Efficient Large‐Scale Synthesis of Picolinic Acid‐Derived Nickel(II) Complexes of Glycine
An efficient, large-scale method for the preparation of 2-[N-(α-picolyl)amino]acetophenone (PAAP) and 2-[N-(α-picolyl)amino]benzophenone (PABP), the hitherto unknown 4-methyl-2-[N-(α-picolyl)amino]benzophenone (4-Me-PABP) and 4-nitro-2-[N-(α-picolyl)amino]benzophenone (4-NO2-PABP), and their corresponding NiII complexes with glycine is described. The key step of the method is the formation of the mixed anhydrides derived from o-picolinic acid and ethyl chloroformate or p-toluenesulfonyl chloride. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)