The Application of Nicardipine in Preventing The Post-operative Adverse-reactions of Patients Undergo Coronary Artery Bypass Graft
Objective To evaluate the effect of nicardipine to prevent the post-operative extubation reaction of patients undergo coronary artery bypass graft(CABG).Methods 60 cases under went off-pump coronary artery bypass graft (OPCABG),anesthezed with isoflurance combined intravenous anesthetics, was divied into two groups-the therapy group and the compared group.When the patients proper for extubating took the extubation,the therapy group received quickly nicardipine 20μg/kg for intravenous injection,while the compared group received epualent 0.9%NS by the same way.Results The mean artery pressure(MAP) of the therapy group changed slightly.While the MAP of the compared group during sucting,extubation ,5,10 minitue followed extubation,were significantly different from the ones before anesthesia and the therapy groups(P0.01).The heart rate of both groups before and after extubation were significantly different from the one before anesthesia (P0.01).3 cases of ventricular premature contraction occurred in the compared groups.Conclution Nicardipine can decrease effectivetly cardiovescular adverse-reactions,especially the arrhythmia,during the extubation for the patient undergo OPCABG.