Diastereodirected Alkylation of Ketones and 1,3-Diketones with N-[1H-Indol-3-yl(phenyl)methyl]-N-methylamine by the Michael Reaction
A method has been developed for introducing the 1H-indol-3-yl(phenyl)methyl residue into position 2 of ketones and 1,3-diketones. The principle of bringing in controlled diastereoselectivity based on the configuration of intermediates is demonstrated.