Stereochemistry, absolute configuration, and crystal structure ofcis-(4S,9S,10R)-1-(S-1-phenylethyl)decahydroquinolin-4-ol. Relative stereochemistry of cycloalkano-2,3-piperidin-4-ols
According to x-ray crystallographic data, thecis-isomer of 1-(1-phenylethyl)decahydroquinolin-4-ol, the predominant product of the stereoselective hydrogenation of1-(1--phenylethyl)-Δ9, 10-octahydroquinoline-4-one with sodium tetrahydroborate, has the (4S, 9S, 10R) configuration. The x-ray crystallographic data for this cisdecahydroquinolin-4-ol have been compared with the previously studied piperidin-4-ones of known absolute configuration. The stereochemical rules for cycloalkano-2,3-piperidine-4-ols are discussed.