I have stage 1 estrogen and progesterone receptive breast cancer...have had a mastectomy...no cancer in lymph nodes....I have been taking tamoxifen for 2.5 years and my doctor just changed me to letrozole....I am very concerned about the side effects...especially weight gain and depression....I have osteopenia and high blood pressure and I am not sure this is a good change What do you think?
HiT hanks for your query. In postmenopausal patients, incorporating metronome gives some extra benefit. Weight gain and depression are not the major concerns but osteopenia is. So you should take calcium, vitamin D, bisphosphonates regularly and monitor bone density while on metronome. Hope this helps, Regards