Synthesis of 2-hydroxy-8'-(hydroxymethyl)-1,1'-binaphthalene (iso-homo-binol). A new structural pattern in the binaphthyl realm
The title compound 7 has been synthesized in a racemic form, using Suzuki coupling ( 8 + 15 → 16 ) as the key step. Pure enantiomer ( S )-(-)- 7 has been obtained by carbonylation of the known bromide ( S )-(+)- 12 followed by reduction of the resulting methyl ester ( S )-(+)- 18 with LiAlH 4 .