Olodaterol + tiotropium resulted in significant improvements over tiotropium + placebo in FEV@ AUC@-@ ( treatment differences : @ L -LSB- P < @ -RSB- , ANHELTO @ ; @ L -LSB- P < @ -RSB- , ANHELTO @ ) and trough FEV@ ( treatment differences : @ L -LSB- P < @ -RSB- , ANHELTO @ ; @ L -LSB- P = @ -RSB- , ANHELTO @ ) ; these were supported by secondary end points .