11248403
Mining Shifting-and-Scaling Co-Regulation Patterns on Gene Expression Profiles
In this paper, we propose a new model for coherent clustering of gene expression data called reg-cluster. The proposed model allows (1) the expression profiles of genes in a cluster to follow any shifting-and-scaling patterns in subspace, where the scaling can be either positive or negative, and (2) the expression value changes across any two conditions of the cluster to be significant. No previous work measures up to the task that we have set: the density-based subspace clustering algorithms require genes to have similar expression levels to each other in subspace; the pattern-based biclustering algorithms only allow pure shifting or pure scaling patterns; and the tendency-based biclustering algorithms have no coherence guarantees. We also develop a novel patternbased biclustering algorithm for identifying shifting-andscaling co-regulation patterns, satisfying both coherence constraint and regulation constraint. Our experimental results show that the reg-cluster algorithm is able to detect a significant amount of clusters missed by previous models, and these clusters are potentially of high biological significance.
14969897
Dynamic adaptive file management in a local area network
In light of advances in processor and networking technology, especially the emergence of network attached disks, the traditional client-server architecture of file systems has become suboptimal for many computation/data intensive applications. We introduce a revised architecture for file management employing network attached storage: the dynamic file server environment (Dynamo). Dynamo introduces two main architectural innovations: to provide high scalability, the file management functions are mainly performed cooperatively by the clients in the system. Furthermore, data is transferred directly to the client's cache from network-attached disks, thus avoiding copies from a disk to the server buffer and then over the network to the client. Secondly, Dynamo uses a cooperative cache management which employs a decentralized lottery-based page replacement strategy. We show via performance benchmarks run on the Dynamo system and simulation results how this architecture increases the system's adaptability, scalability and cost performance.
11841640
Accelerating Profile Queries in Elevation Maps
Elevation maps are a widely used spatial data representation in geographical information systems (GIS). Paths on elevation maps can be characterized by profiles, which describe relative elevation as a function of distance. In this research, we address the inverse of this mapping - given a profile, how to efficiently find paths that could have generated it. This is called the profile query problem. Profiles have a wide variety of uses that include registering tracking information, or even other maps, to a given map. We describe a probabilistic model to characterize the maximal likelihood that a point lying on a path matches the query profile. Propagation of such probabilities to neighboring points can effectively prune the search space. This model enables us to efficiently answer queries of arbitrary profiles with user-specified error tolerances. When compared to existing spatial index methods, our approach supports more flexible queries with orders of magnitude speedup.
19868872
Management Assistance for Work First via a Dynamic Website
The purpose of the Work First project is to assist the state Dept. of Health and Human Services (DHHS) staff and each county Dept. of Social Services (DSS) across the state in the management of welfare reform initiatives. Work First is the cash assistance program in NC. One important objective is to encourage and support program managers to use data on outcomes to assess their performance. This is accomplished by providing them with easy to use and easy to understand comprehensive information on the experiences of families and individuals that have received assistance through their agency over time.
28890
Extension of Lower Probabilities and Coherence of Belief Measures
Coherence is an important concept which is introduced and discussed in a new mathematics branch, Imprecise Probability Theory. By using the Choquet integral, belief measures can be extended to be coherent lower previsions on the linear space consisting of all bounded functions. As a special case, we establish that all belief measures are coherent imprecise probabilities.
62615149
Mining Asynchronous Periodic Patterns in Time Series Data
Periodicy detection in time series data is a challenging problem of great importance in many applications. Most previous work focused on mining synchronous periodic patterns and did not recognize the misaligned presence of a pattern due to the intervention of random noise. In this paper, we propose a more flexible model of asynchronous periodic pattern that may be present only within a subsequence and whose occurrences may be shifted due to disturbance. Two parameters min/spl I.bar/rep and max/spl I.bar/dis are employed to specify the minimum number of repetitions that is required within each segment of nondisrupted pattern occurrences and the maximum allowed disturbance between any two successive valid segments. Upon satisfying these two requirements, the longest valid subsequence of a pattern is returned. A two-phase algorithm is devised to first generate potential periods by distance-based pruning followed by an iterative procedure to derive and validate candidate patterns and locate the longest valid subsequence. We also show that this algorithm cannot only provide linear time complexity with respect to the length of the sequence but also achieve space efficiency.
3416923
Efficient Computation of the Skyline Cube
Skyline has been proposed as an important operator for multi-criteria decision making, data mining and visualization, and user-preference queries. In this paper. we consider the problem of efficiently computing a SKYCUBE, which consists of skylines of all possible non-empty subsets of a given set of dimensions. While existing skyline computation algorithms can be immediately extended to computing each skyline query independently, such "shared-nothing" algorithms are inefficient. We develop several computation sharing strategies based on effectively identifying the computation dependencies among multiple related skyline queries. Based on these sharing strategies, two novel algorithms, Bottom-Up and Top-Down algorithms, are proposed to compute SKYCUBE efficiently. Finally, our extensive performance evaluations confirm the effectiveness of the sharing strategies. It is shown that new algorithms significantly outperform the naive ones.
34993492
Microarray image compression: SLOCO and the effect of information loss
Microarray image technology is a powerful tool for monitoring the expression of thousands of genes simultaneously. Each microarray experiment produces immense amounts of image data, and efficient storage and transmission require compression that takes advantage of microarray image structure. In this paper we develop a compression scheme for microarray images which can be either lossless or lossy with successive refinements. Existing measures of distortion such as mean squared pixel-wise error and visual fidelity are not appropriate for microarray images. We introduce a new measure of distortion for lossy compression: the sensitivity of microarray information extraction to compression loss. Furthermore, our scheme has a coded data structure that allows fast decoding and reprocessing of image sub-blocks, and includes summary statistics and image segmentation information. The average lossless compression ratio is 1.83:1 for our cDNA test images and 2.43:1 for our inkjet test images, comparable or better than state-of-the-art lossless schemas, yet with additional structure and information. At an average lossy compression ratio of 8:1 for cDNA microarrays, we find that our scheme minimizes the effects of compression loss compared to other algorithms. We show that the variability in differential gene expression levels extracted from lossily vs. losslessly compressed microarray images is less than both the variability between different arrays and the variability between different extraction algorithms. In fact, lossy compression can improve the estimation of gene expression levels for cDNA images.
11411776
Holistic Twig Joins on Indexed XML Documents
Finding all the occurrences of a twig pattern specified by a selection predicate on multiple elements in an XML document is a core operation for efficient evaluation of XML queries. Holistic twig join algorithms were proposed recently as an optimal solution when the twig pattern only involves ancestor-descendant relationships. In this paper, we address the problem of efficient processing of holistic twig joins on all/partly indexed XML documents. In particular, we propose an algorithm that utilizes available indices on element sets. While it can be shown analytically that the proposed algorithm is as efficient as the existing state-of-the-art algorithms in terms of worst case I/O and CPU cost, experimental results on various datasets indicate that the proposed index-based algorithm performs significantly better than the existing ones, especially when binary structural joins in the twig pattern have varying join selectivities.
33629250
Robust Visual Tracking Via Incremental Maximum Margin Criterion
Robust visual object tracking is one of the key problems in computer vision. Subspace based tracking method is a promising approach in handling appearance variability. Linear Discriminant Analysis(LDA) has been applied to this problem, but LDA is not a stable algorithm especially for visual tracking. Maximum Margin Criterion(MMC) is a recently proposed discriminant criterion. Its promising specialities make it a better choice for the tracking problem. In this paper, we present a novel subspace tracking algorithm based on MMC. We also proposed an incremental version of the corresponding algorithm so that the tracker can update in realtime. Experiments show our tracking algorithm is able to track objects well under large lighting, pose and expression variation.
45287219
Internet dependency and psychosocial maturity among college students
One salient impact of information technology on students' lives is the ever-increasing use of the Internet. Although there exist many reports in the media regarding the unhealthy Internet use among students, research is still limited and has mainly relied upon on-line self-selected reports on Internet dependency or “Internet addiction”. This paper attempts to look into the alleged Internet dependency within the Eriksonian psychosocial development framework. The results of a survey of the Internet use among 217 students in an Australian regional university are reported. The measures of patterns of the Internet use were correlated with that of psychosocial maturity and self-efficacy. The results showed that the Internet dependency seemed to be independent of the psychosocial maturity and the general perceived self-efficacy. A factor analysis extracted six factors from a set of 28 Internet experience-related questions and indicated that the Internet dependency could be of a multifaceted nature. The findings and their implications were discussed and a contextual perspective was proposed.