Effects of puerarin on blood lipids and inflammatory factors in rats with lower limb arteriosclerosis obliterans
Arteriosclerosis obliterans (ASD) is a disease in which the atherosclerosis lesions involves the peripheral arteries and causes the chronic occlusion. It is a part of systemic arteriosclerosis, and is the lesion arising from the vascular degenerative change (Juergens et al., 1960). Lower limb ASD is the local performance of systemic atherosclerosis at the lower limb. The incidence of lower limb ASD is increasing year by year. If this disease doses not receive proper treatment, it will lead to the occurrence of amputation and even endangers the life of patients, which brings great economic burden to the family and society (Davì et al., 1985; Safar, 1991; Huang et al., 2007). Lower limb ASD will cause extensive multi-segment vascular lesions. It is the main reason of severe ischemia in the lower extremity, and is also a difficult and hot spot in clinical treatment (Phornphibulaya et al., 1981).