The dynamic changes of CD38 expression on T subsets in liver or renal recipients with CMV infection
Objective To identify the dynamic changes of CD38 expression of T subsets in liver or renal recipients with cytomegalovirus(CMV) infection. Methods The lymphocytes of research objects were mixed with corresponding fluorescence labeled McAb, CD38 expressions were detected by flow cytometer. Results The difference of expression between differ sex or ages from the volunteers was no significant(P0.05), CD38 expression was 642.1±107.3 per cell. CD38 expressions markedly increased in liver or renal recipients(3577.8± 1570.5, 3532.9±1692.2) in the presence of CMV infection. CD38 expressions had increased before clinical syndromes and kept at the higher for levels of healthy 3 months after the treatment. [WT5”HZ]Conclusion Quantitatively analysis the CD38 expression of CD8+ T cells by dual color flow cytometry can be clinically used as one of the sensitive and specific diagnostic markers of CMV infection.