Research Progress of C-reactive Protein Analysis
Abstract C-reactive protein (CRP) is an important biomarker for acute inflammation and infection and widely used clinically for the assessment of various diseases and the monitoring of patients’ conditions. At present, the clinical test methods for CRP mainly include immunoturbidimetry, enzyme-linked immunosorbent assays, and lateral flow assays. In recent years, developments in analysis theory and improvements in materials science have resulted in the continual emergence of analytical methods and techniques, such as biosensor technology and microfluidics. In this paper, we summarized the development and application of CRP analytical methods and focus on the developments during the last five years. In addition, we predicted the research directions for novel CRP assays and provide new ideas for the development of CRP analytical methods with high sensitivity and specificity that can meet clinical needs.