PCOS women were treated with pioglitazone @ mg/day and at the beginning and after @ months of treatment were evaluated : menstrual cycle trend , hirsutism and acne , total cholesterolemia and HDL , triglyceridemia , fibrinogenemia , C-reactive protein , oral glucose tolerance test , glycated hemoglobin , FSH , LH , @OH-progesterone , @-estradiol , free and total testosterone , SHBG , DHEA-S , @-androstenedione and adiponectin .