Preparation of Androstanes Related to Aphidicolin
The preparation of 3α,4α,17β-trihydroxy-, 3α,4α,16α,17α- and 2α,3α,16α,17α-tetrahydroxy-5α-androstane derivatives ( 5 , 11 , 18 ) from testosterone as steroidal analogues of diterpenoid inhibitor of DNA polymerase α, aphidicolin, is described. The crystal structure of 5α-androstane-3α,4α,17β-triyl triacetate ( 6 ) is reported.