Effect of different intensity exercise to liver inflammatory state of rats with diabetic mellitus
This study is to discuss the anti-inflammatory effect of different intensity exercise,providing new ideas for the treatment of diabetes.Rat model of diabetes were established by high-fat diet with low-dose streptozotocin intraperitoneally injected,and randomly divided into diabetes control group(DMC),and 3 exercising groups(DME1,DME2,DME3).After adapting to treadmill exercise,exercise groups underwent treadmill training at the speed of 10 m/min(DME1)、15 m/min(DME2)and 25 m/min(DME3),1 h/d,5 d/week,continuous training for 6 weeks.After 6 weeks,the histopathologic changes of livers were evaluated.the serum ALT,AST,the liver NF-κB content were tested.Results: The exercise group FBG were significant decrease(P0.01);DME1,DME2 group of GSP decreased significantly(P0.05,P0.01);FINS was increase significantly in DME3 Group(P0.05),and DME1,DME2 and DME3 group there was significant difference(P0.05);DME1,DME2 group IRI were decreased(P0.05),while the DME3 groups was increased significantly(P0.05),and significantly than DME1,DME2 group(P0.05,P0.01);the exercise group suffered from hepatic TNF-α decreased to different extent,but only DME2 group was decrease significantly(P0.01).The Person correlation analysis,liver TNF-α and FPG,IRI is related.