Serological epidemiology study of HPV-6,11,16,18 in Shanxi rural women
Objective To evaluate the distribution of HPV-6,11,16,18 virus-like particle(VLP)antibodies in Chinese women population in rural area and provide data for implementation of the prophylactic HPV vaccines in China.Methods A cross-sectional study was conducted to interview 884 women aged 19-54 living in Shanxi,China.Questionnaire data,including demography,disease history and menstrual history were collected between 2006 and 2007.HPV-6,11,16,18 antibodies in venous blood were detected by Merck Research Laboratory using fluorescence method.Results Positive rate of HPV-6,11,16,18 VLP antibodies among women in Xiangyuan,Shanxi were 7.35%,2.26%,6.90%,1.58%,respectively.Positive rate of any type of HPV-6,11,16,18 VLP antibodies was 14.93%.HPV-16 VLP antibodies of women with normal,cervical intraepithelial neoplasia( CIN)1 and GIN2+ lesions were 5.36%,14.63%,50.00%,respectively,which was statistical significance using Cochran-Armitage tendency test (P＜0.0001).The seroprevalences of HPV-6/11,HPV-16/18 were much higher in women who had 2 or more lifetime sex partners than those women who had 1 lifetime sex partner(P＜0.05).HPV-6/11 and 16/18 VLP antibodies were not statistically associated with age at first sexual intercourse,smoking status,education and condom using status.Conclusion HPV6 and HPV-16 were the most two popular HPV types in the whole population,while HPV-16 was the most common type in CIN2+ population.HPV-16 seroprevalence increased with severity of cervical intraepithelial neoplasia. 
 
Key words: 
Human papillomavirus antibody; Serological epidemiology; Fluorescence detection