a 50 kvp 1000 μa x - ray source . different embodiments of the present disclosure can utilize different ranges of motion of one or more of the source 10 and detector 20 as well as changing the angularity of one or both . the inventive aspects of the present disclosure differ from the prior art in that in prior art systems either the detector and source move and / or the isocenter is above the sample and not at the detector surface . in accordance with the aspects of the present disclosure , in one embodiment , the source 10 is configured to move , as is described herein , while the detector 20 is configured to remain stationary or in a fixed position . the detector 20 and associated electronics generate image data in digital form for each pixel at each of the angular positions 12 , 14 , 16 of source 10 and translation positions of the detector 20 relative to the sample 18 . while only three positions 12 , 14 , 16 are illustrated in fig1 , in practice more images are taken at differing angles . for example , in one embodiment , images can be taken at approximately every 1 ° of rotation or motion of source 10 . fig2 schematically illustrates one embodiment of the orientation of the source 10 as seen when the door 24 is opened and the source 10 is locate at approximately 0 °, reference point 14 in this example , within the cabinet 22 . in this embodiment , the motion of the source 10 can generally occur from the back to the front of the cabinet 22 with the detector 20 orientated , or otherwise disposed , at the base 26 of the cabinet 22 , within the cabinet chamber 28 . in one embodiment , the detector 20 is suitably coupled to the base 26 of the cabinet 22 . the x - ray spread in this example can be from about 0 kvp to about 50 kvp with the system preferably utilizing an aec ( automatic exposure control ) to ascertain the optimal setting to image the object or sample 18 being examined . in one embodiment , the detector 20 , x - ray source 10 , and the swing arm 50 ( fig5 ) servo mechanism are controlled via a combination of one or more of software and hardware , such as non - transitory machine readable instructions stored in a memory that are executable by one or more processors . on example of such a configuration can include controller cards of a computer 470 ( fig4 ), such as a ms windows based computer . in one embodiment , non - transitory machine readable instructions being executed by one or more processors of the computer 470 is utilized to compile data received from the detector 20 and present resulting images to a suitable display or monitor 472 ( fig4 ). t each imaging position , such as positions 12 , 14 and 16 shown in fig1 , the detector 20 generates the respective digital values for the pixels in a two - dimensional array . the size of detector 20 may range , for example , from about 2 inches by 2 inches to about 16 inches by 16 inches , preferably about 5 inches by 6 inches . in one example , detector 20 has a rectangular array of approximately 1536 × 1944 pixels with a pixel size of 74 . 8 micrometers . the image dataset attained at each respective position may be processed either at the full spatial resolution of detector 20 or at a lower spatial resolution by overlapping or binning a specified number of pixels in a single combined pixel value . for example , if we bin at a 2 × 2 ratio , then there would be an effective spatial resolution of approximately 149 . 6 micrometers . this binning may be achieved within the original programming of the detector 20 or within the computer 470 providing the tomosynthetic compilation and image . fig3 illustrates one embodiment of an exemplary workflow from initiating 302 the system 100 through imaging , reconstruction and display 324 of data images collected of the sample 18 . as will be generally understood , the system 100 is initiated 302 , the cabinet door 24 opened 304 , and the sample 18 placed into 306 the chamber 28 . as shown in fig2 , for example , the sample 18 is positioned on the detector 20 in a suitable manner . the door 24 is closed 308 . the data and information regarding the subject , including any other suitable information or settings relevant to the imaging process and procedure , is entered 310 into the computer 470 . the scan is initiated 312 . the system 100 will take 314 scout or 2 - d images at top dead center , which for purposes of this example is location 14 of fig1 and 2 . the source 10 can then be moved to other locations , such as locations 12 and 16 , and the detector 20 can be used to capture 316 images at various increments along the travel path of the source 10 , such as about every 1 degree . the captured images are stored 318 and digital tomosynthesis is performed 320 . the tomosynthesis image is then displayed 324 . fig4 shows one embodiment of an x - ray cabinet system 400 incorporating aspects of the present disclosure . in this embodiment , the x - ray cabinet system 400 is mounted on wheels 458 to allow easy portability . in alternate embodiments , the cabinet system can be mounted on any suitable base or transport mechanism . the cabinet 422 in this example , similar to the exemplary cabinet 22 of fig1 , is constructed of a suitable material such as steel . in one embodiment , the cabinet 422 comprises painted steel defining a walled enclosure with an opening or cabinet chamber 428 . within the cabinet chamber 428 , behind door 424 , resides an interior space forming a sample chamber 444 , which in this example is constructed of stainless steel . access to the sample chamber 444 is via an opening 446 . in one embodiment , the opening 446 of the sample chamber 444 has a suitable door or cover , such as a moveable cover 448 . in one embodiment , the moveable cover 448 comprises a door which has a window of leaded glass . between the outer wall 421 of cabinet 422 and the sample chamber 444 are sheets of lead 452 that serve as shielding to reduce radiation leakage emitted from the x - ray source 10 . in the example of fig4 , the x - ray source 10 is located in the upper part 456 of the cabinet 422 , in the source enclosure 468 . the detector 20 is housed in the detector enclosure 460 at an approximate midpoint 462 of the cabinet 422 . in one embodiment , a controller or computer 470 controls the collection of data from the detector 20 , controls the swing arm 60 shown in fig5 & amp ; 6 , and x - ray source 10 . a monitor 472 displays the compiled data and can , for example , be mounted on an articulating arm 474 that is attached to the cabinet 422 . the computer 470 receives commands and other input information entered by the operator via a user interface 476 , such as a keyboard and mouse for example . in one embodiment , the computer 470 can comprise a touch screen or near touch screen device . although the aspects of the disclosed embodiments will generally be described with respect to a computer , it will be understood that the computer 470 can comprise any suitable controller or computing device . such computing devices can include , but are not limited to , laptop computers , mini computers , tablets and pad devices . the computer 470 can be configured to communicate with the components of the system 400 in any suitable manner , including hardwired and wireless communication . in one embodiment , the computer 470 can be configured to communicate over a network , such as a local area network or the internet . fig5 shows a front interior view and fig6 shows a lateral interior view of the sample chamber of imaging unit cabinet of fig4 . in this embodiment , a sample 18 is placed or otherwise disposed onto the detector 20 . using the computer system 470 shown in fig4 , the operator enters in the parameters for the scan via the user interface 476 , which can be displayed on the monitor 472 . as used herein , the term “ display ” or “ monitor ” means any type of device adapted to display information , including without limitation crts , lcds , tfts , plasma displays , leds , and fluorescent devices . the computer system 470 then sends the appropriate commands to the x - ray source 10 and detector 20 to activate image collection while the swing arm 60 is moving along a path or arc from location 14 to 12 to 16 ( which are shown in fig1 and 5 ) or vice versa as described , which in this embodiment are at 345 °, 0 °, and 15 ° respectively with 0 ° at top dead center . at the end of the travel of the swing arm 60 at either position 12 or 16 , the computer 470 issues the command to the x - ray source 10 and the detector 20 to cease operating . the individual 2 - dimensional ( 2 - d ) images which were collected , in this example at 1 ° increments , are then tabulated in the computer 470 to create the tomosynthetic images . in one embodiment , the operator may select which images they wish via the user interface 476 as they are being displayed on the monitor 472 . in one embodiment , the devices and components of the cabinet system 400 are suitably communicatively coupled together , including one or more of hard wire connections or wireless connections using a suitable wireless connection and communication transmission protocol , as will generally be understood . the system 400 can also be configured to transfer images via usb , cd - rom , or wifi . the dynamic imaging software of the disclosed embodiments reconstructs three - dimensional images ( tomosynthesis ) from two - dimensional projection images in real - time and on - demand . the software offers the ability to examine any slice depth , tilt the reconstruction plane for multiplanar views and gives higher resolution magnifications . fig7 a , 7 b , and 7 c illustrate exemplary images of an apple using the above process . fig7 a is an image of a slice of the apple at it &# 39 ; s very top . 59 mm from the bottom . fig7 b is an image of an apple computed at 30 . 5 mm up from the detector , and fig7 c is a view of the apple computed at 13 . 5 mm from the bottom . the real - time image reconstruction of the present disclosure enables immediate review , higher throughput , and more efficient interventional procedures reducing patient call backs and data storage needs . multiplanar reconstruction enables reconstruction to any depth , magnification and plane , giving the viewer the greater ability to view and interrogate image data , thereby reducing the likelihood of missing small structures . built - in filters allow higher in - plane resolution and image quality during magnification for greater diagnostic confidence . software is optimized for performance using gpu technology . the reconstruction software used in conjunction with the aspects of the present disclosure provides the users greater flexibility and improved visibility of the image data . it reconstructs images at any depth specified by the user , rather than at fixed slice increments . with fixed slice increments , an object located between two reconstructed slices , such as a calcification , is blurred and can be potentially missed . the aspects of the present disclosure provide for positioning the reconstruction plane so that any object is exactly in focus . this includes objects that are oriented at an angle to the detector 20 . the aspects of the present disclosure provide for the reconstruction plane to be angled with respect to the detector plane . thus , while there have been shown and described and pointed out fundamental novel features of the invention as applied to the exemplary embodiments thereof , it will be understood that various omissions and substitutions and changes in the form and details of devices illustrated , and in their operation , may be made by those skilled in the art without departing from the spirit of the invention . for example , it is expressly intended that all combinations of those elements and / or method steps which perform substantially the same function in substantially the same way to achieve the same results are within the scope of the invention . moreover , it should be recognized that structures and / or elements and / or method steps shown and / or described in connection with any disclosed form or embodiment of the invention may be incorporated in any other disclosed or described or suggested form or embodiment as a general matter of design choice . it is the intention , therefore , to be limited only as indicated by the scope of the claims appended hereto .
a method and system for producing tomosynthesis images of a breast specimen in a cabinet x - ray system . an x - ray source delivers x - rays through a specimen of excised tissue and forms an image at a digital x - ray detector . multiple x - ray images are taken as the x - ray source moves relative to the stationary breast specimen . in the preferred embodiment , the x - ray source moves in a range from about 350 ° to and including about 10 °. the source may travel substantially along a path that generally defines an arc , or linearly , while the detector remains stationary throughout and the source remains substantially equidistant from the specimen platform . the set of x - ray image data taken at the different points are combined to form a tomosynthesis image that can be viewed in different formats , alone or as an adjunct to conventional specimen radiography .