1H-NMR SPECTROSCOPIC EVIDENCE ON CHIRAL DISCRIMINATION OF dl-PIRPROFEN BY β-CYCLODEXTRIN COMPLEXATION
The chiral discrimination of β-cyclodextrin (β-CyD) was demonstrated by measuring 270 MHz 1H-NMR spectra, using dl-pirprofen (PF) as a guest molecule. Upon binding to β-CyD, the induced 1H-chemical shifts of PF, particularly in the phenylpropionic acid portion, were significantly different between the d- and l-isomers, while no enantiometric difference was observed in the absence of β-CyD.