convert this into 2 fill-in questions “What are the differences in the anatomy of both systems?
Parasympathetic Nervous System
Originates from craniosacral nerves
(cranial “from the brain” and sacral
nerves “from spinal cord”):
Cranial nerves III (oculomotor), VII (facial),
IX (glossopharyngeal), X (vagus) & sacral
region (S2 to S4) of the spinal cord
Long pre-ganglionic fibers
Short post-ganglionic fibers
Ganglia is near or on the effector organ
Make synaptic connections in ganglia
Ach is the NT in ganglia & post-ganglia
What are the receptors activated in both systems?
1- Cholinergic receptors which are stimulated or activated by Ach:
Nicotinic (Nn, Nm)
Muscarinic (M1, M2, M3, M4, M5)
Drugs affecting ANS
Sympathetic Nervous System
Originates from thoracolumbar
(thoracic and lumbar nerves of the
spinal cord)
“spinal nerves only”
2- Adrenergic receptors which are stimulated or activated by NA & A:
Alfa receptors ----α1, α2
Beta receptors ---- B₁, B2, B3
1- Cholinergic drugs
2- Adrenergic drugs
Short pre-ganglionic fibers
Long post-ganglionic fibers
Ganglia is in the paravertebral chain
on either side of spinal cord
Terminate on effector organs
Ach is the NT in ganglia &
NA & A are the NT in post-ganglia
act on cholinergic receptors.
act on adrenergic receptors.
11
Cholinergic and adrenergic drugs act by either stimulating (Agonists) or blocking
(Antagonists) receptors of the ANS.
DR. RASHA TAWFIQ-S2-22/23”