CYCLIZATION OF POLYENES XXVII. SYNTHESIS OF OXOCRINOL, dl-CAULERPOL, AND dl-CRINITOL
Novel terpene alcohols, oxocrinol (1a), caulerpol (3a), and crinitol (2a), isolated from marine algae, were synthesized by the alkylation of lithium salt of benzenesulfonyl derivatives, 5, 6, and 11 (R = THP; X = SO2Ph) followed by reductive cleavage of SO2Ph and the protecting groups. The present study confirms unequivocally the proposed structures of oxocrinol, caulerpol, and crinitol, respectively.