List the indications of the drug Oforta based on the following text. Do not list contraindications. The format of the output should be: (1) indication1, (2) indication2. 
INDICATIONS AND USAGE Oforta™ (fludarabine phosphate tablets) is a nucleotide metabolic inhibitor indicated as a single agent for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) whose disease has not responded to or has progressed during or after treatment with at least one standard alkylating-agent containing regimen. Studies demonstrating clinical benefit such as prolongation of survival or relief of symptoms have not been performed. A direct comparison of the clinical efficacy and safety of orally administered Oforta™ relative to intravenously administered fludarabine phosphate has not been studied.