-LRB- CNN -RRB- -- Lionel Messi scored his second hat-trick in four days as titleholders Barcelona marched into the knockout stage of the European Champions League on a night of milestones for the Spanish club on Tuesday . The striker , a big favorite to win his third world player of the year award after heading the 2011 nominations before the match against Viktoria Plzen , passed a double century of goals for Barca to mark coach Josep Guardiola 's 200th match in charge . The Czech champions capitulated to a 4-0 home defeat in the Group H game after having Marian Cisovsky sent off for a foul in the box on Messi , who scored the resulting penalty to open the scoring in the 24th minute with his milestone goal . The Argentine made it 2-0 in the second minute of first-half injury-time after combining with Adriano , and he sealed the rout in stoppage time after a superb backheel pass from central defender Gerard Pique set him free for his 202nd . Is Messi the only candidate for Ballon d'Or ? Barca 's third came in the 72nd minute when Cesc Fabregas -- among eight Barca players in the 23-man FIFA Ballon d'Or Shortlist -- headed home a cross by young winger Isaac Cuenca . Guardiola became only the fifth Barca boss to reach 200 games , suffering just 17 defeats . Messi has scored 160 of the 500 goals netted in that period . The clean sheet meant that Barcelona goalkeeper Victor Valdes set a new club record of 877 minutes without conceding , beating the previous mark set by Miguel Reina in 1973 . The win gave Barca 10 points from four games , leaving the Catalans two clear of second-placed AC Milan with two rounds to play . The Italian champions went through to the second round despite being held 1-1 by BATE Borisov in Belarus in an earlier kickoff . Milan went into the match denying reports that hospitalized striker Antonio Cassano had suffered a stroke . `` I think every patient has the right to privacy , the doctors are working on it and there 's nothing more to say , '' chief executive Adriano Galliani told the club 's website . `` I spoke to him today and he seemed in good form . There was of course a bit of fear because the whole thing was so unexpected . '' Milan took the lead in the 22nd minute through striker Zlatan Ibrahimovic , who won possession out wide on the right and then burst into the box to receive Robinho 's pass and score . But Borisov leveled 10 minutes after halftime with a penalty by Renan Bressan when Ignazio Abate fouled Artem Kontsevoy . Chelsea missed the chance to go through in Group E after being held to a 1-1 draw by Genk in Belgium , as David Luiz missed a penalty for the visitors . Captain John Terry was left on the bench after UK police confirmed he faces a formal investigation into claims the defender racially abused Queen 's Park Rangers ' Anton Ferdinand . The London team , beaten 5-3 by Arsenal at the weekend , took a 26th-minute lead through Ramires but fellow Brazilian Luiz saw his spot-kick saved five minutes before the break . Jelle Vossen leveled just after the hour to leave Chelsea on eight points , and Genk on bottom with two . Second-placed Bayer Leverkusen remained on six points after losing 3-1 at Valencia , who are a point further back following the second-fastest goal in Champions League history . Jonas netted just after 10 seconds , but Stefan Kiessling equalized on the half hour . However , Roberto Soldado -LRB- 65 -RRB- and Adil Rami -LRB- 75 -RRB- kept the Spanish side 's hopes alive ahead of the final two games . Group F leaders Arsenal also failed to qualify for the last 16 after being held to a 0-0 draw at home to Marseille . The French side remained one point behind Arsenal , who have two wins and two draws . German champions Borussia Dortmund moved off the bottom with a 1-0 win over Greek club Olympiakos . Kevin Grosskreutz scored the only goal in the seventh minute with a spectacular strike to put Dortmund within three points of Marseille ahead of the trip to Arsenal on November 23 . Group G was blown wide open when unfancied Cypriot side Apoel Nicosia shocked Europa League winners Porto 2-1 to stay top of the table . Ailton put the home side ahead three minutes before halftime with a penalty , but fellow Brazilian Hulk leveled from the spot for the Portuguese champions in the 89th minute . However , Gustavo Manduca headed a last-gasp winner to put Apoel a point clear of Zenit St. Petersburg . The Russian champions won 1-0 against Ukraine 's Shakhtar Donetsk , who were left bottom on two points after center-back Nicolas Lombaerts headed the only goal in first-half injury-time .