Effects of Triterpenoids on Herpes Simplex Virus Type1 (Hsv-1) In Vitro
The primary symptoms of HSV infection include a prodromal “flu-like” syndrome, with fever, headache, malaise, diffuse myalgias, followed by local symptoms consisting of genital itching, tenderness, dysuria, lesions, and painful papules over genital regions and ulceration [6,7]. Studies have shown that reactivation of latent HSV-1 can occur as a result of physical or emotional stress [8,9]. In Scotland, it found that 40% of genital herpes was due to HSV1. HSV-1 and HSV-2 are able to infect and reactivate in the same anatomic area, although the natural history of these infections is markedly different [10]. The HSV2 recurring more frequently than HSV1, so most clinical reactivations are likely to be due to HSV2 [10].