Adenoid cystic carcinoma of salivary gland with mandible erosion and distant metastases to lung.
The adenoid cystic carcinoma (ACC) is the frequent pathology occurring in the salivary glands. It is usually slow growing, but invasive, and thereby spread via perineural invasion, with haematogenous and lymphatogenous metastasis. In this article, we present a rare asymptomatic case of an ACC of salivary gland with coincident mandible invasion and multiple pulmonary metastasis (PM). Immunohistochemically, a series of molecular markers were used to determine which a biologically subtype exists, and to provide histological and tumor microenvironmental data about PM of ACC. Clinically, it is also valuable in screening PM and in selecting case to identify the primary tumor.