Ablation of the genicular nerves (GN) has emerged as a useful alternative therapeutic modality in chronic knee osteoarthritis (OA) specially for high-risk patients. However, in some cases due to the presence of other articular branches or anatomical variability, it may have a poor impact in relieving pain. Ablation of other or additional articular branches might have different outcomes.
We aimed to investigate the efficacy and safety of using 3 needles as a new technique in ablation of GN and compare it to the classic single-needle approach.
A prospective parallel single-blind randomized study.
Department of Anesthesia and Intensive Care, Faculty of Medicine, Minia University, Egypt, and Pain Management Unit, Assiut University Hospital, Egypt.  METHODS: Fifty patients with advanced knee OA were involved in this clinical study to be treated with radiofrequency ablation of GN using either: the single-needle technique (SN group [n = 25]) or the 3-needle technique (TN group [no = 25]) and assessed for: pain with the Visual Analog Scale (VAS); knee function and disability with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); and patient satisfaction using global-perceived effect throughout 2 weeks, and 1, 3, and 6 months after the procedure.
Significantly longer and better improvement in perceived pain (VAS), function and disability (WOMAC) with more patients' satisfaction were recorded in the TN group than the SN group at all follow-up time points without untoward events.
Short follow-up time; longer period could permit recognition of long-term outcome.
Compared to the conventional single-needle GN ablation technique, the 3-needle  approach appears to be a promising, safe, and more effective ablation technique for patients with chronic knee OA.