To investigate the efficacy of sequential treatment with adductor canal nerve block (ACNB) and cyclooxygenase 2 (COX-2) selective inhibitor (parecoxib and celecoxib) after primary total knee arthroplasty (TKA).
Between January 2015 and December 2015, 90 osteoarthritis patients who met the inclusion criteria were treated, and randomly divided into 3 groups:ACNB+COX-2 group (group A, 
The length of hospital stay was significantly shorter and the incidence of postoperative nausea and vomiting was significantly lower in groups A and B than group C (
探讨人工全膝关节置换术（total knee arthroplasty,TKA）后收肌管神经阻滞（adductor canal nerve block，ACNB）联合环氧合酶2（cyclooxygenase 2,COX-2）选择性抑制剂（帕瑞昔布+塞来昔布）序贯应用的镇痛效果。.
将2015年1月－12月收治并符合选择标准的90例骨关节炎患者，随机分成3组（
A、B组术后住院时间较C组显著缩短、恶心呕吐发生率较C组显著降低（
ACNB联合COX-2选择性抑制剂序贯应用是安全、有效的TKA术后疼痛管理方案，可明显减轻TKA术后疼痛、促进关节功能康复，降低不良反应发生率。.
Sequential treatment with ACNB and COX-2 selective inhibitor is a safe and effective approach for postoperative pain management after primary TKA, and it can alleviate postoperative pain, promote the joint function recovery, and reduce the risk of adverse reactions.