More rapid change ( ie , worsening ) in the UPDRS Part II score ( hazard ratio , @ -LSB- @ % CI , @-@ @ -RSB- for @ scale unit change per @ months ) , the UPDRS Part III score ( hazard ratio , @ -LSB- @ % CI , @-@ @ -RSB- for @ scale unit change per @ months ) , and the Schwab and England Independence Scale score ( hazard ratio , @ -LSB- @ % CI , @-@ @ -RSB- for @ percentage point change per @ months ) was associated with earlier need for symptomatic therapy .