36964410
A Knowledge Object Oriented System for High Throughput Collection and Analysis of Data
29257622
Use of Built-in Features in the Interpretation of High-dimensional Cancer Diagnosis Data
Cancer diagnosis data, for example microarray gene expression profiling data and proteomic profiling data, are often described by thousands of features. To computationally make a diagnosis for new samples, these data are usually input to a learning algorithm, the algorithm then induces a classifier, the classifier then predicts a class label for any test sample. As the data is so high-dimensional, most of the resulting classifiers are very complicated particularly those based on kernel-functions such as support vector machines---the interpretation of the decision results must need all the features to be involved. In this paper, we discuss built-in features and use them to concisely characterize the data and to easily interpret the decisions. Built-in features are features that are used only in the classifiers, and that are only a small subset of the original features, e.g., the features in a decision tree. So, the notion of built-in features is different from input features and also from original features. As there is a significant reduction from the huge size of original features to a small number of relevant features, the complexity of the interpretation can be much eased. The use of built-in features also provides much potential for elucidating the translation between raw data and clinically useful knowledge. In this paper, we also report that the performance of classifiers using built-in features tends to remain stable even input feature space changes, but other types of classifiers fluctuate their performance. So, once again, we promote the use of classifiers that use built-in features since the algorithms can avoid the existing hard problem of selecting best number of features for learning.
15390292
Selection of patient samples and genes for outcome prediction
Gene expression profiles with clinical outcome data enable monitoring of disease progression and prediction of patient survival at the molecular level. We present a new computational method for outcome prediction. Our idea is to use an informative subset of original training samples. This subset consists of only short-term survivors who died within a short period and long-term survivors who were still alive after a long follow-up time. These extreme training samples yield a clear platform to identify genes whose expression is related to survival. To find relevant genes, we combine two feature selection methods - entropy measure and Wilcoxon rank sum test - so that a set of sharp discriminating features are identified. The selected training samples and genes are then integrated by a support vector machine to build a prediction model, by which each validation sample is assigned a survival/relapse risk score for drawing Kaplan-Meier survival curves. We apply this method to two data sets: diffuse large-B-cell lymphoma (DLBCL) and primary lung adenocarcinoma. In both cases, patients in high and low risk groups stratified by our risk scores are clearly distinguishable. We also compare our risk scores to some clinical factors, such as International Prognostic Index score for DLBCL analysis and tumor stage information for lung adenocarcinoma. Our results indicate that gene expression profiles combined with carefully chosen learning algorithms can predict patient survival for certain diseases.
10722883
Use of extreme patient samples for outcome prediction from gene expression data
MOTIVATION
Patient outcome prediction using microarray technologies is an important application in bioinformatics. Based on patients' genotypic microarray data, predictions are made to estimate patients' survival time and their risk of tumor metastasis or recurrence. So, accurate prediction can potentially help to provide better treatment for patients.


RESULTS
We present a new computational method for patient outcome prediction. In the training phase of this method, we make use of two types of extreme patient samples: short-term survivors who got an unfavorable outcome within a short period and long-term survivors who were maintaining a favorable outcome after a long follow-up time. These extreme training samples yield a clear platform for us to identify relevant genes whose expression is closely related to the outcome. The selected extreme samples and the relevant genes are then integrated by a support vector machine to build a prediction model, by which each validation sample is assigned a risk score that falls into one of the special pre-defined risk groups. We apply this method to several public datasets. In most cases, patients in high and low risk groups stratified by our method have clearly distinguishable outcome status as seen in their Kaplan-Meier curves. We also show that the idea of selecting only extreme patient samples for training is effective for improving the prediction accuracy when different gene selection methods are used.
13995613
DNAFSMiner: a web-based software toolbox to recognize two types of functional sites in DNA sequences
UNLABELLED
DNAFSMiner (DNA Functional Sites Miner) is a web-based software toolbox to recognize functional sites in nucleic acid sequences. Currently in this toolbox, we provide two software: TIS Miner and Poly(A) Signal Miner. The TIS Miner can be used to predict translation initiation sites in vertebrate DNA/mRNA/cDNA sequences, and the Poly(A) Signal Miner can be used to predict polyadenylation [poly(A)] signals in human DNA sequences. The prediction results are better than those by literature methods on two benchmark applications. This good performance is mainly attributable to our unique learning method. DNAFSMiner is available free of charge for academic and non-profit organizations.


AVAILABILITY
http://research.i2r.a-star.edu.sg/DNAFSMiner/


CONTACT
huiqing@i2r.a-star.edu.sg.
11034725
Data Mining Tools for Biological Sequences
We describe a methodology, as well as some related data mining tools, for analyzing sequence data. The methodology comprises three steps: (a) generating candidate features from the sequences, (b) selecting relevant features from the candidates, and (c) integrating the selected features to build a system to recognize specific properties in sequence data. We also give relevant techniques for each of these three steps. For generating candidate features, we present various types of features based on the idea of k-grams. For selecting relevant features, we discuss signal-to-noise, t-statistics, and entropy measures, as well as a correlation-based feature selection method. For integrating selected features, we use machine learning methods, including C4.5, SVM, and Naive Bayes. We illustrate this methodology on the problem of recognizing translation initiation sites. We discuss how to generate and select features that are useful for understanding the distinction between ATG sites that are translation initiation sites and those that are not. We also discuss how to use such features to build reliable systems for recognizing translation initiation sites in DNA sequences.
653966
Fan-Type Theorem for Long Cycles Containing a Specified Edge
In this paper, we prove that if G is 3-connected noncomplete graph of order n satisfying min{max{d(u),d(v)}:d(u,v)=2}=μ, then for each edge e, G has a cycle containing e of length at least min{n,2μ}, unless G is a spanning subgraph of Kμ + Kcn−μ or K3+(lKμ−2∪Ks), where n=l(μ−2)+s+3,1≤s≤μ−2.
23971862
Handling Large Unsupervised Data via Dimensionality Reduction
12824352
On Issues of Instance Selection
The digital technologies and computer advances with the booming internet uses have ledto massive data collection (corporate data, data warehouses, webs, just to name a few) andinformation (or misinformation) explosion. Szalay and Gray described this phenomenon as“drowning in data” (Szalay and Gray, 1999). They reported that each year the detectors attheCERNparticlecolliderinSwitzerlandrecord1petabyteofdata;andresearchersinareasof science from astronomy to the human genome are facing the same problems and chokingon information. A very natural question is “now that we have gathered so much data, whatdo we do with it?” Raw data is rarely of direct use and manual analysis simply cannotkeep pace with the fast growth of data. Data mining and knowledge discovery (KDD), as anew emerging ﬁeld comprising disciplines such as databases, statistics, machine learning,comes to the rescue. KDD attempts to turn raw data into nuggets and create special edgesin this ever competitive world for science discovery and business intelligence.TheKDDprocessisdeﬁnedinFayyadetal.(1996)as
7193073
A selective sampling approach to active feature selection
Feature selection, as a preprocessing step to machine learning, has been very effective in reducing dimensionality, removing irrelevant data, increasing learning accuracy, and improving result comprehensibility. Traditional feature selection methods resort to random sampling in dealing with data sets with a huge number of instances. In this paper, we introduce the concept of active feature selection, and investigate a selective sampling approach to active feature selection in a filter model setting. We present a formalism of selective sampling based on data variance, and apply it to a widely used feature selection algorithm Relief. Further, we show how it realizes active feature selection and reduces the required number of training instances to achieve time savings without performance deterioration. We design objective evaluation measures of performance, conduct extensive experiments using both synthetic and benchmark data sets, and observe consistent and significant improvement. We suggest some further work based on our study and experiments.
7863387
Understanding Neural Networks via Rule Extraction
Although backpropagation neural networks generally predict better than decision trees do for pattern classification problems, they are often regarded as black boxes, i.e., their predictions are not as interpretable as those of decision trees. This paper argues that this is because there has been no proper technique that enables us to do so. With an algorithm that can extract rules, by drawing parallels with those of decision trees, we show that the predictions of a network can be explained via rules extracted from it, thereby, the network can be understood. Experiments demonstrate that rules extracted from neural networks are comparable with those of decision trees in terms of predictive accuracy, number of rules and average number of conditions for a rule; they preserve high predictive accuracy of original networks.