This episode in the conquest and colonization of the LOCATION@1 began in the early 16th century , but would prove to be a more difficult and lengthier exercise in subjugation than the equivalent campaigns against the LOCATION@2 and Inca Empires .

This part of the conquest and colonization of the LOCATION@1 began in the early 16th century , but it took more time than the similar campaigns against the LOCATION@2 and Inca Empires .
