Progress in the study of the effects of sports training on the signal channel and inflammatory gene of nuclear transcription factor kappaB
The signal channel of NF-κB(nuclear transcription factor kappaB) plays an important role in immune response as well as cell proliferation,apoptosis and development of the body.Active oxygen and kinetic muscle damage produced by the body during sports training activate the typical signal channel of NF-κB.The effect of NF-κB activity is related to the duration,frequency and intensity of sports training.Acute strenuous exercising causes the one time increase of NF-κB activity;long term regular sports training can lower NF-κB activity increas-ing as a result of aging and chronic inflammatory reaction;long term strenuous sports training results in the chronic,continuous activation of NF-κB,the changing of expression of various indexes on the channel,the increase of the concentration of subunit p65 of NF-κB aggregating in nucleus and transcription target genes,thus significantly in-creases the expression of inflammatory genes;on the one hand,it amplifies the exercise resisting stress of the intrin-sic immune system of the body,while on the other hand,it participates in the formation of kinetic chronic inflam-mation of skeletal muscle.