Association of HLA-DRB1 alleles and polymyositis/dermatomyositis in northern Chinese
Objective To explore the association of HLA-DRB1 alleles with polymyositis(PM)/dermatomyositis(DM) in northern Chinese. Methods HLA-DRB1 typing of 52 patients with PM/DM and 168 control persons from northern Chinese were investigated by polymerase chain reaction and sequence-specific primer method, the frequencies of DRB1 alleles were compared. Results The patients with PM/DM had significantly increased frequencies of the HLA-DRB1*040x and DRB1*120x allele (χ2=29.80, RR=6.61, P c0.01; χ2= 22.22 , RR=5.82, P c0.01). DRB1*070x allele frequency of PM/DM patients group was higher than that of healthy group (χ2=10.68, RR=4.48, P c0.05). Conclusion The results suggest that HLA-DRB1*040x, DRB1*070x and DRB1*120x alleles contribute to genetic susceptibility to PM/DM. [