The structure of the epidemiological process of rheumatoid arthritis (RA) is integrated in a broader framework of multiple interactions between intrinsic predisposing factors and the external environmental factors that may have a triggering or stimulating effect. The summative phenom enon is the result of the additive effect of risk factors, the individualized response of body structures and functions, depending on the genetic makeup explain the complexity of the epidemiologic study.
To evaluate the epidemiological, clinical and biological features of a series of RA patients.
The study included 103 RA patients admitted to the Rheumatology Clinic of the Iasi Rehabilitation Hospital in the interval January, 2010 - December, 2012.
The analysis of epidemiological data provided information on pre-existing infections caused by the living environment conditions, diet, etc., that may cause damage at cellular and molecular level.
The present clinical and epidemiological study describes the biological mechanisms and phenomena dependent on physical and social environment. These mechanisms favor and stimulate the occurrence, expansion and development of the disease at population level.