MANNICH REACTION IN THE SYNTHESIS OF N,S-CONTAINING HETEROCYCLES. 13. ONE-POT METHOD FOR PREPARING PYRIMIDO[4,3- b ][1,3,5]THIADIAZINES BY REACTION OF ALDEHYDES, CYANOTHIOACETAMIDE, FORMALDEHYDE, AND PRIMARY AMINES
Successive reaction of cyanothioacetamide with aliphatic or aromatic aldehydes, formaldehyde, and primary amines gives the corresponding 3,7-disubstituted 3,4,7,8-tetrahydro-2 H ,6 H -pyrimido-[4,3- b ][1,3,5]thiadiazine-9-carbonitriles. Authors: V. V. Dotsenko, K. A. Frolov, and S. G. Krivokolysko. English Translation in Chemistry of Heterocyclic Compounds , 2012, 48 (4), pp 642-649 http://link.springer.com/article/10.1007/s10593-012-1038-7