Interferon α‑2b (IFN α‑2b) is an established and well-tolerated treatment for ocular surface squamous neoplasia (OSSN).
Report of complications in two patients with OSSN and rheumatoid arthritis treated with adjuvant topical IFN α‑2b.
One patient developed a scleral melt and the other one severe keratitis. After discontinuing treatment with IFN α‑2b both patients showed considerable improvement.
Immunosuppressed patients with OSSN under topical IFN α‑2b should be closely monitored for early detection of complications.