Least-square mean spleen volume decreased by @ % ( @ % CI , -@ % to -@ % ) in the eliglustat group ( from @ to @ multiples of normal ) vs an increase of @ % ( @ % CI , -@ % to @ % ) in the placebo group ( from @ to @ multiples of normal ) for an absolute treatment difference of -@ % ( @ % CI , -@ % to -@ % ; P < @ ) .