My daughter was severely anemic, had a blood transfusion (2 bags) and then it was discovered that her red blood cells were too small and her body was not retaining iron, despite her oral iron intake and whatever she ate.  She has had 2 IV iron infusion (Venofer), and she is exhausted, and says her bones still ache.  She is only 23.  Any ideas?  She only takes Topomax daily for migraines, but says that she still wakes up with headaches daily.  After the first Venofer infusion, she had a mild seizure.
Since you are saying that she is very anemic, initially it is very difficult to establish the normal iron level. In this condition her body will not accept and store the iron abruptly. You have to give some time to store the iron. Initially the symptoms which you have mentioned is common. So do not worry go ahead with the therapy. Thnx