Breeding of Production Strains of Spinosads
Spinosads is a macrolide lactone antibiotic fermented in aerobiotic environment by Saccharpolyspora spinosa. Firstly the spores of spinosads producer n-23-108 were treated with ultrasonic waves to increase the permeability of the cell wall. Then the spores were mutated with UV 60Co-γ irradiation N+ transfusion. As a result mutant strain C121 was obtained its chemical titer was increased by 171 % reaching 460 g/mL.