SYNTHESIS AND PROPERTIES OF 6,6-DI(INDOL-3-YL)INDOLO[2,1- b ]QUINAZOLIN-12(6 H )-ONE AND ITS 2,8-DIMETHYL AND 2,8-DIBROMO DERIVATIVES
The condensation of tryptanthrin, as well as its 2,8-dimethyl and 2,8-dibromo derivatives with indole gave previously unreported 6,6-di(indol-3-yl)indolo[2,1- b ]quinazolin-12(6 H )-ones. 2,8-Disubstituted tryptanthrins and 6,6-di(indol-3­-yl)indolo[2,1- b ]quinazolin-12(6 H )-one were shown to inhibit Candida albicans KMM 455. Solutions of tryptanthrin itself and its 6,6-diindolyl derivative upon the absorption of light at 434 and 340 nm exhibited fluorescence maxima at λ max 525 and 500 nm, respectively. Authors: T. V. Moskovkina, A. I. Kalinovskii, E. A. Martyyas, and M. M. Anisimov English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (3), pp 452-456 http://link.springer.com/article/10.1007/s10593-013-1267-4