1474461
A type system for prototyping languages
RAPIDE is a programming language framework designed for the development of large, concurrent, real-time systems by prototyping. The framework consists of a type language and default executable, specification and architecture languages, along with associated programming tools. We describe the main features of the type language, its intended use in a prototyping environment, and rationale for selected design decisions.
215952437
Beyond proof-of-compliance: security analysis in trust management
Trust management is a form of distributed access control that allows one principal to delegate some access decisions to other principals. While the use of delegation greatly enhances flexibility an...
3062362
Managing Digital Rights using Linear Logic
Digital music players protect songs by enforcing licenses that convey specific rights for individual songs or groups of songs. For licenses specified in industry, we show that deciding whether a license authorizes a sequence of actions is NP-complete, with a restricted version of the problem solvable efficiently using a reduction to maximum network flow. The authorization algorithm used in industry is online, deciding which rights to exercise as actions occur, but we show that all online algorithms are necessarily non-monotonic: each allows actions under one license that it does not allow under a more flexible license. In one approach to achieving monotonicity, we exhibit the unique maximal set of licenses on which there exists a monotonic online algorithm. This set of well-behaved licenses induces an approximation algorithm by replacing each license with a well-behaved license. In a second approach, we consider allowing the player to revise its past decisions about which rights to exercise while still ensuring compliance with the license. We propose an efficient algorithm based on linear logic, with linear negation used to revise past decisions. We prove our algorithm monotonic, live, and sound with respect to the semantics of licenses
16397953
Parametricity and Variants of Girard's J Operator
Abstract The Girard–Reynolds polymorphic λ -calculus is generally regarded as a calculus of parametric polymorphism in which all well-formed terms are strongly normalizing with respect to β -reductions. Girard demonstrated that the addition of a simple “non-parametric” operation, J , to the calculus allows the definition of a non-normalizing term. Since the type of J is not inhabited by any closed term, one might suspect that this may play a role in defining a non-normalizing term using it. We demonstrate that this is not the case by giving a simple variant, J′ , of J whose type is otherwise inhabited and which causes normalization to fail. It appears that impredictivity is essential to the argument; predictive variants of the polymorphic λ -calculus admit non-parametric operations without sacrificing normalization.
9031501
Design of a role-based trust-management framework
We introduce the RT framework, a family of role-based trust management languages for representing policies and credentials in distributed authorization. RT combines the strengths of role-based access control and trust-management systems and is especially suitable for attribute-based access control. Using a few simple credential forms, RT provides localized authority over roles, delegation in role definition, linked roles, and parameterized roles. RT also introduces manifold roles, which can be used to express threshold and separation-of-duty policies, and delegation of role activations. We formally define the semantics of credentials in the RT framework by presenting a translation from credentials to Datalog rules. This translation also shows that this semantics is algorithmically tractable.
18708753
Unification and ML-Type Reconstruction
We study the complexity of type reconstruction for a core fragment of ML with lambda abstraction, function application, and the polymorphic let declaration. We derive exponential upper and lower bounds on recognizing the typable core ML expressions. Our primary technical tool is uniication of succinctly represented type expressions. After observing that core ML expressions, of size n, can be typed in DTIME(2 n), we exhibit two diierent families of programs whose principal types grow exponentially. We show how to exploit the expressiveness of the let-polymorphism in these constructions to derive lower bounds on deciding typability: one leads naturally to NP-hardness and the other to DTIME(2 n k)-hardness for each integer k 1. Our generic simulation of any exponential time Turing Machine by ML type reconstruction may be viewed as a nonstandard way of computing with types. Our worst-case lower bounds stand in contrast to practical experience, which suggests that commonly used algorithms for type reconstruction do not slow compilation substantially.
14458363
Guillotine subdivisions approximate polygonal subdivisions: a simple new method for the geometric k-MST problem
A method of mixing poly(neopentylglycol)azelate (NPGA) is disclosed which enhances its solubility in polyurethane binders for composite solid propellants. The method comprises withholding the addition of NPGA from the propellant submix and from the total propellant formulation mixing procedure until after the addition of the curing agent has taken place and reaction has taken place for a predetermined period of time with the bonding agent until a "break" in viscosity occurs. The "break" in viscosity has taken place when the other binder ingredients have reacted with the curing agent HDI (hexamethylenediisocyanate) so that immiscibility between the binder ingredients is reduced. The late NPGA addition method resulted not only in apparently complete solubilization of the NPGA but also yielded a propellant with dramatically lower end of mix viscosity (reduced by a factor of 10), superior flow characteristics, and better physical properties. Propellants made by the disclosed method of mixing have desirable lower modulus and higher tensile strength. Thus, the propellant mixed in accordance with the late NPGA addition method yields a propellant with a high tensile strength to modulus ratio. The high tensile strength to modulus ratio at low temperature is an indicator of a good propellant.
7468814
Coupled optimization in protein docking
Here, we introduce a new approach to macromolecular docking which combines the continuous global optimization algorithm CGU [6, 21] with the grid-based conformational search engine DOT [23]. We also detail the use of this method to dock acetylcholine into the fasciculin-acetylcholinesterase complex. Fasciculin blocks access to the long, narrow pathway leading to the active site, which is located in the interior of the acetylcholinesterase. For this reason, flnding the location computationally is rather non-trivial. We not only successfully identifled the optimal docking conflguration, but were able to do so in a matter of hours.
42803318
File Servers
This chapter discusses file servers that are accessible via some form of local network or internetwork. It characterizes file services from the client point of view along a number of dimensions; distributivity of the service itself, the network environment of the service, the file model supported by the service, the kind(s) of atomic update provided by the service, the techniques used for controlling the allocation of files. It then describes the client interfaces to three existing file services. Finally, the impact of these features on design and implementation is discussed. An appendix contains characterizations of a variety of existing network-based file services using the criteria developed in the chapter.
8879002
Status of clinical gene sequencing data reporting and associated risks for information loss
Clinical gene sequencing is growing in importance and cost-effectiveness. In the past two years, the number of genes associated with disease has grown by roughly 25%. Knowledge of genetic variations will soon guide drug selection and dosages, predict risks from toxin exposures, and inform nutritional needs. Despite the significance of sequencing, methods for reporting results are problematic. Frequent use of paper and infrequent use of naming standards impede data exchange and make incorporation into the electronic medical record difficult. Reports often describe only variations found, rather than all data (all patient bases sequenced). Also, reports frequently do not describe reference data used to define variations. These practices create risks for loss of both data and information. Standardized electronic reporting of all data (all bases sequenced and all reference data) and electronic record systems capable of storing these results would both prevent data loss and simplify the preservation of information those data provide.
6478208
Chemistry in Bioinformatics
AbstractChemical information is now seen as critical for most areas of life sciences. But unlike Bioinformatics, where data is openly available and freely re-usable, most chemical information is closed and cannot be re-distributed without permission. This has led to a failure to adopt modern informatics and software techniques and therefore paucity of chemistry in bioinformatics. New technology, however, offers the hope of making chemical data (compounds and properties) free during the authoring process. We argue that the technology is already available; we require a collective agreement to enhance publication protocols.