The depletion of irisin significantly correlated with changes in some atherogenic-related variables : total cholesterol ( B = @ , P = @ ) , total cholesterol/high-density lipoprotein cholesterol ratio ( B = @ , P = @ ) , low-density lipoprotein cholesterol ( B = @ , P = @ ) and apolipoprotein B ( B = @ , P = @ ) , independently of changes in body weight .