To investigate the inpatient prevalence, characteristics and comorbidities of patients admitted with Takayasu's arteritis (TAK) in the United States (US).
Patients with TAK were identified within the Nationwide Inpatient Sample (NIS) database of the years 2013 and 2014 using the respective ICD-9 diagnostic code. Data on patient characteristics, comorbidities, resource utilization and expenditures was collected. A propensity-matched cohort of individuals without TAK was also created from the same database to serve as comparators.
A total of 2840 patients with TAK were identified from the database, corresponding to an inpatient prevalence of 4.6 cases per 100,000 admissions. Compared to the propensity-matched cohort of individuals without TAK, patients with TAK were found to have significantly increased odds of stroke (adjusted odds ratio (aOR): 4.66, 95% CI: 2.10-10.31, p < 0.01), aortic aneurysm (aOR: 40.76, 95% CI: 9.13-181.7, p < 0.01), aortic valvulopathy (aOR: 4.92, 95% CI: 2.09-11.55, p < 0.01) and peripheral vascular disease (aOR: 4.41, 95% CI: 1.22-3.32, p < 0.01). However, the mortality was not significantly different (aOR: 1.44, 95% CI: 0.58-3.61, p = 0.43). After adjusting for confounders, patients with TAK displayed a mean additional $11,275 (95% CI, $4946-$17,603) for total hospital costs and a mean additional $45,305 (95% CI, $23,063-$67,546) for total hospitalization charges when compared to patients without TAK.
The inpatient prevalence of TAK was higher than what would be expected from the overall incidence. The mean total hospital costs and total hospitalization charges for a patient admitted with TAK were higher than patients without TAK. Analysis of comorbidities found significantly higher odds of several vascular comorbidities compared with a propensity-matched cohort of individuals without TAK.