Antimycobacterial 2-Arylamino-2-Thioxoacetamides
A series of 13 2-arylamino-2-thioxoacetamides was tested against Mycobacterium tuberculosis and M. kansasii . Structure-activity relationships were analyzed quantitatively using the Free-Wilson method. Evaluation of the antimycobacterial profile with regard to equipotency of both activities was accomplished by means of a recently proposed method for evaluation of activity profile with respect to intended therapeutical use.