Below is a paragraph from an academic paper. Polish the writing to meet the academic style, improve the spelling, grammar, clarity, concision and overall readability. When necessary, rewrite the whole sentence.
The term “lipotoxicity” was first coined by Unger in 1994 to describe the deleterious effects of free fatty acids on pancreatic beta-cell (3). Subsequentially, similar phenomenon has also been reported in skeletal muscle, myocardium, and liver upon excess fat deposition, leading to insulin resistance, lipotoxic heart disease, and MAFLD, respectively (4-6).  The ectopic fat, mainly composed by triglycerides, can ubiquitously accumulate as intracellular lipid droplets or as ectopic adipocytes within the almost all mammalian cells or tissues. Although these intracellular lipid droplets and ectopic adipocyte were regarded merely as inert fat reservoirs to buffer excess lipids, they are recently emerged as crucial regulators of energy metabolism, inflammation and cellular stress response. Evidence suggests that lipid droplets can associate with mitochondria through membrane contact sites to maintain energy and redox homeostasis. Lipid droplets can also contact with other cellular organelles to maintain membrane homeostasis by regulating membrane composition and removing damaged proteins and lipids. fatty acids from peri- or intra-tissular adipocyte transferred to the adjacent organ providing fuel for oxidation but also delivering other adipokines and cytokines. The overload of lipids droplet or peri- or intra-tissular adipocyte by excess triglycerides may not only lead to an elevation of free fatty acid levels, but also lead to the perturbation of the normal function of lipid droplet and adipocytes, which extending our comprehending of the mechanism of “lipotoxicity”.
 
