Progress in pathogenic mechanism of hypervirulent Klebsiella pneumoniae
Hypervirulent Klebsiella pneumoniae (hvKP) mainly infects healthy people and causes serious infections, such as liver abscess, meningitis, necrotizing fasciitis, endophthalmitis and severe pneumonia. Studies have shown that hvKP is more virulent than classic Klebsiella pneumoniae characterized by expressing more capsular polysaccharide and carrying the virulence factors including magA, rmpA and iron acquisition molecules. The greater survival and anti-phagocytosis abilities of hvKP strains contribute to the spread and metastasis of hvKP infection. This review describes the virulence factors, colonization and infection of hvKP as well as the host immunity to hvKP. 
 
 
Key words: 
Klebsiella pneumoniae; Virulent; Liver abscess; Immunity