To investigate previously identified and novel correlates of acute calcium pyrophosphate (CPP) crystal arthritis among well-characterized cases.
In this case-control study, we identified cases of acute CPP crystal arthritis using a validated algorithm (positive predictive value 81%) applied in the Partners HealthCare electronic health record (EHR). Cases were matched to general patient controls on year of 1
We identified 1697 cases matched to 6503 controls. Mean age was 73.7 (SD 11.8) years, 56.7% were female, 80.8% White, 10.3% Black. All pre-specified covariates were more common in cases than controls. Osteoarthritis (OR 3.08), male sex (OR 1.35), rheumatoid arthritis (OR 2.09), gout (OR 2.83), proton pump inhibitors (OR 1.94), loop diuretics (OR 1.60), and thiazides (OR 1.46) were significantly associated with acute CPP crystal arthritis after full adjustment. Black race was associated with lower odds for acute CPP crystal arthritis compared to White race (OR 0.47).
Using a validated algorithm to identify nearly 1700 patients with acute CPP crystal arthritis, we confirmed important correlates of this acute manifestation of CPPD. This is the first study to report higher odds for acute CPP crystal arthritis among males.