Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerful tool for assessing inflammatory response in the brain and periphery. To date, however, the development of PET radioligands for COX-2 has had limited success.
The novel PET tracer [
COX-2 binding, expressed as the ratio of specific to nondisplaceable uptake (BP
ClinicalTrials.gov NCT03912428. Registered April 11, 2019.
Taken together, these results indicate that [