Is there any sort of Kneser Milnor decomposition in dimension d larger than or equal to 4?, I mean a family of d-1 dimensional spheres disconnecting the d-dimensional manifold into irreducible components and with some uniqueness?, If so, any reference so far?. Thanks. 



Kneser Milnor decomposition in higher dimensions
Some results are available in dimension 4, although a "complete" answer is not known. As expected, the known results depend on the category: smooth/topological. Here are some references: first two papers by Matthias Kreck, Wolfgang Lück and Peter Teichner: 
"*Counterexamples to the Kneser conjecture in dimension four*", Comment. Math. Helv. 70 (1995), 423–433.
"*Stable prime decompositions of four-manifolds*". Prospects in topology, 251–269, Ann. of Math. Stud., 138, Princeton Univ. Press, Princeton, NJ, 1995. 


The first paper gives various counterexamples to the "naive" guess for 4-dimensional Kneser's conjecture: that a free product decomposition of the fundamental group would lead to a connected sum decomposition. The second paper gives a proof of this "naive" prime decomposition theorem (including uniqueness) *stably*, i.e. up to a connected sum with copies of $S^2\times S^2$. (The existence of such a stable decomposition is also proved by Jonathan Hillman, "*Free products and 4-dimensional connected sums*" Bull. London Math. Soc. 27 (1995), 387–391.)


Some further results are known in the topological category, these hold up to s-cobordism (given that topological surgery and s-cobordism conjectures are not known for "large" fundamental groups, at this point one doesn't expect an actual result up to a homeomorphism). These theorems are of the following flavor: under some restrictions assume the fundamental group splits as a free product and also assume the second homotopy group and the intersection pairing "look like" they correspond to a connected sum decomposition (these are natural algebraic assumptions).Then up to an s-cobordism the manifold splits as a connected sum. Some of the references are:
 A. Cavicchioli, F. Hegenbarth, *On 4-manifolds with free fundamental group*, Forum
Math. 6 (1994), 415-429;
 V. Krushkal, R. Lee, *Surgery on closed 4-manifolds with free fundamental group*, Math. Proc. Cambridge Philos. Soc. 133 (2002), 305–310;
Q. Khan, *Homotopy invariance of 4-manifold decompositions: connected sums*, arXiv:0907.0308


