Inflammatory factors ( including interleukin-@ , interleukin-@ , tumor necrosis factor-alpha ) and coagulation parameters -LSB- including prothrombin time ( PT ) , activated partial thromboplastin time ( APTT ) , fibrinogen ( FIB ) , and D-dimer ( DD ) -RSB- were observed before treatment , and @ , @ , and @ days after treatment in the two groups .