BIMZIP is a simple and easy-to-use BIM CMS and BIM CRM platform that will greatly enhance the capabilities of your sales team in promoting products in traditional sales sectors, but using BIM technologies and a new approach to the organization of the sales chain
You don’t need to wait long while webmaster modifies the content of your website. Our BIM oriented CMS allows you to add BIM ​​model of your equipment to the platform in several clicks, perform the necessary editing and publish it online. Just a several steps and you product is accessible online to the entire industry of designing organizations which are using the BIM technologies already
Think about how many intermediaries usually exist between you and the ultimate counterparty. We reduce this chain to a minimum. You can see who, when and what products the customers were interested in and have the opportunity to contact the customer as quickly as possible and clarify his needs, consult the product line and offer the most effective solution for application in the project even at the earliest stages
We alerady thought about how to present the product the best way, what information is most needed, and also added the ability to promote your products yourself on your own customer
For each product you can asssign the responsible manager, evaluate the quality of promotion and the relevance of BIM content. Evaluating the statistics of the BIM funnel, you can make more informed decisions in your marketing campaigns and make targeted actions that increase the recognizability and relevance of a particular product
The early progression of diabetic nephropathy is notoriously difficult to detect and quantify prior to the occurrence of substantial histological damage. Recently, hyperpolarized [1-13C] pyruvate has demonstrated increased lactate production in the kidney early after the onset of diabetes, implying increased lactate dehydrogenase activity as a consequence of increased nicotinamide adenine dinucleotide substrate availability due to upregulation of the polyol pathway, i.e., pseudohypoxia. In this study, we investigated the role of oxidative stress in mediating these metabolic alterations using state-of-the-art hyperpolarized magnetic resonance (MR) imaging. Ten-week-old female Wistar rats were randomly divided into three groups: healthy controls, untreated diabetic (streptozotocin treatment to induce insulinopenic diabetes), and diabetic, receiving chronic antioxidant treatment with TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl) via the drinking water. Examinations were performed 2, 3, and 4 weeks after the induction of diabetes by using a 3T Clinical MR system equipped with a dual tuned 13C/1H-volume rat coil. The rats received intravenous hyperpolarized [1-13C] pyruvate and were imaged using a slice-selective 13C-IDEAL spiral sequence. Untreated diabetic rats showed increased renal lactate production compared to that shown by the controls. However, chronic TEMPOL treatment significantly attenuated diabetes-induced lactate production. No significant effects of diabetes or TEMPOL were observed on 13C-alanine levels, indicating an intact glucose-alanine cycle, or 13C-bicarbonate, indicating normal flux through the Krebs cycle. In conclusion, this study demonstrates that diabetes-induced pseudohypoxia, as indicated by an increased lactate-to-pyruvate ratio, is significantly attenuated by antioxidant treatment. This demonstrates a pivotal role of oxidative stress for renal metabolic alterations occurring in early diabetes.