IP‐10 is highly involved in HIV infection
HighlightsPlasma levels of IP‐10 are up‐regulated after HIV infection and positively correlated with HIV disease progression.High levels of IP‐10 during HIV infection suppress immune cell function.IP‐10 increases susceptibility of individuals to HIV infection and facilitates viral latency and replication.Possible mechanisms for up‐regulation of IP‐10 during HIV infection. &NA; Interferon‐&ggr; (IFN‐&ggr;)‐induced protein 10 (IP‐10 or CXCL‐10) is a chemokine involved in trafficking immune cells to inflammatory sites. Numerous studies have reported abnormally high plasma IP‐10 levels in the context of human immunodeficiency virus (HIV) infection, and IP‐10 is considered an important pro‐inflammatory factor in the HIV disease process. The data regarding the roles of IP‐10 in HIV infection required collation; this review summarizes the biological characteristics of IP‐10, the positive association between plasma IP‐10 levels and HIV disease progression, the effect of IP‐10 on human immune cells, and potential related mechanisms. This review provides important insights into the role of IP‐10 in HIV monitoring and treatment.