I have been diagnosed with microscopic colitis and keep having problems with my lower legs and ankles swelling. I get ptiing edema and they are very painful. Some lasix and aleve usually work after a couple of days, but it always comes back. I have had doppler studies done and no one can diagnose the problem.
You should have autoimmune, immunological tests like ANA, CBC,ESR, Igm, iGg etc. tested. Often colitis with joint pains is an autoimmune disorder requiring immunosuppressive agents like azathioprine, cyclophosphamide,prednisolone. But confirmation is a must if its autoimmune