Cyclization of N-(2,4,6-trimethylphenyl)-β-alanines
Reaction of 2,4,6-trimethylaniline with acrylic and itaconic acids gives the corresponding N-substituted β=alanines which can be converted to derivatives of tetrahydropyridone, dihydropyrimidinedione, and 4-carboxy-2-pyrrolidinone. Bromination of the aromatic substituent in the synthesized heterocycles has been carried out.