Commentary to 'Environmental, parental and gestational factors that influence the occurrence of hypospadias in male patients'.
Hypospadias is the archetypical malformation that appears to be at the crossroads of genetics, hormones and the environment. Whereas the new-generation sequencingmethodsare still try to identify the gene that could be responsible for this malformation, the increasing incidence of hypospadias in certain regions or timeperiods has led to the suspicion that environmental chemicals may also be detrimental to fetal, male genital development. Twenty years ago, the theory of testicular dysgenesis syndrome was proposed; this seducing hypothesis still remains to be confirmed. Eight percent of all known chemicals exhibit antiandrogen activity, and their