Animal experimental study on U_(14) cell apoptosis induced by Lactobacillus
Objective To explore the growth-inhibition and the apoptosis induced by Lactobacillus(LB ) on murine cervical carcinoma U 14 . Methods The KM mice and 615-strain mice with U 14 were divided into eight groups with different treatments. The inhibitory rate of each group were detected. The apoptosis index was assessed by TUNEL. Results Lactobacillus had greatly significant antitumor effect on KM mice and 615-strain mice bearing U 14 ( P 0.01); the growth rate of transplanted tumors from U 14 in LA ( L.acidophilus ) pre-administration group was slower than that in the model group; the inhibitory rate was significantly higher in the LA, LC ( L.casie ) and DDP(Diaminodichloroplatin) group as compared with the model group respectively( P 0.01), however no significant difference( P 0.05) was found among them. Marked difference was found in AI between LA and DDP, LA and model, DDP and model. Conclusion Lactobacillus showed a marked inhibition effect on occurrence and development of U 14 , and its antitumor mechanism may be associated with inducing apoptosis.