To investigate the immunosuppressive effect of vitamin K2 against mitogen-activated peripheral blood mononuclear cells (PBMCs) of rheumatoid arthritis (RA) patients.
Concanavalin A-stimulated PBMC culture procedure was used to evaluate the pharmacodynamics of vitamin K2 in vitro. Methotrexate was set up as the positive control. The proliferation of PBMCs was detected by MTT assay. Relationship between IC
Vitamin K2 inhibited the proliferation of mitogen-activated PBMCs of RA patients with an IC
The above information suggests that vitamin K2 could provide a benefit for the treatment of RA patients via its immunosuppressive function.