Convert to easy language:” Blunted Δ-9-THC-induced cortisol responses in frequent users Although, Δ-9-THC induced cortisol release in both groups, we show, for the first time to our knowledge, that frequent users had blunted increases in cortisol release compared to healthy controls. We propose two possible explanations for the blunted Δ-9-THC-induced cortisol responses in frequent users: effects of chronic cannabis exposure and inherent differences between the two groups.”