Yellow Mangosteen fruits in colder regions where the purple ones do not.An advantage if you do not live in the tropics. They fruit in the south of Qld. This is a true yellow mangosteen fruit tree & not the one they refer to as the native gardenia yellow mangosteen which is not a mangosteen & not related. The product on offer for sale here is a small tree approx 20-30cm tall in a grow bag & can be shipped in most cases in Australia minus the bag for an additional $32 for up to 4 plants. Limited supply currently so just ask if interested.
Products derived from mangosteen are now distributed increasingly all over the world. This has given rise to a concomitant increase in research on the phytochemical constituents and biological activity of mangosteen.The typical phytochemicals found in mangosteen include catechins, rosin, mangostin, normangostin, xanthones, gartanin and tannins.Amount these components the central phytochemicals that contribute to the biological activity of mangosteens are xanthones such as α-mangostin, a polyphenolic xanthone derivative from mangosteen.Currently, α-mangostin have exhibited antioxidant ,anticancer, anti-inflammatory and synergistic activity with antibiotics against resistant bacteria in lab researches.
Reactive oxygen species (ROS) are important mediators in a number of degenerative diseases and antioxidant can inhibit ROS production through controlling oxidative stress .Therefor natural compounds with antioxidant properties has been hoped to be therapies to decrease oxidative damage and stimulate endogenous cytoprotective systems. Rind of mangosteen is one of the best natural sources of xanthones, which have been reported to have high antioxidant activity.According to research reported on J. Agric. Food Chem in 2006 the antioxidant activities of Garcinia mangostana L (commonly known as mangosteen) was verified and as one mechanism of its anticancer actions . There are 14 highly oxygenated prenylated xanthones were isolated from the extract of the mangosteen pericarp and the antioxidant activities of all isolates were determined using authentic and morpholinosydnonimine-derived peroxynitrite methods . Amount these compositions there are 4 compounds including α-mangostin were the most active.
The anticancer property of mangosteen (Garcinia mangostana L) has been drawing attention to its potential therapeutic applications. A study on International Journal of Molecular Sciences investigated the anti-proliferative effects of four prenylated xanthones from the pericarps in various human cancer cells in 2008 ,and α-mangostin, β-mangostin, γ-mangostin these three all show strong inhibition cell growth at low concentrations from 5 to 20 μM in human colon cancer DLD-1 cells.Another research group conducted an investigation of the anticancer effect of α-mangostin in human PCa cells and its role in targeting cell cycle-related proteins involved in prostate carcinogenesis. On their repoet on Carcinogenesis it is found that a-mangostin significantly decreases PCa cell viability in a dose-dependent manner.Further research showed on ANTIOXIDANTS & REDOX SIGNALING that a-Mangostin resulted in a significant inhibition of Pancreatic cancer cells (PL-45, PANC1, BxPC3, and ASPC1)viability and a dose-dependent increase of apoptosis in PC cells without having any effects on normal human pancreatic duct epithelial cells.Front Pharmacol conluded in 2013 extracts and individual xanthones have been found to induce apoptosis and inhibit proliferation on cancer cells in vitro and in vivo. Based on the reported findings there is clear evidence that these polyphenols target multiple signaling pathways involved in cell cycle modulation and apoptosis.
These findings could provide a relevant basis for the development of xanthones as an agent for cancer prevention and the combination therapy with anti-cancer drugs.
participants, 30 men, and 30 women, ages 18–60 were conducted in 2015 to dtermine the anti- inflammatory activitiy of mangosteen .The report on Food Science & Nutrition the inflammatory biomarkers, in the mangosteen group, between the preintervention and postintervention, the C- reactive protein level significantly decreased by 46%, while no obvious decreases for the same biomarker was observed in the placebo group. Food Chemistry released in 2012 , an investigation for the effect of α-and γ-mangostins on the bone marrow-derived mast cell (BMMC) mediated allergy mechanism induced by phorbol 12-myristate 13-acetate (PMA) plus A23187. α- and γ-mangostins demonstrated to inhibit Interleukin (IL)-6, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) production as well as degranulation in PMA plus A23187 induced BMMC. Furthermore, α- and γ-mangostins were found to repress cyclooxygenase (COX)-2 expression in the reported study. Thus, these results suggest that α- and γ-mangostins may be useful in alleviating mast cell-mediated allergic inflammatory responses.
Early study on J Med Assoc Thai determined the eliminating ability of the mangosteen mangosteen extract on S. Enteritidis .The report suggests that polysaccharides in the extract can stimulate phagocytic cells and kill intracellular bacteria (S. enteritidis).The extract was fractionated by anion exchange chromatography on a DEAE-cellulose column as MDE1-5 fractions. Activating score (mean +/- SD) of nitroblue tetrazolium (NBT) test of 100 polymorphonuclear phagocytic cells were 145 +/- 78, 338 +/- 58, 222 +/- 73, 209 +/- 77, 211 +/- 63, 372 +/- 19, 369 +/- 20, 355 +/- 34 in normal saline control, phorbol myristate acetate (PMA), MDE3, MDE4, indomethacin (I), PMA + MDE3, PMA + MDE4 and PMA+ I, respectively. Superoxide generation test was also shows both MDE3 and MDE4 stimulate superoxide production. The number of S. enteritidis in cultured monocyte with extract of pericarb of mangosteen was killed.