To study the relationship between synovial membrane apoptosis and different arthropathy for the pathogenesis of cartilage lesion in arthropathy.
Synovial specimens (28 cases) were divided into control group (9 cases), osteoarthritis group (7 cases), dislocation group (5 cases), meniscus injury group (5 cases) and arthropyosis group (2 cases). Synovial histological sections were stained with methylene blue, and examined under microscope. DNA was extracted from synovial specimens, and analysed by gel electrophoresis.
DNA ladder pattern was the most clear in the arthropyosis group, moderately clear in the dislocation group (especially in a case of 20 years-old shoulder dislocation), less clear in the osteoarthritis group, the least clear in the meniscus injury group, and was not seen in the control group.
It can be concluded that the increased apoptosis is related to causes, course and seriously of arthropathy, and it might be a pathogenesis of cartilage lesion in arthropathy.