The most frequent grade @ and @ adverse events were thrombocytopenia ( @ % -LSB- TSU-@ + SOX -RSB- vs. @ % -LSB- SOX -RSB- ) , neutropenia ( @ % -LSB- TSU-@ + SOX -RSB- vs. @ % -LSB- SOX -RSB- ) , and anemia ( @ % -LSB- TSU-@ + SOX -RSB- vs. @ % -LSB- SOX -RSB- ) .