14147651
Understanding the evolution of NSAID: a knowledge domain visualization approach to evidence-based medicine
Finding the most rigorous, updated, and well received clinical evidence is a crucial and challenging task in the practice of evidence-based medicine (EBM). In this article, we describe a knowledge domain visualization-based quantitative approach that is designed to support the task of searching for high-quality clinical evidence in the medical literature. We illustrate the use of this new approach with the knowledge domain of non-steroidal anti-inflammatory drugs (NSAIDs). A sample of the literature is visualized in a base map depicting structural and temporal properties of emerging themes and references made by such themes over time. In addition, the visualization highlights the rigorousness of a published clinical trial in terms of the type of study design retrieved dynamically from PubMed. The contribution of this approach is that it offers users an integrated search environment so that the rigorousness, recentness, and consensus of clinical evidence can be assessed with the support of visual exploration facilities.
206109439
How did university departments interweave the Web: A study of connectivity and underlying factors
This paper presents two studies of the use of the WWW in Scottish universities and American land-grant universities. First, we investigated the relationship between the organisational profile of a university department in Scotland and its structural connectivity on the WWW. A Spearman rank order correlation analysis revealed a number of strong correlation relationships between structural connectivity measures and the organisational profile based on research assessment exercise ratings, teaching quality assessments, student‐staff ratios and funding levels. Linkage patterns from 13 Scottish academic sites to commercial sites in Britain and America highlighted the impact of culture and the appropriateness of information technologies on the acceptance of the WWW. The second study is a content survey of WWW-based education activities in American land-grant universities to investigate successful applications of these enabling techniques in education. The two studies together highlighted cultural, political and technological interactions in the use of the WWW. q 1998 Elsevier Science B.V. All rights reserved
46129433
Behavioural Patterns of Collaborative Writing with Hypertext - A State Transition Approach
This study investigates behavioural patterns of collaborative writing with a hypertext system by using a state-transition approach. State-transition models are empirically developed for capturing the dynamic nature of collaborative writing. Users were frequently engaged in tasks such as exploration, organization, and editing, whereas the use of collaborative support functions was transient in nature. The study shows that state-transition analysis is an important approach to task analysis, requirements engineering, and human-computer interaction studies. This study has produced some valuable experiences and lessons for researchers and practitioners in collaborative writing.
15424500
Semantically modified diffusion limited aggregation for visualizing large-scale networks
Diffusion-limited aggregation (DLA) is a model of fractal growth. Computer models can simulate the fast aggregation of millions of particles. We propose a modified version of DLA, called semantically modified DLA (SM-DLA), for visualizing large-scale networks. SM-DLA introduces similarity measures between particles so that instead of attaching to the nearest particle in the aggregation, a new particle is stochastically directed to attach to particles that are similar to it. The results of our initial experiment with a co-citation network using SM-DLA are encouraging, suggesting that the algorithm has the potential as an alternative paradigm for visualizing large-scale networks. Further studies in this direction are recommended.
45076304
Spatial Semantic Virtual Worlds: The Structural Duality and Beyond
468820
Tracing knowledge diffusion
Knowledge diffusion is the adaptation of knowledge in a broad range of scientific and engineering research and development. Tracing knowledge diffusion between science and technology is a challenging issue due to the complexity of identifying emerging patterns in a diverse range of possible processes. In this article, we describe an approach that combines complex network theory, network visualization, and patent citation analysis in order to improve the means for the study of knowledge diffusion. In particular, we analyze patent citations in the field of tissue engineering. We emphasize that this is the beginning of a longer-term endeavor that aims to develop and deploy effective, progressive, and explanatory visualization techniques for us to capture the dynamics of the evolution of patent citation networks. The work has practical implications on resource allocation, strategic planning, and science policy.
40672752
The existence of hyper-L triple-loop networks
27005423
Binding number and toughness for matching extension
Abstract A graph G of even order is said to be k -extendable if every matching of size k in G can be extended to a 1-factor of G . Plummer (1988) showed that a graph G is k -extendable if tough ( G ) > k , and we here prove that G is also k -extendable if bind ( G ) > max {k, (7k + 13)/12}.
14219803
A new method to measure the semantic similarity of GO terms
MOTIVATION
Although controlled biochemical or biological vocabularies, such as Gene Ontology (GO) (http://www.geneontology.org), address the need for consistent descriptions of genes in different data sources, there is still no effective method to determine the functional similarities of genes based on gene annotation information from heterogeneous data sources.


RESULTS
To address this critical need, we proposed a novel method to encode a GO term's semantics (biological meanings) into a numeric value by aggregating the semantic contributions of their ancestor terms (including this specific term) in the GO graph and, in turn, designed an algorithm to measure the semantic similarity of GO terms. Based on the semantic similarities of GO terms used for gene annotation, we designed a new algorithm to measure the functional similarity of genes. The results of using our algorithm to measure the functional similarities of genes in pathways retrieved from the saccharomyces genome database (SGD), and the outcomes of clustering these genes based on the similarity values obtained by our algorithm are shown to be consistent with human perspectives. Furthermore, we developed a set of online tools for gene similarity measurement and knowledge discovery.


AVAILABILITY
The online tools are available at: http://bioinformatics.clemson.edu/G-SESAME.


SUPPLEMENTARY INFORMATION
http://bioinformatics.clemson.edu/Publication/Supplement/gsp.htm.
205000421
A Simple Approach to Implementing Multiplication with Small Tables
Abstract A new approach for implementing multiplication with a small table is presented. This approach is much simpler and thus easier to be implemented.
45241367
Meta-programming through typeful code representation
By allowing the programmer to write code that can generate code at run-time, meta-programming offers a powerful approach to program construction. For instance, meta-programming can often be employed to enhance program efficiency and facilitate the construction of generic programs. However, meta-programming, especially in an untyped setting, is notoriously error-prone. In this paper, we aim at making meta-programming less error-prone by providing a type system to facilitate the construction of correct meta-programs. We first introduce some code constructors for constructing typeful code representation in which program variables are represented in terms of deBruijn indexes, and then formally demonstrate how such typeful code representation can be used to support meta-programming. With our approach, a particular interesting feature is that code becomes first-class values, which can be inspected as well as executed at run-time. The main contribution of the paper lies in the recognition and then the formalization of a novel approach to typed meta-programming that is practical, general and flexible.