A significant interaction grouptime effect was found for pain on HRQOL ( F@ ,@ = @ ; P = @ ; partial @ = @ ) , clinical severity ( F@ ,@ = @ ; P = @ ; partial @ = @ ) , especially for venous edema ( assessed with the VCSS ) , fatigue ( F@ @,@ = @ ; P = @ ; partial @ = @ ) , and heaviness ( F@ @,@ = @ ; P = @ ; partial @ = @ ) , with the experimental group improving from t@ to t@ and t@ to t@ in all of these outcomes .