1945985
A Model of Visuospatial Working Memory in Prefrontal Cortex: Recurrent Network and Cellular Bistability
We report a computer simulation of the visuospatial delayed-response experiments of Funahashi et al. (1989), using a firing-rate model that combines intrinsic cellular bistability with the recurrent local network architecture of the neocortex. In our model, the visuospatial working memory is stored in the form of a continuum of network activity profiles that coexist with a spontaneous activity state. These neuronal firing patterns provide a population code for the cue position in a graded manner. We show that neuronal persistent activity and tuning curves of delay-period activity (memory fields) can be generated by an excitatory feedback circuit and recurrent synaptic inhibition. However, if the memory fields are constructed solely by network mechanisms, noise may induce a random drift over time in the encoded cue position, so that the working memory storage becomes unreliable. Furthermore, a “distraction” stimulus presented during the delay period produces a systematic shift in the encoded cue position. We found that the working memory performance can be rendered robust against noise and distraction stimuli if single neurons are endowed with cellular bistability (presumably due to intrinsic ion channel mechanisms) that is conditional and realized only with sustained synaptic inputs from the recurrent network. We discuss how cellular bistability at the single cell level may be detected by analysis of spike trains recorded during delay-period activity and how local modulation of intrinsic cell properties and/or synaptic transmission can alter the memory fields of individual neurons in the prefrontal cortex.
5101914
Wave Propagation Mediated by GABAB Synapse and Rebound Excitation in an Inhibitory Network: A Reduced Model Approach
A reduction method is used to analyze a spatially structured network model of inhibitory neurons. This network model displays wave propagation of postinhibitory rebound activity, which depends on GABAB synaptic interactions among the neurons. The reduced model allows explicit solutions for the wavefronts and their velocity as a function of various parameters, such as the synaptic coupling strength. These predictions are shown to agree well with the numerical simulations of the conductance-based biophysical model.
15978047
The dynamical stability of reverberatory neural circuits
Abstract. The concept of reverberation proposed by Lorente de Nó and Hebb is key to understanding strongly recurrent cortical networks. In particular, synaptic reverberation is now viewed as a likely mechanism for the active maintenance of working memory in the prefrontal cortex. Theoretically, this has spurred a debate as to how such a potentially explosive mechanism can provide stable working-memory function given the synaptic and cellular mechanisms at play in the cerebral cortex. We present here new evidence for the participation of NMDA receptors in the stabilization of persistent delay activity in a biophysical network model of conductance-based neurons. We show that the stability of working-memory function, and the required NMDA/AMPA ratio at recurrent excitatory synapses, depend on physiological properties of neurons and synaptic interactions, such as the time constants of excitation and inhibition, mutual inhibition between interneurons, differential NMDA receptor participation at excitatory projections to pyramidal neurons and interneurons, or the presence of slow intrinsic ion currents in pyramidal neurons. We review other mechanisms proposed to enhance the dynamical stability of synaptically generated attractor states of a reverberatory circuit. This recent work represents a necessary and significant step towards testing attractor network models by cortical electrophysiology.
17850389
Mean-Driven and Fluctuation-Driven Persistent Activity in Recurrent Networks
Spike trains from cortical neurons show a high degree of irregularity, with coefficients of variation (CV) of their interspike interval (ISI) distribution close to or higher than one. It has been suggested that this irregularity might be a reflection of a particular dynamical state of the local cortical circuit in which excitation and inhibition balance each other. In this balanced state, the mean current to the neurons is below threshold, and firing is driven by current fluctuations, resulting in irregular Poisson-like spike trains. Recent data show that the degree of irregularity in neuronal spike trains recorded during the delay period of working memory experiments is the same for both low-activity states of a few Hz and for elevated, persistent activity states of a few tens of Hz. Since the difference between these persistent activity states cannot be due to external factors coming from sensory inputs, this suggests that the underlying network dynamics might support coexisting balanced states at different firing rates. We use mean field techniques to study the possible existence of multiple balanced steady states in recurrent networks of current-based leaky integrate-and-fire (LIF) neurons. To assess the degree of balance of a steady state, we extend existing mean-field theories so that not only the firing rate, but also the coefficient of variation of the interspike interval distribution of the neurons, are determined self-consistently. Depending on the connectivity parameters of the network, we find bistable solutions of different types. If the local recurrent connectivity is mainly excitatory, the two stable steady states differ mainly in the mean current to the neurons. In this case, the mean drive in the elevated persistent activity state is suprathreshold and typically characterized by low spiking irregularity. If the local recurrent excitatory and inhibitory drives are both large and nearly balanced, or even dominated by inhibition, two stable states coexist, both with subthreshold current drive. In this case, the spiking variability in both the resting state and the mnemonic persistent state is large, but the balance condition implies parameter fine-tuning. Since the degree of required fine-tuning increases with network size and, on the other hand, the size of the fluctuations in the afferent current to the cells increases for small networks, overall we find that fluctuation-driven persistent activity in the very simplified type of models we analyze is not a robust phenomenon. Possible implications of considering more realistic models are discussed.
11647652
Analysis of complex bursting in cortical pyramidal neuron models
Abstract Burst firing is a prominent feature of cortical pyramidal cells and is thought to have significant functional roles in reliable signaling and synaptic plasticity. Modeling studies have successfully elucidated possible biophysical mechanisms underlying complex bursting in pyramidal cells. Based on these results (Pinsky, Rinzel, J. Comput. Neurosci. 1 (1994) 39–60), we have built a simplified two-compartment burst model. Using the fast- and slow-variable analysis method, we show that complex bursting is an instance of square-wave bursting, where the dendritic slow potassium conductance is the single slow variable. The coupling parameters between the two compartments change the topological class of bursting thereby altering the firing patterns of the neuron. These results explain the diverse set of firing patterns seen with different dendritic morphologies (Mainen, Sejnowski, Nature 382 (1996) 363–366).
53307075
Effects of Neuromodulation in a Cortical Network Model of Object Working Memory Dominated by Recurrent Inhibition
Experimental evidence suggests that the maintenance of an item in working memory is achieved through persistent activity in selective neural assemblies of the cortex. To understand the mechanisms underlying this phenomenon, it is essential to investigate how persistent activity is affected by external inputs or neuromodulation. We have addressed these questions using a recurrent network model of object working memory. Recurrence is dominated by inhibition, although persistent activity is generated through recurrent excitation in small subsets of excitatory neurons.Our main findings are as follows. (1) Because of the strong feedback inhibition, persistent activity shows an inverted U shape as a function of increased external drive to the network. (2) A transient external excitation can switch off a network from a selective persistent state to its spontaneous state. (3) The maintenance of the sample stimulus in working memory is not affected by intervening stimuli (distractors) during the delay period, provided the stimulation intensity is not large. On the other hand, if stimulation intensity is large enough, distractors disrupt sample-related persistent activity, and the network is able to maintain a memory only of the last shown stimulus. (4) A concerted modulation of GABAA and NMDA conductances leads to a decrease of spontaneous activity but an increase of persistent activity; the enhanced signal-to-noise ratio is shown to increase the resistance of the network to distractors. (5) Two mechanisms are identified that produce an inverted U shaped dependence of persistent activity on modulation. The present study therefore points to several mechanisms that enhance the signal-to-noise ratio in working memory states. These mechanisms could be implemented in the prefrontal cortex by dopaminergic projections from the midbrain.
9104202
Rate-Adaptive Framing for Interfered Wireless Networks
The majority of existing wireless rate controls are based on the implicit assumption that frames are corrupted due to the random, arbitrary environmental and thermal noises. They generally reduce the channel rate on frame losses, trading lower efficiency in frequency band utilization for more robust modulation so that the current noise level may be tolerable. In highly interfered wireless networks where frames are lost mainly due to interference from other wireless transceivers, simply reducing the channel rate prolongs the frame transmission time and therefore aggravates frame loss ratio. This positive feedback in the rate control loop quickly diverges the interfered transceivers into a suboptimal channel rate and drives the network into a state with high interference. In the worst case, interfered transceivers can be starved. In this paper we present RAF, the rate-adaptive framing that jointly controls the channel rate and frame size according to the observed interference patterns and noise level at the receiver. Based on the inputs from physical layer carrier sense, the receiver derives the optimal channel rate and frame size that maximize throughput, and informs the transmitter of such optimal configuration in a few bits in the per-frame acknowledgement. Through intensive simulations we show that RAF consistently outperforms ARF, RBAR, and OAR in all simulated scenarios.
15818943
Tracking anonymous peer-to-peer VoIP calls on the internet
Peer-to-peer VoIP calls are becoming increasingly popular due to their advantages in cost and convenience. When these calls are encrypted from end to end and anonymized by low latency anonymizing network, they are considered by many people to be both secure and anonymous.In this paper, we present a watermark technique that could be used for effectively identifying and correlating encrypted, peer-to-peer VoIP calls even if they are anonymized by low latency anonymizing networks. This result is in contrast to many people's perception. The key idea is to embed a unique watermark into the encrypted VoIP flow by slightly adjusting the timing of selected packets. Our analysis shows that it only takes several milliseconds time adjustment to make normal VoIP flows highly unique and the embedded watermark could be preserved across the low latency anonymizing network if appropriate redundancy is applied. Our analytical results are backed up by the real-time experiments performed on leading peer-to-peer VoIP client and on a commercially deployed anonymizing network. Our results demonstrate that (1) tracking anonymous peer-to-peer VoIP calls on the Internet is feasible and (2) low latency anonymizing networks are susceptible to timing attacks.
3114897
Multi-graph enabled active learning for multimodal web image retrieval
In this paper, we propose a multimodal Web image retrieval technique based on multi-graph enabled active learning. The main goal is to leverage the heterogeneous data on the Web to improve retrieval precision. Three graphs are constructed on images' content features, textual annotations and hyperlinks respectively, namely Content-Graph, Text-Graph and Link-Graph, which provide complimentary information on the images. By analyzing the three graphs, a training dataset is automatically created and transductive learning is enabled. The transductive learner is a multi-graph based classifier, which simultaneously solves the learning problem and the problem of combining heterogeneous data. This proposed approach, overall, tackles the problem of unsupervised active learning on Web graph. Although the proposed approach is discussed in the context of WWW image retrieval, it can be applied to other domains. The experimental results show the effectiveness of our approach.
149826
Generalized component analysis for text with heterogeneous attributes
We present a class of richly structured, undirected hidden variable models suitable for simultaneously modeling text along with other attributes encoded in different modalities. Our model generalizes techniques such as principal component analysis to heterogeneous data types. In contrast to other approaches, this framework allows modalities such as words, authors and timestamps to be captured in their natural, probabilistic encodings. A latent space representation for a previously unseen document can be obtained through a fast matrix multiplication using our method. We demonstrate the effectiveness of our framework on the task of author prediction from 13 years of the NIPS conference proceedings and for a recipient prediction task using a 10-month academic email archive of a researcher. Our approach should be more broadly applicable to many real-world applications where one wishes to efficiently make predictions for a large number of potential outputs using dimensionality reduction in a well defined probabilistic framework.
7656393
CAMRIT: control-based adaptive middleware for real-time image transmission
Real-time image transmission is crucial to an emerging class of distributed embedded systems operating in open network environments. Examples include avionics mission re-planning over Link-16, security systems based on wireless camera networks, and online collaboration using camera phones. Meeting image transmission deadlines is a key challenge in such systems due to unpredictable network conditions. In this paper, we present CAMRIT, a control-based adaptive middleware framework for real-time image transmission in distributed real-time embedded systems. CAMRIT features a distributed feedback control loop that meets image transmission deadlines by dynamically adjusting the quality of image tiles. We derive an analytic model that captures the dynamics of a distributed middleware architecture. A control theoretic methodology is applied to systematically design a control algorithm with analytic assurance of system stability and performance, despite uncertainties in network bandwidth. Experimental results demonstrate that CAMRIT can provide robust real-time guarantees for a representative application scenario.