For clinicopathological variables , noncurrent smokers ( OR = @ ; P = @ ) , patients positive to anti-cyclic citrullinated peptide ( OR = @ ; P = @ ) and antinuclear antibodies ( OR = @ ; P = @ ) , with higher health assessment questionnaire score ( OR = @ ; P = @ ) , and nonsteroidal anti-inflammatory drug users ( OR = @ ; P = @ ) were also associated with nonresponse .