SYNTHESIS OF CHIRAL DEPSIPEPTIDE BUILDING BLOCK BY THE ASYMMETRIC REDUCTION OF N-(α-KETOACYL)-α-AMINO ESTERS
Asymmetric reduction of N-(α-ketoacyl)-α-amino esters was performed by using homogeneous hydrosilylation and hydrogenation catalyzed by rhodium(I) complexes. The asymmetric hydrosilylation achieved good to high stereoselectivities giving the corresponding N-(α-hydroxyacyl)-α-amino esters, whereas only simple asymmetric induction arising from the chiral center of the substrate was observed in the case of hydrogenation.