Determination and correlation of natamycin solubilities in water and methanol
The solubility data of natamycin in pure water(278.2—341.2 K),methanol(278.2—313.2 K) and water-methanol mixture(278.2—308.2 K) were experimentally determined by the equilibrium method.The data in pure water and methanol were well correlated by artificial neural network.It was found that the solubilities of natamycin in the water-methanol mixture increased with the increase of temperature but decreased with the increase of water content.The solubility data were also well correlated in the form of λh equation by the nonlinear least square technique.The parameters λ and h were expressed by the function of water-methanol ratio.The results by interpolating calculation were satisfactory to some degree,which can be used in the industrial crystallization technology of natamycin.