Nucleophilic Allylation-Heterocyclization via Bis-π-allylpalladium Complexes: Synthesis of Five- and Six-Membered Heterocycles
The reaction of the allylic halides 5–9 having an aldehyde or an imine moiety in the molecule with allyltributylstannane proceeded smoothly in the presence of Pd2•dba3•CHCl3 (5 mol%) in DMF or THF, giving the corresponding heterocycles 10–14 in good to high yields. The Stille coupling product was not obtained under these reaction conditions.