The main pathogenetic mechanisms of disorders of the detoxication function of the liver in endogenous toxemia of various etiologies
: The mechanisms of cell proliferative activity regulation under the effect of growth factors, mitogens, virus transformation, etc. were analyzed. Changes in the location of cAMP-dependent protein kinase caused by these factors, the effect of the nerve growth factor on the activities of protein kinase and high-affinity ATPase, and the mechanism of antiproliferative action of staphylococcal enterotoxin A were specified. Data on receptor-independent intracellular penetration of protein factors hydrophobized by fatty acid residues are overviewed.