14227751
Mining undiscovered public knowledge from complementary and non-interactive biomedical literature through semantic pruning
Two complementary and non-interactive literature sets of articles, when they are considered together, can reveal useful information of scientific interest not apparent in either of the two document sets. Swanson called the existence of such knowledge, undiscovered public knowledge (UDPK). This paper proposes a semantic-based mining model for UDPK. Our method replaces manual ad-hoc pruning with using semantic knowledge from the biomedical ontologies. Using the semantic types and semantic relationships of the biomedical concepts, our prototype system can identify the relevant concepts collected from Medline and generate the novel hypothesis between these concepts. The system successfully replicates Swanson's two famous discoveries: Raynaud disease/fish oils and migraine/magnesium. Compared with previous approaches, our methods generate much fewer but more relevant novel hypotheses, and require much less human intervention in the discovery procedure.
11295819
Biomedical Ontology MeSH Improves Document Clustering Qualify on MEDLINE Articles: A Comparison Study
Document clustering has been used for better document retrieval, document browsing, and text mining. In this paper, we investigate if biomedical ontology MeSH improves the clustering quality for MEDLINE articles. For this investigation, we perform a comprehensive comparison study of various document clustering approaches such as hierarchical clustering methods (single-link, complete-link, and complete link), bisecting K-means, K-means, and suffix tree clustering (STC) in terms of efficiency, effectiveness, and scalability. According to our experiment results, biomedical ontology MeSH significantly enhances clustering quality on biomedical documents. In addition, our results show that decent document clustering approaches, such as bisecting K-means, K-means and STC, gains some benefit from MeSH ontology while hierarchical algorithms showing the poorest clustering quality do not reap the benefit of MeSH ontology
2425436
Cluster Ensemble and Its Applications in Gene Expression Analysis
Huge amount of gene expression data have been generated as a result of the human genomic project. Clustering has been used extensively in mining these gene expression data to find important genetic and biological information. Obtaining high quality clustering results is very challenging because of the inconsistency of the results of different clustering algorithms and noise in the gene expression data. Many clustering algorithms are available and different clustering algorithms may generate different clustering results due to their bias and assumptions. It is a challenging and daunting task for the genomic researchers to choose the best clustering algorithm and generate the best clustering results for their data sets. In this paper, we present a cluster ensemble framework for gene expression analysis to generate high quality and robust clustering results. In our framework, the clustering results of individual clustering algorithm are converted into a distance matrix, these distance matrices are combined and a weighted graph is constructed according to the combined matrix. Then a graph partitioning approach is used to cluster the graph to generate the final clusters. The experiment results indicate that cluster ensemble approach yields better clustering results than the single best clustering algorithm on both synthetic data set and yeast gene expression data set.
2454583
Temporal rule induction for clinical outcome analysis
Clinical outcomes analysis normally covers a particular time period. The sample under study is constantly changing as patients are censored, leave the study or die. In this paper, we present a novel data mining approach to mine temporal rules that reflect characteristics of outcomes analysis. We apply our temporal rule induction algorithm to a set of cancer patients, clinical records that were prospectively collected for 20 years. We analyse clinical data not only based on the static event, such as local recurrence for survival analysis, but also based on the temporal event with censored data for each time unit. The rules extracted from our temporal rule induction algorithm are compared to results from statistical analysis. The importance of this paper is that this novel temporal rule induction algorithm provides valuable insights for clinical data assessment and complements traditional statistical analysis.
14024342
A Semantic Approach for Mining Hidden Links from Complementary and Non-interactive Biomedical Literature
Two complementary and non-interactive literature sets of articles, when they are considered together, can reveal useful information of scientific interest not apparent in either of the two sets alone. Swanson called the existence of such hidden links as undiscovered public knowledge (UPK). The novel connection between Raynaud disease and fish oils was uncovered from complementary and non-interactive biomedical literature by Swanson in 1986. Since then, there have been many approaches to uncover UPK by mining the biomedical literature. These earlier works, however, required substantial manual intervention to reduce the number of possible connections. This paper proposes a semantic-based mining model for undiscovered public knowledge using the biomedical literature. Our method replaces manual ad-hoc pruning by using semantic knowledge from the biomedical ontologies. Using the semantic types and semantic relationships of the biomedical concepts, our prototype system can identify the relevant concepts collected from Medline and generate the novel hypothesis between these concepts. The system successfully replicates Swanson’s two famous discoveries: Raynaud disease/fish oils and migraine/magnesium. Compared with previous approaches such as LSI-based and traditional association rule-based methods, our method generates much fewer but more relevant novel hypotheses, and requires much less human intervention in the discovery procedure
30664092
Mining Candidate Viruses as Potential Bio-terrorism Weapons from Biomedical Literature
In this paper we present a semantic-based data mining approach to identify candidate viruses as potential bio-terrorism weapons from biomedical literature. We first identify all the possible properties of viruses as search key words based on Geissler’s 13 criteria; the identified properties are then defined using MeSH terms. Then, we assign each property an importance weight based on domain experts’ judgment. After generating all the possible valid combinations of the properties, we search the biomedical literature, retrieving all the relevant documents. Next our method extracts virus names from the downloaded documents for each search keyword and identifies the novel connection of the virus according to these 4 properties. If a virus is found in the different document sets obtained by several search keywords, the virus should be considered as suspicious and treated as candidate viruses for bio-terrorism. Our findings are intended as a guide to the virus literature to support further studies that might then lead to appropriate defense and public health measures.
22875771
ACO-Steiner: Ant Colony Optimization Based Rectilinear Steiner Minimal Tree Algorithm
The rectilinear Steiner minimal tree (RSMT) problem is one of the fundamental problems in physical design, especially in routing, which is known to be NP-complete. This paper presents an algorithm, called ACO-Steiner, for RSMT construction based on ant colony optimization (ACO). An RSMT is constructed with ants' movements in Hanan grid, and then the constraint of Hanan grid is broken to accelerate ants' movements to improve the performance of the algorithm. This algorithm has been implemented on a Sun workstation with Unix operating system and the results have been compared with the fastest exact RSMT algorithm, GeoSteiner 3.1 and a recent heuristic using batched greedy triple construction (BGTC). Experimental results show that ACO-Steiner can get a short running time and keep the high performance. Furthermore, it is also found that the ACO-Steiner can be easily extended to be used to some other problems, such as rectilinear Steiner minimal tree avoiding obstacles, and congestion reduction in global routing.
12307619
The use of visual search for knowledge gathering in image decision support
This paper presents a new method of knowledge gathering for decision support in image understanding based on information extracted from the dynamics of saccadic eye movements. The framework involves the construction of a generic image feature extraction library, from which the feature extractors that are most relevant to the visual assessment by domain experts are determined automatically through factor analysis. The dynamics of the visual search are analyzed by using the Markov model for providing training information to novices on how and where to look for image features. The validity of the framework has been evaluated in a clinical scenario whereby the pulmonary vascular distribution on Computed Tomography images was assessed by experienced radiologists as a potential indicator of heart failure. The performance of the system has been demonstrated by training four novices to follow the visual assessment behavior of two experienced observers. In all cases, the accuracy of the students improved from near random decision making (33%) to accuracies ranging from 50% to 68%.
28021583
The Human Use Regulatory Affairs Advisor: A Web Based Information Retrieval System with a User-Friendly Interface Design
38024133
A Comparative Study on Selection of Cluster Number and Local Subspace Dimension in the Mixture PCA Models
How to determine the number of clusters and the dimensions of local principal subspaces is an important and challenging problem in various applications. Based on a probabilistic model of local PCA, this problem can be solved by one of existing statistical model selection criteria in a two-phase procedure. However, such a two-phase procedure is too time-consuming especially when there is no prior knowledge. The BYY harmony learning has provided a promising mechanism to make automatic model selection in parallel with parameter learning. This paper investigates the BYY harmony learning with automatic model selection on a mixture PCA model in comparison with three typical model selection criteria: AIC, CAIC, and MDL. This comparative study is made by experiments for different model selection tasks on simulated data sets under different conditions. Experiments have shown that automatic model selection by the BYY harmony learning are not only as good as or even better than conventional methods in terms of performances, but also considerably supervisory in terms of much less computational cost.
10166803
An-OARSMan: obstacle-avoiding routing tree construction with good length performance
Routing is one of the important steps in VLSI/ULSI physical design. The rectilinear Steiner minimum tree (RSMT) construction is an essential part of routing. Since macro cells, IP blocks, and pre-routed nets are often regarded as obstacles in the routing phase, obstacle-avoiding RSMT (OARSMT) algorithms are useful for practical routing applications. This paper focuses on the OARSMT problem and presents an algorithm, named An-OARSMan, based on ant colony optimization. A greedy obstacle penalty distance (OP-distance) local heuristic is used in the algorithm and performed on the track graph. The algorithm has been implemented and tested on different kinds of obstacles. Experimental results show that An-OARSMan can handle complex obstacle cases including both convex and concave polygon obstacles with good length performance. It can always achieve the optimal solution in the cases with no more than 7 terminals.