There was a significant correlation for the subset of subjects who showed a significantly greater responder rate in the post hoc analysis of the trial , i.e. , subjects who had a @-fold or greater increase in average daily seizure frequency perimenstrually compared with the midfollicular and midluteal phases ( C@ @ : r = -@ , p = @ , and specifically for C@ @ progesterone-treated subjects -LSB- r = -@ , p = @ -RSB- , but not other groups -LSB- C@ @ placebo : r = -@ ; C@ < @ progesterone : r = @ ; C@ < @ placebo : r = @ ; p = not significant -RSB- ) .