Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium.
AIM
To investigate the anti-implantation mechanism of mifepriston.


METHODS
In situ hybridization and immunohistochemistry were applied to determine mRNA and protein.


RESULTS
After mifepriston injection, the number of implantation sites were obviously reduced, mifepriston could inhibit the embryo implantation in mouse. The expression of apoptosis related genes, Fas and FasL, in mouse endometrium was also decreased after mifepriston treatment.


CONCLUSION
The expression of apoptosis related genes Fas and FasL is regulated by mifepriston and the inhibitory effect of mifepriston on the embryo implantation may be mediated by action on the Fas/FasL system.