please rewrite the following text in the tone of the discussion of a Cell paper. Please keep all the information and add more information if necessary: 'Finally, our spatial transcriptomics study also uncovers a spatial differentiation in gene expression between smooth muscle cells and fibroblasts, two major subtypes of mesenchymal cells. Smooth muscle cells showed a higher expression of genes induced by ENCCs at the leading edge than at the trailing region, whereas fibroblasts showed an opposite pattern. Smooth muscle cells may be activated earlier by the arrival of ENCCs and may support their migration, while fibroblasts may be activated later and may facilitate their proliferation and differentiation. In contrast, epithelial cells exhibited heterogeneous expression of genes across different segments of the gut (Figure 6I), implying that epithelial cells may have diverse roles in regulating different stages of ENCC development. HSCR patients often exhibit abnormal morphology and function of the muscle layers in the aganglionic region (NAME_1, 2009; Kubota et NAME_2., 2002), which may result from impaired interactions between ENCCs and gut cells during ENS development, as we observed here.'