My friend was told he has the most severe case of mono. His liver is really infected, his spleen is very swollen, his skin is red and he has a rash that is burning his entire body and he is continuing to lose weight despite still having an appetite. Is this normal and when will these effects subside? Also, when will he be no longer contagious?
If your friend has been diagnosed with mono, also known as infectious mononucleosis, this is caused by a virus called Epstein-Barr virus.  This infection can affect the spleen, liver and cause extreme fatigue.  If he has not been tested for HIV, then I would recommend getting this test because initial HIV infection can also look like mono.  He will hopefully begin to feel better in a few weeks, some patients can take up to 5-6 months to feel back to normal.  The treatment for this is supportive care which means rest and plenty of fluids.  You asked a very good question of how long he will be contagious, this is unknown but is likely at least a few weeks to months.  I would suggest not sharing food or Chat Doctor.  While his spleen is affected, I would also tell him to stay away from contact sports since sudden trauma can cause splenic rupture. Thanks,