The Sarar cohort consists of patients with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) who underwent hip or knee arthroplasties at hospital Sarah-Brasília. The objective of this study was to evaluate clinical and laboratory factors associated with disease activity, functional capacity and radiological damage in RA patients, participants in this cohort.
cross-sectional study, with data collection achieved from medical records review.
Thirty-two patients were included, with a mean time of disease onset of 240 months. Nineteen patients underwenttotal knee (TKA) and 17 total hip (THA) arthroplasty. There was a positive correlation between maximum dose of methotrexate (MTX) and Clinical Disease Activity Index (CDAI) (R = -0.46, p = 0.011), and a negative one with Simplified Erosion and Narrowing Score (SENS) (R = - 0.58, p = 0.004). SENS values were higher in patients with rheumatoid factor (RF) (p = 0.005) and anti-cyclic citrullinated peptide antibody 3 (anti-CCP3) positivity (p = 0.044), in those with higher RF (p = 0.037) and anti-CCP3 (p = 0.025) titers, and lower in patients with family history of RA (p = 0.009). HAQ values were higher in older patients (p = 0.031). In multiple linear regression, only "maximum dose of MTX' and "family history" remained with significant association with SENS (r(2) = 0.73, p <0.001 for both variables). In the model evaluating CDAI only "maximum dose of MTX" remained significantly associated (r(2) = 0.35, p = 0.016).
In the Sarar cohort, clinical and laboratory factors were related to disease activity, functional capacity and radiological damage, similar to studies evaluating patients with lower disease duration.