Palladium‐Catalyzed Selective Synthesis of Perfluoroalkylated Enynes from Perfluoroalkyl Iodides and Alkynes
An interesting palladium-catalyzed procedure for the synthesis of perfluoroalkylated enynes from perfluoroalkyl iodides and alkynes has been developed. The reaction proceeds via an addition of iodoperfluoroalkanes to the terminal alkynes and subsequent Sonogashira coupling reaction with the same alkynes. This transformation conducted under mild reaction conditions with high efficiency and selectivity. Good functional group compatibility can be observed, and a variety of perfluoroalkylated enynes products were isolated in good to excellent yields.