Hi my 8 year old daughter had a positive ANA test of tiger 1:80 about a week and a half ago no symptoms but two of her toe nails changed color they look a little black I got her retested last Thursday still positive with a 1:160 titer DNA and RNP are both negative what can be wrong why are the titer going up
Hi.... raising titles of ANA are suggestive of active disease process in a case of connective tissue disorder or autoimmunity. This may be suggestive of systemic onset or pauciarticular or poly articular juvenile rheumatoid arthritis. I suggest you consult your pediatrician regarding this. As you said DS DNA is negative SHE is an unlikely possibility. Regards -