Because a significant fraction of patients with lupus nephritis (LN) develops renal impairment, there is a need to better understand the mechanisms underlying disease progression. Here, we assessed for cellular senescence in the LN kidney, and its association with disease severity and outcome.
We enumerated the number of cells positive for p16
The presence of p16
We demonstrate, for the first time, that LN biopsies characterised by renal impairment display increased p16