Risk factors for early termination were higher age ( hazard ratio -LSB- HR -RSB- @ , @ % confidence interval -LSB- @ % CI -RSB- @-@ @ ) , functional disability during the preceding year ( HR @ , @ % CI @-@ @ ) , having achieved drug-free remission ( HR @ , @ % CI @-@ @ ) , limited joint damage ( HR @ , @ % CI @-@ @ for actual damage ; HR @ , @ % CI @-@ @ for damage progression ) , and few adverse events ( HR @ , @ % CI @-@ @ ) .