Transient receptor potential vanilloid channel 2 (TRPV2) is a Ca
We examined TRPV2 expression in mouse and human articular cartilage. We analyzed the development of OA in Col2a1-Cre
TRPV2 was expressed in mouse and human articular cartilage and ectopic ossification lesions. In all mouse models of OA examined, Col2a1-Cre
Our findings demonstrate regulation of articular cartilage by TRPV2 through Prg4 induction and suppression of ectopic ossification.