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Background: Runaway youth often have a history of traumatic experiences such as abuse and neglect by parents or caregivers. As a result, they are at high risk for various mental health issues. To address trauma-related mental health needs in this population, this paper proposes a resilience enhancement program focused on developing individual protective factors.  
Objectives: This study aims to evaluate the effects of a resilience enhancement program on resilience, depression, anxiety, and problematic alcohol use in female runaway youth living in shelters.
Design and settings: This quasi-experimental study utilized a non-equivalent control group design with non-synchronized data collection. Participants were recruited from five women's youth shelters and assessed at pre-test, post-test, and 1-month follow-up.  
Participants: The study included 32 shelter-residing female youth aged 12 to 21 (16 in the experimental group and 16 in the control group).  
Methods: A resilience enhancement program was developed based on an extensive literature review and needs assessment. The program incorporated four key protective factors of resilience: self-esteem, self-regulation, relational skills, and problem-solving/goal-setting skills.  After collecting data for the control group, data for the experimental group were collected. Changes in outcome measures over time between groups were analyzed using Generalized Estimating Equations.
Results: There were significant group-by-time interaction effects for resilience, anxiety, and problem drinking at 1-month follow-up. While significant decreases in depression over time occurred in both the experimental and control groups, the number of participants reporting clinically significant reductions in depression was greater in the experimental group.  
Conclusions: The results indicate that a resilience enhancement program is effective in improving resilience, anxiety, and problem drinking in female runaway youth in shelters. The program’s effect on depression was potentially supported when considering the clinical significance of change. This theory-based intervention may be delivered by psychiatric and mental health nurses to support female runaway youth.

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