To study the correlation in the material foundation in compatibility of Ermiao wan categorized formulas (Ermiaowan, Sanmiaowan, Simiaowan and modified Simiaowan) and to explore its characteristics changes.
Determined the fingerprint of the effective parts of Ermiao wan categorized formulas in anti-gouty syndrome of damp and heat and compared the composition features and compatibility changes of total peaks by establishing the HPLC fingerprint and using reference substances to identify the ingredients of the common peaks, the ascription and the source of the chromatographic peaks.
The effective parts of modified Simiao Wan had 60 total peaks which come from the sites of alkaloids, flavonoids, organic acids. There were some change principles in the number of total peaks and relative peak area ratio between basic formula and categorized formulas.
Ermiaowan categorized formulas have same substance-foundation and there are some correlations in the compatibility changes.