Determination of three phenolic compounds migrated from food contact materials and products by ionic liquid extraction coupled with HPLC
A novel method for the determination of three phenolic compounds,such as phenol,bisphenol A and p-tert-butylphenol,has been developed by vortex-assisted ionic liquid extraction couple with highperformance liquid chromatography. An ionic liquid,1-hexyl-3-methylimidazolium hexafluorophosphate([C6mim][PF6]),was used to extract three phenolic compounds from the water and 3% acetic acid(w/v)) soaking solution for food contact materials. Extraction parameters including extractant,vortex time,salt concentration,the volume ratio of extraction solvent to aqueous phase and solution pH have been investigated in details. The method has been found to have good linear relationship between in the range of 0.08~2.0 mg/L. Recoveries of the six primary aromatic amines were in the range of 89.2%~115.5%,limits of detection(S/N=3) were 0.04 mg/L,0.02 mg/L and 0.04 mg/L. The proposed method was fast,simple and efficient,and has been successfully applied to analyze PC cup samples with satisfactory results.