Hi, My wife and I are expecting our third child, however right at the start of the pregnancy she was diagnosed with Typhoid. While, she has recovered from it and does not have fever, we are worried about the effects of the medicine given to her, on our unborn child. I am listing the sequence of events below and would appreciate if someone would assist us. 2nd week of March, baby conceived. 25th March severe food poisoning and fever (2 weeks of weakness and loss of appetite). Pregnancy confirmed in the 2nd week of April. At the same time, severe flu, bronchitis and fever for ten days (advised Cefspan 400mg for 7 days + Panadol Also Zantac 150mg, twice a day for one month prescribed as Gynecologist suspected UTI. Widal test conducted on 21st April - Salmonella TO 1:80 (doctor failed to diagnose typhoid) 2nd May Typhoid IgG and Typhoid Igm positive, Antibody Index 1.8 Rocephin 1g Iv twice a day for 3 days advised. 2 days gap - Symptoms prevailed so Rocephin 2g IV once a day for 3 days advised again. 21st May Fever, weakness, indigestion and loss of appetite still persisted - Infectious Disease Consultant visited - advised Rocephin 2g IV advised once a day for 15 days (21st may till 4th Jun) 28th May 2010 Unable to retain food or medicine - physician advises Abdominal USG Readings: Liver 135mm (upper 160mm), outlines smooth, no dilatation of the hepatobiliary ducts, no focal defect. Gall bladder normal in size and shape BUT contains thick echogenic sludge. No stone or mass - Spleen measures 100mm (upper 120mm) - Pancreas normal, no para-aortic lymph nodes or mass seen - Right Kidney 101x40x15mm - Left Kidney 97x51x20mm - Gravid uterus 12.5 weeks Fever completely finished on the 1st of June, though there were temporary relapses after even slight exertion. Currently no fever but weakness, indigestion and nausea still persist. The above has left my wife extremely weak and she is still unable to retain anything complex and has to instead rely on basic items like milk and bread. Our physician has also indicated that she might have an ulcer in her stomach. In light of the cocktail of medicines given to her, we are extremely perturbed about the condition of the baby and the effects the medicines might have had on it. So far, we have only had the Anomaly scan done, readings of which are listed below. I would appreciate if someone could share some advise about what other tests we could get done to ensure the well being of both the mother and the baby, and whether there is any research available on the administration of the medicine cocktail on pregnant humans. Obstetrical USG (anomaly scan) conducted on 28th May 2010 Reading: Single Intrauterine fetus, cardiac activity present, fetal movements present, liquour amnii adequate, placenta fundal POSTERIOR upper mid uterine segment, B.P.D 18mm 12.6 weeks. Femur length 8mm 12.4 weeks. F.A.C 61mm 12.6 weeks. Gestational age 12.5 weeks. EDD 05-12-2010, Fetal weight approx 75gms. Nuchal Translucency measures 1.3mm (upper 3mm). No gross fetal anomaly seen.
Hi, Chat Doctor.  I welcome you to Chat Doctor VIRTUAL CLINIC. I have gone through your question, and I think I have understood your concern. Furthermore, I will suggest you the best possible treatment options. First do not panic. The medicines that she was prescribed belong to cephalosporin group of