Chirality Transfer from Epoxide to Carbanion: Base‐Induced Alkylation of O‐Carbamoyl Cyanohydrins of β‐Silyl‐α,β‐epoxy Aldehyde
Enantioselective C–C bond formation at an α-position of a nitrile group with an external electrophile can be realized, although in modest ee, with the aid of both the concerted process of an epoxysilane rearrangement and a carbamoyl group. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)