Increased Wisp1 expression was previously reported in experimental and human osteoarthritis (OA). Moreover, adenoviral overexpression of Wisp1 in naïve mouse knee joints resulted in early OA-like cartilage lesions. Here, we determined how the matricellular protein WISP1 is involved in the pathology that occurs in the complex osteoarthritic environment with aging and experimental OA in wild type (WT) and Wisp1
WT and Wisp1
With aging, spontaneous cartilage degeneration in Wisp1
WISP1 plays an aggravating role in the development of post-traumatic experimental OA.