Memory Disorders in Multiple Sclerosis
Short-term memory disorders are the earliest and most frequently seen changes to cognitive functions in multiple sclerosis (MS). Complex neuropsychological investigations and MRI brain scans were performed in 100 patients with MS. The results showed that memory disorders were encountered in MS patients regardless of the duration and type of disease. The main pathophysiological mechanism of cognitive disorders in MS consists of interruption of projection, commissural, and long associative fibers, which leads to impairment of the integrative activity of the brain and activation of the cortex by deep structures.