Stabilizer distribution on surface of solid lipid microparticles and SLM stability: mesoscale simulation and experiments
Dissipative particle dynamics(DPD) simulation was used to model the distribution of stabilizers(lecithin,poroxamer and PVA)on the surface of ibuprofen-loaded solid lipid microparticles(SLM).It was shown from DPD simulation results that lecithin totally enwrapped the surface of SLM when the molar fraction of ibuprofen was 1% and 2%.However,when the molar fraction of ibuprofen was increased to 3% and 5%,lecithin could not cover the place with a higher concentration of ibuprofen molecules.Poloxamer 407 and PVA totally enwrapped the surface of SLM when the molar fraction of ibuprofen was increased from 1% to 5%.The experimental results could be interpreted with the simulation results.DPD simulation provides an insight into the microstructure of a drug carrier and helps to analyze the experimental results,which is helpful in stabilizer selection for SLM.