Coexpression of GABAA receptor γ1 and γ2 subunits in the rat trigeminal ganglion
Abstract We examined the expression of γ-aminobutyric acid (GABA) A receptor γ1 and γ2 subunit mRNAs in the rat trigeminal ganglion using in situ hybridization histochemistry. Most ganglion cells expressed both γ1 and γ2 mRNAs simultaneously. These findings are a marked contrast to the findings in the central nervous system where areas expressing both subunits are rare. In addition, we demonstrated using immunohistochemistry that the γ1 subunit is also expressed at the protein level in trigeminal ganglion neurons and fibers in the trigeminal spinal nucleus.