Assume $V$ is a handlebody and $C$ be a simple closed curve contained in the interior of $V$. 
As Sam said, there exists some simple closed curve such that every dehn surgery along it produces a handlebody. So I assume $C$ can not be isotopic to a simple closed curve in $\partial V$. 


Obviously, trivial dehn surgery along $C$ produces a handlebody. So My question is:


Is there a different dehn surgery along $C$ which produces a handlebody? 


Can we classify all the dehn surgery along $C$ which produce handlebodies?



Dehn surgery on handlebody
There's an extensive literature on this and more general questions. 


First, let's consider a more precise formulation of the question. 
Let $H$ be a handlebody, and let $K\subset H$ be a knot. Let's
assume that $\partial H \subset H-K$ is incompressible. Otherwise,
$H=H\_0 \natural H\_1$ the boundary connect sum of two handlebodies,
such that $K\subset H\_0$, and $\partial H\_0 \subset H\_0-K$ is
incompressible. Then a surgery on $K$ makes $H$ a handlebody if
and only if the corresponding surgery makes $H\_0$ a handlebody. 
Thus, one may reduce to considering the case that $K$ is *diskbusting*.


With this reformulation of the question, the case that $K$ is
a core curve corresponds to when $H$ is a solid torus, and $K$ is
a core curve (since this is the only case in which a core curve is
diskbusting). So assume that $K$ is not a core curve. If $K$
is isotopic into $\partial H$, then there are infinitely many surgeries
which yield $H$. In this case, there is an annulus going between the
knot and $\partial H$. The surgery slopes which intersect the annulus
slope once give back $H$. Surgery along the annular slope gives
a manifold containing an incompressible surface, by Jaco's lemma. 
If the intersection with the annulus slope is $>1$, then the manifold
has incompressible boundary by Theorem 2.4.3 of the [cyclic surgery paper](http://www.ams.org/mathscinet-getitem?mr=881270). 


A [result of Wu](http://www.ams.org/mathscinet-getitem?mr=1167169) implies that for knots $K$ which
are not isotopic into the boundary, the distance between boundary-reducible
surgeries is at most one, and therefore there are at most two non-trivial
surgeries which may yield a handlebody.


In the case that $H$ is a solid torus, it was proved by [Berge](http://www.ams.org/mathscinet-getitem?mr=1093862)
and [Gabai](http://www.ams.org/mathscinet-getitem?mr=991095) that $K$ must be a 1-bridge braid, and a complete description
was given. There is a famous example (the Berge link) which yields 3 solid torus surgeries,
which shows that Wu's estimate is sharp (there is a 3-fold symmetry permuting
the slopes). 


Wu has [further results](http://www.ams.org/mathscinet-getitem?mr=1401956) on the case of 1-bridge knots in handlebodies. 
**Added:** [Frigerio, Martelli and Petronio](http://www.ams.org/mathscinet-getitem?mr=2032111) show that there are 1-bridge
knots in handlebodies with three handlebody fillings (including the trivial one),
generalizing the example of the Berge link to higher genus boundary, and showing
that Wu's theorem is sharp in general. It seems to be an open question whether
all such examples are 1-bridge (see discussion in [another of Wu's papers](http://www.ams.org/mathscinet-getitem?mr=1202395)). 


