12427163
MetaCyc: a multiorganism database of metabolic pathways and enzymes
MetaCyc is a database of metabolic pathways and enzymes located at http://MetaCyc.org/. Its goal is to serve as a metabolic encyclopedia, containing a collection of non-redundant pathways central to small molecule metabolism, which have been reported in the experimental literature. Most of the pathways in MetaCyc occur in microorganisms and plants, although animal pathways are also represented. MetaCyc contains metabolic pathways, enzymatic reactions, enzymes, chemical compounds, genes and review-level comments. Enzyme information includes substrate specificity, kinetic properties, activators, inhibitors, cofactor requirements and links to sequence and structure databases. Data are curated from the primary literature by curators with expertise in biochemistry and molecular biology. MetaCyc serves as a readily accessible comprehensive resource on microbial and plant pathways for genome analysis, basic research, education, metabolic engineering and systems biology. Querying, visualization and curation of the database is supported by SRI's Pathway Tools software. The PathoLogic component of Pathway Tools is used in conjunction with MetaCyc to predict the metabolic network of an organism from its annotated genome. SRI and the European Bioinformatics Institute employed this tool to create pathway/genome databases (PGDBs) for 165 organisms, available at the BioCyc.org website. These PGDBs also include predicted operons and pathway hole fillers.
23937565
MetaCyc: a multiorganism database of metabolic pathways and enzymes
The MetaCyc database (see URL http://MetaCyc.org) is a collection of metabolic pathways and enzymes from a wide variety of organisms, primarily microorganisms and plants. The goal of MetaCyc is to contain a representative sample of each experimentally elucidated pathway, and thereby to catalog the universe of metabolism. MetaCyc also describes reactions, chemical compounds and genes. Many of the pathways and enzymes in MetaCyc contain extensive information, including comments and literature citations. SRI's Pathway Tools software supports querying, visualization and curation of MetaCyc. With its wide breadth and depth of metabolic information, MetaCyc is a valuable resource for a variety of applications. MetaCyc is the reference database of pathways and enzymes that is used in conjunction with SRI's metabolic pathway prediction program to create Pathway/Genome Databases that can be augmented with curation from the scientific literature and published on the world wide web. MetaCyc also serves as a readily accessible comprehensive resource on microbial and plant pathways for genome analysis, basic research, education, metabolic engineering and systems biology. In the past 2 years the data content and the Pathway Tools software used to query, visualize and edit MetaCyc have been expanded significantly. These enhancements are described in this paper.
36753167
k-Geodomination in graphs
6799021
Task-based interaction with an integrated multilingual, multimedia information system: a formative evaluation
This paper describes a formative evaluation of an integrated multilingual, multimedia information system, a series of user studies designed to guide system development. The system includes automatic speech recognition for English, Chinese, and Arabic, automatic translation from Chinese and Arabic into English, and query-based and profile-based search options. The study design emphasizes repeated evaluation with the same (increasingly experienced) participants, exploration of alternative task designs, rich qualitative and quantitative data collection, and rapid analysis to provide the timely feedback needed to support iterative and responsive development. Results indicate that users presented with materials in a language that they do not know can generate remarkably useful work products, but that integration of transcription, translation, search and profile management poses challenges that would be less evident were each technology to be evaluated in isolation.
5702445
The role of moderating factors in user technology acceptance
Along with increasing investments in new technologies, user technology acceptance becomes a frequently studied topic in the information systems discipline. The last two decades have seen user acceptance models being proposed, tested, refined, extended and unified. These models have contributed to our understanding of user technology acceptance factors and their relationships. Yet they have also presented two limitations: the relatively low explanatory power and inconsistent influences of the factors across studies. Several researchers have recently started to examine the potential moderating effects that may overcome these limitations. However, studies in this direction are far from being conclusive. This study attempts to provide a systematic analysis of the explanatory and situational limitations of existing technology acceptance studies. Ten moderating factors are identified and categorized into three groups: organizational factors, technological factors and individual factors. An integrative model is subsequently established, followed by corresponding propositions pertaining to the moderating factors.
27857321
Human-computer interaction research in the management information systems discipline
Research in Human-Computer Interaction (HCI) crosses various disciplines, including Management Information Systems (MIS), Computer Science, Industrial Engineering, Information Science, Psychology, Sociology, and Anthropology (Nah et al., 2005). Recent years have witnessed a steady growth of HCI research in the MIS discipline (Zhang et al., 2002; Zhang and Dillon 2003; Zhang et al., 2004; Nah et al., 2005; Zhang and Li, 2005; Zhang et al., 2005). HCI has become an important theme at major MIS conferences while cross-disciplinary research in HCI is also increasing. In this special section, we showcase exemplary HCI research in MIS. It is our hope that the sharing of these works with the HCI community in other disciplines will help to develop more synergy across areas.
25784724
On Resolving Acyclic Partitions of Graphs