However , CaD supplementation had differential effects ( P interaction = @ ) in subgroups stratified by baseline risk status of HF defined by the presence ( high risk = @ @ ) or absence ( low risk = @ @ ) of pre-existing HF precursors including coronary heart diseases , diabetes mellitus , or hypertension : @ % ( hazard ratio , @ -LSB- @ % confidence interval , @-@ @ -RSB- ) lower risk of HF in the low-risk versus hazard ratio , @ ; P = @ , in the high-risk subgroups .