THE ROLE OF INTERLEUKIN 6 IN INTERFERON-γ PRODUCTION IN THERMALLY INJURED MICE
Abstract Following traumatic injury, patients suffer from compromised immunity increasing their susceptibility to infection. Previous studies from this laboratory demonstrated that female BALB/c mice subjected to a 15% total body surface area (TBSA) scald injury exhibit a decrease in cell-mediated immunity 10 days post-burn. Studies described herein revealed that concanavalin A (Con A; 2 μg/ml)-stimulated splenocytes from sham treated animals produced 3557±853 pg/ml of IFN-γ while splenocytes from burn injured animals released two-fold more cytokine ( P P P P