Recent transcriptome analyses revealed that 15-fold expanded HLA-DR
We combined functional assays using primary human materials and focused bioinformatic analyses of mass cytometry and transcriptomics patient datasets.
We detected enriched and activated FcɣRIIIA(CD16)+ NK cells in synovia from active RA. CD16 recognized immune complexes in synovial fluid, potentially contributing to NK cell activation in RA. In vitro, NK cell-derived IFNɣ induced HLA-DR and an inflammatory, cytokine secreting, HLA-DR
HLA-DR