Forty-one patients with active RA despite disease-modifying antirheumatic drug therapy were randomised @:@ to CZP ( CZP loading dose @mg every @weeksat weeks @-@ ; CZP @mg every @weeksat weeks @-@ ) or placeboCZP ( placebo at weeks @-@ ; CZP loading dose at weeks @-@ ; CZP @mg every @weeks at weeks @-@ ) .