Pyrrolopyrimidines. 1. Electrophilic substitution reactions of 1,3-dimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
The reactions of halogenation, aminomethylation, acylation, and azo coupling in 1,3-dimethylpyrrolo[3,2-d]pyrimidine-2,4 dione proced at position 7, whereas nitration in acetic acid is directed primarily to position 6. In a num of cases, products of substitution of both hydrogen atoms in the pyrrole ring have been synthesized.