Shared epitope (SE)-coding 
3-month old naïve transgenic mice that carry the human SE-coding allele 
Transgenic mice expressing the SE-coding 
A human SE-coding allele increases the propensity to spontaneous bone-destructive periodontal inflammation and skeletal bone damage in transgenic mice. These findings provide new insights into the previously documented but poorly understood association of the SE with accelerated bone erosion in RA and several other human diseases.