Hello Sir, My brother was diagnosis with leukemia AML M3 (APL) and was under going treatment with ATRA and Chemotherapy. Induction therapy was completed and presently he is in consolidation therapy. Before this treatment started PML/ RARa translocation Assay (quantitative) test was done 30/03/2015 and the report shows that the PML-RARa/ABL1 transcript ratio (%) was 11.662% in the leukocytes of the specimen, after completing induction therapy and undergoing consolidation therapy, the PML-RARa translocation test was done on 28/04/2015 and the result shows that the PML-RARa/ABL1 transcript ratio raise to 57.434% in the leukocytes of the specimen. therefore I wanted to know whether he is responding to ATRA treatment or not.
Hello, By definition, at the end of consolidation the PML/ RAR transcripts Should be undetectable. As it is still present and has actually increased from end of induction suggest resistance.  Hence, he should be offered salvage therapy.  Kindly discuss the matter with your treating Oncologist. Regards