Interleukin-1β (IL-1β) is involved in osteoarthritis pathogenesis and mediates a series of toxic processes including the production of matrix metalloproteinase and inflammatory regulators which are suppressed by activation of silent information regulator 1 (SIRT1). We aimed to determine the effects of ferulic acid (FA) on IL-1β-induced osteoarthritis chondrocyte degeneration.
We examined the effects of FA on osteoarthritis chondrocyte viability and SIRT1 activation. The impact of FA on IL-1β-induced osteoarthritis chondrocyte toxicity was determined by prostaglandin E2 (PGE
We found that FA activated SIRT1/AMPK/PGC-1α signaling pathway and attenuated IL-1β-induced osteoarthritis chondrocyte degeneration by suppressing the production of IL-6, PGE
Our findings reveal that FA prevents IL-1β-induced osteoarthritis chondrocyte toxicity, which suggests that FA may be a potential therapy for osteoarthritis and warrants further investigation for its clinical application.