[Microdialysis sampling and microbore liquid chromatography with electrochemical detection for determination of serotonin in rat brain striatum].
AIM
To develop a sensitive method for determination of serotonin in biological samples.


METHODS
A combination of microdialysis sampling and microbore liquid chromatography with electrochemical detection (LCEC) was established.


RESULTS
Changes of serotonin in fg or pg in microdialysates from brain striatum of the free moving rat were easily determined.


CONCLUSION
This developed method was useful for living animal research. Serotonin level in corpus striatum healthy rats was quite stable.