GENERAL METHOD OF STEREOSPECIFIC SYNTHESIS OF NATURAL POLYPRENOLS. SYNTHESIS OF BETULAPRENOL-6, -7, -8, AND -9
A stereoselective synthesis of (Z,Z,Z)-12-benzyloxy-1-chloro-2,6,10-trimethyldodeca-2,6,10-triene (3) was achieved starting from (Z,Z)-farnesol. All the components of betulaprenols were synthesized using the C15 block 3 and its lower homologue (C10 block) as the key building blocks for the cisoid polyprenyl skeletone.