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Sixty eight patients dropped out in association with adverse events during the reporting  period. Of these, 55 patients were administered ZB3579 (5 at 5 mg, 9 at 10 mg, 11 at 20 mg 
and 30 at 40 mg) and 13 patients received esomeprazole. Eighteen patients were withdrawn due to serious adverse events; twelve patients received ZB3579, five received esomeprazole 
and one received lansoprazole. The most common adverse events leading to withdrawal were non-serious in nature, most often gastrointestinal symptoms, headache or skin rash. 
Details of the adverse events leading to withdrawal during the period under review are presented in the table below, with the SAEs highlighted in bold. 