I have been given 500mg of metformin to take once a day to start for insulin resistance.  Currently this is the third day and I have a horribly upset GI tract, and my arms/legs feel like lead weights with extreme fatigue.  I have heard an alternative is NAC, that does not have these same sides.  Is this a valid alternative? Link to NAC:  WWW.WWWW.WW
Hi, Thanks for asking. Based on your query, my opinion is as follows.1. Metformin is better with treating insulin resistance, as it promotes weight gain too.2. N-acetyl cysteine is not useful in reducing insulin resistance. It helps in preventing progression of further complications related to diabetes mellitus.3. You are having possibly gastritis due to metformin. Try taking proton pump inhibitors like pantoprazole for 2-3 weeks. It will reduce symptoms. Also need adequate HY Chat Doctor. 4. Also, additionally, moderate aerobic exercises is necessary for weight reduction. Hope it helps. Any further queries, happy to help again.