The observed @-month PFS rate was @ % ( @ % confidence interval ( CI ) , -LSB- @-@ @ % -RSB- ) in arm A reaching the Fleming decision rules criteria to reject H@ and @ % ( @ % CI -LSB- @-@ @ % -RSB- ) in arm B. Objective response rates were @ % ( @-@ % ) in arm A and @ % ( @-@ % ) in arm B. Median PFS ( @ versus @ months , hazard ratio ( HR ) = @ -LSB- @-@ @ -RSB- ) and overall survival ( @ versus @ months , HR = @ -LSB- @-@ @ -RSB- ) were higher in arm A compared to arm B.