Effects of matrix material content on soluble drug release from matrix
The effects of different matrix material content s on the release of soluble drug’s mixed matrix were studied.With dissolu tion as guideline,and Captopril as model drug the effect of matrix material cont ents on the release of Captopril from hydrophilic gel matrix, wax matrix and mix ed matrix were compared.The content of the matrix material had greater influence on the release of Captopril from mixed matrix than that from former single matr ix. Moreover, the effect of Compritol 888 contents was more significant than th at of HPMC K4M in mixed matrix.