Methodology for stereochemical control in bioactive natural product synthesis - new methods toward enediyne antitumor antibiotics
ABSTRACT Acetylenic compounds are of great interests in the development of the synthetic methodologies directed toward enediyne antitumor antibiotics. This paper discusses on the new asymmetric synthesis via heteroconjugate addition methodology by utilizing acetylide carbanions as the nucleophiles. On the other hand, silyl acetylenes can be nucleophiles under acidic condition and the products are quite useful as the precursor of heteroolefins. Most of the reactions undergo in highly stereoselective.