Mode d'action des mycotoxines
Abstract The present paper is an attempt to review the hypothesis concerning the mechanism of the physiopathological effects induced by mycotoxins, in particular by the aflatoxins and PR toxin. We shall first examine to what extent the alterations produced on some metabolic pathways can explain the short term toxic effects. The problem of the long effects of aflatoxin, B 1 , i.e. the hepatocarcinogenic effects, will be discussed taking into account the results concerning the action of the mycotoxin on DNA and DNA repair.