Recently , we documented the likely non-inferiority of Combinatietherapie Bij Reumatode Artritis ( COBRA ) - light therapy ( methotrexate increased to @mg/week with initial prednisolone @mg/day ) compared with the original COBRA therapy ( methotrexate @ mg/week , sulfasalazine @g/day , with initial prednisolone @mg/day ) after @weeks in patients with early active rheumatoid arthritis ( RA ) .