Distribution and antibiotic resistance of 532 bacterial panthogens in blood culture in a hematology department
Objective 
To analyze the distribution and antibiotic resistance of bacterial pathogens in blood culture in the Department of Hematology of the First Affiliated Hospital of Nanjing Medical University from 2013 to 2017. 
 
 
Methods 
BACTEC FX automatic blood culture instrument was used for blood culture. VITEK-2 Compact automatic microbial identification and drug susceptibility system was used for bacterial identification, drug sensitivity testing and fungal identification. K-B and ATB FUNGUS 3 methods were used for Streptococcus and fungi susceptibility testing, respectively. WHONET5.6 software was used for statistical analysis. 
 
 
Results 
The positive results of blood culture accounted for 7.6% during 2013 to 2017 and the top five isolated pathogenic bacteria were Escherichia coli (20.9%), Klebsiella pneumoniae (18.0%), coagulase negative Staphylococcus (12.4%), Pseudomonas aeruginosa (11.5%) and Enterobacter cloacae (3.6%). Carbapenems (94.4%) were the most active antibiotics against Enterobacteriaceae. Pseudomonas aeruginosa strains were sensitive to all antibacterial dugs except aztreonam. Acinetobacter baumannii strains had a lower sensitivity to almost all antibacterial dugs. Vancomycin, linezolid and teicoplanin were active antimicrobial agents against gram-positive cocci. 
 
 
Conclusion 
Patients with hematological diseases are more susceptible to nosocomial infection, which should be paid more attention to in clinical and laboratory practice. Rational antimicrobial therapy is an effective way for control of antimicrobial resistance. 
 
 
Key words: 
Blood culture; Pathogenic bacteria; Antibiotic; Antimicrobial susceptibility