29539871
On the effectiveness of classification trees for test case construction
Abstract The notion of the classification-hierarchy table and the classification-tree construction algorithm provide a systematic approach to the construction of classification trees from given sets of classifications and their associated classes. Using classification trees, the set of all possible test cases can be constructed from functional specifications. This paper extends their study by introducing a metric to measure the effectiveness of a classification tree with respect to the construction of test cases, and providing ways to improve this effectiveness.
12141135
Construction of classification trees via the classification-hierarchy table
Abstract The classification-tree method developed by Grochtmann and coworkers is a black box testing technique to assist test engineers to construct test cases systematically from the functional specifications, via the construction of classification trees. This paper supplements their studies by proposing a methodology to construct classification trees systematically from given sets of classifications and their associated classes, via the notion of the classification-hierarchy table. The intuition of the classification-hierarchy table is to capture the hierarchical relationship for every pair of distinct classifications from which classification trees can be constructed.
28566545
A new heuristic for test suite reduction
Abstract A testing objective has to be defined in testing a program. A test suite is then constructed to satisfy the testing objective. The constructed test suite contains redundancy when some of its proper subsets can still satisfy the same testing objective. Since the costs of executing test cases and maintaining a test suite for regression testing may be expensive, the problem of test suite reduction arises. This paper proposes a heuristic towards the optimization of a test suite.
44900435
Two test data selection strategies towards testing of Boolean specifications
Test data selection for software represented as Boolean formulae has not received much attention until the last decade. Most of the approaches are expression driven because generation of test cases is based on the Boolean formulae being tested. The paper discusses test data generation using a fault based approach in the sense that generation of test cases is based on particular types of faults occurring in the Boolean expression. Two special types of faults are considered. Moreover, two strategies of test case selection that guarantee the detection of these two types of faults are proposed.
5643714
On Some Characterisation Problems of Subdomain Testing
Subdomain testing is a very general approach to the selection of test cases. It captures the characteristics of testing strategies that require the test suite to cover some predefined testing requirements. This paper attempts to characterise precisely the failure distributions for the best and worst case of any given subdomain testing strategy. Our analysis has revealed some crucial factors and principles that affect the effectiveness of subdomain testing strategies.
26835658
On the test allocations for the best lower bound performance of partition testing
A partition testing strategy divides the program's input domain into subdomains according to a partitioning scheme, and selects test cases from each subdomain according to a test allocation scheme. Previous studies have shown that partition testing strategies can be very effective or very ineffective in detecting faults, depending on both the partitioning scheme and the test allocation scheme. Given a partitioning scheme, the maximin criterion chooses a test allocation scheme that will maximally improve the lower bound performance of the partition testing strategy. In an earlier work, we have proved that the Basic Maximin Algorithm can generate such a test allocation scheme. In this paper, we derive further properties of the Basic Maximin Algorithm and present the Complete Maximin Algorithm that generates all possible test allocation schemes that satisfy the maximin criterion.
60400
A dynamic programming approach to de novo peptide sequencing via tandem mass spectrometry
Tandem mass spectrometry fragments a large number of molecules of the same peptide sequence into charged molecules of prefix and suffix peptide subsequences and then measures mass/charge ratios of these ions. The de novo peptide sequencing problem is to reconstruct the peptide sequence from a given tandem mass spectral data of k ions. By implicitly transforming the spectral data into an NC-spectrum graph G (V, E) where /V/ = 2k + 2, we can solve this problem in O(/V//E/) time and O(/V/2) space using dynamic programming. For an ideal noise-free spectrum with only b- and y-ions, we improve the algorithm to O(/V/ + /E/) time and O(/V/) space. Our approach can be further used to discover a modified amino acid in O(/V//E/) time. The algorithms have been implemented and tested on experimental data.
2057857
Gene-finding via tandem mass spectrometry
We propose a new gene-finding methodology that combines high performance liquid chromatograph (HPLC)-tandem mass spectrometry experiments with a fast computer algorithm to locate coding regions and introns. Proteins are first extracted from cells and digested by enzymes, and then the resulting peptides are separated and analyzed by HPLC-tandem mass spectrometry. We designed an algorithm to find DNA coding sequences, corresponding to open reading frames (ORF), in the genome such that their translated amino acid sequences are optimally correlated with these tandem mass spectra. In this algorithm, we also allow one gap, corresponding to an intron, between two DNA coding sequences, such that their concatenation becomes one coding sequence. Finally, the algorithm assembles these candidate coding sequences and introns into gene structures. Our algorithm was implemented to predict genes on 4 contigs with a total of 123 kbps using two sets of simulated digestion- HPLC-tandem mass spectrometry data of 2523 Caenorhabditis elegans Chromosome IV proteins, digested by trypsin and Asp-N respectively. Among 15 annotated genes in the forward strand, all 98 exons are hit by the predicted no-gap coding sequences, and 60 out of 83 introns are correctly predicted. We also tested gene structure prediction in a contig containing 3 genes. Combining splicing site predictions with predicted coding sequences and introns, we found all 3 gene structures.
2301190
On the Informational Asymmetry between Upper and Lower Bounds for Ultrametric Evolutionary Trees
This paper addresses the informational asymmetry for constructing an ultrametric evolutionary tree from upper and lower bounds on pairwise distances between n given species. We show that the tallest ultrametric tree exists and can be constructed in O(n2) time, while the existence of the shortest ultrametric tree depends on whether the lower bounds are ultrametric. The tallest tree construction algorithm gives a very simple solution to the construction of an ultrametric tree. We also provide an efficient O(n2)-time algorithm for checking the uniqueness of an ultrametric tree, and study a query problem for testing whether an ultrametric tree satisfies both upper and lower bounds.
10712046
Algorithms for identifying protein cross-links via tandem mass spectrometry
Cross-linking technology combined with tandem mass spectrometry (MS-MS) is a powerful method that provides a rapid solution to the discovery of protein-protein interactions and protein structures. We studied the problem of detecting cross-linked peptides and cross-linked amino acids from tandem mass spectral data. Our method consists of two steps: the first step finds two protein subsequences whose mass sum equals a given mass measured from the mass spectrometry; and the second step finds the best cross-linked amino acids in these two peptide sequences that are optimally correlated to a given tandem mass spectrum. We designed fast and space-efficient algorithms for these two steps, and implemented and tested them on experimental data of cross-linked Hemoglobin proteins.
19799763
An approach to isochronous slot reuse for multimedia services on DQDB network
This paper discusses an isochronous connection management protocol and its slot-reuse scheme for multimedia services on DQDB network. For asynchronous services, slot-reuse improves slot utilization, which has already been discussed in depth. However only few literature addressed the slot-reuse for synchronous services. Our proposed scheme reuses video slots for either synchronous or asynchronous services according to the need of downstream nodes. Simulation shows that the scheme significantly increases the maximum number of video connections as well as reduces the failure rate of connection request comparing with that without slot-reuse.