208013251
Modeling the Effect of Size on Defect Proneness for Open-Source Software
Quality is becoming increasingly important with the continuous adoption of open-source software. Previous research has found that there is generally a positive relationship between module size and defect proneness. Therefore, in open-source software development, it is important to monitor module size and understand its impact on defect proneness. However, traditional approaches to quality modeling, which measure specific system snapshots and obtain future defect counts, are not well suited because open-source modules usually evolve and their size changes over time. In this study, we used Cox proportional hazards modeling with recurrent events to study the effect of class size on defect-proneness in the Mozilla product. We found that the effect of size was significant, and we quantified this effect on defect proneness.
17890414
Identifying significant genes from microarray data
Microarray technology is a recent development in experimental molecular biology which can produce quantitative expression measurements for thousands of genes in a single, cellular mRNA sample. These many gene expression measurements form a composite profile of the sample, which can be used to differentiate samples from different classes such as tissue types or treatments. However, for the gene expression profile data obtained in a specific comparison, most likely only some of the genes will, be differentially expressed between the classes, while many other genes have similar expression levels. Selecting a list of informative differential genes from these data is important for microarray data analysis. In this paper, we describe a framework for selecting informative genes, called ranking and combination analysis (RAC), which combines various existing informative gene selection methods. We conducted experiments using three data sets and six existing feature selection methods. The results show that the RAC framework is a robust and efficient approach to identify informative gene for microarray data. The combination approach on two selecting methods almost always performed better than the less efficient individual, and in many cases, better than both. More significantly, when considering all three data sets together, the combination approach, on average, outperforms each individual feature selection method. All of these indicate that RCA might be a viable and feasible approach for the microarray gene expression analysis.
35256277
Generalized shuffle-exchange digraphs: Hamiltonian properties
The k-ary n-dimensional shuffle-exchange directed network S(k, n) consists of k/sup n/ nodes such that each node is represented as an k-ary n-tuple vector, a/sub 1/a/sub 2/...a/sub n/, where a/sub i/ is in [0, k-1]. Node a/sub 1/a/sub 2/...a/sub n/ is adjacent to node a/sub 2/a/sub 3/...a/sub n/a/sub 1/ (one shuffle link) and k-1 other nodes a/sub 1/a/sub 2/...a/sub n-1/b, where b/spl isin/[0, k-1] and b/spl ne/a/sub n/ (k-1 exchange links). S(k, n) have been widely used as topologies for VLSI networks, parallel architectures, and communication systems. However, since S(k, n) does not exist for the number of nodes between k/sup n/ and k/sup n+1/, Liu and Hsu have recently proposed a class of digraphs GS(k, N), which generalized S(k, n) to any number N of nodes. They also showed that GS(k, N) retains all the nice properties of S(k, n). In this paper, we survey these combinatorial properties and study Hamiltonian properties of GS(k, N). In particular, we have successfully obtained a Hamiltonian circuit for GS(k, k(k+1)) for any k>2.
17120587
Combination methods in microarray analysis
Microarray technology and experiment can produce thousands or tens of thousands of gene expression measurements in a single cellular mRNA sample. Selecting a list of informative differential genes from these measurement data has been the central problem for microarray analysis. Many methods to identify informative genes have been proposed in the past. However, due to the complexity of biological systems, each proposed method seems to perform nicely in a particular data set or specific experiment. It remains a great challenge to come up with a selection method for a wider spectrum of experiments and a broader variety of data sets. In this paper, we take the approach of method combination using data fusion and rank-score graph which have been used successfully in other application domains such as information retrieval, pattern recognition and tracking, and molecular similarity search. Our method combination is efficient and flexible and can be extended to become a general learning system for microarray gene expression analysis.
267445
Biological Nomenclatures: A Source of Lexical Knowledge and Ambiguity
There has been increased work in developing automated systems that involve natural language processing (NLP) to recognize and extract genomic information from the literature. Recognition and identification of biological entities is a critical step in this process. NLP systems generally rely on nomenclatures and ontological specifications as resources for determining the names of the entities, assigning semantic categories that are consistent with the corresponding ontology, and assignment of identifiers that map to well-defined entities within a particular nomenclature. Although nomenclatures and ontologies are valuable for text processing systems, they were developed to aid researchers and are heterogeneous in structure and semantics. A uniform resource that is automatically generated from diverse resources, and that is designed for NLP purposes would be a useful tool for the field, and would further database interoperability. This paper presents work towards this goal. We have automatically created lexical resources from four model organism nomenclature systems (mouse, fly, worm, and yeast), and have studied performance of the resources within an existing NLP system, GENIES. Using nomenclatures is not straightforward because issues concerning ambiguity, synonymy, and name variations are quite challenging. In this paper we focus mainly on ambiguity. We determined that the number of ambiguous gene names within the individual nomenclatures, across the four nomenclatures, and with general English ranged from 0%-10.18%, 1.187%-20.30%, and 0%-2.49% respectively. When actually processing text, we found the rate of ambiguous occurrences (not counting ambiguities stemming from English words) to range from 2.4%-32.9% depending on the organisms considered.
2276859
Dynamically Generating a Protein Entity Dictionary Using Online Resources
With the overwhelming amount of biological knowledge stored in free text, natural language processing (NLP) has received much attention recently to make the task of managing information recorded in free text more feasible. One requirement for most NLP systems is the ability to accurately recognize biological entity terms in free text and the ability to map these terms to corresponding records in databases. Such task is called biological named entity tagging. In this paper, we present a system that automatically constructs a protein entity dictionary, which contains gene or protein names associated with UniProt identifiers using online resources. The system can run periodically to always keep up-to-date with these online resources. Using online resources that were available on Dec. 25, 2004, we obtained 4,046,733 terms for 1,640,082 entities. The dictionary can be accessed from the following website: http://biocreative.ifsm.umbc.edu/biothesaurus/.
2931442
G-ToPSS: fast filtering of graph-based metadata
RDF is increasingly being used to represent metadata. RDF Site Summary (RSS) is an application of RDF on the Web that has considerably grown in popularity. However, the way RSS systems operate today does not scale well. In this paper we introduce G-ToPSS, a scalable publish/subscribe system for selective information dissemination. G-ToPSS is particularly well suited for applications that deal with large-volume content distribution from diverse sources. RSS is an instance of the content distribution problem. G-ToPSS allows use of ontology as a way to provide additional information about the data. Furthermore, in this paper we show how G-ToPSS can support RDFS class taxonomies. We have implemented and experimentally evaluated G-ToPSS and we provide results in the paper demonstrating its scalability compared to alternatives.
207609303
Discretization: An Enabling Technique
Discrete values have important roles in data mining and knowledge discovery. They are about intervals of numbers which are more concise to represent and specify, easier to use and comprehend as they are closer to a knowledge-level representation than continuous values. Many studies show induction tasks can benefit from discretization: rules with discrete values are normally shorter and more understandable and discretization can lead to improved predictive accuracy. Furthermore, many induction algorithms found in the literature require discrete features. All these prompt researchers and practitioners to discretize continuous features before or during a machine learning or data mining task. There are numerous discretization methods available in the literature. It is time for us to examine these seemingly different methods for discretization and find out how different they really are, what are the key components of a discretization process, how we can improve the current level of research for new development as well as the use of existing methods. This paper aims at a systematic study of discretization methods with their history of development, effect on classification, and trade-off between speed and accuracy. Contributions of this paper are an abstract description summarizing existing discretization methods, a hierarchical framework to categorize the existing methods and pave the way for further development, concise discussions of representative discretization methods, extensive experiments and their analysis, and some guidelines as to how to choose a discretization method under various circumstances. We also identify some issues yet to solve and future research for discretization.
2204750
A model of textual affect sensing using real-world knowledge
This paper presents a novel way for assessing the affective qualities of natural language and a scenario for its use. Previous approaches to textual affect sensing have employed keyword spotting, lexical affinity, statistical methods, and hand-crafted models. This paper demonstrates a new approach, using large-scale real-world knowledge about the inherent affective nature of everyday situations (such as "getting into a car accident") to classify sentences into "basic" emotion categories. This commonsense approach has new robustness implications.Open Mind Commonsense was used as a real world corpus of 400,000 facts about the everyday world. Four linguistic models are combined for robustness as a society of commonsense-based affect recognition. These models cooperate and compete to classify the affect of text. Such a system that analyzes affective qualities sentence by sentence is of practical value when people want to evaluate the text they are writing. As such, the system is tested in an email writing application. The results suggest that the approach is robust enough to enable plausible affective text user interfaces.
23971862
Handling Large Unsupervised Data via Dimensionality Reduction
7863387
Understanding Neural Networks via Rule Extraction
Although backpropagation neural networks generally predict better than decision trees do for pattern classification problems, they are often regarded as black boxes, i.e., their predictions are not as interpretable as those of decision trees. This paper argues that this is because there has been no proper technique that enables us to do so. With an algorithm that can extract rules, by drawing parallels with those of decision trees, we show that the predictions of a network can be explained via rules extracted from it, thereby, the network can be understood. Experiments demonstrate that rules extracted from neural networks are comparable with those of decision trees in terms of predictive accuracy, number of rules and average number of conditions for a rule; they preserve high predictive accuracy of original networks.