Secondary Metabolites Isolated from an Endophytic Phoma sp. – Absolute Configuration of Tetrahydropyrenophorol Using the Solid‐State TDDFT CD Methodology
The known macrolide pyrenophorol (synonym helmidiol) (1), the new 2,3,10,11-tetrahydropyrenophorol (3), and (4S,7R)-4,7-dihydroxyoctanoic acid (4), the monomeric acid of the sixteen-membered cyclic diolide 1, were isolated from an endophytic Phoma sp. The relative configuration of tetrahydropyrenophorol (3) was confirmed by X-ray single crystal analysis and its absolute configuration determined by the solid-state TDDFT CD methodology. Compounds 1 and 4 show antifungal activity and the acid 4 is also an algicide. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)