Reply to “The Connection between Celiac Disease and Hepatic Steatosis: High Levels of Pigment Epithelium-Derived Factor”
ing, the PEDF-deficient mouse can also develop hepatic steatosis [6]. Yoshida et al. [7] investigated the effect of intramuscular administration of PEDF on hepatic steatosis in mice and found that PEDF can retard steatohepatitis. At this point, it is difficult to state that PEDF can induce hepatic steatosis in CD. In addition, measurement of PEDF in CD for assessment of hepatic steatosis is neither feasible nor cost-effective. Further tissue-based studies on PEDF in hepatic steatosis in patients with CD will clarify this issue.