The main goal of this study was to provide a proof-of-concept demonstrating that hyperosmolar K
A 3-dimensional in vitro model with poly(ethylene glycol) diacrylate (PEGDA) hydrogels was used. Catabolic and pro-inflammatory protein production from encapsulated OACs was assessed following culture for 1 or 7 days in the presence or absence of 80 mM K
Relative to untreated controls, OACs treated with hyperosmolar (80 mM Na
Hyperosmolar K