Synthesis and DNA Cleaving Activity of Copper-complex of Macrocyclic Compound Containing 1,10-Phenanthroline
Copper-complexes of 1,14: 7,8-diethenotetrapyrido-[2,1,6-de: 2′,1′,6′-gh: 2″, 1″, 6″-kl: 2″′,1″′, 6″′-na][1,5,8,12] tetraaza-[3,10] dithiocyclotetradecine (SMC) consisting of two 1,10-phenanthroline molecules bridged by sulfur, was synthesized. Interaction of Cu-SMC with DNA was examined by spectroscopic methods. Cu-SMC binds with DNA and cleaves DNA in the presence of a reducing agent under an aerobic condition.