Controlling Helix Handedness in Water‐Soluble Quinoline Oligoamide Foldamers
For biological applications, the control of the helix handedness of water-soluble quinoline-based oligoamide foldamers has been investigated by the installation of chiral end groups at either the C or N terminus. This has resulted in the development of monomer units capable of unequivocally inducing helical sense without impacting the aqueous solubility. Furthermore, we showed that very slow helix handedness inversion in water can be exploited. The incorporation of a chiral moiety with no handedness-induction properties allows the chromatographic separation of P and M helices as diastereoisomers with kinetically locked handedness.