Liver enzymes were over 600 two weeks ago after being on sulfasalazine for two weeks for RA.  Now my alt is down to 147 but my ast is going up and is 80.  I feel fine with the usual joint pain and fatigue - but nothing new.  Should I be concerned?
Dear FriendWelcome to Chat Doctor. Methrotexate used for RA is the most common culprit causing liver dysfunction following:1. Ultrasound abdomen2. Liver Function Test- Complete3. Viral Markers. Review with these reports and the prescription paper. Stay Healthy Chat Doctor.