I just finished teaching a class in combinatorics in which I included a fairly easy upper bound on the number of domino tilings of a region in the plane as a function of its area. So this led to this question, which I suspect is an open problem: Does a $2n \times 2n$ square have the most domino tilings among all regions with area $4n^2$? I aired this question in a mailing list, which is one reason that I think that it's an open problem. The discussion there did lead to a great answer from Rick Kenyon, who says that using his methods, the conjecture is asymptotically true for dilated rectilinear regions. (In other words, if you take any fixed polyomino and dilate it by a sufficiently large factor, then it will have fewer tilings than a square with the same area or very slightly less area.)


Still, I just came up with the question in my class, so I don't really know if it's open or previously stated. (This is my excuse for posting it MO.) I Googled some, without success. It is also easy to pose generalizations:


(1) The inequality might also hold for regions that map to the plane with multiple sheets (immersions) or branch points, at least when such regions are topological disks and the branch points are at vertices of the tiling by unit squares. (Kenyon's methods might also apply to these cases.)


(2) Does the $d$-dimensional cube $[0,2n]^d$ have the most tilings by domino bricks, among all regions in $\mathbb{R}^d$ with volume $(2n)^d$?


(3) Given an integer $k > 2$, does a $kn \times kn$ square have the most tilings by $k \times 1$ rectangles, among regions with area $k^2n^2$?


(4) Mutual generalizations of (1)-(3), and tilings by a rectangular brick with some other shape.


Kenyon's work is a (deep) extension of the permanent-determinant method of Kasteleyn and Percus to count matchings of a planar graph, so it would not apply to cases (2) and (3).



Which region in the plane with a given area has the most domino tilings?
Some answers are given in P. A. and L. Jordan, [Enumeration of border strips and Weil-Peterson volumes](https://arxiv.org/abs/1805.09778). [*Journal of Integer Sequences*, Vol. **22** (2019), Article 19.4.5](https://cs.uwaterloo.ca/journals/JIS/VOL22/Alexandersson/alex4.html).


We look at a certain type of regions (containing rectangles) parametrized by a binary word, and show that rectangles maximize the number of tilings. In contrast, all the shapes in the family admits the same number of border-strip tableaux, as in the Murnaghan-Nakayama rule.
This partially answers question (3), and I would not be surprised if one can reduce the general question to this case. 
We also look at a natural $q$-analogue of tilings, that might be of interest.


Also, I think your question was in the back of my mind and partially inspired our paper.


