Effects of histamine H3 receptor modulators on sedative effects induced by ethanol
Conclusion Methods Animals 310 Female Swiss mice (8-10weeks) were used for th e experiments. Drugs Alcohol injections (3.0-4.0 g/kg) were 20% (v/v), diluted from 99.99% ethanol with 0.9% saline solution Immepip(10.0-20.0mg/kg), imetit(5.020.0mg/kg), A331440(5.0-20.0mg/kg) and thioperamide (10.0-20.0mg/kg) were dissolved in 0.9% saline and injected at a vol ume of 0.01 ml/g of body weight. The various H3R modulators were injected (i .p.) 30 minutes before