To develop a Childhood Lupus Improvement Index (CHILI) as a tool to measure response to therapy in childhood-onset systemic lupus erythematosus (cSLE), with a focus on clinically relevant improvement (CRI
Pediatric nephrology and rheumatology subspecialists (n = 213) experienced in cSLE management were invited to define CRI
During an international consensus conference, unanimous agreement on a definition of CRI
The CHILI is a new, seemingly highly accurate index for measuring CRI in cSLE over time. This index is useful to categorize the degree of response to therapy in children and adolescents with cSLE.