< +
9 OTO
.
Gastropathy and acute gastritis
X
Causes
• When cell injury and regeneration are present but
inflammatory cells are rare or absent, the term
gastropathy is applied
• Gastritis results from mucosal injury. When
neutrophils are present, the lesion is referred to as
acute gastritis
Gastropathy and acute gastritis
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Alcohol
< >
at
Heavy smoking
Bile reflux
Stress-induced injury
Acute mucosal erosion or hemorrhage, such as Curling ulcers or
lesions following disruption of gastric blood flow, for example, in
portal hypertension
Hypoxemia and decreased oxygen delivery/high altitudes   < +
Causes
●
9 OTO
Gastropathy and acute gastritis
X
• The gastric injury that occurs in uremic patients and those
infected with urease-secreting H. pylori
●
Ingestion of harsh chemicals, particularly acids or bases,
either accidentally or in a suicide attempt/radiation therapy
The term hypertrophic gastropathy is applied to a specific
group of diseases exemplified by Ménétrier disease and
Zollinger-Ellison syndrome (characterized by multiple peptic
ulcerations in the stomach, duodenum, and even jejunum, is
caused by uncontrolled release of gastrin by a tumour and
the resulting massive acid production)
Stress-Related Mucosal Disease
Gastropathy and acute gastritis
• It occurs in patients with severe trauma, extensive burns,
intracranial disease, major surgery, serious medical disease, and
other forms of severe physiologic stress
In some cases, the associated ulcers are given specific names
based on location and clinical associations. Examples are as
follows:
- Stress ulcers affecting critically ill patients with shock, sepsis, or severe
trauma
- Curling ulcers occur in the proximal duodenum and are associated
with severe burns or trauma
- Cushing ulcers arise in the stomach, duodenum, or esophagus of
those with intracranial disease and have a high incidence of perforation.  < +
999 TO
Gastropathy and acute gastritis
Morphology of acute gastritis
X
- Mild acute gastritis the lamina propria shows only moderate
edema and slight vascular congestion/ The surface epithelium is
intact, but hyperplasia of foveolar mucus cells with characteristic
corkscrew profiles is present/ Neutrophils, lymphocytes, and
plasma cells are not prominent
- The presence of neutrophils above the basement membrane in
contact with epithelial cells is abnormal in all parts of the
gastrointestinal tract and signifies active inflammation, or, at this
site, gastritis (rather than gastropathy)
الله أوقات يوصل في الأوعية الدموية ويصيرتريف
في المعدة
Gastropathy and acute gastritis
Morphology of acute gastritis
< >
- Acute erosive hemorrhagic gastritis: concurrent presence of
erosion and hemorrhage/ more severe mucosal damage,
erosions and hemorrhage develop/ Hemorrhage may manifest
as dark punctae in an otherwise hyperemic mucosa
Centranetk
nd
- Stress-related gastric mucosal injury: Acute ulcers are rounded
and typically less than 1 cm in diameter/ are found anywhere in
the stomach and are often multiple/They are sharply
demarcated, with essentially normal adjacent mucosa/Healing
with complete re-epithelialization occurs within days to weeks
dritic
NI
intra
epithelial make mcq