By univariate Cox regression analysis , low baseline soluble protein levels were associated with lower risk of progression/death ( all P < @ ) : in both treatment arms , baseline VEGF-A and IL-@ were associated with overall survival ( OS ) and baseline VEGF-C with progression-free survival ( PFS ) ; in the sunitinib arm , baseline VEGF-A was associated with PFS and baseline sVEGFR-@ with PFS and OS ; in the IFN - arm , baseline IL-@ was associated with PFS .