However , patients with more frequent wine consumption had a significantly better perception of health status ( Kansas City Cardiomyopathy Questionnaire score , adjusted P < @ ) , less frequent symptoms of depression ( Geriatric Depression Scale , adjusted P = @ ) , and lower plasma levels of biomarkers of vascular inflammation ( osteoprotegerin and C-terminal proendothelin-@ , adjusted P < @ , and pentraxin-@ , P = @ ) after adjusting for possible confounders .