Toxicities of Benzoic Acid to Photobacterium phosphoreum and Quantitative Structure - Activity Relationship Study
The acute toxicities of 9 benzoic acids to Photobacterium phosphoreum were measured at pH 7.0. Quantitative structure-activity relationships (QSARs) were established using two physico-chemical parameters TSA and ELUMO, based on which the toxic mechanism of benzoic acid was preliminarily discussed. Results showed that the acute toxicities of benzoic acid varied with kind and position of substituents at the same pH. The toxic mechanism of benzoic acids to Photobacterium phosphoreum was mainly electrophilic and toxicities could be described by TSA in combination with ELUMO.