DI was randomized as follows : standard risk ( SR ) , two @-week intensive elements ( protocol III ) versus one @-week protocol II ; intermediate risk ( IR ) , protocol III @ versus protocol II @ ; high risk ( HR ) , protocol III @ versus either protocol II @ ( Associazione Italiana Ematologia Oncologia Pediatrica -LSB- AIEOP -RSB- option ) , or @ HR blocks plus single protocol II ( Berlin-Frankfurt-Mnster -LSB- BFM -RSB- option ) .