Synthesis of 6H-Isoindolo[2,1-a]indol-6-ones Through Wittig Reaction and Tandem Reductive Cyclization–Lactamization
A convenient and efficient two-step route to 6H-Isoindolo[2,1-a]indol-6-ones has been developed starting from o-nitrobenzaldehydes. The methodology involves Wittig reaction followed by tandem reductive cyclization–lactamization. A series of isoindoloindolones incorporating different substituents on the indole nucleus has been prepared.