Gene transfer of the transcription factor SOX9 with clinically adapted recombinant adeno-associated virus (rAAV) vectors offers a powerful tool to durably enhance the repair process at sites of osteochondral injuries and counteract the development of perifocal osteoarthritis (OA) in the adjacent articular cartilage.
To examine the ability of an rAAV 
Controlled laboratory study.
Standardized osteochondral defects created in the knee joints of adult sheep were treated with rAAV-FLAG-h
Effective, prolonged 
The delivery of therapeutic rAAV 
rAAV-mediated 