Synthesis of (2-oxo-1-pyrrolidinyl)pyrimidines
Abstract(2-Oxo-1-pyrrolidinyl)pyrimidines have been synthesized by thermal cyclization of certain N-(pyrimidinyl)-γ-aminobutyric acids. Reaction of 2-methyl-4-chloro-6-(2-oxo-1-pyrrolidinyl)pyrimidine with the sodium salts of acetone or acetophenone oximes gave the corresponding pyrimidinylketoximes. The iodomethylation of pyrrolidinylpyrimidines is reported.