Biological functional analysis of autoreactive T cells from BXSB mice
Objective Analyzing biological function of ATL, an autoreactive T cell line from lupus-prone mice BXSB to study the feasibility of TCV (T cell vaccine) in the SLE. Method Detecting the proliferation of ATL with 3H-TdR incorporation and the level of antibodies with ELISA. Results When ATL cells are adoptively transferred into prenephritogenic female BXSB mice, they significantly increased the level anti-DNA, histone, BSA and OVA and cytokine IFN-γ in the serum of IgG. Moreover, the ability of humoral immune response against foreign antigen decreased in these mice. Conclusion Adoptively transfer of ATL could affect the autoimmune response and humoral response against foreign antigen. [