2174685
Privacy-enhancing personalized web search
Personalized web search is a promising way to improve search quality by customizing search results for people with individual information goals. However, users are uncomfortable with exposing private preference information to search engines. On the other hand, privacy is not absolute, and often can be compromised if there is a gain in service or profitability to the user. Thus, a balance must be struck between search quality and privacy protection. This paper presents a scalable way for users to automatically build rich user profiles. These profiles summarize a user.s interests into a hierarchical organization according to specific interests. Two parameters for specifying privacy requirements are proposed to help the user to choose the content and degree of detail of the profile information that is exposed to the search engine. Experiments showed that the user profile improved search quality when compared to standard MSN rankings. More importantly, results verified our hypothesis that a significant improvement on search quality can be achieved by only sharing some higher-level user profile information, which is potentially less sensitive than detailed personal information.
304685
Anonymizing sequential releases
An organization makes a new release as new information become available, releases a tailored view for each data request, releases sensitive information and identifying information separately. The availability of related releases sharpens the identification of individuals by a global quasi-identifier consisting of attributes from related releases. Since it is not an option to anonymize previously released data, the current release must be anonymized to ensure that a global quasi-identifier is not effective for identification. In this paper, we study the sequential anonymization problem under this assumption. A key question is how to anonymize the current release so that it cannot be linked to previous releases yet remains useful for its own release purpose. We introduce the lossy join, a negative property in relational database design, as a way to hide the join relationship among releases, and propose a scalable and practical solution.
30385305
Genome-Wide Discovery of Modulators of Transcriptional Interactions in Human B Lymphocytes
Transcriptional interactions in a cell are modulated by a variety of mechanisms that prevent their representation as pure pairwise interactions between a transcription factor and its target(s). These include, among others, transcription factor activation by phosphorylation and acetylation, formation of active complexes with one or more co-factors, and mRNA/protein degradation and stabilization processes. 
 
This paper presents a first step towards the systematic, genome-wide computational inference of genes that modulate the interactions of specific transcription factors at the post-transcriptional level. The method uses a statistical test based on changes in the mutual information between a transcription factor and each of its candidate targets, conditional on the expression of a third gene. The approach was first validated on a synthetic network model, and then tested in the context of a mammalian cellular system. By analyzing 254 microarray expression profiles of normal and tumor related human B lymphocytes, we investigated the post transcriptional modulators of the MYC proto-oncogene, an important transcription factor involved in tumorigenesis. Our method discovered a set of 100 putative modulator genes, responsible for modulating 205 regulatory relationships between MYC and its targets. The set is significantly enriched in molecules with function consistent with their activities as modulators of cellular interactions, recapitulates established MYC regulation pathways, and provides a notable repertoire of novel regulators of MYC function. The approach has broad applicability and can be used to discover modulators of any other transcription factor, provided that adequate expression profile data are available.
2992297
Global and localized parallel preconditioning techniques for large scale solid Earth simulations
We investigate and compare a few parallel preconditioning techniques in the iterative solution of large sparse linear systems arising from solid Earth simulation with and without using contact information in the domain partitioning process. Previous studies are focused on using static or matrix pattern-based incomplete LU (ILU) preconditioners in a localized preconditioner implementation. Our current studies are concerned about preconditioner performance for solving two different problem configurations with and without known contact information. For the cases with contact information, we use localized threshold value-based ILU (ILUT) preconditioner to improve efficiency. For the cases without contact information, we use a global sparse approximate inverse preconditioner with a static sparsity pattern to achieve robustness. Numerical results from simulating ground motion on a parallel supercomputer are given to compare the effectiveness of these parallel preconditioning techniques.
384033
Forgetting in Managing Rules and Ontologies
The language of HEX-programs under the answer-set semantics is designed for interoperating with heterogeneous sources via external atoms and for meta-reasoning via higher-order literals in the context of the semantic Web. As an important technique in managing knowledge bases, the notion of forgetting has received increasing interest in the knowledge-representation area. In this paper, we introduce a semantics-based theory of forgetting for HEX-programs and, in turn, for a class of OWL/RDF(S) ontologies which allows to fully employ semantic information in managing ontologies like editing, merging, aligning, and redundancy removal
1885288
A Theory of Forgetting in Logic Programming
The study of forgetting for reasoning has attracted considerable attention in AI. However, much of the work on forgetting, and other related approaches such as independence, irrelevance and novelty, has been restricted to the classical logics. This paper describes a detailed theoretical investigation of the notion of forgetting in the context of logic programming. We first provide a semantic definition of forgetting under the answer sets for extended logic programs. We then discuss the desirable properties and some motivating examples. An important result of this study is an algorithm for computing the result of forgetting in a logic program. Furthermore, we present a modified version of the algorithm and show that the time complexity of the new algorithm is polynomial with respect to the size of the given logic program if the size of certain rules is fixed. We show how the proposed theory of forgetting can be used to characterize the logic program updates.
52857819
QUICK: graphical user interface to multiple databases
Formulating queries to access multiple databases can be a formidable task, especially when many terms from various databases and complex constraints are involved. To specify a multidatabase query, the user usually has to search through documents for exact database terms and learn the multidatabase language. The report presents QUICK (QUery Interface to CPL-Kleisli), a graphical user interface to multiple databases, CPL is a high-level multidatabase language built on top of an open query system Kleisli. QUICK allows users to handle overwhelming information from different data sources in an intuitive and uniform manner. The query specification is reduced to specifying user's terms in his/her own world, selecting paths and specifying constraints in a graph. QUICK is able to automatically generate a CPL query that corresponds to the user's intent.