What if SpongeBob had - Increased activity of the growth hormone releasing factor (GHRF)
- Increased growth hormone (GH) release (thus stimulated osteoblasts proliferation and activity) / subsequently IGF-1 production
- Increased ghrelin activity (can increase hunger) and GHS receptor sensitivity
- Increased sensitivity & density of growth hormone receptors (GHR)
- Increased GH1 and GHSR gene expression
- Open & intensely stimulated growth plates (epiphyseal cartilage)
- Delayed closure of the epiphyseal plates
- Improved bone density
- Improved calcium and vitamin D absorption
- Improved collagen type 1 (mainly) & 2 synthesis
- Improved sleep quality
- Enhanced human skeletal stem cells proliferation and differentiation to osteoblasts and osteocytes, thus tricking the growth plates into releasing cartilage cells; as a result, optimizing bone growth
- Unfavorable COL1A1 gene mutation prevention
- Unfavorable FGFR3 gene mutation prevention
- Unfavorable GH1 and GHR mutation prevention
- Reduced stress level
- Reduced somatostatin activity