Hello, I am 33 years old and healthy. My first pregnancy ended in miscarriage at 7 weeks. I got pregnant quickly after trying for 2 cycles. I did not need a D&C. I did not have a cycle following the miscarriage and got pregnant again-I had a miscarriage around 4-5 weeks (difficult to know exact dates b/c I did not have my period after the first miscarriage). I did not require a D&C the second time either. I did have a w/u for recurrent miscarriage: normal thyroid, lupus abs, LH, estrogen, progesterone, normal hysterosalpingogram. I have had 2 normal cycles and will start trying again soon. I was prescribed a vaginal progesterone suppository (even though my level at day 21 was not low) b/c of the recurrent miscarriage. I was prescribed progesterone 25 mg intravaginal once daily (needs to be compounded). I read that doses of upwards of 200 mg are used, but when I called by OB, he said that this is the vaginal dosing traditonally used. I understand that oral progesterone s bioavailability would be much lower so 200 mg QD would need to be used, but is this vaginal dosing reasonable? I was prescribed Crinone originally, but it was not covered by insurance. Thank you!
This dosing is reasonable, but you need to rule out antiphospholipid syn Chat Doctor.  Please talk to your doctor regarding this.