321115
Compressed pattern matching in DNA sequences
We propose derivative Boyer-Moore (d-BM), a new compressed pattern matching algorithm in DNA sequences. This algorithm is based on the Boyer-Moore method, which is one of the most popular string matching algorithms. In this approach, we compress both DNA sequences and patterns by using two bits to represent each A, T, C, G character. Experiments indicate that this compressed pattern matching algorithm searches long DNA patterns (length > 50) more than 10 times faster than the exact match routine of the software package Agrep, which is known as the fastest pattern matching tool. Moreover, compression of DNA sequences by this method gives a guaranteed space saving of 75%. In part the enhanced speed of the algorithm is due to the increased efficiency of the Boyer-Moore method resulting from an increase in alphabet size from 4 to 256.
16579446
Mining Correlation between Motifs and Gene Expression
One of the major challenges in the post-genomic era is to determine all DNA-binding transcription factors (TFs) and their regulatory binding sites (motifs) within the genomes. To discover the relationship between the motifs and changes in gene expression, we propose a new algorithm, co-miner (correlation miner). Correlation rules are generated based on the expression profiles of genes with significant expression change through the time course of gene expression. Thus, we may consider the change in gene expression to be causatively associated with the transcription binding sites in the upstream sequences. In addition, we introduce partition and constraint pushing techniques to improve the performance and demonstrate their effectiveness by our experiments. By applying co-miner to a yeast dataset, the relationships between motifs and gene expression revealed by co-miner are confirmed in the literature.
6486168
A Dataflow-Oriented Atomicity and Provenance System for Pipelined Scientific Workflows
Scientific workflows have gained great momentum in recent years due to their critical roles in e-Science and cyberinfrastructure applications. However, some tasks of a scientific workflow might fail during execution. A domain scientist might require a region of a scientific workflow to be "atomic". Data provenance, which determines the source data that are used to produce a data item, is also essential to scientific workflows. In this paper, we propose: (i) an architecture for scientific workflow management systems that supports both provenance and atomicity; (ii) a dataflow-oriented atomicity model that supports the notions of commit and abort; and (iii) a dataflow-oriented provenance model that, in addition to supporting existing provenance graphs and queries, also supports queries related to atomicity and failure.
7682350
Incremental genetic K-means algorithm and its application in gene expression data analysis
BackgroundIn recent years, clustering algorithms have been effectively applied in molecular biology for gene expression data analysis. With the help of clustering algorithms such as K-means, hierarchical clustering, SOM, etc, genes are partitioned into groups based on the similarity between their expression profiles. In this way, functionally related genes are identified. As the amount of laboratory data in molecular biology grows exponentially each year due to advanced technologies such as Microarray, new efficient and effective methods for clustering must be developed to process this growing amount of biological data.ResultsIn this paper, we propose a new clustering algorithm, Incremental Genetic K-means Algorithm (IGKA). IGKA is an extension to our previously proposed clustering algorithm, the Fast Genetic K-means Algorithm (FGKA). IGKA outperforms FGKA when the mutation probability is small. The main idea of IGKA is to calculate the objective value Total Within-Cluster Variation (TWCV) and to cluster centroids incrementally whenever the mutation probability is small. IGKA inherits the salient feature of FGKA of always converging to the global optimum. C program is freely available at http://database.cs.wayne.edu/proj/FGKA/index.htm.ConclusionsOur experiments indicate that, while the IGKA algorithm has a convergence pattern similar to FGKA, it has a better time performance when the mutation probability decreases to some point. Finally, we used IGKA to cluster a yeast dataset and found that it increased the enrichment of genes of similar function within the cluster.
18131628
Automatic workflow verification and generation
Correctness is an important aspect of workflow management systems. However, most of the workflow literature focuses only on the modeling aspects and assumes that a workflow is correct if during the execution it respects the control and data dependency specified by the workflow designer. To address the correctness question properly we propose a new workflow model based on Hoare semantics that allows to: (1) automatically check if the desired outcome of a workflow can be produced by its actual implementation, (2) automatically synthesize a workflow implementation from the workflow specification and a given task library.In particular we: (1) formalize the semantics of workflows and tasks with pre-and postconditions, (2) for each control construct we provide a set of sound inference rules formalizing its semantics. While most of our workflow constructs are standard, two of them are new: the universal and the existential constructs. We then describe algorithms for automatically checking the correctness of workflows and for automatic workflow generation.
14239575
Semantics based verification and synthesis of BPEL4WS abstract processes
We introduce a logic model to formally specify the semantics of workflows and their composite tasks described as BPEL4WS abstract processes. Based on the model, we present a set of inference rules to deduce the strongest postcondition and weakest precondition of a workflow and demonstrate that automatic workflow verification is possible due to the restrictions on data manipulation in an abstract process. We then sketch an algorithm that automatically synthesizes a workflow given its specification and a task library.
12297349
Creating and using models for engineering design: a machine-learning approach
An adaptive and interactive modeling system (AIMS) that integrates simulation, optimization and machine learning to help engineers make design decisions is described. AIMS views engineering decision making as a two-phase process of creating and then using models. The competitive relation learner and the induce-and-select optimizer, AIMS's two main components, and their roles in both phases of decision-making are discussed. AIMS's role in supporting the design of a diesel engine that outputs power within the 440- to 460-kW range and consumes the least amount of fuel is also discussed.<<ETX>>
15553830
A distributed artificial intelligence approach to integrated engineering design
This paper reports the development of a computer-based integrated engineering design environment which facilitates design decision-making by providing a medium for increased communication and cooperation amongst product development participants. A refinement and constraint propagation model for product development is used within a distributed artificial intelligence (DAI) architecture to support the cooperative design effort. Within such an environment, product and process designers can integrate the recommendations and expertise of all product development concerns as early as possible within the design-cycle. Our prototype system, ENVIED (Environment for Integrated Engineering Design), provides a domain-independent framework for human designers, artificial intelligence systems, and traditional software systems to cooperatively perform product and process design.
35812356
A Study of How Domain Knowledge Improves Knowledge-Based Learning Systems
Abstract A knowledge-based learning system is developed to demonstrate that intelligently selecting a subset of examples based on domain knowledge for rule induction can be more productive than using all provided examples. Knowledge-based learning uses an incomplete domain theory and examples to induce knowledge missing in the theory. Knowledge-based learning systems determine where knowledge is missing in a domain theory, select a relevant subset of examples to use in induction, and induce new rules or modify existing rules.
13148267
Fair scheduling in wireless packet networks
Fair scheduling of delay and rate-sensitive packet flows over a wireless channel is not addressed effectively by most contemporary wireline fair scheduling algorithms because of two unique characteristics of wireless media: (a) bursty channel errors, and (b) location-dependent channel capacity and errors. Besides, in packet cellular networks, the base station typically performs the task of packet scheduling for both downlink and uplink flows in a cell; however a base station has only a limited knowledge of the arrival processes of uplink flows.In this paper, we propose a new model for wireless fair scheduling based on an adaptation of fluid fair queueing to handle location-dependent error bursts. We describe an ideal wireless fair scheduling algorithm which provides a packetized implementation of the fluid model while assuming full knowledge of the current channel conditions. For this algorithm, we derive the worst-case throughput and delay bounds. Finally, we describe a practical wireless scheduling algorithm which approximates the ideal algorithm. Through simulations, we show that the algorithm achieves the desirable properties identified in the wireless fluid fair queueing model.
11410811
Fair scheduling in wireless packet networks
Fair scheduling of delay and rate-sensitive packet flows over a wireless channel is not addressed effectively by most contemporary wireline fair-scheduling algorithms because of two unique characteristics of wireless media: (1) bursty channel errors and (2) location-dependent channel capacity and errors. Besides, in packet cellular networks, the base station typically performs the task of packet scheduling for both downlink and uplink flows in a cell; however, a base station has only a limited knowledge of the arrival processes of uplink flows. We propose a new model for wireless fair-scheduling based on an adaptation of fluid fair queueing (FFQ) to handle location-dependent error bursts. We describe an ideal wireless fair-scheduling algorithm which provides a packetized implementation of the fluid mode, while assuming full knowledge of the current channel conditions. For this algorithm, we derive the worst-case throughput and delay bounds. Finally, we describe a practical wireless scheduling algorithm which approximates the ideal algorithm. Through simulations, we show that the algorithm achieves the desirable properties identified in the wireless FFQ model.