There is some controversy over the identity of the disease , but in its virulent form , after the Great Plague of LOCATION@1 in NUMBER@1 -- NUMBER@2 , the Great Plague of NUMBER@3 -LRB- which hit eastern LOCATION@2 -RRB- , and the MISC@1 plague of NUMBER@4 , it seems to have disappeared from LOCATION@2 in the 19th century .

There is some controversy over the identity of the disease , but in its virulent form seems to have disappeared from LOCATION@2 in the 18th century .
