To compare biomechanical and clinical outcome of laterally wedged insoles (LWI) and an ankle-foot orthosis (AFO) in patients with medial knee osteoarthritis.
Single-centre, block-randomized, cross-over controlled trial.
Outpatient clinic.
About 39 patients with symptomatic medial knee osteoarthritis.
Patients started with either LWI or AFO, determined randomly, and six weeks later changed to the alternative.
Change in the 1st maximum of external knee adduction moment (eKAM) was assessed with gait analysis. Additional outcomes were other kinetic and kinematic changes and the patient-reported outcomes EQ-5D-5L, Oxford Knee Score (OKS), American Knee Society Clinical Rating System (AKSS), Hannover Functional Ability Questionnaire - Osteoarthritis and knee pain.
Mean age (SD) of the study population was 58 (8) years, mean BMI 30 (5). Both aids significantly improved OKS (LWI 
AFO reduces medial knee load more than LWI. Nevertheless, no clinical superiority of either of the two aids could be shown.