The stereospecific synthesis of reserpine
A stereospecific lynthesis of reserpine in its correct absolute stereochemistry was achieved by constructing a system which has the five asymmetric centers present in ring E. problem of the stereochemistry of the C3 center. has now been solved, in a generally applicable manner, so that it is now possible to produce, at will, either the more stable arrangement (equatorial indole) or the less stable (axial indole) at the C3 center. arrangement corresponds to that in reserpine. At this point, we were left with the This long-satnding problem