Patients who received cediranib had more grade @-@ toxic effects than did patients who received placebo : hypertension ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ; p = @ ) , diarrhoea ( eight -LSB- @ % -RSB- vs two -LSB- @ % -RSB- ; p = @ ) ; platelet count decreased ( ten -LSB- @ % -RSB- vs four -LSB- @ % -RSB- ; p = @ ) , white blood cell decreased ( @ -LSB- @ % -RSB- vs seven -LSB- @ % -RSB- ; p = @ ) and fatigue ( @ -LSB- @ % -RSB- vs seven -LSB- @ % -RSB- ; p = @ ) .