Pasteur and PERSON@1 By the middle of the 19th century , the theory of biogenesis had accumulated so much evidential support , due to the work of PERSON@2 and others , that the alternative theory of spontaneous generation had been effectively disproven .

PERSON@1 and Pasteur By the middle of the 19th century , PERSON@2 and other scientists showed that living organisms did not arise spontaneously from non-living matter .
