Application of Capillary Introduction Mass Spectrometer to Direct Analysis of Liquid
Capillary introduction was widely employed in miniature mass spectrometer to permit atmospheric sampling of gas analyte.Feasibility of direct liquid analysis using capillary introduction mass spectrometer was explored in this study.All the experiments were carried out on a newly developed miniature mass spectrometer,which consisted of a capillary interface,an electron impact ionization source and a quadrupole analyzer.Direct analysis of liquid conduced to the decrease of air injection,hence air interference could be effectively reduced even the analysis was performed at atmosphere.The results indicated that the miniature mass spectroemter was capable of performing direct analysis of liquid when a 5-μm capillary was used as the sampling interface.Furthermore,to improve the ionization efficiency of analyte,electrospray was used as a nebulization technique to transfer liquid sample into aerosol,which could evidently increase the sensitivity.