Mutation of p53 gene in nasopharyngeal carcinoma tissues
Three nasopharyngeal carcinoma(NPC)cultured cell lines CNE-1, CNE-2, CNE-3, and 5 biopsies of NPC, have been screened for mutations at codon 249 of the p53 gene. Any changes to the second or third bases of codon 249 in exon 7 of the p53 gene result in the abolition of a restriction site for enzyme. All NPC samples were cleaved by HaeⅢ at codon 249 of p53 gene. None was found to have mutations at this position.