To delineate the activities of decorin and biglycan in the progression of post-traumatic osteoarthritis (PTOA).
Three-month-old inducible biglycan (Bgn
In the DMM model, Bgn
In PTOA, decorin plays a more crucial role than biglycan in regulating cartilage degeneration, while biglycan is more important in regulating subchondral bone structure. The two have distinct activities and modest synergy in the pathogenesis of PTOA.