To determine the repeatability and response to therapy of dynamic contrast-enhanced (DCE) MRI biomarkers of synovitis in the hand and wrist of rheumatoid arthritis (RA) patients, and in particular the performance of the transfer constant K 
DCE-MRI and RA MRI scoring (RAMRIS) were performed with meticulous standardisation at baseline and 6 and 24 weeks in a substudy of fostamatinib monotherapy in reducing synovitis compared with placebo or adalimumab. Analysis employed statistical shape modelling to avoid biased regions-of-interest, kinetic modelling and heuristic analyses. Repeatability was also evaluated.
At early study termination, DCE-MRI data had been acquired from 58 patients in 19 imaging centres. K 
• DCE-MRI biomarkers are feasible in large multicentre studies of joint inflammation. • DCE-MRI K 
This demonstrated repeatability of K 