Synthesis of 2- and 6-arylaminopyrimidinediones
Methods for the synthesis of 6-arylamino-5,5-diethyl-3H,5H-pyrimidine-2,4-diones from the corresponding 6-thioxo and 6-amino derivatives were developed. The isomeric 2-arylamino-5,5-diethyl-1H,5H-pyrimidine-4,6-diones were obtained by the reaction of 2-mercapto- and 2-methylthio-1H,5H-pyrimidine-4,6-diones with substituted anilines. The ionization constants of the compounds obtained were determined.