according to the present invention , the more particularly preferred compounds of formula ( i ) are those for which at least one , and preferably all , of the conditions below are respected : r 1 and r 2 , taken together , form an aromatic ring such as described above , r 3 is a hydrogen , a lower alkenyl radical , a no lower alkyl radical or an -- or 7 radical r 5 is a radical of formula ( i ) or ( iii ), an object of the present invention is likewise processes for preparation of the compounds of formula ( i ), in particular according to the reaction schemes given in fig1 . thus the compounds of general formula ( i ) can be obtained ( fig1 ) starting from the ketone ( ii ), by halogenation , for example by means of a brominating agent such as bromine . the compound ( iii ) obtained is then coupled to the compound ( iv ), in the presence of a base such as potassium carbonate or sodium hydride . the coupled derivative ( v ) is subjected to the action of a phosphine or of a phosphonate in the presence of a base leading to the compound ( vi ). the compound ( vi ) is cyclized by the action of a metallic catalyst such as palladium diacetate , in the presence of a hydride donor such as formic acid or of a nucleophile such as vinyltributyltin or lithium acetate and if necessary of a base . the addition of salts or of silver zeolites such as ag 3 po 4 and of chiral phosphines such as binap allows only one of the enantiomers to be obtained . the products of general formula ( i ) thus obtained can serve as starting products for the production of other compounds of general formula ( i ). these products are obtained according to the classical synthesis methods employed in chemistry , such as those described in &# 34 ; advanced organic chemistry &# 34 ; by j . march ; john willey and sons , 1985 . for example , it is possible to carry out the functional modifications on the r 5 group as indicated below : ______________________________________carboxylic acid → esterester → carboxylic acidacid → acid chlorideacid chloride → amideacid → amideacid → alcoholalcohol → aldehydeamide → aminethiol → thioetherthioether → sulphoxidethioether → sulphonesulphonic acid → sulphonic estersulphonic acid → sulphonamidesulphinic acid → sulphinic ester______________________________________ when r 3 is the -- coon : radical , the compounds are preferentially prepared by protecting r 3 by a protecting group of allyl , benzyl or tert - butyl type . in the case of an allyl protecting group , by means of a catalyst such as certain transition metal complexes in the presence of a secondary amine . in the case of a benzyl protecting group , by debenzylation in the presence of hydrogen , by means of a catalyst such as palladium on carbon . in the case of a tert - butyl protecting group by means of trimethylsilyl iodide . when r 5 is an alcohol function the compounds can be obtained starting from corresponding aldehyde derivatives by action of an alkali metal hydride , such as sodium borohydride , in an alcoholic solvent ( for example methanol ), or by coupling of the corresponding halogenated derivative to a derivative of 3 -( tributyltin ) allyl alcohol . when r 5 is an aldehyde function , the compounds can be obtained starting from alcohol derivatives by oxidation in the presence of manganese oxide , pyridinium dichromate or swern &# 39 ; s reagent . when r 5 is an amide function the compounds can be obtained starting from corresponding carboxylic derivatives by reaction with aliphatic , aromatic or heterocyclic amines either by the intermediary of an acid chloride or in the presence of dicyclohexylcarbodiimide or of carbonyldiimidazole . certain of these compounds are bound to rxr receptors , some having an agonist activity , others an antagonist activity . the binding and transactivation properties as agonist to the rxr receptors are determined by methods known in the art , such as , for example : martin , b . et al ., skin pharmacol ., 1992 , 5 , 57 - 65 ; cavey , m . t . et al ., anal . biochem ., 1990 , 186 , 19 - 23 ; lever et al ., nature 1992 , 355 , 359 - 61 ; allenby et al ., proc . natl . acad . scd ., 1993 , 90 , 30 - 4 ; allenby et al ., j . biol . chem ., 1994 , 269 , 16689 - 95 . the rxr agonist activity is also determined by the test such as is described in the french patent application no . 95 - 07301 filed on jun . 19 , 1995 by the applicant . this test comprises the following steps : ( i ) a sufficient quantity of a compound which is an active ligand of at least one receptor of the steroid / thyroid nuclear receptor superfamily other than a specific ligand of the rxr receptors and able to heterodimerize with the rxrs such as an agonist molecule of the rars is applied topically to one part of the skin of a mammal , ( ii ) a molecule capable of having an agonist activity on the rxrs is administered by the systemic or topical route to this same part of the skin of the mammal before , during or after step ( i ), ( iii ) the response on the part of the mammal skin treated in this way is evaluated . thus the response to a topical application on the ear of a mammal of an rar agonist molecule which corresponds to an increase in the thickness of this ear can be increased by the administration by the systemic or topical route of an rxr receptor agonist molecule . the rxrα antagonist activity is evaluated in the transactivation test by determination of the dose ( ic 50 ) which inhibits the transactivator activity of a selective rxrα agonist by 50 %: 6 -( 3 , 5 , 5 , 8 , 8 - pentamethyl - 5 , 6 , 7 , 8 - tetrahydro - 2 - naphthylthio ) nicotinic acid ( cd 2809 ) according to the following protocol : the hela cells are co - transfected with an expression vector coding for rxrα ( p565 - rxrα ) and a reporter plasmid containing the response element 1 / 2 crbp ii cloned upstream of the thymidine kinase heterologous promoter and of the chloramphenicolm acetyl transferase ( cat ) reporter gene . eighteen hours after co - transfection the cells are treated with a fixed concentration of cd 2809 and increasing concentrations of the molecule to be evaluated . after twenty four hours &# 39 ; treatment , the determination of the cat activity is carried out by elisa . the fixed concentration of cd2809 used is 5 10 - 8 m and corresponds to its ec 50 . certain of the compounds according to the invention are bound to the rar receptors and have an activity in the mouse embryonic teratocarcinoma cell ( f9 ) differentiation test ( cancer research 43 , p . 5268 , 1983 ) and / or in the ornithine decarboxylase inhibition test after induction by tpa in the mouse ( cancer research 38 , p . 793 - 801 , 1978 ). these tests show the activities of these compounds respectively in the fields of differentiation and of cell proliferation . an object of the present invention is thus the compounds of formula ( i ) such as defined above by way of medicament . the compounds according lo the invention are particularly well - suited in the following fields of treatment : 1 ) to treat dermatological conditions connected with a keratinization disorder bearing on differentiation and on proliferation , especially to treat acne vulgaris , comedonian acne , polymorphic acne , acne rosacea , nodulocystic acne , acne conglobata , senile acne , secondary acne such as solar acne , acne medicamentosa or occupational acne , 2 ) to treat other types of keratinization disorders , especially ichthyosis , ichthyosiform states , darrier &# 39 ; s disease , keratosis palmaris and plantaris , leucoplakias and leucoplakiform states , cutaneous or mucous ( buccal ) lichen , 3 ) to treat other dermatological conditions connected with a keratinization disorder with an inflammatory and / or immunoallergic component and especially all the forms of psoriasis whether it is cutaneous , mucous or ungual , and even arthropathic psoriasis , or alternatively cutaneous atopy , such as eczema or respiratory atopy or alternatively gingival hypertrophy ; the compounds can likewise be used in certain inflammatory conditions not presenting a keratinization disorder , 4 ) to treat all the dermal or epidermal proliferations whether they are benign or malignant , whether or not they are of a viral origin such as verruca vulgaris , verruca plana and epidermodysplasia verruciformis , oral or florid papillomatosis and proliferations able to be induced by ultra - violet , especially in the case of basal and spinocellular epithelioma , 5 ) to treat other dermatological disorders such as bullosis and collagen diseases , 7 ) to repair or combat aging of the skin , whether it is photoinduced or chronological , or to reduce pigmentation and actinic keratosis , or any pathologies associated with chronological or actinic aging , 8 ) to prevent or cure the stigmata of epidermal and / or dermal atrophy induced by local or systemic corticosteroids , or any other form of cutaneous atrophy , 9 ) to prevent or treat cicatrization disorders , to prevent or to repair vibices , or alternatively to promote cicatrization , 10 ) to combat sebaceous function disorders such as hyperseborrhoea of acne or simple seborrhoea , 13 ) in the treatment of any disorder of viral origin at the cutaneous or general level , 15 ) in the treatment of dermatological or general disorders with an immunological component , 16 ) in the treatment of disorders of the cardiovascular system such as arteriosclerosis , 17 ) in the treatment of cutaneous disorders due to exposure to u . v . rays . in the therapeutic fields mentioned above , the compounds according to the invention can be advantageously employed in combination with other compounds of retinoid type activity , with d vitamins or their derivatives , with corticosteroids , with anti - free radicals , α - hydroxy or α - keto acids or their derivatives , or in addition alternatively with ion channel blockers . d vitamins or their derivatives are understood , for example , as meaning the derivatives of vitamin d 2 or d 3 and in particular 1 , 25 - dihydroxy vitamin d 3 . anti - free radicals are understood , for example , as meaning α - tocopherol , super oxide dismutase , ubiquinol or certain metal chelators . α - hydroxy or α - keto acids or their derivatives are understood , for example , as meaning lactic , malic , citric , glycolic , mandelic , tartaric , glyceric or ascorbic acid or their salts , amides or esters . finally , ion channel blockers are understood , for example , as meaning minoxidil ( 2 , 4 - diamino - 6 - piperidinopyrimidine - 3 - oxide ) and its derivatives . an object of the present invention is likewise medicament compositions comprising at least one compound of formula ( i ) such as defined above , one of its optical or geometric isomers or one of its salts . an object of the present invention is thus a novel medicament composition intended especially for the treatment of the abovementioned conditions , and which is characterized by the fact that it comprises , in a support which is pharmaceutically acceptable and compatible with the method of administration reserved for the latter , at least one compound of formula ( i ), one of its optical or geometric isomers or one of its salts . the administration of the compounds according to the invention can be carried out by the enteral , parenteral , topical or ocular route . by the enteral route , the medicaments can be present in the form of tablets , gelatin capsules , coated tablets , syrups , suspensions , solutions , powders , granules , emulsions , microspheres or nanospheres or lipid or polymer vesicles allowing controlled liberation . by the parenteral route , the compositions can be present in the form of solutions or suspensions for perfusion or for injection . the compounds according to the invention are generally administered in a daily dose of approximately 0 . 01 mg / kg to 100 mg / kg of body weight , and the latter at the rate of 1 to 3 administrations . by the topical route , the base pharmaceutical compositions of compounds according to the invention are more particularly intended for the treatment of the skin and of the mucous membranes and can then be present in the form of ointments , creams , milks , lotions , powders , impregnated pads , solutions , gels , sprays , lotions or suspensions . they can likewise be present in the form of microspheres or nanospheres or lipid or polymer vesicles or polymer patches and hydrogels allowing controlled liberation . these compositions by the topical route can in addition be present either in anhydrous form , or in an aqueous form , according to the clinical indication . these compositions for topical or ocular use contain at least one compound of formula ( i ) such as defined above , or one of its optical or geometric isomers or additionally one of its salts , at a preferred concentration of between 0 . 001 % and 5 % by weight with respect to the total weight of the composition . the compounds of formula ( i ) according to the invention likewise have an application in the cosmetic field , in particular in body and hair hygiene and especially for the treatment of skins prone to acne , for the regrowth of the hair , prevention of hair loss , for combating a greasy appearance of the skin or of the hair , in protection against harmful aspects of the sun or in the treatment of physiologically dry skins , to prevent and / or to combat photoinduced or chronological aging . in the cosmetic field , the compounds according to the invention can additionally be advantageously employed in combination with other compounds of retinoid type activity , with the d vitamins or their derivatives , with corticosteroids , with anti - free radicals , α - hydroxy or α - keto acids or their derivatives , or alternatively with ion channel blockers , all these different products being such as defined above . the present invention is thus likewise directed at a cosmetic composition which is characterized by the fact that it comprises , in a support which is cosmetically acceptable and suitable for topical application , at least one compound of to formula ( i ) such as defined above or one of its optical or geometric isomers or one of its salts , this cosmetic composition especially being able to be present in the form of a cream , a milk , a lotion , a gel , microspheres or nanospheres or lipid or polymer vesicles , a soap or a shampoo . the concentration of compound of formula ( i ) in the cosmetic compositions according to the invention is advantageously between 0 . 001 % and 3 % by weight with respect to the whole of the composition . the medicament and cosmetic compositions according to the invention can additionally contain inert or even pharmacodynamically or cosmetically active additives or combinations of these additives , and especially : wetting agents ; depigmenting agents such as hydroquinone , azelaic acid , caffeic acid or kojic acid ; emollients ; hydrating agents such as glycerol , peg 400 , thiamorpholinone , and its derivatives or alternatively urea ; antiseborrhoeic or antiacne agents , such as s - carboxymethylcysteine , s - benzylcysteamine , their salts and their derivatives , or benzoyl peroxide ; antibiotics such as erythromycin and its esters , neomycin , clindamycin and its esters , tetracyclines ; antifungal agents such as ketoconazole or 4 , 5 - polymethylene - 3 - isothiazolidones ; agents promoting the regrowth of the hair , such as minoxidil ( 2 , 4 - diamino - 6 - piperidinopyrimidine - 3 - oxide ) and its derivatives , diazoxide ( 7 - chloro - 3 - methyl - 1 , 2 , 4 - benzothiadiazine - 1 , 1 - dioxide ) and phenytoin ( 5 , 5 - diphenylimidazolidine - 2 , 4 - dione ); non - steroidal anti - inflammatory agents ; carotenoids and , especially , β - carotene ; anti - psoriatic agents such as anthralin and its derivatives ; and finally eicosa - 5 , 8 , 11 , 14 - tetraynoic and eicosa - 5 , 8 , 11 - trynoic acids , their esters and amides . the compositions according to the invention can likewise contain flavour - improving agents , preservatives such as the esters of parahydroxybenzoic acid , stabilizers , moisture regulators , ph regulators , osmotic pressure modifying agents , emulsifiers , uv - a and uv - b filters , antioxidants , such as α - tocopherol , butylhydroxyanisole or butylhydroxytoluene . there will now be given , by way of illustration and without any limiting character , several examples of obtainment of active compounds of formula ( i ) according to the invention , as well as various actual formulations based on such compounds . a 3 . 6 % solution of sodium perchlorate is added dropwise to a mixture of 4 - hydroxybenzoic acid ( 1 , 2 . 75 g , 0 . 92 mol ), sodium ( 3 . 7 g , 0 . 92 mol ), sodium iodide ( 13 . 85 g , 0 . 92 mol ) in methanol ( 350 ml ) at 0 ° c . the mixture is stirred for two hours at 0 ° c . 100 ml of a solution of 10 % sodium thiosulphate are added . after stirring , the mixture is acidified to ph 1 with hydrochloric acid . it is extracted with 600 ml of ethyl ether . the organic phase is washed twice with 400 ml of water , dried over magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . 1 h [ lacuna ] nmr ( dmso , 250 mhz ): 6 . 74 ( 1h ar , d , j = 8 . 4 hz ), 7 . 71 ( 1h ar , d , j = 8 . 4 hz ), 8 . 13 ( 1h ar , s ), 10 . 16 ( 1h , s ), 11 . 12 ( 1h , s ). a solution of 3 - iodo - 4 - hydroxybenzoic acid ( 28 . 76 g , 0 . 11 mol ) and sulphuric acid ( 6 . 6 ml ) in methanol ( 160 ml ) is heated to reflux for 6 h . 300 ml of water are added and the mixture is alkalized to neutrality with sodium bicarbonate . it is extracted with ethyl ether ( 600 ml ). the organic phase is washed twice with 400 ml of water , dried over magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ethyl acetate 10 %, ch 2 cl 2 90 %) white solid . mass : 19 . 1 g . yield : 63 %. m . p . : 133 ° c . ( c ) methyl 4 -[( 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthoyl ) methyloxy ]- 3 - iodobenzoate . a solution of 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - bromoacetonaphthone ( 9 . 8 g , 0 . 032 mol ), methyl 4 - hydroxy - 3 - iodobenzoate ( 8 . 8 g , 0 . 032 mol ) and potassium carbonate ( 8 . 5 g , 0 . 062 mol ) in methyl ethyl ketone ( 450 ml ) is heated to reflux for 1 day . the reaction mixture is filtered , then concentrated in a rotary evaporator . 500 ml of water and 500 ml of ethyl ether are added . after stirring and separation , the organic phase is washed twice with 500 ml of water , dried over magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ethyl acetate 10 %, heptane 90 %). 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 30 ( 6h , s ), 1 . 32 ( 6h , s ), 1 . 71 ( 4h , s ), 3 . 88 ( 3h , s ), 5 . 40 ( 2h , s ), 6 . 70 ( 1h ar , d , j = 8 . 7 hz ), 7 . 43 ( 1h ar , d , j = 8 . 5 hz ), 7 . 74 ( 1h ar , dd , j = 2 hz , j = 8 . 5 hz ), 7 . 93 ( 1h ar , dd , j = 8 . 7 , j = 2 . 3 hz ), 7 . 98 ( 1h ar , d , j = 2 hz ), 8 . 48 ( 1h ar , d , j = 2 . 3 hz ). a 30 % solution of sodium methoxide ( 2 . 67 g , 14 . 83 mmol ) is added in 8 hours to a mixture of methyl 4 -[ 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthoyl )- methyloxy ]- 3 - iodobenzoate ( 7 . 50 g , 14 . 8 mmol ) and methyltryphenylphosphine bromide ( 7 . 30 g , 20 . 42 mmol ) in thf ( 80 ml ). the solution is stirred at ambient temperature for 18 h . the mixture is concentrated in vacuo at 40 ° c . in a rotary evaporator . it is extracted with 90 ml of ethyl ether and 90 ml of water . after separation , the organic phase is washed twice with 90 ml of water , dried over anhydrous magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ch 2 cl 2 70 %, heptane 30 %). 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 29 ( 6h , s ), 1 . 30 ( 6h , s ), 1 . 69 ( 4h , s ), 3 . 89 ( 3h , s ), 4 . 99 ( 2h , s ), 5 . 55 ( 1h , s ), 5 . 59 ( 1h , s ), 6 . 87 ( 1h ar , d , j = 8 . 7 hz ), 7 . 21 to 7 . 33 ( 2h ar , m ), 7 . 38 ( 1h ar , d , j = 1 . 8 hz ), 8 . 00 ( 1h ar , dd , j = 8 . 7 , j = 2 hz ), 8 . 48 ( 1h ar , d , j = 2 hz ) 13 c [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 31 . 79 , 31 . 90 , 34 . 16 , 34 . 33 , 34 . 96 , 35 . 10 , 52 . 09 , 70 . 81 , 85 . 85 , 111 . 35 , 112 . 73 , 114 . 05 , 123 . 33 , 124 . 17 , 124 . 46 , 126 . 71 , 129 . 67 , 131 . 45 , 131 . 74 , 135 . 23 , 141 . 06 , 141 . 99 , 145 . 05 , 145 . 10 , 160 . 67 , 165 . 47 . a mixture of tributhylamine ( 2 . 28 ml , 9 . 6 mmol ), palladium diacetate ( 0 . 06 g , 0 . 3 mmol ), formic acid ( 0 . 29 ml , 7 . 4 mmol ) and methyl 3 - iodo - 4 -[ 2 -[ 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthyl ]- 1 - propenylloxy benzoate ( 1 . 37 g , 2 . 72 mmol ) in acetonitrile ( 25 ml ) is heated at 95 ° c . for 4 h . the reaction mixture is concentrated in vacuo at 40 ° c . in a rotary evaporator . 40 ml of water and 40 ml of ethyl ether are added . after separation , the organic phase is washed twice with 20 ml of water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ch 2 cl 2 50 % heptane 50 %) 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 20 to 1 . 24 ( 12h , m ), 1 . 65 ( 4h , s ), 1 . 73 ( 3h , s ), 3 . 83 ( 3h , s ), 4 . 51 ( 1h , d , j = 8 . 7 hz ), 4 . 66 ( 1h , d , j = 8 . 7 hz ), 6 . 87 ( 1h ar , d , j = 8 . 3 hz ), 6 . 96 ( 1h ar , dd , j = 8 . 3 , j = 2 hz ), 7 . 19 to 7 . 24 ( 2h ar , m ), 7 . 73 ( 1h ar , d , j = 1 . 8 hz ), 7 . 92 ( 1h ar , dd , j = 8 . 3 , j = 2 hz ). 13 c [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 26 . 63 , 31 . 99 , 32 . 08 , 32 . 11 , 34 . 18 , 35 . 21 , 35 . 32 , 49 . 45 , 52 . 04 , 87 . 37 , 109 . 82 , 123 . 31 , 123 . 98 , 124 . 36 , 126 . 46 , 126 . 85 , 131 . 41 , 136 . 62 , 142 . 56 , 143 . 49 , 145 . 04 , 163 . 91 , 167 . 19 . a mixture of methyl 3 -( 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthyl )-( 3 - methyl )- 2 , 3 - dihydrobenzofuran - 5 - carboxylate ( 510 mg , 135 mmol ), sodium hydroxide ( 0 . 33 g , 7 . 9 mmol ), and lithium hydroxide ( 0 . 33 g , 7 . 9 mmol ) is stirred 5 days at ambient temperature . it is concentrated in vacuo at 40 ° c . in a rotary evaporator . 10 ml of water and 10 ml of ethyl acetate are added again . the mixture is acidified to ph 1 with a concentrated hydrochloric acid solution . after separation , the organic phase is washed twice with 10 ml of water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the solid obtained is washed with heptane . 1 h [ lacuna ] nmr ( dmso , 250 mhz ): 1 . 20 to 1 . 23 ( 12h , m ), 1 . 64 ( 4h , s ), 1 . 74 ( 3h , s ), 3 . 83 ( 3h , s ), 4 . 44 ( 1h , d , j = 8 . 7 hz ), 4 . 66 ( 1h , d , j = 8 . 7 hz ), 6 . 85 ( 1h ar , d , j = 7 . 5 hz ), 6 . 96 ( 1h ar , dd , j = 8 . 3 , j = 2 hz ), 7 . 19 to 7 . 24 ( 2h ar , m ), 7 . 73 ( 1h ar , d , j = 1 . 8 hz ), 7 . 92 ( 1h ar , dd , j = 8 . 3 , j = 2 hz ). 13 c [ lacuna ] nmr ( dmso , 250 mhz ): 26 . 26 , 31 . 63 , 31 . 72 , 31 . 75 , 33 . 83 , 34 . 25 , 34 . 96 , 35 . 06 , 49 . 14 , 87 . 01 , 109 . 34 , 123 . 36 , 123 . 74 , 124 . 03 , 126 . 41 , 126 . 52 , 131 . 38 , 136 . 25 , 142 . 39 , 143 . 02 , 144 . 60 , 163 . 59 , 167 . 90 . 7 . 7 ml of a 1m solution of borane in thf are added dropwise at 0 ° c . to a solution of 3 -( 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthyl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - carboxylic acid ( 1 . 7 g , 4 . 7 mol ) in thf ( 10 ml ). the mixture is stirred for 4 hours at ambient temperature and then 2 ml of a solution of thf and water ( 1 : 1 ) are added . after concentration in vacuo at 40 ° c . in a rotary evaporator . the mixture is extracted with ethyl acetate . the organic phase is washed with water , dried over anhydrous magnesium sulphate , concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column . 1 h [ lacuna ] ( cdcl 3 ): 1 . 20 to 1 . 25 ( 12h , m ) 1 . 66 ( 4h , s ), 1 . 72 ( 3h , s ), 3 . 47 ( 1h , s ), 4 . 44 ( 1h , d , j = 8 . 8 hz ), 4 . 59 ( 2h , s ), 4 . 60 ( 1h , d , j = 8 . 8 hz ), 6 . 84 ( 1h ar , d , j = 8 hz ), 7 . 01 ( 1h ar , dd , j = 8 . 3 , j = 2 . 3 hz ), 7 . 05 ( 1h ar , d , j = 1 . 8 hz ), 7 . 17 to 7 . 22 ( 3h ar , m ). 13 c [ lacuna ] ( cdcl 3 ): 25 . 86 , 31 . 39 , 31 . 48 , 31 . 51 , 33 . 55 , 33 . 97 , 34 . 65 , 34 . 75 , 49 . 25 , 65 . 05 , 86 . 02 , 109 . 29 , 123 . 07 , 123 . 45 , 123 . 78 , 126 . 11 , 127 . 26 , 133 . 18 , 135 . 93 , 142 . 38 , 142 . 65 , 144 . 27 , 159 . 00 . a mixture of alcohol obtained above ( 1 g , 2 . 86 mmol ) pyridinium dichromate 2 . 15 g , 5 . 7 mmol ) in dichloromethane is stirred at ambient temperature for 3 h . after filtration and concentration in vacuo at 40 ° c . in a rotary evaporator , the product is purified by flash chromatography on a silica column . 1 h [ lacuna ] ( cdcl 3 ): 1 . 20 to 1 . 26 ( 12h , m ), 1 . 67 ( 4h , s ), 1 . 76 ( 3h , s ), 4 . 57 ( d , 1h , j = 8 . 9 ), 4 . 73 ( d , 1h , j = 8 . 9 ), 6 . 96 ( 1h ar , s ), 7 . 00 ( 1h ar , s ), 7 . 20 to 7 . 25 ( 2h ar , m ), 7 . 59 ( 1h ar , d , j = 1 . 5 hz ), 7 . 74 ( 1h ar , dd , j = 8 . 3 hz , j = 1 . 8 hz ), 9 . 83 ( 1h , s ). 13 c [ lacuna ] ( cdcl 3 ): 26 . 44 , 31 . 77 , 31 . 87 , 31 . 91 , 33 . 99 , 34 . 39 , 34 . 98 , 35 . 09 , 49 . 04 , 87 . 45 , 110 . 26 , 123 . 74 , 124 . 12 , 125 . 52 , 126 . 75 , 130 . 90 , 132 . 95 , 137 . 68 , 141 . 99 , 143 . 48 , 144 . 94 , 155 . 10 , 190 . 67 . 80 % sodium hydride in oil ( 41 mg , 1 . 38 mmol ) is added to a mixture of aldehyde obtained above and triethylphosphonoacetate ( 0 . 27 ml , 1 . 38 mmol ) in thf ( 10 ml ). the mixture is stirred for 4 h at ambient temperature , extracted with ethyl acetate and washed with water . after drying the organic phase is concentrated in vacuo at 40 ° c . in a rotary evaporator , the product is purified by flash chromatography on a silica column . 1 h [ lacuna ] ( cdcl 3 ): 1 . 18 to 1 . 33 ( 15h , m ), 1 . 67 ( 4h , s ), 1 . 73 ( 3h , s ), 4 . 22 ( 2h , q , j = 7 . 1 hz ), 4 . 49 ( 1h , d , j = 8 . 8 hz ), 4 . 63 ( 1h , d , j = 8 . 8 hz ), 6 . 24 ( 1h , d , 15 . 8 hz ), 6 . 87 ( 1h ar , d , j = 8 . 5 hz ), 6 . 99 ( 1h ar , dd , j = 8 . 3 hz , j = 2 . 3 hz ), 7 . 21 to 7 . 24 ( 3h ar , m ), 7 . 36 ( 1h ar , d , j = 8 . 3 hz ), 7 . 62 ( 1h ar , d , j = 15 . 8 hz ). 13 c [ lacuna ] ( cdcl 3 ): 14 . 36 , 26 . 34 , 31 . 79 , 31 . 91 , 33 . 99 , 34 . 40 , 35 . 03 , 35 . 14 , 49 . 47 , 60 . 25 , 86 . 93 , 110 . 23 , 115 . 24 , 123 . 79 , 124 . 21 , 126 . 66 , 127 . 83 , 129 . 67 , 137 . 10 , 142 . 32 , 143 . 32 , 144 . 71 , 144 . 86 , 161 . 79 , 167 . 38 . a mixture of methyl 3 -[ 3 -( 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthyl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - yl ] acrylate ( 330 mg , 0 . 79 mmol ), a 2n methanolic sodium hydroxide solution ( 4 ml , 7 . 9 mmol ) in thf ( 3 ml ) is heated for 5 hours at 60 ° c . the mixture is acidified to ph 1 with a concentrated hydrochloric acid solution , extracted with ethyl acetate and washed with water . after drying the organic phase is concentrated in vacuo at 40 ° c . in a rotary evaporator , the product is purified by flash chromatography on a silica column . yellow solid . mass : 45 mg , yield : 58 %. m . p . 160 ° c . nmr δ ppm : 1 h [ lacuna ] ( cdcl 3 ): 1 . 21 to 1 . 26 ( 12h , m ), 1 . 67 ( 4h , s ), 1 . 74 ( 3h , s ), 4 . 50 ( 2h , q , j = 7 hz ), 4 . 64 ( 1h , d , j = 8 . 8 hz ), 4 . 63 ( 1h , d , j = 8 . 8 hz ), 6 . 27 ( 1h , d , 15 . 8 hz ), 6 . 88 ( 1h ar , d , j = 8 . 5 hz ), 6 . 99 ( 1h ar , d , j = 8 . 3 hz ), 7 . 21 to 7 . 24 ( 3h ar , m ), 7 . 38 ( 1h ar , d , j = 8 . 3 hz ), 7 . 69 ( 1h ar , d , j = 15 . 8 hz ). 13 c [ lacuna ] ( cdcl 3 ): 26 . 35 , 31 . 78 , 31 . 89 , 33 . 96 , 34 . 38 , 35 . 02 , 35 . 11 , 49 . 43 , 86 . 93 , 110 . 27 , 115 . 05 , 123 . 74 , 124 . 06 , 124 . 16 , 126 . 65 , 127 . 68 , 129 . 92 , 137 . 11 , 142 . 26 , 143 . 31 , 144 . 86 , 146 . 24 , 161 . 98 , 172 . 16 . tetrabromomethane ( 1 . 22 g , 3 . 67 mmol ) is added to a mixture of triphenylphosphine ( 1 . 93 g , 7 . 35 mmol ) in dichloromethane ( 10 ml ) at 0 ° c . the mixture is stirred at ambient temperature for 1 h , then a solution of 3 -( 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthyl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - carbaldehyde ( 850 mg , 2 . 45 mmol ) in dichloromethane ( 2 ml ) is added at 0 ° c . the stirring is continued for 2 h at ambient temperature , then the suspension is concentrated in vacuo in a rotary evaporator . the product is purified by chromatography on a silica column . a 1 . 6 m butyllithium solution ( 2 . 35 ml , 3 . 55 mmol ) is added to a solution of 5 -( 2 , 2 - dibromovinyl )- 3 - methyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran ( 860 mg , 1 . 71 mmol ) in thf ( 20 ml ) at - 78 ° c . stirring is continued for 1 h at - 78 ° c . and then carbon dioxide is bubbled in for 15 min . the temperature is allowed to return to ambient temperature . the solution is treated with ethyl acetate and with a solution of ammonium chloride , the organic phase is washed twice with water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the solid obtained is recrystallized in a heptane / ethyl ether mixture . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 22 to 1 . 25 ( 12h , d ) 1 . 66 ( 4h , s ), 1 . 71 ( 3h , s ), 4 . 50 ( 1h , d , j = 8 . 7 hz ), 4 . 67 ( 1h , d , j = 8 . 7 hz ), 6 . 64 ( 1h ar , d , j = 8 . 5 hz ), 6 . 94 ( 1h ar , dd ), 7 . 13 to 7 . 24 ( 3h ar , m ), 7 . 45 ( 1h ar , dd ). a mixture of calcium carbonate ( 100 mg , 1 mmol ), palladium diacetate ( 10 mg , 0 . 05 mmol ), sodium formate ( 68 mg , 1 mmol ), methyl 3 - iodo - 4 -[ 2 -[ 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthyl ]- 1 - propenyloxy benzoate ( 250 mg , 05 mmol ), ( s )-(-)- 2 , 2 &# 39 ;- bis ( diphenylphosphino )- 1 , 1 &# 39 ;- binaphthyl ( 65 mg , 0 . 1 mmol ), and silver zeolite ( aldrich 35 , 860 - 9 ) in acetonitrile ( 7 ml ) is heated at 60 ° c . for 4 d . the reaction mixture is filtered on celite and concentrated in vacuo at 40 ° c . in a rotary evaporator . water and ethyl ether are added . after separation , the organic phase is washed twice with water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column . white solid . mass : 75 mg , yield : 40 %. α d [ chcl 3 ]: + 116 . the remainder of the synthesis is identical to that of the racemic mixture ( example 1 ). the remainder of the synthesis is identical to that of the racemic mixture ( example 1 ). the experimental procedure is analogous to hat followed for example 1c applied to methyl 3 - iodo - 4 - hydroxybenzoate and 5 , 6 , 7 , 8 - tetrahydro - 3 , 5 , 5 , 8 , 8 - pentamethyl - 2 - bromoacetonaphthone . 1 h [ lacuna ] nmr ( cdcl 3 ) d : 1 . 29 ( 6h , s ), 1 . 31 ( 6h , s ), 1 . 70 ( 4h , s ), 2 . 49 ( 3h , s ), 3 . 88 ( 3h , s ), 5 . 30 ( 2h , s ), 7 . 19 ( 1h ar , s ), 7 . 30 ( 1h ar , s ), 7 . 37 ( 1h ar , d , j = 8 hz ), 7 . 63 ( 1h ar , s ), 7 . 87 ( 1h ar , d , j = 8 hz ) the experimental procedure is analogous to that followed for example 1d applied to methyl 3 - iodo - 4 -[ 2 - oxo - 2 -( 3 , 5 , 5 , 8 , 8 - pentamethyl - 5 , 6 , 7 , 8 - tetrahydronapthalen - 2 - yl ) ethoxy ] benzoate . 1 h [ lacuna ] nmr ( cdcl 3 ) d : 1 . 26 ( 6h , s ), 1 . 29 ( 6h , s ) 1 . 67 ( 4h , s ), 2 . 29 ( 3h , s ), 3 . 89 ( 3h , s ), 4 . 75 ( 2h , s ), 5 . 23 ( 1h , d , j = 1 . 6 hz ), 5 . 77 ( 1h , d , j = 1 . 6 hz ), 6 . 79 ( 1h ar , d , j = 8 . 7 hz ), 7 . 09 ( 1h ar , s ), 7 . 13 ( 1h ar , s ), 7 . 98 ( 1h ar , dd , j = 8 . 7 hz , j = 2 . 1 hz ), 8 . 47 ( 1h ar , d , hz ) the experimental procedure is analogous to that followed for example 1e applied to methyl 3 - iodo - 4 -[ 2 -( 3 , 5 , 5 , 8 , 8 - pentamethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl ) allyloxy ] benzoate . 1 h [ lacuna ] nmr ( cdcl 3 ) d : 1 . 24 to 1 . 28 ( 12h , m ), 1 . 67 ( 4h , s ), 1 . 76 ( 3h , s ), 1 . 92 ( 3h , s ), 3 . 85 ( 3h , s ), 4 . 52 ( 1h , d , j = 9 . 1 hz ), 4 . 81 ( 1h , d , j = 9 . 1 hz ), 6 . 85 ( 1h ar , d , j = 8 . 4 hz ), 7 . 01 ( 1h ar , s ), 7 . 32 ( 1h ar , s ), 7 . 65 ( 1h ar , d , j = 1 . 8 hz ), 7 . 92 ( 1h ar , dd , j = 8 . 4 hz , j = 1 . 8 hz ). 13 c [ lacuna ] nmr ( cdcl 3 ) d : 21 . 15 ( ch 3 ), 29 . 52 ( ch 3 ) 31 . 61 ( ch 3 ttnn ), 31 . 71 ( ch 3 ttnn ), 31 . 88 ( cch 3 ttnn ) 31 . 95 ( ch 3 ttnn ), 33 . 72 ( c . ttnn ), 34 . 07 ( c ttnn ), 35 . 14 ( ch 2 ttnn ), 35 . 22 ( ch 2 ttnn ), 49 . 28 ( c ), 51 . 82 ( och 3 ) 85 . 32 ( ch 2 o ), 109 . 30 ( ch ar ), 122 . 78 ( c ar ), 125 . 14 ( ch ar ), 124 . 36 ( ch ar ), 125 . 96 ( ch ar ), 130 . 77 ( ch ar ), 131 . 12 ( ch ar ), 131 . 56 ( c ar ), 133 . 53 ( c ar ), 138 . 60 ( c ar ), 141 . 86 ( c ar ), 143 . 64 ( c ar ), 163 . 67 ( c -- o ar ), 167 . 29 ( coo ). a 1m solution of diisobutylaluminium hydride in toluene ( 5 . 82 ml , 5 . 82 mmol ) is added dropwise at 0 ° c . to a solution of methyl 3 -( 5 , 6 , 7 , 8 - tetrahydro - 3 , 5 , 5 , 8 , 8 - pentamethyl - 2 - naphthyl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - carboxylate ( 1 g , 2 . 55 mmol ) in toluene ( 30 ml ). the solution is stirred for 1 h at 0 ° c ., then treated with a solution of double tartrate of sodium and potassium , filtered on celite and taken up again in a mixture of ethyl ether and water . the organic phase is washed with water , dried over magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . a mixture of alcohol obtained above ( 1 g , 2 . 55 mmol ) pyridinium dichromate ( 2 g , 5 . 3 mmol ) in dichloromethane is stirred at ambient temperature for 4 h . after filtration and concentration in vacuo at 40 ° c . in a rotary evaporator , the product is purified by flash chromatography on a silica column . 1 h [ lacuna ] nmr ( cdcl 3 ) d : 1 . 25 to 1 . 27 ( 12h , m ), 1 . 67 ( 4h , s ), 1 . 78 ( 3h , s ), 1 . 91 ( 3h , s ), 4 . 56 ( 1h , d , j = 9 . 2 hz ), 4 . 85 ( 1h , d , j = 9 . 2 hz ), 6 . 95 ( 1h ar , d , j = 8 . 2 hz ), 7 . 02 ( 1h ar , s ), 7 . 32 ( 1h ar , s ), 7 . 52 ( 1h ar , d , j = 1 . 7 hz ), 7 . 72 ( 1h ar , dd , j = 8 . 7 hz , j = 1 . 7 hz ), 9 . 82 ( 1h , s ). the experimental procedure is analogous to that followed for example 1i applied to 3 -( 5 , 6 , 7 , 8 - tetrahydro - 3 , 5 , 5 , 8 , 8 - pentamethyl - 2 - naphthyl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - carbaldehyde . 1 h [ lacuna ] nmr ( cdcl 3 ) d : 1 . 25 to 1 . 33 ( 15h , m ), 1 . 68 ( 4h , s ), 1 . 76 ( 3h , s ), 1 . 94 ( 3h , s ), 4 . 21 ( 2h , q , j = 7 . 2 hz ), 4 . 49 ( 1h , d , j = 9 . 1 hz ), 4 . 78 ( 1h , d , j = 9 . 1 hz ), 6 . 23 ( 1h , d , j = 16 hz ), 6 . 83 ( 1h ar , d , j = 8 . 3 hz ), 7 . 02 ( 1h ar , s ), 7 . 15 ( 1h ar , s ), 7 . 31 ( 1h ar , d , j = 1 . 8 hz ), 7 . 34 ( 1h ar , d , j = 8 . 3 hz ), 7 . 61 ( 1h , d , j = 16 hz ). a solution of ethyl 3 -[ 3 - methyl - 3 -( 3 , 5 , 5 , 8 , 8 - pentamethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 5 - yl ] acrylate ( 320 mg , 0 . 74 mmol ), water ( 40 μl ) and sodium hydroxide ( 240 mg , 6 mmol ) in thf is heated to reflux for 24 h . the reaction mixture is poured onto an acoet / water mixture , acidified to ph = 1 with a concentrated hydrochloric acid solution , and extracted once with ethyl acetate . after separation the organic phase is washed twice with water , dried over magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . the solid obtained is crystallized in heptane . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 24 to 1 . 27 ( 12h , m ), 1 . 68 ( 4h , s ), 1 . 77 ( 3h , s ), 1 . 95 ( 3h , s ), 4 . 50 ( 1h , d , j = 9 . 1 hz ), 4 . 79 ( 1h , d , j = 9 . 1 hz ), 6 . 22 ( 1h , d , j =-- 5 . 9 hz ), 6 . 85 ( 1h ar , d , j = 8 . 3 hz ), 7 . 03 ( 1h ar , s ), 7 . 17 ( 1h ar , s ), 7 . 31 ( 1h ar , s ), 7 . 37 ( 1h ar , d , j = 8 . 3 hz ), 7 . 70 ( 1h , d , j = 15 . 9 hz ). 13 c [ lacuna ] nmr ( cdcl 3 ): 21 . 1 , 29 . 2 , 31 . 5 , 31 . 7 , 31 . 8 , 31 . 9 , 33 . 6 , 33 . 9 , 35 . 0 , 35 . 1 , 49 . 4 , 84 . 8 , 109 . 8 , 115 . 7 , 123 . 4 , 125 . 0 , 127 . 4 , 129 . 5 , 130 . 6 , 133 . 1 , 137 . 1 , 138 . 7 , 141 . 7 , 143 . 4 , 144 . 5 , 161 . 4 , 168 . 9 , 186 . 4 . the experimenal procedure is analogous to that followed for example 1c applied to methyl 2 - bromo - 1 - naphthalen - 2 - yl - ethanone and 4 - hydroxy - 3 - iodobenzoate . 1 h [ lacuna ] nmr ( cdcl 3 ): 3 . 88 ( 3h , s ), 5 . 51 ( 2h , s ) 6 . 77 ( 1h , d , j = 8 . 7 hz ), 7 . 58 to 8 . 05 ( 8h ar , m ), 8 . 48 ( 1h ar , d , j = 2 . 05 hz ). the experimental procedure is analogous to that followed for example 1d applied to methyl 3 - iodo - 4 -[ 2 -( naphthalen - 2 - yl )- 2 - oxoethoxy ) benzoate . 1 h [ lacuna ] nmr ( cdcl 3 ): 3 . 88 ( 3h , s ), 5 . 12 ( 2h , s ) 5 . 71 ( 1h , s ), 5 . 80 ( 1h , s ), 6 . 92 ( 1h , d , j = 8 . 7 hz ), 7 . 48 to 7 . 52 ( 2h ar , m ), 7 . 63 ( 1h ar , dd , j = 1 . 8 hz , 9 . 7 hz ), 7 . 852 to 7 . 99 ( 3h ar , m ), 8 . 01 (! h ar , dd , j = 8 . 7 hz ), 8 . 48 ( 1h ar , d , j = 2 . 2 hz ). the experimental procedure is analogous to that followed for example 1e applied to methyl 3 - iodo - 4 -[ 2 -( naphthalen - 2 - yl ) allyloxy ] benzoate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 89 ( 3h , s ), 3 . 88 ( 3h , s ) 4 . 62 ( 1h , d , j = 8 . 9 hz ), 4 . 80 ( 1h , d , j = 8 . 9 hz ), 6 . 93 ( 1h , d , j = 8 . 5 hz ), 7 . 34 ( 1h , dd , j = 2 hz , j = 8 . 7 hz ), 7 . 45 to 7 . 49 ( 2h , m ), 7 . 71 to 7 . 73 ( 2h , m ), 7 . 78 to 7 . 82 ( 3h , m ), 7 . 97 ( 1h , dd , j = 1 . 8 hz , j = 8 . 5 hz ). the experimental procedure is analogous to that followed for example 8d applied to methyl 3 - iodo - 4 -[ 2 -( naphthalen - 2 - yl ) allyloxy ] benzoate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 91 ( 3h , s ), 4 . 67 ( 1h , d , j = 9 hz ), 4 . 85 ( 1h , d , j = 9 hz ), 7 . 02 ( 1h , d , j = 8 . 3 hz ), 7 . 36 ( 1h , dd , j = 2 hz , j = 8 . 7 hz ), 7 . 46 to 7 . 50 ( 3h , m ), 7 . 60 ( 1h , d , j = 1 . 7 hz ), 7 . 74 to 7 . 82 ( 4h , m ), 8 . 82 ( 1h , s ). the experimental procedure is analogous to that followed for example 1i applied to 3 - methyl - 3 -( naphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 5 - carbaldehyde . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 28 ( 3h , t , j = 7 hz ), 1 . 88 ( 3h , s ), 4 . 20 ( 2h , q , j = 7 hz ), 4 . 59 ( 1h , d , j = 8 . 9 hz ), 4 . 76 ( 1h , d , j = 8 . 9 hz ), 6 . 23 ( 1h , d , j = 16 hz ), 6 . 92 ( 1h , d , j = 8 . 3 hz ), 7 . 21 ( 1h , d , j = 1 . 7 hz ), 7 . 35 to 7 . 49 ( 4h , m ), 7 . 61 ( 1h , d , j = 15 . 9 hz ), 7 . 74 to 7 . 82 ( 4h , m ). the experimental procedure is analogous to that followed for example 9 applied to ethyl 3 -[ 3 - methyl - 3 -( naphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 5 - yl ] acrylate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 88 ( 3h , s ), 4 . 59 ( 1h , d , j = 8 . 9 hz ), 4 . 76 ( 1h , d , j = 8 . 9 hz ), 6 . 21 ( 1h , d , j = 15 . 9 hz ), 6 . 92 ( 1h , d , j = 8 . 3 hz ), 7 . 22 ( 1h , s ), 7 . 33 to 7 . 93 ( 9h , m ). the experimental procedure is analogous to that followed for example 1c applied to 5 , 6 , 7 , 8 - tetrahydro - 8 , 8 - dimethyl - 2 - bromoacetonaphthone and to methyl 4 - hydroxy - 3 - iodobenzoate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 31 ( 5h , s ), 1 . 66 to 1 . 71 ( 2h , m ), 1 . 79 to 1 . 89 ( 2h , m ), 2 . 82 ( 2h , t , j = 6 . 1 hz ), 3 . 88 ( 3h , s ), 5 . 39 ( 2h , s ), 6 . 71 ( 1h ar , d , j = 8 . 8 hz ), 7 . 16 ( 1h ar , d , j = 8 . 0 hz ), 7 . 69 ( 1h ar , dd , j = 1 . 7 hz , j = 8 . 0 hz ), 7 . 93 ( 1h ar , dd , j = 8 . 8 hz , j = 2 . 0 hz ), 7 . 99 ( 1h ar , d , j = 1 . 7 hz ), 8 . 47 ( 1h ar , d , j = 2 . 0 hz ). the experimental procedure is analogous to that followed for example 1d applied to methyl 4 -[ 2 -( 8 , 8 - dimethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 - oxoethoxy ]- 3 - iodobenzoate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 30 ( 6h , s ), 1 . 65 to 1 . 69 ( 2h , m ), 1 . 77 to 1 . 86 ( 2h , m ), 2 . 77 ( 2h , t , j = 6 . 1 hz ), 3 . 89 ( 3h , s ), 4 . 99 ( 2h , s ), 5 . 55 ( 1h , s ), 5 . 57 ( 1h , s ), 6 . 87 ( 1h ar , d , j = 8 . 6 hz ), 7 . 05 ( 1h ar , d , j = 7 . 9 hz ), 7 . 17 ( 1h ar , dd , j = 7 . 9 hz , j = 1 . 8 hz ), 7 . 40 ( 1h ar , d , j = 1 . 8 hz ), 7 . 99 ( 1h ar , dd , j = 8 . 6 hz , j = 2 . 1 hz ), 8 . 47 ( 1h ar , d , j = 2 . 1 hz ). the experimental procedure is analogous to that followed for example 1e applied to methyl 4 -[ 2 -( 8 , 8 - dimethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl ) allyloxy ]- 3 - iodobenzoate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 22 ( 3h , s ), 1 . 25 ( 3h , s ) 1 . 62 to 1 . 66 ( 2h , m ), 1 . 75 ( 3h , s ), 1 . 77 to 1 . 83 ( 2h , m ), 2 . 73 ( 2h , t , j = 6 . 3 hz ), 3 . 84 ( 3h , 5 ), 4 . 54 ( 1h , d , j = 8 . 8 hz ), 4 . 66 ( 1h , d , j = 8 . 8 hz ), 6 . 89 ( 1h ar , d , j = 8 . 5 hz ), 6 . 9 to 7 . 00 ( 2h ar , m ), 7 . 25 ( 1h ar , d , j = 1 . 8 hz ), 7 . 72 ( 1h ar , d , j = 1 . 8 hz ), 7 . 93 ( 1h ar , dd , j = 8 . 4 , j = 1 . 9 hz ). 13 c [ lacuna ] nmr ( cdcl 3 ) d : 19 . 61 ( ch 2 ), 26 . 41 ( ch 3 ), 30 . 26 ( ch 2 ttnn ), 31 . 84 and 31 . 87 ( ch 3 ttnn ), 34 . 00 ( c ttnn ), 39 . 25 ( ch 2 ttnn ), 49 . 33 ( c ), 57 . 76 ( och 3 ), 87 . 19 ( ch 2 o ), 109 . 62 ( ch ar ), 123 . 20 ( c ar ), 123 . 51 ( ch ar ), 124 . 32 ( ch ar ), 126 . 13 ( ch ar ), 129 . 20 ( ch ar ), 131 . 23 ( ch ar ), 134 . 70 ( c ar ), 136 . 44 ( c ar ), 142 . 92 ( c ar ), 145 . 88 ( c ar ), 163 . 68 ( c -- o ar ), 166 . 89 ( coo ). the experimental procedure is analogous to that followed for example 8d applied to methyl 3 -( 8 , 8 - dimethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - carboxylate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 21 ( 3h , s ), 1 . 26 ( 3h , s ), 1 . 62 to 1 . 67 ( 2h , m ), 1 . 76 ( 3h , s ), 1 . 76 to 1 . 83 ( 2h , m ), 2 . 73 ( 2h , t , j = 6 . 2 hz ), 4 . 58 ( 1h , d , j = 8 . 9 hz ), 4 . 72 ( 1h , d , j = 8 . 9 hz ), 6 . 91 to 7 . 01 ( 3h ar , m ), 7 . 24 ( 1h ar , d , j = 1 . 8 hz ), 7 . 57 ( 1h ar , d , j = 1 . 7 hz ), 7 . 74 ( 1h ar , dd , j = 1 . 8 hz , j = 8 . 3 hz ), 9 . 82 ( 1h , s ). the experimental procedure is analogous to that followed for example 1i applied to 3 -( 8 , 8 - dimethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - carbaldehyde . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 22 to 1 . 33 ( 9h , m ), 1 . 62 to 1 . 67 ( 2h , m ), 1 . 74 ( 3h , s ), 1 . 74 to 1 . 81 ( 2h , m ), 2 . 73 ( 2h , t , j = 6 . 4 hz ), 4 . 21 ( 2h , q , j = 7 . 1 hz ), 4 . 50 ( 1h , d , j = 8 . 7 hz ), 4 . 62 ( 1h , d , j = 8 . 7 hz ), 6 . 23 ( 1h , d , j = 15 . 9 hz ), 6 . 88 ( 1h ar , d , j = 8 . 3 hz ), 6 . 96 to 7 . 01 ( 2h , ar , m ), 7 . 20 ( 1h ar , d , j = 1 . 8 hz ), 7 . 26 ( 1h , s ), 7 . 36 ( 1h ar , dd , j = 1 . 8 hz , j = 8 . 3 hz ), 7 . 61 ( 1h ar , d , j = 15 . 9 hz ). 13 c [ lacuna ] nmr ( cdcl 3 ): 14 . 3 , 19 . 6 , 26 . 3 , 30 . 3 , 31 . 9 , 34 . 0 , 39 . 2 , 49 . 5 , 60 . 3 , 87 . 0 , 110 . 2 , 115 . 2 , 123 . 6 , 124 . 4 , 127 . 9 , 129 . 2 , 129 . 7 , 134 . 8 , 137 . 1 , 142 . 9 , 144 . 7 , 145 . 9 , 161 . 7 , 167 . 4 . the experimental procedure is analogous to that followed for example 9 applied [ lacuna ] ethyl 3 -[ 3 -( 8 , 8 ,- dimethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - yl ] acrylate . 1 h [ lacuna ] nmr ( cdcl 3 ): 0 . 98 ( 3h , s ), 1 . 01 ( 3h , s ) 1 . 38 to 1 . 43 ( 2h , m ), 1 . 51 ( 3h , s ), 1 . 51 to 1 . 57 ( 2h , m ), 2 . 49 ( 2h , t , j = 6 . 1 hz ), 4 . 27 ( 1h , d , j = 8 . 7 hz ), 4 . 38 ( 1h , d , j = 8 . 7 hz ), 5 . 97 ( 1h , d , j = 15 . 9 hz ), 6 . 63 ( 1h ar , d , j = 8 . 3 hz ), 6 . 68 to 6 . 77 ( 2h ar , m ), 6 . 97 ( 1h ar , d , j = 1 . 6 hz ), 7 . 00 ( 1h , s ), 7 . 12 ( 1h , d , j = 1 . 7 hz , j = 8 . 3 hz ), 7 . 33 ( 1h ar , d , j = 15 . 9 hz ). 13 c [ lacuna ] nmr ( cdcl 3 ): 20 . 1 , 26 . 8 , 30 . 1 , 32 . 3 , 34 . 4 , 39 . 7 , 49 . 9 , 87 . 5 , 110 . 8 , 114 . 7 , 124 . 0 , 124 . 5 , 124 . 8 , 127 . 9 , 129 . 7 , 130 . 6 , 135 . 2 , 137 . 7 , 143 . 2 , 146 . 3 , 147 . 5 , 162 . 6 , 173 . 5 . a solution of bromoacetyl bromide ( 24 . 7 g , 0 . 28 mol ) in 200 ml of ch 2 cl 2 is added dropwise to a solution of aluminium chloride ( 51 . 5 g , 0 . 39 mol ) in 100 ml of ch 2 cl 2 at 0 ° c . the mixture is stirred for 1 h at 0 ° c ., then a solution of 5 , 6 , 7 , 8 - tetrahydro - 3 - bromo - 5 , 5 - dimethyl - 2 - acetonaphthone ( 60 g , 0 . 25 mol ) in ch 2 cl 2 ( 100 ml ) is added dropwise . the stirring is continued for 2 h and then the mixture is poured onto water and ice and extracted with ch 2 cl 2 . the organic phase is washed twice with water , dried over magnesium sulphate and concentrated in vacuo in a rotary evaporator . 1 h [ lacuna ] nmr ( cdcl 1 ): 1 . 28 ( 6h , s ), 1 . 63 to 1 . 68 ( 2h , m ), 1 . 76 to 1 . 84 ( 2h , m ), 2 . 73 ( 2h , t , j = 6 hz ), 3 . 88 ( 3h , s ), 5 . 26 ( 2h , s ), 6 . 72 ( 1h ar , d , j = 8 . 6 hz ), 7 . 24 ( 1h ar , s ), 7 . 53 ( 1h ar , s ), 7 . 97 ( 1h ar , dd , j = 2 . 0 hz , j = 8 . 6 hz ), 8 . 44 ( 1h ar , d , j = 2 . 0 hz ). the experimental procedure is analogous to that followed for example 1c applied to 5 , 6 , 7 , 8 - tetrahydro - 3 - bromo - 5 , 5 - dimethyl - 2 - bromoacetonaphthone and to methyl 4 - hydroxy - 3 - iodobenzoate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 28 ( 6h , s ), 1 . 63 to 1 . 68 ( 2h , m ), 1 . 76 to 1 . 84 ( 2h , m ), 2 . 73 ( 2h , t , j = 6 hz ), 3 . 88 ( 3h , s ), 5 . 26 ( 2h , s ), 6 . 72 ( 1h ar , d , j = 8 . 6 hz ), 7 . 24 ( 1h ar , s ), 7 . 53 ( 1h ar , s ), 7 . 97 ( 1h ar , dd , j = 2 . 0 hz , j = 8 . 6 hz ), 8 . 44 ( 1h ar , d , j = 2 . 0 hz ). the experimental procedure is analogous to that followed for example 1d applied to methyl 4 -[ 2 -( 3 - bromo - 5 , 5 - dimethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 - oxoethoxy ]- 3 - iodobenzoate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 28 ( 6h , s ), 1 . 62 to 1 . 66 ( 2h , m ), 1 . 77 to 1 . 81 ( 2h , m ), 2 . 69 ( 2h , t , j = 6 hz ), 3 . 89 ( 3h , s ), 4 . 86 ( 2h , s ), 5 . 28 ( 1h , s ), 5 . 70 ( 1h , s ), 6 . 87 ( 1h ar , d , j = 8 . 7 hz ), 6 . 98 ( 1h ar , s ), 7 . 49 ( 1h ar , s ), 7 . 98 ( 1h ar , dd , j = 2 . 0 hz , j = 8 . 7 hz ), 8 . 45 ( 1h ar , d , j = 2 . 0 hz ). the experimental procedure is analogous to that followed for example 1e applied to methyl 4 -[ 2 -( 3 - bromo - 5 , 5 - dimethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- allyloxy ]- 3 - iodobenzoate doubling the molar equivalents of tributylamine and formic acid . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 18 ( 6h , s ), 1 . 55 to 1 . 59 ( 2h , m ), 1 . 66 ( 3h , s ), 1 . 69 to 1 . 74 ( 2h , m ), 2 . 61 ( 2h , t , j = 6 hz ), 3 . 78 ( 3h , s ), 4 . 44 ( 1h , d , j = 8 . 8 hz ), 4 . 61 ( 1h , d , j = 8 . 8 hz ), 6 . 88 ( 1h ar , d , j = 8 . 4 hz ), 6 . 91 ( 1h ar , s ), 7 . 01 ( 1h ar , dd , j = 2 . 2 hz , j = 8 . 3 hz ), 7 . 23 to 7 . 27 ( 2h ar , m ), 7 . 74 ( 1h ar , d , j = 2 . 2 hz ), 7 . 93 ( 1h ar , dd , j = 8 . 4 , j = 2 . 2 hz ). the experimental procedure is analogous to that followed for example 8d applied to methyl 3 -( 5 , 5 - dimethyl - 5 , 6 , 7 , 8 - tetrahydronapthalen - 2 - yl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - carboxylate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 18 ( 3h , s ), 1 . 19 ( 3h , s ), 1 . 53 to 1 . 58 ( 2h , m ), 1 . 67 ( 3h , s ), 1 . 67 to 1 . 74 ( 2h , m ), 2 . 65 ( 2h , t , j = 6 . 3 hz ), 4 . 48 ( 1h , d , j = 9 hz ), 4 . 66 ( 1h , d , j = 9 hz ), 6 . 76 to 6 . 96 ( 3h , m ), 6 . 18 ( 1h ar , d , j = 8 . 3 hz ), 7 . 51 ( 1h ar , d . j = 1 . 8 hz ), 7 . 65 ( 1h ar , dd , j = 1 . s hz , j = 8 . 3 hz ), 9 . 75 ( 1h , s ). the experimental procedure is analogous to that followed for example 1i applied to 3 -( 5 , 5 - dimethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - carbaldehyde . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 26 to 1 . 33 ( 9h , s ), 1 . 62 to 1 . 66 ( 2h , m ), 1 . 72 ( 3h , s ), 1 . 76 to 1 . 79 ( 2h , m ), 2 . 72 ( 2h , t , j = 6 . 2 hz ), 4 . 22 ( 2h , q , j = 7 hz ), 4 . 48 ( 1h , d , j = 8 . 8 hz ), 4 . 65 ( 1h , d , j = 8 . 8 hz ), 6 . 24 ( 1h , d , j = 15 . 9 hz ), 6 . 72 ( 1h ar , d , j = 8 . 3 hz ), 6 . 85 ( 1h ar , s ), 7 . 01 ( 1h ar , d ), 7 . 20 to 7 . 27 ( 2h ar , m ), 7 . 35 ( 1h , d , j = 8 . 3 hz ), 7 . 61 ( 1h , d , j = 15 . 9 hz ). the experimental procedure is analogous to that followed for example 9 applied to ethyl 3 -[ 3 -( 5 , 5 - dimethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - yl ] acrylate . 1 h [ lacuna ] nmr ( cdcl 3 ): 1 . 26 ( 6h , s ), 1 . 62 to 1 . 66 ( 2h , m ), 1 . 73 ( 3h , s ), 1 . 72 to 1 . 79 ( 2h , m ), 2 . 72 ( 2h , t , j = 6 . 2 hz ), 4 . 49 ( 1h , d , j = 8 . 8 hz ), 4 . 66 ( 1h , d , j = 8 . 8 hz ), 6 . 25 ( 1h , d , j = 15 . 9 hz ), 6 . 88 ( 1h ar , d , j = 8 . 3 hz ), 6 . 94 ( 1h ar , s ), 7 . 02 ( 1h ar , d ), 7 . 25 to 7 . 28 ( 2h ar , m ), 7 . 38 ( 1h , d , j = 8 . 3 hz ), 7 . 71 ( 1h , d , j = 15 . 9 hz ). a 3 . 6 % sodium perchlorate solution is added dropwise to a mixture of 4 - hydroxybenzoic acid ( 2 . 55 g , 18 . 5 mmol ), sodium hydroxide ( 0 . 74 g , 18 . 5 mmol ), sodium iodide ( 2 . 77 g , 18 . 5 mmol ) in methanol ( 50 ml ) at 0 ° c . the mixture is stirred for two hours at 0 ° c . 20 ml of a 10 % sodium thiosulphate solution are added . after stirring , the mixture is acidified to ph 1 with hydrochloric acid . it is extracted with 100 ml of ethyl ether . the organic phase is washed twice with 80 ml of water , dried over magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . 1 h [ lacuna ] nmr ( dmso , 250 mhz ): 7 . 13 ( 1h ar , dd , j = 1 . 08 hz , j = 7 . 55 hz ), 7 . 41 ( 1h ar , d , j = 1 . 08 hz ), 7 . 76 ( 1h ar , d , j = 7 . 55 hz ), 10 . 71 ( 1h , s ), 12 . 96 ( 1h , s ). a solution of 4 - iodo 3 - hydroxybenzoic acid ( 2 . 71 g , 10 mmol ) and sulphuric acid ( 0 . 7 ml ) in methanol ( 17 ml ) is heated to reflux for 6 h . 20 ml of water are added and the mixture is alkalinized to neutrality with sodium bicarbonate . it is extracted with ethyl ether ( 60 ml ). the organic phase is washed with twice 30 ml of water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ethyl acetate 50 %, heptane 50 %). 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 3 . 91 ( 3h , s ), 5 . 70 ( 1h , s ), 7 . 33 ( 1h ar , d , j = 8 . 16 hz ), 7 . 64 ( 1h ar , s ), 7 . 75 ( 1h ar , d , j = 8 . 16 hz ). the experimental procedure is analogous to that followed for example 1c applied to 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - bromoacetonaphthone and to methyl 3 - hydroxy - 4 - iodobenzoate . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 31 ( 6h , s ), 1 . 32 ( 6h , s ), 1 . 71 ( 4h , s ), 3 . 88 ( 3h , s ), 5 . 42 ( 2h , s ), 7 . 35 to 7 . 41 ( 2h ar , m ), 7 . 43 ( 1h ar , d , j = 8 . 25 hz ), 7 . 74 ( 1h ar , dd , j = 8 . 25 , j = 2 . 5 hz ), 7 . 90 ( 1h ar , d , j = 7 . 5 hz ) 7 . 98 ( 1h ar , d , j = 2 . 5 hz ). the experimental procedure is analogous to that followed for example 1d applied to methyl 4 - iodo - 3 -[ 2 - oxo - 2 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl ) ethoxy ] benzoate . the product is purified by flash chromatography on a silica column ( ch 2 cl 2 60 %, heptane 40 %). 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 29 ( 6h , s ), 1 . 30 ( 6h , s ), 1 . 69 ( 4h , s ), 3 . 91 ( 3h , s ), 4 . 98 ( 2h , s ), 5 . 58 ( 2h , s ), 7 . 20 to 7 . 41 ( 4h ar , m ), 7 . 50 ( 1h ar , d , j = 1 . 15 hz ), 7 . 87 ( 1h ar , d , j = 8 . 00 ). 13 c [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 31 . 34 , 31 . 44 , 33 . 71 , 33 . 88 , 34 . 55 , 34 . 69 , 51 . 86 , 70 . 47 , 92 . 84 , 112 . 25 , 113 . 66 , 123 . 01 , 123 . 06 , 123 . 89 , 131 . 08 , 135 . 05 , 139 . 12 , 142 . 01 , 144 . 53 , 156 . 85 , 166 . 05 . the experimental procedure is analogous to that followed for example 1e applied to methyl 4 - iodo - 3 -( 2 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl ) allyloxy ] benzoate . the product is purified by flash chromatography on a silica column ( ch 2 cl 2 60 % heptane 40 %) 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ) 1 . 20 ( 3h , s ), 1 . 22 ( 3h , s ), 1 . 25 ( 6h , s ), 1 . 66 ( 4h , s ), 1 . 73 ( 3h , s ), 3 . 91 ( 3h , s ), 4 . 48 ( 1h , d , j = 8 . 75 hz ), 4 . 62 ( 1h , d , j = 8 . 75 hz ), 7 . 00 ( 1h , dd , j = 2 hz , j = 8 . 25 hz ), 7 . 09 ( 1h ar , d , j = 8 hz ), 7 . 18 to 7 . 24 ( 2 h ar , m ), 7 . 52 ( 1h ar , s ), 7 . 63 ( 1h ar , d , j = 8 . 00 hz ). 13 c [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 26 . 16 , 31 . 77 , 31 . 87 , 33 . 96 , 34 . 37 , 35 . 01 , 35 . 10 , 49 . 79 , 52 . 09 , 86 . 48 , 110 . 82 , 122 . 84 , 123 . 67 , 123 . 93 , 124 . 30 , 126 . 60 , 130 . 56 , 141 . 35 , 142 . 15 , 143 . 32 , 144 . 88 , 159 . 80 , 166 . 97 . the experimental procedure is analogous to that followed for example 8d applied to methyl 3 - methyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 6 - carboxylate . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 20 ( 3h , s ), 1 . 23 ( 3h , s ), 1 . 26 ( 5h , s ), 1 . 66 ( 4h , s ), 1 . 75 ( 37 , s ), 4 . 51 ( 1h , d , j = 8 . 7 hz ), 4 . 66 ( 1h , d , j = 8 . 7 hz ), 7 . 00 ( 1h , dd , j = 2 . 1 hz ), j = 8 . 3 hz ), 7 . 16 to 7 . 25 ( 3h ar , m ), 7 . 36 ( 1h ar , d , j = 1 . 3 hz ), 7 . 44 ( 1h ar , dd , j = 1 . 3 hz , j = 7 . 6 hz ). the experimental procedure is analogous to that followed for example 1i applied to 3 - methyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 6 - carbaldehyde . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 21 ( 3h , s ), 1 . 23 ( 3h , s ), 1 . 26 ( 6h , s ), 1 . 34 ( 3h , t , j = 7 . 1 hz ), 1 . 66 ( 4h , s ), 1 . 73 ( 3h , s ), 4 . 26 ( 2h , t , j = 7 . 1 hz ), 4 . 47 ( 1h , d , j = 8 . 7 hz ), 4 . 61 ( 1h , d , j = 8 . 7 hz ), 6 . 39 ( 1h , d , j = 16 hz ), 6 . 98 to 7 . 06 ( 4h ar , m ), 7 . 19 to 7 . 25 ( 2h ar , m ), 7 . 66 ( 1h , d , j = 16 hz ), 9 . 95 ( 1h , s ). the experimental procedure is analogous to that followed for example 9 applied [ lacuna ] ethyl 3 -[ 3 - methyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 6 - yl ]- acrylate . white solid . mass : 1 . 05 g . yield : 80 %. m . p .= 190 ° c . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 22 ( 3h , s ), 1 . 23 ( 3h , s ), 1 . 26 ( 6h , s ), 1 . 66 ( 4h , s ), 1 . 73 ( 3h , s ), 4 . 48 ( 1h , d , j = 8 . 7 hz ), 4 . 62 ( 1h , d , j = 8 . 7 hz ), 6 . 42 ( 1h , d , j = 16 hz ), 6 . 98 to 7 . 09 ( 4h ar , m ), 7 . 20 to 7 . 25 ( 2h ar , m ), 7 . 78 ( 1h , d , j = 16 hz ). a mixture of palladium diacetate ( 345 mg , 0 . 46 mmol ), tributylvinyltin ( 1 . 3 ml , 4 . 56 mmol ), tributylamine ( 675 μl , 4 . 56 mmol ) and methyl 3 - iodo - 4 -[ 2 -[ 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthyl ]- 1 - propenyloxybenzoate ( 2 . 3 g , 4 . 56 mmol ) in acetonitrile ( 50 ml ) is heated at 70 ° c . for 8 d adding tributylvinyltin ( 0 . 8 ml ) again every 24 h . the reaction mixture is concentrated in vacuo at 40 ° c . in a rotary evaporator and treated with water and ethyl ether . after separation , the organic phase is washed twice with 40 ml of water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ch 2 cl 2 70 % heptane 30 %) 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 22 to 1 . 26 ( 12h , m ) 1 . 69 ( 4h , s ), 2 . 88 ( 2h , d , j = 7 . 3 hz ), 3 . 86 ( 3h , s ), 4 . 63 ( 1h , d , j = 9 hz ), 4 . 69 ( 1h , d , j = 9 hz ), 5 . 03 ( 1h , s ), 5 . 08 ( 1h , d , j = 5 . 4 ), 5 . 58 ( 1h , m ), 6 . 84 to 6 . 90 ( 2h ar , m ), 7 . 20 to 7 . 24 ( 2h ar , m ), 7 . 91 ( 1h ar , d , j = 1 . 9 hz ), 7 . 93 ( 1h ar , dd , j = 1 . 8 hz , j = 8 . 3 hz ). the experimental protocol is analogous to that followed for example 8d applied to methyl 3 -[ 3 - allyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 5 - yl ]- carboxylate . the product is purified by flash chromatography on a silica column ( acoet 10 % heptane 90 %). 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 22 to 1 . 26 ( 12h , m ) 1 . 67 ( 4h , s ), 2 . 88 ( 2h , t , j = 7 . 3 hz ), 4 . 68 ( 1h , d , j = 9 . 1 hz ), 4 . 73 ( 1h , d , j = 9 . 1 hz ), 5 . 04 ( 1h , s ), 5 . 08 ( 1h , s ), 5 . 57 ( 1h , m ), 6 . 93 to 7 . 01 ( 2h ar , m ), 7 . 21 to 7 . 25 ( 2h ar , m ), 7 . 64 ( 1h ar , d , j = 1 . 7 hz ), 7 . 25 ( 1h ar , dd , j = 1 . 8 hz , j = 8 . 3 hz ), 9 . 87 ( 1h , s ). the experimental procedure is analogous to that followed for example 1i applied to 3 -[ 3 - allyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 5 - yl ] carbaldehyde . the product is purified by flash chromatography on a silica column ( acoet 80 % heptane 80 %) 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 18 to 1 . 34 ( 15h , m ), 1 . 67 ( 4h , s ), 2 . 86 ( 2h , t , j = 7 . 6 hz ), 4 . 23 ( 2h , q , j = 7 hz ), 4 . 58 ( 1h , d , j = 9 hz ), 4 . 64 ( 1h , d , j = 9 hz ), 5 . 03 ( 1h , s ), 5 . 08 ( 1h , d , j = 3 hz ), 5 . 80 ( 1h , m ), 6 . 25 ( 1h , d , 15 . 9 hz ), 6 . 85 ( 1h ar , d , j = 8 . 3 hz ), 7 . 00 ( 1h ar , dd , j = 2 hz , j = 8 . 3 hz ), 7 . 21 to 7 . 27 ( 3h ar , m ), 7 . 37 ( 1h ar , dd , j = 1 . 8 hz , j = 8 . 3 hz ), 7 . 67 ( 1h ar , d , j = 15 . 8 hz ). a solution of ethyl 3 -[ 3 - allyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 5 - yl ] acrylate ( 790 mg , 1 . 78 mmol ) and sodium hydroxide ( 720 mg , 17 . 8 mmol ) in thf ( 20 ml ) is heated to reflux for 24 h . the mixture is treated with water and ethyl acetate , and acidified to ph 1 with a concentrated hydrochloric acid solution . after separation , the organic phase is washed twice with water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the solid obtained is washed with heptane . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 23 to 1 . 26 ( 12h , m ) 1 . 67 ( 4h , s ), 2 . 87 ( 2h , t , j = 7 . 6 hz ), 4 . 60 ( 1h , d , j = 9 hz ), 4 . 66 ( 1h , d , j = 9 hz ), 5 . 04 ( 1h , s ), 5 . 08 ( 1h , d , j = 3 hz ), 5 . 58 ( 1h , m ), 6 . 25 ( 1h , d , 15 . 8 hz ), 6 . 87 ( 1h , ar , d , j = 8 . 3 hz ), 7 . 00 ( 1h ar , d , j = 8 . 3 hz ), 7 . 22 to 7 . 29 ( 3h ar , m ), 7 . 40 ( 1h ar , d , j = 8 . 3 hz ), 7 . 73 ( 1h , d , j = 15 . 8 hz ). a 1 . 6m methyllithium solution in ethyl ether ( 3 . 4 ml , 5 . 4 mmol ) is added to a solution of 3 - methyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 5 - carboxylic acid ( example 2 ) ( 900 mg , 4 . 47 mmol ) in thf ( 50 ml ) at - 20 ° c . the mixture is stirred for 4 h at - 20 ° c . and is then poured onto ethyl acetate and a 1n hydrochloric acid solution . the organic phase is washed 2 times with water , dried over anhydrous magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 21 ( 3h , s ), 1 . 24 ( 3h , s ), 1 . 26 ( 6h , s ), 1 . 66 ( 4h , s ), 1 . 75 ( 3h , s ), 2 . 53 ( 3h , s ), 4 . 53 ( 1h , d , j = 8 . 8 hz ), 4 . 68 ( 1h , d , j = 8 . 7 hz ), 6 . 90 ( 1h ar , d , j = 8 . 3 hz ), 6 . 98 ( 1h ar , dd , j = 8 . 3 hz , j = 2 hz ), 7 . 20 to 7 . 25 ( 2h ar , m ), 7 . 69 ( 1h ar , d , j = 1 . 8 hz ), 7 . 86 ( 1h ar , dd , j = 8 . 3 hz , j = 2 hz ). 13 c [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 26 . 5 ,, 31 . 8 , 31 . 9 , 34 . 0 , 35 . 0 , 35 . 1 , 49 . 25 , 87 . 3 , 109 . 6 , 123 . 8 , 124 . 2 , 125 . 0 , 126 . 7 , 130 . 6 , 131 . 2 , 136 . 8 , 142 . 2 , 143 . 4 , 144 . 9 , 163 . 9 , 196 . 7 . a solution of buli in hexane 2 . 5 m ( 1 . 74 [ lacuna ], 4 . 3 mmol ) is added dropwise to a solution of diisopropylamine ( 639 μl , 4 . 6 mmol ) in thf ( 10 ml ) at - 0 ° c . the mixture is stirred for 15 min at - 0 ° c ., then methyl ( trimethylsilyl ) acetate ( 850 μl , 5 . 2 mmol ) is added at - 78 ° c . the mixture is stirred for 15 min at - 78 ° c . and then a solution of 1 -[ 3 - methyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 5 - yl ] ethanone ( 880 mg , 2 . 43 mmol ) in thf ( 5 ml ) is added at - 78 ° c . the reaction mixture is stirred for 1 h at - 78 ° c . and then treated with ethyl acetate and an aqueous ammonium chloride solution . after separation the organic phase is washed twice with water , dried over anhydrous magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( acoet 3 %, heptane 97 %). colourless oil . mass : 460 mg , yield : 44 %. 1 h [ lacuna ] nmr ( dmos , 250 mhz ): 1 . 17 ( 6h , s ), 1 . 20 ( 6h , s ), 1 . 60 ( 4h , s ), 1 . 71 ( 3h , s ), 2 . 49 ( 3h , s ), 3 . 64 ( 3h , s ), 4 . 47 ( 1h , d , j = 8 . 9 hz ), 4 . 63 ( 1h , d , j = 8 . 9 hz ), 6 . 12 ( 1h , s ), 6 . 89 ( 1h ar , d , j = 9 . 2 hz ), 7 . 01 ( 1h ar , dd ), 7 . 20 to 7 . 26 ( 2h ar , m ), 7 . 43 to 7 . 46 ( 2h ar , m ). the ( z ) isomer is separated from the ( e ) isomer during flash chromatography on a silica column ( acoet 3 %, heptane 97 %). 1 h [ lacuna ] nmr ( dmso , 250 mhz ): 1 . 16 ( 3h , s ), 1 . 17 ( 3h , s ), 1 . 20 ( 6h , s ), 1 . 60 ( 4h , s ), 1 . 67 ( 3h , s ), 2 . 14 ( 3h , d , j = 1 . 2 hz ), 3 . 41 ( 3h , s ), 4 . 46 ( 1h , d , j = 8 . 8 hz ), 4 . 59 ( 1h , d , j = 8 . 8 hz ), 5 . 88 ( 1h , d , j = 1 . 2 hz ), 6 . 82 ( 1h ar , d , j = 8 . 1 hz ), 7 . 00 to 7 . 10 ( 3h ar , m ), 7 . 18 ( 1h ar , d , j = 2 . 1 hz ), 7 . 24 ( 1h ar , d , j = 8 . 3 hz ). the experimental procedure is analogous to that followed for example 9 applied to methyl ( e )- 3 -[ 3 - methyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzofuran - 5 - yl ] but - 2 - enoate . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 21 ( 3h , s ), 1 . 24 ( 3h , s ), 1 . 26 ( 6h , s ), 1 . 67 ( 4h , s ), 1 . 74 ( 3h , s ), 2 . 56 ( 3h , d , j = 1 hz ), 4 . 48 ( 1h , d , j = 8 . 7 hz ), 4 . 60 ( 1h , d , j = 8 . 7 hz ), 6 . 10 ( 1h , d , j = 1 hz ), 6 . 87 ( 1h ar , d , j = 8 . 4 hz ), 7 . 00 ( 1h ar , dd , j = 2 . 1 hz , j = 8 . 3 hz ), 7 . 20 to 7 . 22 ( 2h ar , m ), 7 . 39 ( 1h ar , dd , j = 2 hz , j = 7 . 5 hz ). 13 c [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 18 . 0 , 26 . 1 , 31 . 5 , 31 . 5 , 33 . 7 , 34 . 1 , 34 . 7 , 34 . 8 , 49 . 4 , 86 . 6 , 109 . 5 , 113 . 8 , 122 . 3 , 123 . 5 , 124 . 0 , 126 . 4 , 127 . 0 , 134 . 5 , 136 . 2 , 142 . 1 , 143 . 0 , 144 . 6 , 158 . 2 , 160 . 9 , 171 . 7 . a solution of 4 - hydroxy - 3 - nitrobenzoic acid ( 10 g , 54 . 6 mmol ) and concentrated sulphuric acid ( 1 . 8 ml ) in methanol ( 90 ml ) is heated to reflux for 8 h . the reaction mixture is treated with a sodium bicarbonate solution . after extraction with ethyl ether . the organic phase is washed twice with water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . 80 % nah ( 1 . 93 g , 65 . 52 mmol ) is added to a methyl 4 - hydroxy - 3 - nitrobenzoate solution ( 10 . 5 g , 53 . 25 mmol ) in dm - 7 ( 50 ml ) at 0 ° c . stirring is continued for 30 min and then a dimethylthiocarbamoyl chloride solution ( 8 . 56 g , 69 . 2 mmol ) in dmf ( 50 ml ) is added dropwise at 0 ° c . the mixture is stirred for 24 h at ambient temperature and treated with an aqueous nh4cl solution and ethyl ether . the organic phase is washed twice with water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ethyl acetate 30 %, heptane 70 %). methyl 4 - dimethylthiocarbamoyloxy - 3 - nitrobenzoate ( 10 . 6 g , 37 . 3 mmol ) is heated at 180 ° c . for 15 min . a concentrated hydrochloric acid solution is added dropwise at 0 ° c . to a mixture of iron ( 12 . 7 9 ) and methyl 4 - dimethylthiocarbamoyloxy - 3 - nitrobenzoate ( 10 . 6 g , 37 . 3 mmol ) in ethanol at 0 ° c . the reaction mixture is stirred at ambient temperature for 5 h and then treated with a sodium bicarbonate solution . after extraction with dichloromethane , the organic phase is washed twice with water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ethyl acetate 50 %, heptane 50 %). a solution of methyl 3 - amino - 4 - dimethylcarbamoylsulphanylbenzoate ( 5 . 98 g , 23 . 5 mmol ) isopentyl nitrite ( 16 . 2 ml ) in dilodomethane ( 138 ml ) is heated at 70 ° c . for 2 h . the diiodomethane is distilled at 10 - 1 atm . ; then the product is purified by flash chromatography on a silica column ( ch 2 cl 2 90 %, heptane 10 %). a mixture of methyl 4 - dimethylcarbamoylsulphanyl - 3 - iodobenzoate ( 3 . 9 g , 16 . 6 mmol ), potassium carbonate ( 2 g ,) in methanol is stirred for 12 h at ambient temperature . the mixture is treated with a concentrated hydrochloric acid solution qs ph = 1 . after extraction with dichloromethane , the organic phase is washed twice with water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . 75 % nah ( 45 mg , 1 . 4 mmol ) is added to a solution of 2 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl ) acrylic acid ( 300 mg , 1 . 16 mmol ) { synthesis described in wo patent 9206948 } in dmf ( 10 ml ). stirring is continued for 1 h . at ambient temperature , then iodomethane ( 87 ul , 1 . 4 mmol ) is added dropwise . the mixture is stirred for 1 h . at ambient temperature , and treated with water and ethyl ether . the organic phase is washed twice with water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ethyl acetate 20 %, heptane 80 %). 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 28 ( 6h , s ), 1 . 29 ( 6h , s ), 1 . 69 ( 4h , s ), 3 . 82 ( 3h , s ), 5 . 87 ( 1h , d , j = 1 . 3 hz ), 6 . 30 ( 1h , d , j = 1 . 3 hz ), 7 . 21 ( 1h ar , dd , j = 2 hz , j = 8 hz ), 7 . 29 ( 1h ar , d , j = 8 hz ), 7 . 35 ( 1h ar , d , j = 2 hz ). a 1m diisobutylaluminium hydride solution in toluene ( 2 . 78 ml , 2 . 78 mmol ) is added at 78 ° c ., dropwise , to a solution of methyl 2 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl ) acrylate ( 310 mg , 1 . 14 mmol ) in dichloromethane ( 3 ml ). the solution is stirred for 1 h at 0 ° c ., then treated with a solution of double tartrate of sodium [ lacuna ] and filtered through silica . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 28 ( 6h , s ), 1 . 30 ( 6h , s ), 1 . 77 ( 4h , s ), 4 . 53 ( 2h , d , j = 5 . 4 hz ), 5 . 29 ( 1h , s ), 5 . 43 ( 1h , s ), 7 . 21 ( 1h ar , dd , j = 1 . 9 hz , j = 8 . 2 hz ), 7 . 29 ( 1h ar , d , j = 8 . 2 hz ), 7 . 38 ( 1h ar , d , j = 1 . 9 hz ). tetrabromomethane ( 1 . 21 g , 3 . 8 mmol ) is added to a mixture of triphenylphosphine ( 970 mg , 3 . 8 mmol ) in ethyl ether ( 20 ml ). a solution of 2 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl ) prop - 2 - en - 1 - ol ( 300 mg , 1 . 2 mmol ) in ethyl ether ( 2 ml ) is added . stirring is continued for 24 h , then the reaction mixture is treated with water and ethyl acetate . the organic phase is washed with water and then concentrated in vacuo in a rotary evaporator . the oil obtained is taken up in heptane and filtered through silica . the filtrate is concentrated in vacuo in a rotary evaporator . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ); 1 . 28 ( 6h , s ), 1 . 31 ( 6h , s ), 1 . 78 ( 4h , s ), 4 . 37 ( 2h , s ), 5 . 44 ( 1h , s ), 5 . 55 ( 1h , s ), 7 . 23 to 7 . 28 ( 2h ar , m ), 7 . 44 ( 1h ar , s ). 75 % nah ( 115 mg , 3 . 58 mmol ) is added to a solution of methyl 3 - iodo - 4 - mercaptobenzoate ( 531 mg , 3 . 25 mmol ) in dmf ( 20 ml ) at 0 ° c . stirring is continued for 20 min at ambient temperature , then a solution of 6 -( 1 - bromomethylvinyl )- 1 , 1 , 4 , 4 - tetramethyl - 1 , 2 , 3 , 4 - tetrahydronaphthalene ( 1 g , 3 . 25 mmol ) in dmf ( 5 ml ) is added dropwise . the mixture is stirred for 2 h at ambient temperature , and treated with an aqueous hydrochloric acid solution and ethyl ether . the organic phase is washed twice with water , dried over magnesium sulphate , and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ch 2 cl 2 50 % heptane 50 %). white solid . mass : 680 mg , yield : 54 %. m . p .= 142 ° c . 1 h ( lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 28 ( 6h , s ), 1 . 30 ( 6h , s ), 1 . 69 ( 4h , s ), 3 . 89 ( 3h , s ), 4 . 02 ( 2h , s ), 5 . 37 ( 1h , s ), 5 . 51 ( 1h , s ), 7 . 18 ( 1h ar , d , j = 8 . 3 hz ), 7 . 21 to 7 . 31 ( 2h ar , m ), 7 . 39 ( 1h ar , d , j = 1 . 7 hz ), 7 . 91 ( 1h ar , dd , j = 8 . 3 hz , j = 1 . 7 hz ), 8 . 43 ( 1h ar , d , j = 1 . 7 hz ). 13 c [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 32 . 1 , 32 . 2 , 34 . 5 , 34 . 7 , 35 . 3 , 35 . 4 , 38 . 9 , 52 . 6 , 97 . 5 , 115 . 9 , 123 . 6 , 124 . 5 , 126 . 2 , 127 . 0 , 128 . 2 , 129 . 7 , 136 . 8 , 140 . 5 , 141 . 8 , 145 . 3 , 145 . 4 , 148 . 7 , 165 . 8 . a mixture of tributhylamine ( 881 ul , 3 . 7 mmol ), tetrakis ( triphenylphosphine ) palladium ( 367 mg , 0 . 32 mmol ), formic acid ( 63 ul , 1 . 7 mmol ) and methyl 3 - iodo - 4 -[ 2 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl ) allylsulphanyl ] benzoate ( 655 mg , 1 . 7 mmol ) in acetonitrile ( 25 ml ) is heated at 80 ° c . for 4 h . the reaction mixture is concentrated in vacuo at 40 ° c . in a rotary evaporator treated with water and ethyl ether . after separation , the organic phase is washed twice with water , dried over magnesium sulphate , and concentrated in vacuo at ; 40 ° c . in a rotary evaporator . the product is purified by flash chromatography on a silica column ( ch 2 cl 2 50 % heptane 50 %) 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 19 ( 3h , s ), 1 . 23 ( 3h , s ), 1 . 26 ( 6h , s ), 1 . 66 ( 4h , s ), 1 . 76 ( 3h , s ), 3 . 39 ( 1h , d , j = 11 hz ), 3 . 64 ( 1h , d , j = 11 hz ), 3 . 84 ( 3h , s ), 6 . 93 ( 1h ar , dd , j = 2 hz , j = 8 . 4 hz ), 7 . 19 to 7 . 24 ( 2h arm ), 7 . 29 ( 1h ar , d , j = 8 . 1 hz ), 7 . 55 ( 1h ar , d , j = 1 . 6 hz ), 7 . 85 ( 1h ar , dd , j = 1 . 7 , j = 8 . 1 hz ). 13 c [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 26 . 38 , 32 . 3 , 32 . 4 , 34 . 40 , 34 . 8 , 35 . 5 , 35 . 6 , 49 . 7 , 52 . 3 , 55 . 2 , 122 . 4 , 124 . 4 , 125 . 1 , 126 . 6 , 126 . 9 , 127 . 0 , 129 . 7 , 143 . 1 , 143 . 8 , 145 . 1 , 148 . 4 , 148 . 6 , 167 . 4 . a 1m diisobutylaluminium hydride solution in toluene ( 0 . 67 ml , 0 . 67 mmol ) is added at 0 ° c ., dropwise , to a solution of methyl 3 - methyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzo [ b ] thiophene - 5 - carboxylate ( 121 mg , 0 . 31 mmol ) in toluene ( 5 ml ). the solution is stirred for 2 h at 0 ° c ., and then treated with a solution of double tartrate of sodium and potassium filtered and taken up in a mixture of ethyl ether and water . the organic phase is washed with water , dried over magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . a mixture of alcohol obtained above ( 120 mg , 0 . 31 mmol ), manganese ( iv ) oxide ( 270 mg , 3 . 1 mmol ) in dichloromethane ( 5 ml ) is stirred at ambient temperature for 3 h . the manganese oxide is removed by filtration through silica . the product is obtained by concentration in vacuo at 40 ° c . in a rotary evaporator . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 11 ( 3h , s ), 1 . 17 ( 3h , s ), 1 . 20 ( gh , s ), 1 . 60 ( 4h , s ), 1 . 79 ( 3h , s ), 3 . 32 ( 1h , d , j = 11 . 3 hz ), 3 . 63 ( 1h , d , j = 11 . 3 hz ), 6 . 93 ( 1h ar , dd , j = 2 . 2 hz , j = 8 . 2 hz ), 7 . 14 to 7 . 18 ( 2h ar , m . ), 7 . 28 ( 1 - 8 , d , j = 15 hz ), 7 . 31 ( 1h ar , d , j = b hz ), 7 . 59 ( 1h ar , dd , j = 1 . 5 , j = 8 hz ), 9 . 76 ( 1h , s ). the experimental procedure is analogous to that followed for example 1i applied to 3 - methyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzo [ b ] thiophene - 5 - carbaldehyde . the product is purified by filtration on silica ( ch 2 cl 2 ) 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 19 to 1 . 33 ( 15h , m ), 1 . 67 ( 4h , s ), 1 . 74 ( 3h , s ), 3 . 35 ( 1h , d , j = l1 hz ), 3 . 65 ( 1h , d , j = l1 hz ), 4 . 22 ( 2h , q , j = 7 . 1 hz ), 6 . 27 ( 1h , d , j = 15 . 9 hz ), 6 . 99 to 7 . 03 ( 2h ar , m ), 7 . 21 to 7 . 27 ( 3h ar , m ), 7 . 33 ( 1h ar , d , j = 8 . 1 hz ), 7 . 57 ( 1h , dd , j = 1 . 5 , j = 8 hz ). the experimental procedure is analogous to that followed for example 9 applied to ethyl 3 -[ 3 - methyl - 3 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl )- 2 , 3 - dihydrobenzo [ b ] thiophen - 5 - yl ] acrylate . 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 19 ( 3h , s ), 1 . 25 ( 3h , s ), 1 . 27 ( 6h , s ), 1 . 67 ( 4h , s ), 1 . 75 ( 3h , s ), 3 . 35 ( 1h , d , j = 11 . 2 hz ), 3 . 66 ( 1h , d , j = 11 . 2 hz ), 6 . 26 ( 1h , d , j = 15 . 9 hz ), 7 . 00 to 7 . 03 ( 2h ar , m ), 7 . 21 to 7 . 37 ( 4h ar , m ), 7 . 67 ( 1h ar , d , j = 15 . 9 hz ). the experimental procedure is analogous to that followed for example 23j applied to 5 - iodovanilin and to 6 -( 1 - bromomethylvinyl )- 1 , 1 , 4 , 4 - tetramethyl - 1 , 2 , 3 , 4 - tetrahydronaphthalene . the product is purified by flash chromatography on a silica column ( ch 2 cl 2 50 % heptane 50 %). 1 h [ lacuna ] nmr ( cdcl 3 , 250 mhz ): 1 . 28 ( 6h , s ), 1 . 29 ( 6h , s ), 1 . 69 ( 4h , s ), 3 . 91 ( 3h , s ), 4 . 99 ( 2h , s ), 5 . 55 ( 1h , s ), 5 . 59 ( 1h , s ), 7 . 29 ( 2h ar , s ), 7 . 41 to 7 . 45 ( 2h ar , m ), 7 . 84 ( 1h ar , d , j = 1 . 8 hz ), 9 . 83 ( 1h s ). the experimental procedure is analogous to that followed for example 1e applied to 3 - iodo - 5 - methoxy - 4 -[ 2 -( 5 , 5 , 8 , 8 - tetramethyl - 5 , 6 , 7 , 8 - tetrahydronaphthalen - 2 - yl ) allyloxy ] benzaldehyde . the product is purified by flash chromatography on a silica column ( ch 2 cl 2 50 % heptane 50 %). 1 h [ lacuna ] ( cdcl 3 ): 1 . 20 to 1 . 26 ( 12h , m ), 1 . 67 ( 4h , s ), 1 . 77 ( 3h , s ), 3 . 98 ( 3h , s ), 4 . 64 ( 1h , d , j = 8 . 9 hz ), 4 . 77 ( 1h , d , j = 8 . 9 hz ), 6 . 99 ( 1h , dd , j = 2 . 2 hz , j = 8 . 2 hz ), 7 . 20 to 7 . 26 ( 3h ar , m ), 7 . 37 ( 1h ar , d , j = 1 . 3 hz ), 9 . 79 ( 1h , s ). the experimental procedure is analogous to that followed for example 1i applied to 3 -( 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthyl )- 7 - methoxy - 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - carbaldehyde . the product is purified by filtration on silica ( ch 2 cl 2 ). 1 h [ lacuna ] ( cdcl 3 ): 1 . 21 to 1 . 33 ( 15h , m ), 1 . 67 ( 4h , s ), 1 . 73 ( 3h , s ), 3 . 94 ( 3h , s ), 4 . 23 ( 2h , q , j = 7 . 1 hz ), 4 . 55 ( 1h , d , j = 8 . 8 hz ), 4 . 69 ( 1h , d , j = 8 . 8 hz ), 6 . 26 ( 1h , d , 15 . 9 hz ), 6 . 85 ( 1h ar , s ), 6 . 96 to 7 . 02 ( 2h ar , m ), 7 . 20 to 7 . 26 ( 2h ar , m ), 7 . 60 ( 1h ar , d , j = 15 . 9 hz ). the experimental procedure is analogous to that followed for example 9 applied to ethyl 3 -[ 3 -( 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthyl )- 7 - methoxy - 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - yl ] acrylate . the product is purified by crystallization . 1 h [ lacuna ] ( cdcl 3 ): 1 . 21 to 1 . 26 ( 12h , m ), 1 . 67 ( 4h , s ), 1 . 74 ( 3h , s ), 3 . 95 ( 3h , s ), 4 . 57 ( 1h , d , j = 8 . 8 hz ), 4 . 70 ( 1h , d , j = 8 . 8 hz ), 6 . 25 ( 1h , d , 15 . 9 hz ), 6 . 88 ( 1h ar , s ), 6 . 99 to 7 . 03 ( 2h ar , m ), 7 . 21 to 7 . 26 ( 2h ar , m ), 7 . 69 ( 1h ar , d , j = 15 . 9 hz ). a solution of 3 -[ 3 -( 5 , 6 , 7 , 8 - tetrahydro - 5 , 5 , 8 , 8 - tetramethyl - 2 - naphthyl )- 7 - methoxy - 3 - methyl - 2 , 3 - dihydrobenzofuran - 5 - yl ] acrylic acid ( 150 mg , 0 . 357 mmol ), 1 - hydroxybenzotriazole ( 96 mg , 0 . 714 mmol ), 1 , 3 - dicyclohexylcarbodiimide ( 147 mg , 0 . 714 mmol ) and 4 - aminophenol ( 39 mg , 0 . 357 mmol ) in 5 ml of thf and 5 ml of dmf is stirred at ambient temperature for 15 hours . water and ethyl acetate are added . after stirring and separation , the aqueous phase is extracted with ethyl acetate . the organic phases are then combined and washed twice with water , then dried over magnesium sulphate and concentrated in vacuo at 40 ° c . in a rotary evaporator . the product is then purified by flash chromatography on a silica column ( heptane 50 %, ethyl acetate 50 %) 1 h [ lacuna ] ( cdcl 3 ): 1 . 21 to 1 . 25 ( 12h , m ), 1 . 66 ( 4h , s ), 1 . 73 ( 3h , s ), 3 . 92 ( 3h , s ), 4 . 54 ( 1h , d , j = 8 . 8 hz ), 4 . 67 ( 1h , d , j = 8 . 8 hz ), 6 . 34 ( 1h , d , 15 . 4 hz ), 6 . 77 ( 2h ar , d , j = 8 . 7 hz ), 6 . 87 ( 1h ar , s ), 6 . 94 ( 1h ar , s ), 7 . 01 ( 1h ar , d , j = 8 . 2 hz ), 7 . 20 to 7 . 24 ( 2h ar , m ), 7 . 32 to 7 . 36 ( 2h ar , m ), 7 . 63 ( 1h ar , d , j = 15 . 4 hz ). ( a ) the following composition is prepared in the form of a 0 . 8 g tablet ______________________________________compound of example 1 0 . 005 gpregelatinized starch 0 . 265 gmicrocrystalline cellulose 0 . 300 glactose 0 . 200 gmagnesium stearate 0 . 030 g______________________________________ for the treatment of acne , 1 to 3 tablets per day will be administered to an adult individual for 3 to 6 months according to the seriousness of the case treated . ( b ) a drinkable suspension is prepared which is intended to be packaged in 5 ml ampoules ______________________________________compound of example 2 0 . 050 gglycerol 0 . 500 g70 % sorbitol 0 . 500 gsodium saccharinate 0 . 010 gmethyl parahydroxybenzoate 0 . 040 gflavour q . s . purified water q . s . p . 5 ml______________________________________ for the treatment of acne , 1 ampoule per day will be administered to an adult individual for 3 months according to the seriousness of the case treated . ( c ) the following formulation intended to be packaged in gelatin capsules is prepared : ______________________________________compound of example 1 0 . 025 gcorn starch 0 . 060 glactose q . s . 0 . 300 g______________________________________ the gelatin capsules used are composed of gelatin , titanium oxide and a preservative . in the treatment of psoriasis , 1 gelatin capsule per day will be administered to an adult individual for 30 days . ______________________________________compound of example 2 0 . 100 gmixture of emulsive lanolin alcohols , 39 . 900 gwaxes and refined oils , sold by bdfunder the name &# 34 ; eucerine anhydre &# 34 ; methyl parahydroxybenzoate 0 . 075 gpropyl parahydroxybenzoate 0 . 075 gsterile demineralized water q . s . 100 . 000 g______________________________________ this cream will be applied to a psoriatic skin 1 to 2 times per day for 30 days . ( b ) a gel is prepared by carrying out the following formulation : ______________________________________compound of example 1 0 . 050 gerythromycin base 4 . 000 gbutylhydroxytoluene 0 . 050 ghydroxypropylcellulose sold by 2 . 000 ghercules under the name of &# 34 ; klucel hf &# 34 ; ethanol ( 95 °) q . s . 100 . 000 g______________________________________ this gel will be applied to a skin suffering from dermatosis or a skin with acne 1 to 3 times per day for 6 to 12 weeks according to the seriousness of the case treated . ( c ) an antiseborrhoeic lotion is prepared by proceeding with the mixture of the following ingredients : ______________________________________compound of example 2 0 . 030 gpropylene glycol 5 . 000 gbutylhydroxytoluene 0 . 100 gethanol ( 95 °) q . s . 100 . 000 g______________________________________ this lotion will be applied two times per day to a seborrhoeic scalp and a significant improvement is noted within a period of between 2 and 6 weeks . ( d ) a cosmetic composition against the harmful effects of the sun is prepared by proceeding with the mixture of the following ingredients : ______________________________________compound of example 1 1 . 000 gbenzylidene camphor 4 . 900 gfatty acid triglycerides 31 . 000 gglyceryl monostearate 6 . 000 gstearic acid 2 . 000 gcetyl alcohol 1 . 200 glanolin 4 . 000 gpreservatives 0 . 300 gpropylene glycol 2 . 000 gtriethanolamine 0 . 500 gperfume 0 . 400 gdemineralized water q . s . 100 . 000 g______________________________________ this composition will be applied daily , it allows light - induced aging to be combated , ______________________________________compound of example 2 0 . 500 gvitamin d3 0 . 020 gcetyl alcohol 4 . 000 gglyceryl monostearate 2 . 500 gpeg 50 stearate 2 . 500 9shea butter 9 . 200 gpropylene glycol 2 . 000 gmethyl parahydroxybenzoate 0 . 075 gpropyl parahydroxybenzoate 0 . 075 gsterile demineralized water q . s . 100 . 000 g______________________________________ this cream will be applied to a psoriatic skin 1 to 2 times per day for 30 days . ( f ) a topical gel is prepared by proceeding with the mixture of the following ingredients : ______________________________________compound of example 1 0 . 050 gethanol 43 . 000 gα - tocopherol 0 . 050 gcarboxyvinyl polymer sold under the name 0 . 500 g &# 34 ; carbopol 941 &# 34 ; by &# 34 ; goodrich &# 34 ; triethanolamine in 20 % by weight 3 . 800 gaqueous solutionwater 9 . 300 gpropylene glycol qs 100 . 000 g______________________________________ this gel will be applied in the treatment of acne 1 to 3 times per day for 6 to 12 weeks according to the seriousness of the case treated . ( g ) an anti - hair loss hair lotion and lotion for the regrowth of the hair is prepared by proceeding with the mixture of the following ingredients : ______________________________________compound of example 2 0 . 05 gcompound sold under the name &# 34 ; minoxidil &# 34 ; 1 . 00 gpropylene glycol 20 . 00 gethanol 34 . 92 gpolyethylene glycol ( molecular mass = 400 ) 40 . 00 gbutylhydroxyanisole 0 . 01 gbutylhydroxytoluene 0 . 02 gwater qs 100 . 00 g______________________________________ this lotion will be applied 2 times per day for 3 months to a scalp which has undergone a significant loss of hair . ( h ) an anti - acne cream is prepared by proceeding with the mixture of the following ingredients : ______________________________________compound of example 1 0 . 050 gretinoic acid 0 . 010 gmixture of glyceryl stearates and of 15 . 000 gpolyethylene glycol ( 75 mol ) sold underthe name of &# 34 ; gelot 64 &# 34 ; by &# 34 ; gattefosse &# 34 ; kernel oil polyoxyethylenated with 6 mol 8 . 000 gof ethylene oxide sold under the name of &# 34 ; labrafil m2130 cs &# 34 ; by &# 34 ; gattefosse &# 34 ; perhydrosqualene 10 . 000 gpreservatives qspolyethylene glycol ( molecular mass = 400 ) 8 . 000 gdisodium salt of ethylendiaminetetra - 0 . 050 gacetic acidpurified water qs 100 . 000 g______________________________________ this cream will be applied to a skin suffering from dermatitis or a skin with acne 1 to 3 times per day for 6 to 12 weeks . ( i ) an oil - in - water cream is prepared by producing the following formulation : ______________________________________compound of example 1 0 . 020 gbetamethasone 17 - valerate 0 . 050 gs - carboxymethylcysteine 3 . 000 gpolyoxyethylene stearate ( 40 mol of 4 . 000 gethylene oxide ) sold under the name of &# 34 ; myrj 52 &# 34 ; by &# 34 ; atlas &# 34 ; sorbitan monolaurate , polyoxyethylenated 1 . 800 gwith 20 mol of ethylene oxide sold underthe name of &# 34 ; tween 20 &# 34 ; by &# 34 ; atlas &# 34 ; mixture of mono and distearate of 4 . 200 gglycerol sold under the name of &# 34 ; geleol &# 34 ; by &# 34 ; gattefosse &# 34 ; propylene glycol 10 . 000 gbutylhydroxyanisole 0 . 010 gbutylhydroxytoluene 0 . 020 gcetostearyl alcohol 6 . 200 gpreservatives q . s . perhydrosqualene 18 . 000 gmixture of caprylic / capric triglycerides 4 . 000 gsold under the name of &# 34 ; miglyol 812 &# 34 ; by &# 34 ; dynamit nobel &# 34 ; triethanolamine ( 99 % by weight ) 2 . 500 gwater q . s . 100 . 000 g______________________________________ this cream will be applied 2 times per day for 30 days on a skin suffering from dermatitis . ______________________________________lactic acid 5 . 000 gcompound of example 1 0 . 020 gpolyoxyethylene stearate ( 40 mol of 4 . 000 gethylene oxide ) sold under the nameof &# 34 ; myrj 52 &# 34 ; by &# 34 ; atlas &# 34 ; sorbitan monolaurate , polyoxyethylenated 1 . 800 gwith 20 mol of ethylene oxide sold underthe name of &# 34 ; tween 20 &# 34 ; by &# 34 ; atlas &# 34 ; mixture of mono and distearate of glycerol 4 . 200 gsold under the name of &# 34 ; geleol &# 34 ; by &# 34 ; gattefosse &# 34 ; propylene glycol 10 . 000 gbutylhydroxyanisole 0 . 010 gbutylhydroxytoluene 0 . 020 gcetostearyl alcohol 6 . 200 gpreservatives q . s . perhydrosqualene 18 . 000 gmixture of caprylic / capric triglycerides 4 . 000 gsold under the name of &# 34 ; miglyol 812 &# 34 ; by &# 34 ; dynamit nobel &# 34 ; water q . s . 100 . 000 g______________________________________ this cream will be applied 1 time per day , it helps to combat aging whether it is light - induced or chronological .
the present invention provides novel heteroaryl compounds having the general formula : ## str1 ## their pharmaceutical compositions to be used as human and veterinary medicine , particularly in the treatment of dermatological , rheumatic , respiratory , cardiovascular and ophthalmologic conditions , and their use in cosmetic compositions .