To review the research progress of cartilage oligomeric matrix protein (COMP).
Domestic and abroad literature about COMP was reviewed and summarized.
COMP was one of the osteoarthritis (OA) biomarkers of being widely studied. Most studies in recent years could draw the conclusion that COMP was associated with OA. COMP was the foremost biomarker among investigated biomarkers. It could been continuously expressed and predicted knee OA progression.
Precisely what role COMP plays in OA pathogenesis remains unclear, using COMP as a tool to early diagnose OA more studies would be needed.