various approaches were taken in the pursuit of a stable solution of posaconazole that would be useful as an intravenous formulation of sufficient bioavailability and other pharmaceutically desired characteristics . cyclodextrins , and their derivatives , are known to display the characteristic of enhancing the aqueous solubility of certain compounds , as taught in u . s . pat . no . 5 , 134 , 127 . however , this reference is silent as to whether or not cyclodextrins can enhance the aqueous solubility of posaconazole , or any related azole compounds . example 32 of u . s . pat . no . 7 , 635 , 773 purports to teach the stabilization of posaconazole with sulfobutyl ether - β - cyclodextrin ( sbe 66 - β - cd ) that had undergone single or double treatment with activated carbon . captisol ® is the trade name for a sulfobutyl ether - β - cyclodextrin shown below , and marketed by cydex pharmaceuticals , inc ., lenexa , kans . the chemical structure of captisol ® is as follows : in an effort to evaluate the range of posaconazole solubilities that could be achieved at feasible ph &# 39 ; s , a series of solutions was prepared with a fixed captisol ® concentration . utilizing an acidic solution of 20 % captisol ® ( w / v ), the solubility of posaconazole was increased more than 1000 times and it was determined that a target concentration of 5 mg / ml could be achieved . table 2 displays posaconazole solubilities in 20 % captisol ® solutions at various ph values . posaconazole solubility was also evaluated in acidified solutions with different captisol ® concentrations . as shown in fig1 , posaconazole solubility increases with ph , as well as captisol ® concentration . however , fig1 also shows that at each ph the increase in posaconazole solubility is non - linear with respect to the captisol ®, and at ph 3 . 0 and 4 . 5 , there is a greater than linear increase in posaconzole concentration . therefore , at some ph values , as the captisol ® concentration increases , the ratio of captisol ® to solubilized posaconazole will decrease . based on this solubility effect , a formulation could be developed whereby for the same posaconazole daily dosage , the daily dose of captisol ® could be decreased . for example at a ph of 3 . 1 , the posaconazole solubility in 20 % captisol ® was calculated to be 7 . 8 mg / ml ( see table 2 ), whereas in 40 % captisol ®, the solubility was determined to be 22 . 5 mg / ml . in this case the captisol ® concentration was increased by a factor of 2 whereas , the posaconazole solubility was increased by a factor of 2 . 9 . however , if increasing captisol ® concentration has a greater than linear effect on posaconazole solubility , the opposite effect would also be expected , i . e ., dilution of captisol ® solutions containing posaconazole at or near posaconazole equilibrium solubility should result in precipitation of posaconazole . this effect is of significance in that the preferred delivery of the posaconazole formulation is dilution with either normal saline or 5 % dextrose , followed by infusion . surprisingly however , following dilution of the posaconazole / captisol ® formulation , no precipitation was seen for at least 24 hours . hydrochloric acid was used as an acidifier in the posaconazole formulation . however , several additional acidifiers ( i . e ., citric , sulfuric , maleic , phosphoric , acetic , l - tartaric , d - tartaric , dl - tartaric , methanesulfonic , naphthalenesulfonic , p - toluenesulfonic , lactic , l - lactic , l - ascorbic and malic acid , as well as , glycine hydrochloride ) were also evaluated in regard to posaconzole solubilization . however , at the same ph , no improvement in solubility was seen with these acidifiers . in an effort to explore further improvements to the formulation , the effects of various co - solvents and non - ionic surfactants , on the solubility of posaconazole in a 100 mm captisol ® solution , were examined . the captisol ® solutions were adjusted with hcl to ph 4 . 5 and an appropriate amount of co - solvent was added . an excess amount of posaconazole was added to the ph - adjusted cyclodextrin / co - solvent solution and the solutions were allowed to equilibrate for a period of three days . the contents of the vials were then centrifuged and the supernatant was assayed for posaconazole . table 3 shows the impact of the various co - solvents and several surfactants ( 0 . 1 % 0 . 2 % v / v poloxamer f - 68 , tween 20 or tween 80 ) on the solubility of posaconazole . the surfactants that were tested did not enhance the solubility of posaconazole , and the co - solvents decreased the solubility . the solubilities of posaconazole in each of several modified β and γ - cyclodextrins were evaluated . solubilization of posaconazole was tested with three gamma cyclodextrins ; sbe ( 5 . 2 )- gamma , sbe ( 5 . 2 ) et ( 3 . 9 )- gamma and sbe ( 5 . 2 ) et ( 4 . 9 )- gamma cyclodextrin , ( cydex , inc .). at cyclodextrin concentrations of 100 mm and ph 4 . 5 , the highest posaconazole solubility achieved was 0 . 189 mg / ml , approximately 8 fold less than the 1 . 51 mg / ml achieved with captisole , sbe ( 6 . 5 ) − β cyclodextrin , under similar conditions ( see fig2 ). on the other hand , some changes in β - cyclodextrin substitutions did lead to greater solubilization . utilizing 100 mm cyclodextrin solutions at ph 4 . 5 , solubilization of posaconazole with sbe ( 4 . 6 ) − β , sbe ( 4 . 6 ) − et ( 3 . 5 ) − β and sbe ( 4 . 6 ) − et ( 8 . 5 ) − β cyclodextrins , versus captisol ®, was evaluated . the sbe ( 4 . 6 ) − et ( 3 . 5 ) − β and sbe ( 4 . 6 ) − et ( 8 . 5 ) − β cyclodextrins solubilized 2 . 6 and 6 . 6 fold more posaconazole ( respectively ) than did captisol ® ( see fig2 ). however , the extensive captisol ® safety information outweighed the potential benefits of greater solubilization and , for this reason , formulations with other sulfobutyl ether cyclodextrins were not further developed . finally , stability screening studies also showed that captisol ® formulations of posaconazole undergo color changes under accelerated conditions . solutions of 10 mg / ml posaconazole , in 40 % captisol ® at ph 3 . 0 , were prepared , both with and without 1 mg / ml edta , and with and without nitrogen overlay . after 20 days at 40 ° c ., the solutions were evaluated for color changes with a colorimeter , whereby color formation is indicated by a “ b *” value ( solutions with a b * value of 3 or greater appear yellow ). as shown in table 4 , the development of color was minimized by both edta and nitrogen overlay . however , in the solution containing edta , no additional improvement was seen by inclusion of a nitrogen overlay . based on these studies , as well as further formulation screening , edta is used in the current formulation at level of 0 . 2 mg / ml , which is suitable for parenteral delivery . in addition , although posaconazole is stable in acidified captisol ® solutions under room temperature and accelerated conditions , as described below , a storage temperature of 5 ° c . is suggested in order to further minimize development of yellow color . a set of studies was conducted to explore the stability of posaconazole solutions of varied composition and ph . the accelerated stability of 10 mg / ml posaconazole in a 200 mm captisol ® solution at ph 3 . 0 was examined over a period of three months . posaconazole was added to a ph - adjusted solution of 200 mm captisol ® and mixed for 24 hours . the solution was then filtered and placed on stability at 4 ° c ., 25 ° c ./ 60 % rh , and 40 ° c ./ 75 % rh . the sample did not contain a chelating agent and was not sparged with nitrogen . results are shown in fig3 . the temperature had minimal impact on the degradation of posaconazole over the three month time period . however , the solution became pale yellow within two weeks and grew darker with time . thus , it was concluded that the chelating agent is important to obtain compositions according to the present invention . a similar time study of the stability of posaconazole ( 5 mg / ml ) in 100 mm captisol ® solution at ph 3 . 0 was conducted over a period of three months . posaconazole was added to a ph - adjusted solution of 100 mm captisol ® and mixed for 24 hours . the solution was then filtered and placed on stability at 4 ° c ., 25 ° c ./ 60 % rh , and 40 ° c ./ 75 % rh . the sample did not contain a chelating agent and was not sparged with nitrogen . results are shown in fig4 . the temperature had minimal impact on the degradation of posaconazole over the three month time period . however , the solution became pale yellow within two weeks and grew darker with time . a study of the stability of posaconazole ( 18 mg / ml ) in 400 mg / ml captisol ® solution at ph 3 . 0 was also conducted over a period of nine months . the sample was manufactured using the most current clinical manufacturing process . edta was dissolved in water for injection . captisol ® was then dissolved in the edta solution and the solution was then acidified with hcl . posaconazole was then added and dissolved . additional hcl was added to the solution , as necessary to adjust the ph . the solution was also sparged with nitrogen during the entire process . the prepared solution was then aspetically filtered , filled into vials , and placed on stability under different storage conditions . as shown in fig5 , the temperature had minimal impact on the degradation of posaconazole over the nine month time period . several prototype formulations , based on either solutol hs 15 ( macrogol ® 15 hydroxysterate ph . eur .) or cyclodextrins , were also evaluated . these formulations were found to have sufficient physical and chemical stability to support further development but , as described below , toxicological testing showed unexpectedly superior results for the 40 % captisol ® formulation . six prototype formulations , reflected in tables 5 and 6 , were prepared . table 5 displays the composition of three solutol ® based formulations ( nos . 1 - 3 ) and table 6 displays the compositions of another three cyclodextrin based formulations ( nos . 4 - 6 ). these six formulations were the subject of a toxicological screening study using the suspension formula as a control . the formulations were dosed to rats via intravenous infusion for 15 min . over a period of 2 weeks . the posaconazole dose for all animals was 10 mg / kg . in addition , the hemolytic potential of each formula was tested in vitro prior to dosing . the 30 % solutol formulation that was directly injected ( formula no . 1 ) produced hemolysis in the in vitro screening and showed severe local intolerance . and in vivo hemolysis was indicated . this study was stopped before completion and the animals were sacrificed . the 30 % solutol formulation that was diluted 1 : 5 before infusion ( formula no . 2 ) produced hemolysis in vitro , similar to that produced by formula no . 1 . based on this result , animals were not dosed . the 75 % solutol formulation that was diluted 1 : 5 before infusion ( formula no . 3 ) showed some evidence of hemolysis in vitro ( time dependent ). in addition , clinical signs of local intolerance were seen in some animals . similar results were seen for both the 20 % hpβcd formulation , diluted 1 : 5 before infusion ( formula no . 4 ), and the 20 % captisol ® formulation , diluted 1 : 2 . 5 before infusion ( formula no . 5 ). for both formulations , the in vitro hemolysis testing showed no hemolysis but , slight effects on rat kidney tubule cells were seen . in addition , animal studies have suggested that hpβcd sterile dosage forms have significant toxicological potential . the 40 % captisol ® formulation ( formula no . 6 ) was diluted 1 : 10 before infusion . this formulation did not produce hemolysis in vitro and showed no clinical signs of toxicity or effects on clinical pathology parameters . thus , only the 40 % captisol ® formulation had no toxicological findings and , interestingly , this formulation was also superior to the 20 % captisol ® formulation . the reason for this difference is assumed to be that , for an equivalent posaconazole dose , the 20 % formulation requires twice as much captisol ® as that of the 40 % formulation . the final formulation , based on the 40 % captisol ® solution , included modifications to ensure posaconazole solubilization over any potential variability in the formulation . for example , both a target ph and an acceptable ph range are required for manufacturing , and the formulation must be stable over the entire specified range . in order to meet these criteria , the concentration of posaconazole was reduced slightly , from 20 mg / ml to 18 mg / ml , and the ph was reduced from 3 . 0 to 2 . 6 . the clinical composition of intravenous posaconazole solution formulation is shown in table 7 . a dilution study was conducted in order to evaluate the likelihood of precipitation during dilution prior to administration to a patient . a ten percent excess of the required amount posaconazole was weighed into an amber vial . captisol ® solution adjusted to the target ph using hcl was added to the vial . the vial was capped and gently mixed at room temperature for 24 hours . after 24 hours , the test vials were filtered through 0 . 22 micron millipore pvdf millex - gv ® filter . a portion of the filtered sample ( 10 ml ) was added to a 100 ml volumetric flask . the sample was diluted to the 100 ml mark with either 0 . 9 % sodium chloride injection usp ( normal saline ) or 5 % dextrose injection usp (“ d5w ”). samples were observed for 24 hours at 4 ° c . and ambient temperature . the results of using normal saline and d5w as diluents are summarized in tables 8 and 9 . solid precipitate was visually observed in the following formulations of posaconazole 24 hours after dilution with normal saline : 20 mg / ml posaconazole in 200 mm captisol ® at ph 3 , 3 mg / ml posaconazole in 100 mm captisol ® at ph 4 , and 5 mg / ml posaconazole in 150 mm or 200 mm captisol ® at ph 4 . all of the other diluted samples were clear after 24 hours . solid precipitate was visually observed in the following formulations of posaconazole 24 hours after dilution with d5w : 5 mg / ml posaconazole at ph 3 , 10 mg / ml posaconazole at ph 3 , 20 mg / ml posaconazole in 200 mm captisol ® at ph 3 , 3 mg / ml posaconazole in 100 or 200 mm captisol ® at ph 4 , and 5 mg / ml posaconazole in 150 mm captisol ® at ph 4 . all of the other diluted samples were clear after 24 hours . this experiment indicates that it is possible to prepare posaconazole formulations that will not precipitate out when diluted for delivery to the patient . in order to further evaluate the potential for precipitation during infusion of the diluted solution into a vein , a dynamic precipitation study was performed by using a yalkowsky et al . method ( j . l . h . johnson , y . he , s . h . yalkowsky , validation of an in vitro model for prediction of in vivo phlebitis , aaps , 2002 , poster # 14919 ) with small modifications . the flow rate of isotonic sorenson &# 39 ; s phosphate buffer ( ispb ) was 5 ml / min which is comparable to that of human blood flow in readily accessible veins . a peristaltic pump ( master flex ® model 7518 - 10 ) provided flow of an aqueous phase at a rate of 5 ml / min through flexible tubing ( cole - parmer &# 39 ; s l / s 14 silicone ( platinum ) which has an internal diameter of 1 . 6 mm ), then through a uv flow - cell . the aqueous phase served as a blood surrogate and consisted of isotonic sorenson &# 39 ; s phosphate buffer ( ispb ) at ph 7 . 4 . the sample solution was injected into the tubing through a needle inserted 30 cm upstream of the flow cell . a syringe pump was used to control the rate of sample injection . the injection rate varied from 0 . 05 to 10 ml / min . the appearance of a precipitate was detected by beckman du - 7 spectrophotometer at 540 nm . this study was conducted at room temperature . the filtered test sample was diluted 1 : 10 with normal saline or d5w before injection . results of the dynamic precipitation study for samples injected at 1 . 0 ml / min are illustrated in table 10 . the results of dynamic precipitation study suggest that various formulations can be prepared and diluted without resulting in precipitation . less precipitation was also seen in samples injected at rates less than 1 . 0 ml / min . filter an appropriate volume of edta + sbe - β - cyclodextrin solution through a clarifying filter into the main compounding vessel . the total filtered volume of edta + sbe - β - cyclodextrin solution is dependent on the mixing efficiencies of the equipment used during compounding . add 1n hcl to vessel in order to acidify the filtered solution . add posaconazole into the filtered solution . when compounding with equipment that provides sufficient agitation , posaconazole may be charged as a powder . when compounding with equipment that provides limited agitation pre - wet the posaconazole in wfi in a separate vessel using a ratio of one part posaconazole to five parts water ( 1 : 5 ratio ) and mix until a homogeneous suspension is formed . add pre - wetted posaconazole suspension to main vessel and mix until dissolved . add any additional 1n hcl or 1n naoh in order to adjust the ph to the appropriate level . q . s . ad water for injection to obtain the final batch volume and mix to obtain a homogenous solution . aseptic filter pharmaceutical composition through a 0 . 22 μm filter . package filtered product into 6rdin glass vials . stopper and crimp cap . during the development of the manufacturing method , different manufacturing procedures were evaluated including optimizing the posaconazole : wfi ratio , changing the order of excipient addition , and charging the powder excipients concurrently . based on the development studies , the above detailed manufacturing method provides the optimal manufacturing process for the solution . a three vessel manufacturing process was used for the 200 l commercial - scale batches . to ensure adequate mixing , overhead mixers were utilized to help dissolve the captisol and posaconazole . nitrogen sparging was utilized during the compounding process . fig6 displays the process flow diagram for the commercial scale developmental batches , which process is summarized as follows : the edta and captisol are dissolved in nitrogen - sparged water for injection ( wfi ) in the first vessel . the edta + captisol solution is then filtered through a 0 . 22 μm clarifying membrane filter into the drug product compounding vessel . in the drug product compounding vessel , the filtered edta + captisol solution is acidified with hydrochloric acid , and the api is charged into the acidified solution . the solution is mixed until the api dissolves . the ph is then adjusted to 2 . 6 using hydrochloric acid and / or sodium hydroxide as necessary , and the product is brought to final volume . the drug product is then filtered through a 0 . 22 μm bioburden reducing membrane filter into a receiving vessel . from the receiving vessel , the solution is sterilized through an in - line 0 . 22 μm sterilizing filter and aseptically filled and stoppered into sterile , depyrogenated glass vials in a grade a filling area . the diluted intravenous solution ( admixture ) for infusion can be prepared according to the following procedure : the following concentrations and dose ranges bracket the lower and upper levels of the rising single dose study defined in the clinical protocol . allow the posaconazole injectable solution , 18 mg / ml drug product to equilibrate to room temperature . gently invert the drug product vial ten times . remove an appropriate volume of diluent ( 0 . 9 % nacl or 5 % dextrose ) from admixture bag so that 142 ml of diluent remains in the bag . withdraw 8 . 4 ml of posaconazole injectable solution , 18 mg / ml with an appropriately sized syringe and inject the entire amount of drug product into the iv bag . mix the contents of the bag with ten gentle inversions . allow the posaconazole injectable solution , 18 mg / ml drug product to equilibrate to room temperature . gently invert the drug product vial ten times . remove an appropriate volume of diluent ( 0 . 9 % nacl or 5 % dextrose ) from admixture bag so that 125 ml of diluent remains in the bag . withdraw 25 ml of posaconazole injectable solution , 18 mg / ml with an appropriately sized syringe and inject the entire amount of drug product into the iv bag . mix the contents of the bag with ten gentle inversions . a phase 1 , single - site , randomized , evaluator - blind ( within dose level ) placebo - controlled , single - dose study was conducted to evaluate the pharmacokinetics , safety and tolerability of posaconazole intravenous solution when administered as single dose and as multiple doses . the first group , received a single dose of posaconazole 200 mg . posaconazole intravenous was admixed in 150 ml of 5 % dextrose to provide a final concentration of approximately 1 . 33 mg / ml of posaconazole in solution for the 200 mg dose , and was infused in a peripheral vein in the arm over 90 minutes . although central line administration is generally recommended to infuse low ph formulations , the lack of signal in nonclinical toxicology studies supported the use of posaconazole intravenous solution administered via peripheral lines in this study . a cohort of 12 subjects ( 9 active and 3 dextrose placebo ) received a single infusion of posaconazole intravenous solution on day 1 . six out of 9 subjects experienced post - infusion local reactions , manifested as erythema , induration and tenderness . one subject had extravasation and resulting arm swelling . the events were reported between 4 and 24 hours post - infusate . local intolerability is likely due to the irritation caused by the low ph of the infusate , administered slowly via peripheral lines . the local intolerability observed prompted the discontinuation of this trial in healthy volunteers that received posaconazole intravenous via peripheral infusion . alternative infusion strategies ( rapid or slow infusion via peripheral lines ) will be explored in healthy volunteers . formulations with low ph are better tolerated if infused via central lines . therefore , a strategy was designed to continue the program in patients with central lines . the pharmacokinetic profile of posaconazole intravenous was typical of an intravenous drug ( see fig7 ) with low variability . median t max was 1 hour , mean c max 1470 ng / ml , mean auc ( 0 - 24 ) 13 , 500 hr · ng / ml , ( estimated c avg 563 ng / ml ) and variability for all parameters around 25 % or less . table 11 displays mean ( cv %) posaconazole plasma pharmacokinetic parameters of posaconazole following single dose , 200 mg intravenous solution of posaconazole to healthy adult volunteers ( all subjects included ). c max and t max were observed pharmacokinetic parameters . individual plasma concentration data were used to estimate the following pharmacokinetics parameters : auc ( tf ), auc ( i ), t 1 / 2 , vd / f , and c avg . the terminal phase rate constant ( k ) was calculated as the negative of the slope of the log - linear terminal portion of the plasma concentration - time curve using linear regression . the t 1 / 2 was calculated as : t 1 / 2 = ln ( 2 )/ k . the auc ( tf ) was calculated using the linear trapezoidal method and extrapolated to infinity , auc ( i ), as follows : auc ( i )= auc ( tf )/ cest tf / k , where cest tf is the estimated concentration at the time of the last measurable sample , determined from the linear regression of the terminal portion . as shown in table 11 , the c avg range following 200 mg single dose is anticipated to be about 900 to about 1900 ng / ml that meets the target c avg targeted for bridging with posaconazole oral suspension . therefore , the likely dose is 200 mg qd , provided patient pharmacokinetic data are no different than the healthy volunteer data and no non - linearity is observed upon the multiple dosing . fig8 displays a summary of observed posaconazole steady - state exposures and the projected exposure distribution for the posaconazole intravenous solution . each box represents 25th to 75th percentiles , the line inside the box represents median value , whiskers represent 10th and 90th percentile , and points beyond whiskers represent outlier values ; outliers not shown for projected exposure distribution . thus , in some embodiments of the invention , the composition is one that delivers 200 mg of posaconazole to a patient , wherein administration of such a dose results in a c max of about 1470 ng / ml and an auc last of about 27 , 000 hr * ng / ml . bioequivalent doses and formulations are within the scope of the invention . for systemically absorbed drugs , bioavailability is commonly defined as displaying relevant pharmacokinetic parameters ( e . g ., c max and auc ) of between 80 % and 125 % of the reference drug . thus , in some embodiments of the invention , the composition is one that delivers 200 mg of posaconazole to a patient , wherein administration of such a dose results in a c max of between about 1176 and about 18375 ng / ml , and an auc last of between about 21 , 600 and about 33 , 750 hr * ng / ml . the present invention encompasses methods of prevention and treatment of a variety of infection caused by a broad spectrum of infectious agents . the term “ infection ” is understood to include , but not be limited to , those disease state caused by molds , yeasts , and other infectious agents such as : candida , dermatophytes , dimorphics , dematiaceous , ( e . g ., alternaria and bipoiaris ), aspergillus , acremonium , basidiomycetes , bjerkandera , coprinus , paecilomyces , microsporum , trichophyton , pseudallescheria , schizophyllum , crytococcus , histoplasma , blastomyces , coccidioides , fusarium , exophiala , zygomycocetes ( e . g ., absidia , mucor , rhizopus , and rhizomucor ), kluyveromyces , saccharomyces , yarrowia , pichia , epidermophyton , paracoccidioides , scedosporium , apophysomyces , curvularia , penicillium , fonsecaea , wangiella , sporothrix , pneumocystis , trichosporon , cladophialophora , ramichloridium , syncephalastrum , madurella , scytalidium , or protozoa such as leshmania , trichomononas and trypanosoma . the present invention is intended to treat both opportunistic and non - opportunistic infections , where the term “ opportunistic ” as used herein denotes those infections caused by organisms capable of causing a disease only in a host whose resistance is lowered , e . g ., by chemotherapy or hiv . posaconazole can be used to treat the progression of invasive fungal infections including prophylaxis , empiric , pre - emptive , primary , and refractory treatments . in particular , posaconazole is useful in the prevention and / or treatment of the following disease states : initial ( first line ) treatment of oropharyngeal or esophageal candidiasis ; salvage therapy of azole - refractory oropharyngeal and esophageal candidiasis ( e . g . in patients who have failed oral fluconazole and / or intraconazole ); initial treatment of invasive aspergillosis , candidiasis , fusariosis , scedosporiosis , infections due to dimorphic fungi ( e . g ., cryptococcosis , coccidioidomycosis , paracoccidioidomycosis , histoplasmosis , blastomycosis ), zygomycosis , and invasive infections due to rare molds and yeasts ; salvage therapy for invasive mycoses in patients who are refractory to or intolerant of other therapies ( e . g ., amphotericin b , lipid formulations of amphotericin b , fluconazole , caspofungin , micafungin , anidulafungin , voriconazole and / or intraconazole ); prevention of invasive candidiasis , invasive mold infections ( including zygomycosis and aspergillosis ) in patients at high risk , including patients who have undergone intensive chemotherapy and / or radiation therapy for hematologic malignancies , bone marrow or peripheral stem cell transplant conditioning regimens , and patients receiving combination immunosuppressive therapy for the treatment of acute or chronic graft - versus - host disease or prevention of solid organ transplantation ; chagas disease ( trypanosomiasis due to t . cruzi ) including acute and chronic forms ; and leishmaniasis , including visceral and localized forms . in some embodiments , the invention encompasses a method of treating or preventing an infection in an animal in need thereof which comprises administering to said animal an effective amount of the formulation . in some embodiments , the animal is a mammal , a bird , a fish , or a reptile . in some embodiments , the animal is a mammal , including , but not limited to a human . in some embodiments , the infection is caused by a fungus or parasite . in some embodiments , the invention encompasses a method wherein said formulation is administered intravenously . immuno - suppressant therapy ( e . g . chemotherapy , radiation therapy , myeloablative conditioning regimens ) often results in one of more of the above - referenced infections . the present invention encompasses the administration of a posaconazole formulation adjunctive to immuno - suppressant therapy , wherein the posaconazole formulation functions prophylactically with regard to opportunistic infections including the above - referenced disease states . the present invention encompasses a variety of modes of administration to any part , organ , interstice of cavity of an animal &# 39 ; s body that is subject to and infection . a non - limiting set of examples of modes by which the posaconazole formulations of the present invention may be administered includes : intravenously , intramuscularly , via inhalation , or intravascularly . co - formulation or co - administrations comprising combinations of posaconazole and at least one other active ingredient are also within the scope of the present invention . non - limiting examples of such active ingredients include : antifungals such as echinocandins ( including caspofungin , micafungin , and anidulafungin ) and azoles ; amphotericin b ; deoxycholate amphotericin b ; flucytosine ; and terbinafine . also within the scope of this invention are combinations with an antibacterial , antiviral , steroid , or nonsteroidal anti - inflammatory drugs (“ nsaids ”), chemotherapeutics , and / or anti - emitics . similarly , co - administration of posaconazole with at least one of the above active ingredients , aside from within a single formulation , is also within the scope of the present invention . in certain embodiments , the pharmaceutical compositions described herein may be administered to a patient in need thereof at a dose of 100 mg to 400 mg every 12 to 24 hours . in certain such embodiments , a dose may comprise at least one intravenous dosage form . in certain embodiments , the pharmaceutical compositions described herein may be administered to a patient in need thereof at a dose of 100 mg to 400 mg every 12 to 24 hours . in some preferred embodiments , the composition is administered in an amount sufficient to deliver a dose of between about 180 and about 220 mg posaconazole to the patient . in some more preferred embodiments , this dose is about 200 mg posaconazole . the administration may occur once per day or twice per day . the pharmaceutical compositions of the present invention are administered to a patient according to a dosing regimen . it should be understood that the specific dosing regimen for any particular patient will depend on a variety of factors , including species , age , body weight , body surface area , height , general health , sex , diet , time of administration , rate of excretion , drug combination , specific disease being treated , the severity of the condition , the renal and hepatic function of the patient , the particular active ingredient employed , and the judgment of the treating physician . other features and embodiments of the invention will become apparent by the following examples which are given for illustration of the invention rather than limiting its intended scope . unless defined otherwise , all technical and scientific terms used herein have the same meaning as those commonly understood by one of ordinary skill in the art to which this invention belongs . although methods and materials similar or equivalent to those described herein can be used tin the practice or testing of the present invention , suitable methods and materials are described below . the materials , methods and examples are illustrative only , and are not intended to be limiting . all publications , patents and other documents mentioned herein are incorporated by reference in their entirety . as used herein , the phrase “ small - volume parenteral unit ” refers to a single - dose or multiple - dose small - volume injection labeled as , or actually containing 100 ml or less . as used herein , the term “ injectable ” means adapted to parenteral administration . as used herein , the term “ fungus ” includes but is not limited to one of the diverse morphologic forms of yeasts and molds . fungi include organisms in the following groups or genera : candida , dermatophytes , dimorphics , dematiaceous , ( e . g ., alternaria and bipolar &# 39 ; s ), aspergillus , acremonium , basidiomycetes , bjerkandera , coprinus , paecilomyces , microsporum , trichophyton , pseudallescheria , schizophyllum , crytococcus , histoplasma , blastomyces , coccidioides , fusarium , exophiala , zygomycocetes ( e . g ., absidia , mucor , rhizopus , and rhizomucor ), kluyveromyces , saccharomyces , yarrowia , pichia , epidermophyton , paracoccidioides , scedosporium , apophysomyces , curvularia , penicillium , fonsecaea , wangiella , sporothrix , pneumocystis , trichosporon , cladophialophora , ramichloridium , syncephalastrum , madurella , scytalidium , or protozoa such as leshmania , trichomononas and trypanosome . as used herein , the term “ dematiaceous ” means dark - walled conidia and / or hyphae , and includes as non - limiting examples : alternaria , and bipolaris . phaeohyphomycosis is an example of a dematiaceous fungal infection . as used herein , the term “ parasite ” means an organism that lives on or in another and draws its nourishment from them . parasites include leishmania , trypanosoma , and trichomonas , among others . as used herein , the term “ auc ” is the area under the plasma concentration - time curve from time zero to a certain time period of the sample . for example , auc ( 4 h ) means the area under the plasma concentration - time curve from time zero to 4 hours . the term “ patient ” refers to an animal including a mammal ( e . g . human ). the term “ pharmaceutically acceptable excipient ” refers to a non - toxic excipient that may be administered to a patient , together with the weakly basic and poorly - aqueous soluble azoles as describe herein , which does not destroy the pharmacological activity thereof . the term “ treating ” or “ treatment ” is intended to mean prophylactic use to prevent disease or mitigating or alleviating the symptoms of the recited condition , disease or disorder in a mammal such as a human . the term “ pharmacokinetics ” refers to the process by which a drug is absorbed , distributed , metabolized and eliminated by the body . pharmacokinetic parameters include , but are not limited to “ maximum plasma concentration ” or “ c max ”, “ area under the plasma concentration time curve or “ auc ”, and “ time to c max ” or “ t max ”. as used herein , the term “ t 1 / 2 ” refers to the half - life of the drug . the present invention is not to be limited in scope by the specific embodiments describe herein . indeed , various modification of the invention in addition to those described herein will become apparent to those skilled in the art from the foregoing description . such modifications are intended to fall within the scope of the appended claims .
the present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration . these compositions include a solubilizing agent , such as a modified β - cyclodextrin in an acidified solution , which can also include a chelating agent such as disodium edetate . in clinical trials , a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties .