Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin)
X-ray crystal structures of the cyclosporin A analogue E-ISA247 (voclosporin) and its stereoisomer Z-ISA247 bound to cyclophilin A suggest the molecular basis for the differences in their binding affinities and immunosuppressive efficacies.