A CLINICAL TRIAL OF AMITRIPTYLINE IN DEPRESSIVE PATIENTS.
Seventy depressed patients, 45 endogenous and 25 reactive, were included in a double blind controlled trial to assess the value of amitriptyline in such cases. A favourable result to a statistically significant degree was seen in reactive depression. In endogenous depression the results, though in favour of the drug, did not reach statistical significance. Side-effects were not very marked at a dosage of 50 mg. t.d.s. A further trial to compare chlorpromazine with amitriptyline in hospitalized reactive depressive patients would seem worth while.