Angiotensin II-Induced Renal Vasodilation Mediated by Cytochrome P-450 Arachidonic Acid Metabolites
Objective: Activation of AT<sub>2</sub> angiotensin II receptor release cytochrome P-450 arachidonic acid metabolites (CYP-AA). The presence of the AT<sub>2</sub> receptor and its ability to mediate renal vasodilation through CYP-AA metabolites were evaluated. Methods: Vascular response to angiotensin II in the isolated perfused kidney of the rat was evaluated in the absence and presence of angiotensin II AT<sub>1</sub> and AT<sub>2</sub> receptor blockers. Results: Blockade of the AT<sub>1</sub> receptor unmasked a vasodilatory response that was inhibited by AT<sub>2</sub> receptor blockade and AA metabolism. Conclusion: The findings indicate that blockade of the AT<sub>1</sub> angiotensin II receptor, activation of AT<sub>2</sub> receptors, releases CYP-AA metabolites that induce renal vasodilation.