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text:
"Knights of Cydonia" é uma canção da banda inglesa de rock alternativo Muse, pertencente ao álbum Black Holes and Revelations. Foi lançado como single nos EUA em 13 de junho de 2006 e na Inglaterra foi lançado em novembro do mesmo ano e chegou a atingir a posição n° 10 no UK Singles Chart. A rádio BBC Radio 1 descreveu a música como "seis minutos e 7 segundos de pura genialidade". Na Austrália, "Knights of Cydonia" chegou a 1ª posição no Triple J Hottest 100.

Cydonia é uma região do planeta Marte, famosa pelo "Rosto de Marte".

A canção é apresentada no jogo Guitar Hero III: Legends of Rock.

Faixas

Tabelas musicais

Ligações externas

Singles de 2006
Canções gravadas por Muse
Música de ficção científica

redpajama_set_name: RedPajamaWikipedia


Wasteland Ninja - an action on Android with pixel 2D graphics, to be played for Rebec, a teenager who became famous for having destroyed three hundred alien invaders with a bomb. Waking up, after an accident at the ceremony, she discovers that she is in a strange place, while enemies are around. Jump on platforms, push off walls, dodge enemies and their costumes, destroying attackers with weapons.


PLEASE NOTE THAT SOME ITEMS MAY HAVE TO BE ORDERED IN. PLEASE ALLOW UP TO 14 DAYS DELIVERY WHERE NECESSARY! PLEASE CHECK SIZE CAREFULLY AS REFUNDS OR EXCHANGES CANNOT BE GIVEN ON PRINTED ITEMS! POSTAGE: Due to some items having to be personalised, the postage cost is for the service you require once the items in your order have been personalised. 1. �7.75 - Courier Service. 2. �5.00 - Royal Mail 1st Class Signed For. 3. �3.50 - Royal Mail 1st Class.


text:
Great color
Galaxy Note 8 in 'Deep Sea Blue' coming to the U.S. as Best Buy exclusive for the holidays
A fresh color in time for the holiday shopping season.
Andrew Martonik
The Galaxy Note 8 launched in four colors: Midnight Black, Maple Gold, Orchid Grey and Deep Sea Blue. Unfortunately, those in the U.S. only ever saw photos of the Deep Sea Blue color, as the closest it got to the country was availability up North in Canada. But now Samsung has announced U.S. availability of this great color option, and it's coming exclusively from Best Buy. You'll be able to get the Verizon, AT&T and Sprint models of the phone, as well as the U.S. unlocked model, in sleek deep blue.
See at Best Buy
The addition of the Deep Sea Blue color option strikes a nice balance between the all-dark Midnight Black and possibly too-light Orchid Grey previously available. The rich Deep Sea Blue shade does a better job of masking scuffs and scratches than Orchid Grey, while certainly standing out from the crowd better than Midnight Black. And considering its later launch, it's far more unique in the U.S.
Perhaps at some point Samsung will decide to release the fourth Note 8 color, Maple Gold, in the U.S. as well. We can dream, right?
Best Buy's "exclusive" for this color isn't entirely exclusive, as it only pertains to the carrier versions of the phone in that color. If you want the U.S. unlocked model, you can pick it up from Best Buy or Samsung's online store — some people may go for the latter to take advantage of Samsung's trade-in or financing offers. Either way, you won't be seeing this color available from other retailers or directly from the carriers.
Galaxy Note 8 review
Galaxy Note 8 vs. Galaxy S8+
Which Note 8 color is best?
Complete Galaxy Note 8 specs
Join our Galaxy Note 8 forums
Samsung adds Deepsea Blue color to Galaxy Note8 Portfolio in the U.S.
Just in time for the holidays, the Galaxy Note8 Deepsea Blue will be available exclusively at Best Buy stores and online at BestBuy.com and Samsung.com
Ridgefield Park, NJ – November 8, 2017 – Samsung Electronics America, Inc. today announced that the Galaxy Note8 Deepsea Blue will be available to U.S consumers beginning November 16 – just in time for the holiday shopping season. Consumers will be able to choose from AT&T, Sprint and Verizon carrier-specific versions of the Galaxy Note8 at Best Buy stores and BestBuy.com, as well as the unlocked versions available at Best Buy and Samsung.com.
With the addition of Deepsea Blue to the Galaxy Note8 portfolio, consumers will now have another color option to choose from in addition to Orchid Gray and Midnight Black.
Introduced in August, the Galaxy Note8, is the next level Note for people who want to do bigger things. With Galaxy Note8, consumers get Samsung's most powerful smartphone camera featuring two 12MP rear cameras with Optical Image Stabilization (OIS) on both the wide-angle and telephoto lenses to capture stunning photos, even in lowlight environments, a bigger Infinity Display that fits comfortably in one hand and the S Pen to communicate in more personal ways. The Galaxy Note8 is designed for the way consumers lead their lives and lean on technology today.
Samsung Trade-In Program
For U.S. customers who trade-in an eligible device, they can receive an instant trade-in credit towards a Galaxy Note8 in any color. For more information on Samsung's trade-in program, visit Samsung.com/trade-in
Galaxy Note8 Features:
Infinity Display: The Galaxy Note8 has the biggest screen ever on a Note device. The 6.3-inch Quad HD+ Super AMOLED Infinity Display lets you see more and scroll less. The Galaxy Note8 gives you more room to watch, read and draw—making it the ultimate multitasking smartphone.
S Pen: Since its introduction, the S Pen has been one of the Note's defining features. With the Note8, the enhanced S Pen includes a finer tip and improved pressure sensitivity, unlocking new ways to write, draw and interact with the phone and communicate with others, including:
Live Messages which allows users to bring messages to life. Users can now handwrite a message, add special effects and share it as an animated GIF on several popular messaging and social apps.
An improved Translate feature lets users not only translate individual words, but full sentences in 71 languages and instantly convert units and foreign currencies.
Always On Display: This feature allows users to stay on top of notifications without unlocking their phone. In addition, the screen off memo allows you to take notes as soon as you take out the S Pen. From there, you can pin a note to the Always On Display, edit it right there and write as many pages as you need—up to 100 pages.
Best-in-Class Camera: Samsung has set the standard for smartphone cameras, and with the Galaxy Note8 Samsung is delivering its most powerful camera yet
The Galaxy Note8 is the first smartphone with two 12MP rear cameras with Optical Image Stabilization (OIS) on both the wide-angle and telephoto lenses with a 2x optical zoom, so you can take great shots, even when zoomed. It also features an 8MP Smart Auto Focus front-facing camera for sharp selfies and video chats.
For more advanced photo taking, the Galaxy Note8 Live Focus feature lets you control the depth of field, unlike some other smartphone cameras, by allowing you to adjust the bokeh effect in preview mode and even after you take the photo.
In Dual Capture mode, both rear cameras take two pictures simultaneously—and you can keep both images: one close-up shot from the telephoto lens and one wide-angle shot that shows the entire background. The camera also has a Dual Pixel sensor with rapid auto focus, so you can capture sharp and clear shots even in low-light environments.
The Galaxy Note8 is built on the Galaxy legacy—a collection of unique features and capabilities that, together, have redefined the mobile experience, including:
IP68 Water and Dust Resistance
Fast wireless charging
Samsung Knox defense-grade security
Powerful performance with 64GB of storage, 6GB RAM and expandable memory up to 256GB
For more information, visit: https://news.samsung.com/us/ or www.samsung.com/galaxy
The best heavy duty cases for the Galaxy Note 8
Keep your Note 8 looking good for years to come by protecting it with a heavy duty case!

redpajama_set_name: RedPajamaCommonCrawl


Jen came to visit this weekend and we managed not to get pictures of ourselves, which is unheard of.
Usually we pick someone thoroughly undeserving of the torture (Eric, Shawn…), hand them a camera and put them through a rigorous endurance test by demanding to see every picture they take. We argue over each one, Jen rearranges my hair 2-3 times and the room 3-4 times, she finds the best angle and then says to them "Can't you stand somewhere higher so we're looking up instead of down? What's with this lighting? I think we need something closer/further away/darker/better…" The last time Eric was pressed into service he demanded a protein bar and a bottle of water half way in.
and Mr. Miyagi on keyboards, but I'm sure both those men have better things to do than torture us with music that should have died 30 years ago.
Which made it all the more fantastic. The sooner it happens again, the better.
This entry was posted in Arizona, Good eating, Jen, Tucson and tagged BK Carne Asada and Hot Dogs, Harry Potter, Jasper Tucson, Jen and Katie, Jen Wilson White, killing me with their songs, Lionel Ritchie, Little Ruby, the picture of Mr. Miyagi is hilarious and disturbing. Bookmark the permalink.
Yes I cant believe that we didnt get any pictures either. I guess we just needed to spend more of our time together enjoying each other. Fabulous weekend darling. I love you!


text:
Iran Protests French Ambassador's Remarks On Nuclear Deal
Iran's top nuclear negotiator, Abbas Araqchi, talks to journalists after meeting senior officials from the United States, Russia, China, Britain, Germany, and France in Vienna in 2015.
Iran has protested to France about remarks made by the French ambassador in Washington over Tehran's right to enrich uranium after 2025.
Iran agreed under a 2015 deal with world powers to curb its nuclear program in return for the lifting of crippling economic sanctions.
Some of these limits are due to expire after 10 years, and others after 15 years.
But U.S. President Donald Trump pulled Washington out from the deal last year, saying one of the weaknesses in the agreement is that limits to Iran's nuclear program would expire.
In a tweet on April 13, France's ambassador to the United States, Gerard Araud, said: "It's false to say that at the expiration of [the nuclear deal], Iran will be allowed to enrich uranium," adding that sanctions could be reimposed.
Iranian Deputy Foreign Minister Abbas Araqchi said on April 14 that Araud's comments were "a major violation of the object and purpose of the" deal, adding they needed "immediate clarification by Paris, or we act accordingly."
Iran also summoned the French ambassador in Tehran on April 14.
Despite Washington's withdrawal, other signatories to the nuclear deal -- Britain, China, France, Germany, and Russia -- are still trying to salvage the agreement.
Based on reporting by Reuters and AP


Ash and I went at it again. Our 3-month expiration date from the first baby food experiment was two days away. I forgot my food processor, but her extremely nice and helpful neighbor brought over her brand-new, never-before-used baby food maker, the Babea Babycook. This little machine, which we thought would be a disaster, is designed for making a day to a weeks worth of food at once. Say you want to make carrots (which unfortunately Ash's baby HATES, so we didn't try it with them), you just pop in the hard, fresh carrots, add water to the left compartment in the picture and flip the switch to steam. Wa-lah. No extra dishes. One you are done steaming the carrots all you need to do is remove the plastic steamer part and replace with the orange cover. The blender/food processor does it all. It will mash these to the perfect pureed consistency needed for baby food. I'd stray away from the recipes in the book, but if you want to create gourmet baby food, they incorporated together such things as tomatoes, basil and pasta. The book did have a great way of showing the food groups and how you met all of them for your baby.
This time around, Ash and I used our brains to make everything run more smoothly, or so we thought. This really is a process, but if you only do it every three months, worth every minute spent. So, thanks again to Tobi for teaching me how to cook a butternut squash because it saved us half an hour of sawing, trying not to cut our fingers off, and a much easier cook time/mash span. All you have to do is cut the squash in half, add a little olive oil to a roasting pan to keep it from sticking, and broil for 15-25 minutes or until the squash is soft all around. The peel will then just spoon off and you can easily run your knife through to create manageable sized pieces for blending. We also found roasting the potatoes, while creating another skin, uses less time. The steamer would have been perfect for the sweet potatoes. We also utilized the potato peeler and apple cutter this time around.
As Ash's baby is now in the 6-9 month range, we were able to eliminate adding formula to his fruits and veggies. Also, there was no allergic reaction to the first round, so we were able to mix and match. Ash found that he wasn't a huge fruit fan, so hopefully by making combinations such as squash, apple, banana, and pineapple he will be more keen on eating the fruits. Squash and sweet potatoes were among his favorites, so we made extra of these. We also used new fruits and vegetables, not mixing the new ones together but rather putting one new fruit in with a mix of things we know he is not allergic too. The only downfall to not adding formula this time around was the fruits are naturally watery and needed something extra to make them less of a soupy disarray. The sweet potatoes, corn, apples, and banana needed the added juice to fully dissolve, so were great pairs for the marsh-like fruits such as cantaloupe, honey-dew melon, clementine and pineapple.
The corn, green beans, and peas were a LOT easier this time. We learned from shelling sweet peas, that all your hard work amounts to minimal food. The frozen vegetables and fruits aren't coated in a syrup or anything unheard of for babies to eat. We were able to heat these up in the microwave or on the stove top then simply liquefy them in the blender.
It was easiest to blend everything, set each food aside next to a label and then mix them all together at the end in a bowl. This created a lot of dishes, but wasn't a problem thanks to her handy dishwasher. Her sticker label system and perfectly portioned containers again worked great for stacking in her freezer and pulling one by one to defrost in the fridge. It's a fun project for anyone that has children starting on solids.


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Home » Admissions » Admissions FAQs
Q: What kind of therapeutic supports and treatment services will my student receive:
A: Upon admission, each student is assigned to a Masters level School Counselor and/or Social Worker to address the issues identified as leading to his placement. Individual and group sessions are assigned based on IEP need, as indicated, and focus on strength based and solution focused skills to achieve his goals. Throughout placement, students work on developing various pro-social and emotional regulation skills which are needed to appropriately engage in the learning process and to more successfully function in his school & community environments; Such services include anger management, navigating social and interpersonal relationships, improving communication, decision making skills, effective problem solving, taking responsibility for personal actions, participating in behavioral health services, and regaining momentum in his academic growth.
Q: What services does LaSalle provide to the family of a student?
A: From the very beginning, as a family member, your experiences and knowledge help lead to our understanding of the issues and concerns that were interfering with your student's progress in school and/or his community. The family and child both participate in the goal setting process, and staff assist everyone to take a serious look at what changes are needed for him to succeed. For many students, issues outside of the school setting have led to the current situation. Family meetings, family sessions, and case conferences all provide opportunities to work together collaboratively to support each student's progress. The LaSalle School Treatment Team works with community-based services already in place, to be sure our efforts are well-coordinated. When there is an unmet need identified, the LaSalle Treatment Team assists the family to identify resources to address such.
Q: Will my son be academically challenged if he is enrolled in LaSalle School?
A: LaSalle School is approved and certified by the New York State Education Department (NYSED) to provide educational services/Regents-Level curriculum to students in grades 6-12. Our departmentalized program has course offerings designed to meet all requirements at those grade levels. LaSalle's students take the same statewide assessments that NYSED requires public school students to take. Our small classes, experienced teachers and well-trained Therapeutic staff provide an environment with structure, support and services students need.
Q: How long will my son attend LaSalle School?
A: Our goal is to provide treatment and therapeutic services which will prepare him to return to his home school district and community with success. Throughout a student's placement, we continually assess his readiness to successfully transition back to his local community. We involve the student, his family and the district in those discussions. Some students are ready to return after one school year, and others take longer.
We see a student's PERMANENCY as an urgency to which we continuously work towards starting on DAY ONE.


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Q: Quarkus Mutiny Multi filter Exception handling What is the proper way to handle exceptions in the filter method of a multi, since we can only return a boolean and can not propagate failure? This is how my code looks like right now, how should I handle the exception in the filter properly?
Multi multi = ...;//
multi.filter(data -> {
        try{
            return applyFilter(data);
        } catch(Exception e){
            logger.error("exception occurred while checking filter", e);
            //instead of returning false, how should I propagate the exception?
            return false;
        }
    }
).onItem().transform(data -> {
       return transformData(data);
   }
});

A: If the filter predicate throws an exception, that exception is propagated downstream as a failure. If, in that case, you want to return false, you need to do as you did (try/catch and return false).
In the exception case, the predicate can only throw runtime exceptions. You can use the unchecked utility methods (https://smallrye.io/smallrye-mutiny/guides/unchecked) if you want to throw a checked exception. It wraps the exception in a runtime exception for you.

redpajama_set_name: RedPajamaStackExchange


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Bill Gates Backs Solar Energy Start-up….Heliogen.
Today, industrial processes like those used to make cement, steel, and other materials are responsible for more than a fifth of all emissions. These materials are everywhere in our lives but we don't have any proven breakthroughs that will give us affordable, zero-carbon versions of them. If we're going to get to zero carbon emissions overall, we have a lot of inventing to do. I'm pleased to have been an early backer of Bill Gross's novel solar concentration technology. Its capacity to achieve the high temperatures required for these processes is a promising development in the quest to one day replace fossil fuel.
Bill Gates, Gates Ventures
Bill Gates the world's richest man is joining other investors in backing a new venture which aims to turn sunlight into a source of heat exceeding 1,000C that could help replace fossil fuels.
Heliogen, the clean energy company that is transforming sunlight to create and replace fuels, announced its launch on the 19th November 2019 and that it has, for the first time commercially, concentrated solar energy to exceed temperatures greater than 1,000 degrees Celsius. At that temperature, Heliogen can replace the use of fossil fuels in critical industrial processes, including the production of cement, steel and petrochemicals, dramatically reducing greenhouse gas emissions from these activities.
Heliogen is a clean energy company focused on eliminating the need for fossil fuels in all sectors of the economy. Heliogen's mission is to create the world's first technology that can commercially replace fossil fuels in industrial processes with carbon-free, ultra-high temperature heat from the sun and to transform sunlight into fuels, including hydrogen, at scale – taking a major step towards solving climate change. Its heat technology represents a key technical breakthrough for concentrated solar thermal. Previous commercial concentrating solar thermal systems have been designed to reach temperatures of up to only 565 degrees Celsius – useful for power generation, but insufficient for many industrial processes. Many of these processes require much higher temperatures, which have traditionally been reached through the burning of fossil fuels.
The world has a limited window to dramatically reduce greenhouse gas emissions. We've made great strides in deploying clean energy in our electricity system. But electricity accounts for less than a quarter of global energy demand. Heliogen represents a technological leap forward in addressing the other 75 percent of energy demand: the use of fossil fuels for industrial processes and transportation. With low-cost, ultra-high temperature process heat, we have an opportunity to make meaningful contributions to solving the climate crisis."
Bill Gross, CEO & Founder, Heliogen and Founder & Chairman, Idealab.
Bill Gross, the chief executive and founder of California-based Heliogen, said the company represents a technological leap forward in tackling the emissions from industry and transport that make up 75% of the world's carbon footprint.
Gross said creating low-cost, ultra-high-temperature process heat gives the company an opportunity to make meaningful contributions to solving the climate crisis.
The technology can generate temperatures high enough to manufacture cement without fossil fuels. Cement production alone accounts for more than 7% of global CO2 emissions – the world's third largest source of emissions behind oil and coal. If left unaddressed, cement production would pose a major threat to the targets set by the Paris agreement.
"Today, industrial processes like those used to make cement, steel, and other materials are responsible for more than a fifth of all emissions," said Bill Gates. "These materials are everywhere in our lives, but we don't have any proven breakthroughs that will give us affordable, zero-carbon versions of them. If we're going to get to zero-carbon emissions overall, we have a lot of inventing to do. I'm pleased to have been an early backer of Bill Gross's novel solar concentration technology. Its capacity to achieve the high temperatures required for these processes is a promising development in the quest to one day replace fossil fuel."
For more information visit heliogen.com.


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A Deeper Understanding: Interview with Dr. Weerts
Do Women Have a Higher Risk of Cannabis Withdrawal Symptoms?
Elise M. Weerts, Ph.D., a behavioral pharmacologist, neuroscientist, and professor of psychiatry and behavioral sciences at Johns Hopkins Medicine, is undertaking a clinical study focused on withdrawal symptoms in women who are regular cannabis users. Talking with CBMD, she discussed her research, why she's interested in studying the effects of cannabis, and especially, why she's exploring how cannabis affects women.
CBMD: How did your academic and professional background lead to your current research interests?
Dr. Weerts (EW): I became interested in studying cannabis primarily because of its widespread use. My background includes studies examining the rewarding effects of drugs and determining whether or not various drugs produce physical dependence. I am particularly interested in how chronic drug use affects the brain and the relationship of these neuroadaptive changes on behavior. The cannabinoid system is really interesting in that it regulates many key behavioral processes such as appetite, food intake, learning and memory, and mood. It also interacts with other key systems in the body involved in stress and reward processing.
In collaboration with my colleague, Dr. Ryan Vandrey, we examined data collected in treatment-seeking cannabis users. We asked men and women about different symptoms they experienced the last time they attempted to quit. This included questions about a range of different behaviors and effects including ones specific to cannabis withdrawal.
Our study revealed that women reported more withdrawal symptoms than men, despite using similar amounts of cannabis. In particular, women had higher scores than men in two specific domains: changes in mood and nausea and stomach pain. They also experienced these symptoms as being more severe.
The primary behavioral effects of cannabis are attributed to its major constituent delta-9-THC, which activates cannabinoid receptors in the brain. There are two major types of these receptors—type 1, which are primarily in the brain, and type 2, which are in organs and tissues throughout the body. We can measure cannabinoid receptors in the human brain using a technique called positron emission tomography (PET) brain imaging. In PET imaging, we inject a radiotracer that binds to the cannabinoid type 1 receptor and allows us to visualize cannabinoid receptors in the brain and the density of receptors in different brain regions.
By comparing images from people who use cannabis with scans of people who do not use cannabis, we can learn more about potential cannabis-induced changes in the brain's cannabinoid system. This study is an early phase study that focuses specifically on women.
CBMD: What was the impetus for the study?
EW: Prior PET imaging to explore the effects of cannabis use on the cannabinoid system has included almost all men. Those studies found that type 1 cannabinoid receptors were lower in men with cannabis use disorder, when compared to healthy volunteers, and this was correlated with expression of withdrawal during early abstinence. After a month of abstinence, scans were repeated and cannabinoid receptors had increased.
These data suggest that with repeated cannabis use, the brain adapts by downregulating the number of cannabinoid receptors, and such downregulation may be the primary mechanism associated with cannabis withdrawal. But since these studies did not include women, we still don't know if women show changes similar to those seen in men. PET studies in male and female healthy normal volunteers who do not use cannabis have shown women have more cannabinoid type 1 receptors than men in many key regions. These biological differences in cannabinoid receptor density may be important for observed sex-related differences in the effects of cannabis. Women also show a faster progression from first use of cannabis to first admission for treatment of cannabis use disorder, and experience worse treatment outcomes.
There is good evidence from preclinical studies in animal models, that females are more sensitive to some cannabinoids like delta-9-THC. When compared to males, females show higher cannabinoid-induced motor impairment. Females also developed tolerance to these effects more rapidly when exposed to the same dosing regimen as males and were more sensitive to the dependence-producing effects of cannabinoids.
These data lead me to believe that innate sex differences in cannabinoid receptors and cannabis sensitivity, combined with possible sex-specific neuroadaptive changes associated with chronic cannabis use, may contribute to greater withdrawal severity and relapse in females with cannabis use disorder.
The current study will help us learn more about how cannabis use affects the brains of women and about cannabis withdrawal under supervised abstinence undertaken in inpatient conditions.
CBMD: Why is it important that this study focuses on women?
EW: Women are underrepresented in the majority clinical studies, particularly those with brain imaging. Even when women are included in research, the numbers enrolled are generally lower, and studies often don't include enough women to demonstrate sex-specific differences in behavioral or physiological outcomes.
Females have been excluded from studies involving neuroimaging and studies examining drug withdraw prospectively, largely due to difficulty in controlling for the estrous cycle (changes caused by reproductive hormones) and its potential impact on withdrawal symptom expression or on changes in the brain. This has slowed our understanding of potentially important sex differences in cannabis withdrawal and effects of cannabis on the brain.
CBMD: How common is the occurrence of withdrawal symptoms in cannabis users?
EW: Physical dependence on any drug and occurrence of withdrawal symptoms are typically related to the duration and amount of use. The more you use and the longer you use the more likely you are to experience symptoms when you stop using it.
CBMD: What is cannabis use disorder?
EW: A substance use disorder has a number of features that differ from medical use and many different drugs, including cannabis, share these features, which include:
Using more
Difficulty stopping or controlling use of the drug
Spending significant amounts of time getting, using, or recovering from use of the drug
Using a drug in risky situations, like driving a car or continuing to use despite worsened psychological or physical problems
Experiencing psychological and physiological symptoms when abruptly stopping drug use
CBMD: How do cannabis withdrawal symptoms compare in severity to withdrawal symptoms from other substances?
EW: Abrupt discontinuation of cannabis use can lead to discomfort and symptoms that are clinically meaningful. Common symptoms are:
Irritability, anger, or aggression
Nervousness or anxiety
Sleep difficulty (for example, insomnia, disturbing dreams)
Decreased appetite or weight loss
Depressed mood
Common physical symptoms include abdominal pain, shakiness/tremors, sweating, fever, chills, or headache.
Some of these symptoms are comparable to withdrawal from other substances but are most comparable to those in heavy tobacco users who quit smoking, although cannabis withdrawal symptoms but can be more severe.
CBMD: What are the potential applications of the study data beyond an expanded understanding of how cannabis affects cannabinoid receptors and withdrawal symptoms?
EW: This study is the first step towards increasing our understanding of cannabis' effects on the brain. The study will also examine the subjective drug effects of cannabis, and its effects on cognitive performance. By comparing these data in women with data we already have in men, we can examine differences in cannabis effects in men and women.
CBMD: What do you think are the biggest roadblocks to cannabis-focused research and how can they be overcome?
EW: Cannabis and all drugs derived from the plant are classified by the Drug Enforcement Agency (DEA) as a Schedule 1 compound. Drugs in Schedule 1 are those with no verified medical use and are highly controlled. Researchers who want to study cannabis or any of its components have to first be approved by the DEA for a Schedule 1 drug license, and usually an additional certificate from the state for controlled dangerous substances. Then, once completing this hurdle, researchers have to obtain the drug from government resources that have carefully tested and verified its purity. This is a lengthy process. Not all the compounds scientists are interested in studying are available for human research. Rescheduling cannabidiol or allowing exceptions for research of cannabis and other cannabinoid constituents, would greatly increase the ability to study these drugs. There just aren't enough studies demonstrating medical potential.
CBMD: How long does it take to become dependent on cannabis and does dependence always develop?
EW: First, I'd like to highlight that the word "dependence" is often misunderstood by the general public. The medical term "dependence" refers to physical dependence. Physical dependence is defined by physiological and behavioral symptoms that emerge when a person stops taking a drug and which can be reversed by administration of the drug. These symptoms are typically referred to as withdrawal. Withdrawal is time-delimited, in that symptoms emerge and then gradually decline over time. The fact that withdrawal is reversed by administration of the original drug provides evidence that the symptoms are related to drug use. Cannabis withdrawal has been empirically demonstrated and is included in the most recent revision to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).
CBMD: What percentage of users become dependent on medical cannabis?
EW: Prospective studies evaluating the development of physical dependence in medical cannabis users is lacking.
Analysis of data from medical cannabis dispensaries have shown medical cannabis users also can develop problems and cannabis use disorder with increasing use, particularly in younger users.
With regard to cannabis use in general, the National institute on Drug Abuse recently publish a report suggesting about 30% of cannabis users develop cannabis use disorder. Of these, about 9% can show physical symptoms of dependence.
CBMD: Are there common medical or co-conditions for dependence on medical cannabis and other substances?
EW: Co-use of cannabis with other substances and comorbid substance use disorder is common. In particular, cannabis co-use is often reported by individuals who also use alcohol, tobacco or other nicotine products, opioids, or cocaine. Unfortunately, people who have problems with one drug often misuse other drugs as well.
Substance use disorders are also more common in individuals who have psychological disorders.
CBMD: Do you think cannabis and/or cannabidiol have a role to play in helping people with substance use disorders?
EW: The cannabis plant contains hundreds of constituents, many of which we know very little about. I maintain an open mind about the potential medical utility of cannabis and its constituents. I think it's critical that medical use of any drug, including cannabis and/or cannabidiol, be based on scientific data. The gold standard is the placebo controlled, double blind, clinical trial. For medical use, we must demonstrate that the effectiveness of a treatment is greater than that of a placebo, determine appropriate dosing information, and also assess potential risks, including adverse effects, misuse liability, and possible drug interactions.
There is promise for the medical use of cannabidiol. It does not appear to produce psychoactive effects like delta-9-THC or synthetic cannabinoids and has no known misuse liability. Recently, the FDA approved an oral formulation of pure cannabidiol for the treatment of seizures associated with severe forms of epilepsy. The DEA has not yet made a scheduling determination for this formulation, although medical use would most likely require reclassification from its current status as Schedule 1 controlled drug.
There is also some exciting work that suggests cannabidiol may have utility for reducing neuroinflammation and may help reduce use of opioids.
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Tracks he's written have been used in international commercials for Audi, Mazda, Skechers and Verizon, as well as trailers for Star Wars: The Mandalorian, Maleficent 2, Disney's Cinderella, Ocean's 8, Susperia, Narcos, Sneaky Pete, as well as a Super Bowl Ad for Amazon Prime's Jack Ryan series.
His "4 Step Plan to Licensing Success" is a highly effective process that gives independent musicians world-wide the ability to generate sync placements on a consistent basis.
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Featuring Phantogram, MGMT, Royksopp, Fischerspooner, Foster the People, Depeche Mode, Austra, Crystal Castles, Ash Code, New Order, Grimes, CHVRCHES, Editors, Feathers, Gunship, Owl Eyes, Drab Majesty, Boy Harsher, Bat for Lashes. And so much more.