To introduce a novel preclinical animal model of psoriatic arthritis (PsA) in R26Stat3C
We characterized a novel murine model of Th17-driven cutaneous and synovio-entheseal disease directed by T cell-specific expression of a hyperactive Stat3 allele. By crossing R26Stat3C
R26Stat3C
Perturbation of the IL-23/Th17 axis instigates Th17-mediated inflammation in R26Stat3C