A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with rheumatoid arthritis (RA) and atopic dermatitis (AD). However, there still existed studies that did not confirm this correlation.
The objective of this study was to evaluate the relationships of RANTES and RA and AD using a meta-analysis.
Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers, and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated.
Eight studies were enrolled, including a total of 548 RA cases and 493 controls of -403G/A, 305 RA cases and 303 controls of -28C/G, and 705 AD cases and 578 controls of -403G/A in this meta-analysis. In RA, the overall OR and 95% CI of -403A were 1.41, 1.10-1.82 (p = 0.391) and 2.18, 1.30-3.66 (p = 0.335) in dominant and recessive models, respectively. The overall OR and 95% CI of -28G in RA were 1.35, 0.91-2.01 (p = 0.707) and 3.32, 1.29-8.52 (p = 0.559) in dominant and recessive models, respectively. Moreover, the overall OR and 95% CI of -403A in AD were 1.38, 1.08-1.76 (p = 0.421) and 1.06 and 0.65-1.72 (p = 0.361) in dominant and recessive models, respectively.
This meta-analysis showed that RANTES -403G/A and -28C/G were not associated with RA and AD.