Elevated levels of type I interferons (IFNs) are a characteristic feature of the systemic autoimmune rheumatic diseases (SARDs) and are thought to play an important pathogenic role. However, it is unknown whether these elevations are seen in anti-nuclear antibody-positive (ANA
Healthy ANA
The mean IFN5 scores were increased in all ANA
An IFN signature is seen in a significant proportion of ANA