Gout and hyperuricemia incidence is increasing worldwide, reflecting pandemic overweight and obesity. However, the magnitude of the association of body mass index (BMI) changes with serum uric acid (SUA) level in the general population has remained unevaluated.
This retrospective cohort study enrolled 27,422 Korean men who underwent comprehensive health checkup between 2015 and 2017. BMI change was categorized into seven groups. The relationship between BMI change and SUA level alteration was determined using multivariable regression models.
The mean age, BMI, and SUA were 38.8 years, 24.7 kg/m
BMI change could have a significant association with the alteration of SUA levels of apparently healthy men. Despite its small effect size, the health risks and benefits of BMI change would be emphasized for the SUA level alteration.