I have noticed unexplained bruising on my thighs (currently a total of 5 bruises). I have tested with a positive ANA (low positive) and have suffered from muscle pain and fatigue for the past 5 years, with no firm diagnosis.  I also have had unexplained blood in my urine, but have had a full work up on my bladder (CT and cystoscopy), with no material findings (my mother also has this).  A full CBC run just a few months ago was normal, except for the ANA. I have also tested postive for the Smith antibody and am positive for MTHFR.  Is this bruising possibly related to an auto immune condition?  Does the MTHFR have an impact?  I am not on any medication, but do take a B12 and folic acid daily.  I also took a very small dosage for predisone about 4 weeks ago, to help relieve inflammation from a back injury (twisted too much in yoga).  Not sure if the predisone could cause bruising so much later?
Hello.thanks for using Chat Doctor .autoimmune condition can cause bruising by platelet destruction. But since you had one episode of blood in urine, i will recommend you to consult hematologist. He may advise you to go for complete coagulation assay.since you are positive for MTHFR you should take active form of folic acid like l-methyl folate.it is less likely that steroid causes bruising so lately...hope I have answered your quarries satisfactorily.have a nice day ahead.