16182314
Improved Fixed-Parameter Algorithms for Two Feedback Set Problems
Settling a ten years open question, we show that the NP-complete Feedback Vertex Set problem is deterministically solvable in O(ck · m) time, where m denotes the number of graph edges, k denotes the size of the feedback vertex set searched for, and c is a constant. As a second result, we present a fixed-parameter algorithm for the NP-complete Edge Bipartization problem with runtime O(2k · m2).
14944633
On Exact and Approximation Algorithms for Distinguishing Substring Selection
The NP-complete Distinguishing Substring Selection problem (DSSS for short) asks, given a set of “good” strings and a set of “bad” strings, for a solution string which is, with respect to Hamming metric, “away” from the good strings and “close” to the bad strings.
6610579
Exact algorithms and applications for Tree-like Weighted Set Cover
We introduce an NP-complete special case of the Weighted Set Cover problem and show its fixed-parameter tractability with respect to the maximum subset size, a parameter that appears to be small in relevant applications. More precisely, in this practically relevant variant we require that the given collection C of subsets of a base set S should be ''tree-like''. That is, the subsets in C can be organized in a tree T such that every subset one-to-one corresponds to a tree node and, for each element s of S, the nodes corresponding to the subsets containing s induce a subtree of T. This is equivalent to the problem of finding a minimum edge cover in an edge-weighted acyclic hypergraph. Our main result is an algorithm running in O(3^[email protected]?mn) time where k denotes the maximum subset size, n:=|S|, and m:=|C|. The algorithm also implies a fixed-parameter tractability result for the NP-complete Multicut in Trees problem, complementing previous approximation results. Our results find applications in computational biology in phylogenomics and for saving memory in tree decomposition based graph algorithms.
14425036
Parameterized Intractability of Distinguishing Substring Selection
Abstract
A central question in computational biology is the design of genetic
markers to distinguish between two given sets of (DNA) sequences. This question is formalized as 
the NP-complete Distinguishing Substring Selection problem (DSSS for short) which asks, given a set of "good" strings and a set of "bad" strings, for a solution string which is, with respect to the Hamming metric, "away" from the good strings and "close" to the bad strings. More precisely, given integers dg, db, and L, we ask for a length-L string s such that s has Hamming distance at least dg to every length-L substring of the good strings and such that every bad string has a length-L substring with Hamming distance at most db to s. Studying the parameterized complexity of DSSS, we show that, already for binary alphabet, DSSS is W[1]-hard with respect to its natural parameters. This, in particular, implies that a recently given polynomial-time approximation scheme (PTAS) by Deng et al. cannot be replaced by a so-called efficient polynomial-time approximation scheme (EPTAS) unless an unlikely collapse in parameterized complexity theory occurs. This is seemingly the first computational biology problem for which such a border between PTAS (which exists) and EPTAS (which is unlikely to exist) could be established. By way of contrast, for a special case of DSSS, we present an exact fixed-parameter algorithm solving the problem efficiently. In this way we also exhibit a sharp border between fixed-parameter tractability and intractability results.

919046
Fixed-Parameter Tractability Results for Feedback Set Problems in Tournaments
Complementing recent progress on classical complexity and polynomial-time approximability of feedback set problems in (bipartite) tournaments, we extend and partially improve fixed-parameter tractability results for these problems. We show that Feedback Vertex Set in tournaments is amenable to the novel iterative compression technique. Moreover, we provide data reductions and problem kernels for Feedback Vertex Set and Feedback Arc Set in tournaments, and a depth-bounded search tree for Feedback Arc Set in bipartite tournaments based on a new forbidden subgraph characterization.
1715544
Pattern matching for arc-annotated sequences
We study pattern matching for arc-annotated sequences. An O(nm) time algorithm is given for the problem to determine whether a length m sequence with nested arc annotation is an arc-preserving subsequence (aps) of a length n sequence with nested arc annotation, called APS(NESTED,NESTED). Arc-annotated sequences and, in particular, those with nested arc annotation are motivated by applications in RNA structure comparison. Our algorithm generalizes results for ordered tree inclusion problems and it is useful for recent fixed-parameter algorithms for LAPCS(NESTED,NESTED), which is the problem of computing a longest arc-preserving common subsequence of two sequences with nested arc annotations. In particular, the presented dynamic programming methodology implies a quadratic-time algorithm for an open problem posed by Vialette.
5572698
Concept exchange: constructing interoperable electronic product catalogues in an emergent environment
Research in interoperability of electronic product catalogues has primarily focused on resolving semantic conflicts arisen from the heterogeneously designed electronic product catalogues. We argue that while existing integration strategies providing static connections between various heterogeneous catalogues over mediating ontologies, ontologies themselves exhibit heterogeneity and lack of evolvability. What's more, reclassifying terms to link public ontologies is very difficult to avoid inaccuracy problem that is critical to electronic commerce. This paper highlights the problems of flexibility, exactness and evolvability that have received little attention in the literature and provides an overview of the concept exchange approach to interoperability. It illustrates why this is able to better solve the identified problems, presents the different features compared with other approaches and suggests how the concept exchange framework is working.
30330476
Measurement Models for Survivability and Competitiveness of Very Large E-marketplace
E-Marketplace is a man-made profit center with emergent customer requirements. This emergence nature poses many difficulties for e-marketplace to satisfy its customers and thus affects its survivability and competitiveness. To challenge this issue, this paper has introduced a novel emergent emarketplace model, and analyzed and quantified the emergent properties of emarketplace from simple ESMs to very large complex electronic intermediary EIMs. The measurement models developed in this paper are very useful for producing dynamic interaction records appropriate for further simulation model of e-marketplaces.
43856313
The waiting time distribution for a TDMA model with a finite buffer
Detailed analytic formulas for the density and probability distribution of the waiting time in a TDMA model with a finite buffer is obtained. On successive intervals of length equal to the duration of a slot, the density is expressed as (infinite) linear combinations of beta densities with positive coefficients. A recursive scheme, obtained by a matrix-analytic derivation, allows for the highly efficient computations of the coefficient sequences.
9204785
Achieving Transparent Integration of Information, Documents and Processes
While progress is made in the individual integration of business information, documents and processes, the issue of how to vertically integrate these individually integrated results needs to be resolved. This paper proposes a novel TRANSCODE approach to the issue. The approach represents business information, business documents and business processes in three TRANSCODE structures, which are then implemented, conceptualized and reified in an integrated and flexible 3-layer TRANSCODE model
13379605
Protein Fold Recognition Through Application of Residual Dipolar Coupling Data
Residual dipolar coupling (RDC) represents one of the most exciting emerging NMR techniques for studying protein structures. However, solving a protein structure using RDC data alone is a highly challenging problem as it often requires that the starting structure model be close to the actual structure of a protein, for the structure calculation procedure to be effective. We report in this paper a computer program, RDC-PROSPECT, for identification of a structural homolog or analog of a target protein in PDB, which best matches the 15N-1H RDC data of the protein recorded in a single ordering medium. The identified structural homolog/analog can then be used as a starting model for RDC-based structure calculation. Since RDC-PROSPECT uses only RDC data and predicted secondary structure information, its performance is virtually independent of sequence similarity between a target protein and its structural homolog/analog, making it applicable to protein targets out of the scope of current protein threading techniques. We have tested RDC-PROSPECT on all 15N-1H RDC data (representing 33 proteins) available in the BMRB database and the literature. The program correctly identified the structural folds for approximately 80% of the target proteins, significantly better than previously reported results, and achieved an average alignment accuracy of 97.9% residues within 4-residue shift. Through a careful algorithmic design, RDC-PROSPECT is at least one order of magnitude faster than previously reported algorithms for principal alignment frame search, making our algorithm fast enough for large-scale applications.