To understand the relationship between T cell clonotypes and RA invasion through clonotypes of analysis of T cells accumulated in 4 feet joints of SKG mice.
Comparative analysis of T cells clonotypes of accumulated in the joints of SKG mice, a spontaneous RA mouse model, was carried out by RT-PCR/SSCP at the initial and late-stages of RA.
The identical rate of Vbeta2 and Vbeta8.2 T cell clonotypes in 4 feet joints increased significantly at the late stage of RA (72.3% and 60.2%, respectively).
The T cells with Vbeta2 or Vbeta8.2 TCR may play an important role in the RA development of SKG mice.