Relative changes in BV between baseline and week @ ranged from -@ % to +@ % ( median , -@ % ; @th percentile , -@ % ; @th percentile , +@ % ) and were significantly associated with OS using quartiles as cutoffs ( @ months vs not reached , P = @ ) and PFS using the median as cutoff ( @ months vs not reached , P = @ ) , with larger reductions associated with longer survival .