please rewrite the following paragraphs using the tone of the discussion of a cell paper: 'While the intestinal microenvironment provides crucial regulatory cues for ENCDC development, emerging evidence suggests ENCDCs themselves actively remodel the local extracellular matrix (ECM) environment to facilitate their migration (NAME_1 et NAME_2., 2013; NAME_3 and NAME_4, 2006a; NAME_5 et NAME_2., 1980; NAME_6 et NAME_2., 2016; NAME_3 2018). Our study further extended this finding by showing that wavefront ENCCs cause a broad gene expression change in other intestinal cells. Using spatial transcriptomics, we were able to visualize how ENCCs orchestrate the sequential activation of gene expression in different cell types in the gut wall. At the leading edge of the migratory wavefront, where ENCCs first encounter the gut mesenchyme, genes involved in signal transduction, mesenchymal cell differentiation, and Wnt signaling pathway are enriched. These genes may promote ENCC migration and colonization. For instance, we detected a high expression of Sfrp1, a gene encoding a secreted Wnt inhibitor that may create a gradient of Wnt activity along the gut axis. In contrast, at the segment where the trailing ENCC reside, we detected an upregulation of genes related to neuronal development and ECM structural constituent. These genes may reflect the specification and differentiation of ENCCs and their interactions with the surrounding ECM. For example, we found a high expression of Asb4, which encode a ubiquitin ligase that regulates the fate and function of ENCCs by targeting specific proteins for degradation. In addition to the global gene expression changes in other intestinal cells, our scRNAseq analysis also reveals that several ligands, including Vegfb, Mif, Tgfb2, and cell adhesion molecules, are highly expressed by wavefront ENCCs to communicate with gut cells, which may promote the development those gut cells expressing the receptors. 
Finally, our spatial transcriptomics analyses uncovered previously unappreciated spatial heterogeneity in gene expression between two cardinal mesenchymal cell types, smooth muscle cells and fibroblasts, during enteric nervous system (ENS) development. Smooth muscle cells exhibited markedly higher expression of genes induced by migrating enteric neural crest cells (ENCCs) at the leading edge compared to the trailing region of ENCC migration. In contrast, fibroblasts displayed the opposite pattern with higher expression of ENCC-induced genes at the trailing edge. These data suggest a model wherei