CLINICAL PRESENTATION OF LEPTIN LEVELS IN PATIENTS WITH HISTORY OF PARENTAL OBESITY
Objective: The role of adipose tissue as an endocrine organ is of great interest and leptin seems to be involved in it. The aim of this study is to document the characteristic of subjects with respect to leptin and BMI, with both parental history of central obesity and to describe the association in it. Study design : This was a cross sectional study. The subjects with both parental history of central obesity were selected in both normal and diabetic study population along with the controls. Results: Leptin values obtained was higher in those subjects with both parental history of central obesity with a mean difference of 11.1units (P<0.001) in diabetic subjects and  6.44 units (P<0.001) among the normal subjects though BMI showed no much difference between the groups. Conclusion: The data of this study demonstrated the  genetic relationship between leptin levels and obesity.