Mello and Fire 's research , conducted at the ORGANIZATION@1 -LRB- Fire -RRB- and the ORGANIZATION@2 -LRB- Mello -RRB- , had shown that in fact RNA plays a key role in gene regulation .

Mello and Fires research , at the ORGANIZATION@1 -LRB- Fire -RRB- and the ORGANIZATION@2 -LRB- Mello -RRB- , had shown that MISC@1 is very important in gene control .
