Hi Dr Grief.I am writing on behalf of my husband.  He as been loosing weight over the last 2 years (he is normally very tall and lean anyway). He has seen a doctor about this and had blood tests.  the test have come back with an elevated LFT reading he has since had a liver biopsy and that came back inconclusive (no cancer or Hep).  We do not have any definitive results can you help with what other test he should do?Annick
Hello, I have gone through your query and understand your concern. There are numerous causes for weight loss. One of the most common because you have to rule out is stress and Depression. Because it is difficult to identify without any careful evaluation of possible psychological causes such as depression. Further it can not be detected by routine examination and investigations. Other possible causes are Malabsorption and Malignancy (Cancer), autoimmune diseases, HIV, tuberculosis (Abdominal Tuberculosis is common in Unexplained weight loss).Thus, he needs the further evaluation like Nutritional evaluation like levels of vitamins and minerals, Endoscopy, Colonoscopy, Bone marrow aspiration and HIV serology. Depending on the cause, we have to treat him accordingly. For example: if he's suffering from any depression, then he needs Psychological counselling and support. If the weight loss is due to nutritional deficiency, then we have to give the supplements for him. Hope this helps. Please write back for further queries. Wishing you good health.