Brain Network Topology Maps the Dysfunctional Substrate of Cognitive Processes in Schizophrenia.
Using a novel network analysis of spontaneous low-frequency functional MRI data recorded at rest, we study the functional network that describes the extent of synchronization among different areas of the brain. Comparing forty-four medicated patients and forty healthy subjects, we detected significant differences in the robustness of these functional networks. Such differences resulted in a larger resistance to edge removal (disconnection) in the graph of schizophrenic patients as compared to healthy controls. This paper shows that the distribution of connectivity strength among brain regions is spatially more homogeneous in schizophrenic patients with respect to healthy ones. As a consequence, the precise hierarchical modularity of healthy brains is crumbled in schizophrenic ones, making possible a peculiar arrangement of region-to-region interaction that, in turns, produces several topologically equivalent backbones of the whole functional brain network. We hypothesize that the manifold nature of the basal scheme of functional organization within the brain, together with its altered hierarchical modularity, contributes to positive symptoms of schizophrenia. Our work also fits the disconnection hypothesis that describes schizophrenia as a brain disorder, characterized by abnormal functional integration among brain regions.