Mango gum tablet formulation
54022931
Evaluation of Mangifera indica gum as tablet binder.
The aim of the present study is to evaluate the gum of mangifera indica (mango) as a tablet binder employing paracetamol as a model drug. Natural gums are economic, easily available and found useful as tablet binder. To the best of our knowledge, no significant work has been reported on mango gum as a tablet binder. Paracetamol tablets were prepared by wet granulation technique using mangifera indica gum as a tablet binder. The prepared tablets were evaluated for physico chemical characteristics. The friability of the tablets ranges from 1.12 to 0.26 and the disintegration time from 3 to 8 min. The binding efficacy of the mangifera indica gum was compared with the standard binder gum acacia at similar concentration (5% w/w) The tablets hardness prepared from mangifera indica gum varies from 6.3 to 6.8 kg/cm which are comparable with the standard binder, gum acacia (4.8 kg/cm) In conclusion, MIG could be used well as a binding agent in the formulation of tablet dosage forms.
A K Singh Vipul Kumar Shingala Rajakar Selvam Thangavel Sivakumar
139809601
NOVEL APPROACH OF EXTRACTION AND CHARACTERIZATION OF OKRA GUM AS A BINDER FOR TABLET FORMULATION
Objective: The major objective of the present investigation was to extract a natural polymer (okra gum) with its characterization as pharmaceutical binder and to formulate, develop, and evaluate the compression coated tablet using okra as binder along with synthetic hydrophilic polymers like various grades of hydroxypropyl methylcellulose (HPMC).Methods: A novel extraction method was carried out using fresh unripe pods of okra (ladies finger) with the aid of organic solvents and its characterization was done. The core tablets were prepared by direct compression method which was compression coated with okra gum and HPMC.Results: After the extraction of the okra gum was carried out, the yield of mucilage obtained was 10% It is considered as a proof for the purity of the mucilage extract. The above study reveals that the polymers were subjected to the Fourier transform infrared and differential scanning calorimetry thermogram had no significant interactions between the drug and the polymers. The characterization of the new polymer okra showed that it has swelling properties, and in spite of being a hydrophilic polymer, it can be successfully used in pharmaceutical formulation as a good binder.Conclusion: In the present aspect of the study was to evaluate the efficacy of okra gum that has been used as a tablet binder. It is easily available and inexpensive. Okra gum as a binder produces tablet formulations with good physicochemical properties and good candidate for sustained release formulations.
Shayeri Chatterjee Rana Mazumder
216683656
Comparative evaluation of the binding properties of okra gum and other hydrocolloids in the formulation of erythromycin stearate tablet
Binders constitute a major class of excipients that are used to hold the active pharmaceutical ingredients and other inactive ingredients together in a cohesive mass during granulation. The type and concentration of a binder influences the physicochemical characteristics of a compressed tablet. The aim of this study therefore is to examine and compare the binding and release properties of okra gum with those of microcrystalline cellulose (Avicel) and acacia gum in erythromycin stearate tablet dosage form. Okra gum was extracted from the pods of locally cultivated Hibiscus esculentus in Okada Town. Unripe okra fruits were purchased from Edo State, Nigeria. The dried okra gum was then milled and sieved into fine powder form and evaluated for angle of repose, flow rate, solubility, pH and viscosity. The gum powder was used as a binder in the formulation of tablets using wet granulation and compression methods. Erythromycin stearate was used as a model drug and the efficiency of okra gum as a binder was determined by comparing with microcrystalline cellulose (Avicel) and acacia gum. The tablets were evaluated for hardness, friability, disintegration and dissolution rate. The okra gum had a moisture content of 15.21% was slightly soluble in water and insoluble in organic solvents, had pH 6.63 and viscosities of 61.45 cP for 0.5 %w/v concentration and 232.3 cP for 1%w/v. The hardness of all the tablets was satisfactory (4.2 4.5 kgf. All the tablet batches passed the friability test with values ranging from 0.30 0.68. The mean disintegration time (min) of the tablets was within the Pharmacopoeial acceptable time limit of 15 min for uncoated tablets. The tablets formulated with Avicel and acacia gum released 70% of the drug at 45 min, while those of okra gum demonstrated a slow release profile for the concentration range as none released up to 70% at 45 min. From the release profile, Abelmoschus esculentus (okra) gum may be effective as a controlled release polymer for delayed release erythromycin stearate tablets and other oral solid dosage forms. Keywords: okro, gum, binder, Avicel, acacia, erythromycin Journal of Pharmaceutical and Allied Sciences Vol. 16 No.4 (2019)
Aiwaguore Johnbull Obarisiagbon Al Muktar Adamu Yahuza
104194695
Evaluation of the binding potential of Chrysophyllum albidum seed gum in paracetamol tablet formulation
Pharmaceutical excipients control the physicochemical properties as well as the release profiles and availability of the drug in the formulation. One of such commonly used groups of compounds is natural polymers. They are polysaccharides composed of a large group of polymers with varying chemical compositions, and a wide range of molecular weights. They are characterized by low toxicity, high stability and biodegradability. These properties make them appealing as pharmaceutical excipients. Binders are excipients added to tablet formulation to impart plasticity and thus increase the inter particulate bonding strength within the tablet. They hold the ingredients in a tablet together and give volume to low active dose tablets. Binders give adhesiveness to the powder during the preliminary granulation and to the compressed tablet. They ensure improved granulation qualities in terms of granule size and hardness which on compression give an intact tablet. Gums have been found useful in producing tablets of different mechanical strength and drug release properties for different pharmaceutical purposes. 3 5 Gums can exist as exudates or extractives from barks and fruits or seeds of plants, respectively. As a result of the versatile applications of gums,
Modupe O Ologunagba Chukwuemeka P Azubuike Oluwamayowa Sadiku Boladale Olanrewaju Silva
202757513
EVALUATION OF Alstonia congensis ENGL. (APOCYNACEAE) GUM AS A BINDING AGENT IN TABLET FORMULATION
Natural gums are economical, easily available and have been found useful as binders in tablet formulations. In the present study, A. congensis was studied and employed as a binder in drug formulation with Paracetamol as a model drug at concentrations of 1.0 5.0% w/w and gelatin mp (standard binder) Paracetamol tablets were prepared by wet granulation technique using A. congensis gum (ACG) as a tablet binder. The properties of the prepared tablets were evaluated for crushing strength, friability, disintegration and dissolution time of the tablets. Studies showed that increase in binding concentration of ACG increases the crushing strength which ranges between 25+ 2.64 to 120.55+ 1.64 which are comparable with the standard binder and the disintegration time ranging from 1.55+ 0.617.58+ 1.46. Also, there was an increase in the dissolution rate at t50(23.20+ 1.46 to 100.50+ 0.24) and t90(73.20+ 1.64 to 260.4+ 3.1) of Paracetamol tablets formulated with ACG compared to the standard binder. The studies also showed that increase in binding concentration of ACG, decreases the percentage friability of the Paracetamol tablets with range between 1.22+ 0.04 to 0.60+ 0.04 compared to the standard binder (1.10+ 0.08 to 0.78+ 0.06) Results obtained indicated that there is a significant difference between ACG and gelatin (p<0.05) as a binder in Paracetamol tablets, hence should be explored and used as a binder in drug formulations.
A U Emmanuel Taher Md Abu Japhet Joel Gongden Abbas-A Hassanatu
139469856
FORMULATION DEVELOPMENT AND EVALUATION OF ALMOND GUM BASED SUSTAINED RELEASE MATRIX TABLET OF INDOMETHACIN
Objective: The aspiration of the current research involves employing various concentrations of polymer and filler to develop indomethacin sustained release (SR) matrix tablets. The objective of this research work is to reduce dosing frequency thereby increasing patients compliance and enhanced therapeutic activity.Methods: Polymers such as Almond gum (AG) polyvinylpyrrolidone (PVP) and starch at different concentrations were used for formulating SR polymeric matrix tablets. Evaluation of pre compression and post compression parameters was done for both granules and formulated tablets.Results: Results obtained from pre compression parameters and post compression parameters suggested that all the parameters are within the prescribed limits, demonstrating that formulated granules had shown better flow properties. The morphological characteristics of the developed tablet were observed by employing scanning electron microscope where the surface of the tablet was found to be smooth from the in vitro dissolution study, combination of AG (30 mg) with PVP (30 mg) and starch used as a filler has sustained the release of drug up to 10 h.Conclusion: Therefore, developed polymeric matrix tablet exhibited enhanced potency over a conventional tablet by exhibiting an excellent dissolution profile for a period of 10 h.
S RuchiSunayana Gowda Dv N VishalGupta Praveen Sivadasu M Manjunath
103413899
FAST DISINTEGRATING TABLET FORMULATION OF GINGER (ZINGIBER OFFICINALE ROSC. EXTRACT USING COPROCESSED EXCIPIENT OF PRE GELATINIZED CASSAVA STARCH ACACIA GUM
Objective: Fast disintegrating tablets (FDTs) are tablets that disintegrate and/or dissolve rapidly in the mouth, thereby helping patients who have difficulty in swallowing tablets. Ginger extract contains gingerol and is generally known for its antiemetic property. This study aimed to obtain and use coprocessed excipients of pre gelatinized cassava starch (PCS) with acacia gum (AG) in FDT formulations of ginger extract. Materials and Methods: In this research, five types of PCS AG coprocessed excipients (Co PCS AG) were prepared by mixed PCS and AG with the following ratios mass of PCS and AG were 5:5, 6:4, 7:3, 8:2, and 9:1. The prepared Co PCS AG excipients were characterized in terms of morphology, particle size distribution, moisture content, pH, flow ability properties, and swelling index. Based on the results, three types of Co PCS AG excipients, which were 7:3, 8:2, and 9:1, were selected for use in FDT formulation of ginger extract. The FDTs were then examined for tablet hardness, tablet friability, wetting time, and disintegration time. Results: The results indicated that Co PCS AG 9:1 was ideal excipient to be used in FDT formulation, as it revealed good flow properties and swelling index compare to the other ratios. The Co PCS AG excipients were formulated into tablets and evaluated. Analysis of the ginger extract FDTs revealed that the FDT prepared using Co PCS AG 9:1 excipient had the best performance with tablet hardness, friability, wetting time, and disintegration time of 0.7 kp, 2.12% 93 seconds, and 134 seconds, respectively. Conclusions: Co PCS AG 9:1 excipient is a potential excipient with ideal binder, disintegrant, and filler properties for use in FDT formulation.
Baginda Sati Pituanan Silvia Surini
204116760
Acrylamide grafted neem (Azadirachta indica) gum polymer: Screening and exploration as a drug release retardant for tablet formulation.
The study was initiated with the intent to synthesize acrylamide grafted neem gum polymer (AAm g NG) and screen its drug release retardation ability both in vitro and in vivo. Different batches (NGP 1 to NGP 9) of tablet formulation were prepared by varying polymer concentration using propranolol HCl and compared with HPMC K100 M and marketed SR tablets. FTIR study proved the grafting phenomenon and showed no incompatibility between AAm g NG and propranolol HCl. AAm g NG showed significant swelling and water retention capacity than NG. AAm g NG was found to be biodegradable and exhibited no toxicity to Artemia salina. After 12 h, NGP 6 showed non significant (p 0.05; f2= 90) percent drug release (80.52 3.41% compare to marketed formulation (79.65 4.08% Significant swelling of the matrix caused slower diffusion of the drug. NGP 6 and marketed formulation in rabbits showed the non significant difference between Cmax and Tmax, hence NGP 6 meets the requirement of sustained release tablets.
Carbohydrate polymers
Durgacharan A Bhagwat Vandana R Kolekar Sameer J Nadaf Prafulla B Choudhari Harinath N More Suresh G Killedar
212560124
Formulation and Evaluation of Gastroretantive Floating Tablet using Carbopol with Xanthan Gum and Guar Gum
The Floating tablets of Domperidone were prepared by wet granulation process. All tablets were evaluated for their physical parameters for both, pre compression and postcompression. FTIR and DSC studies proved that no chemical interaction in Domperidone and polymers.All the batches evaluated for swelling and floating properties also, the batches containing combination of Carbopol with natural polymers Guar and Xanthan Gum shows good swelling properties since natural gums swells rapidly and efficiently in water. The invitro drug release studies revealed the drug release from the formulation depended upon the polymer concentration and the polymer used. The sustained drug release with better floating was achieved with natural polymers. The developed floating tablet of Domperidone used to prolong drug release for more than 12 hrs, thereby improving bioavailability and better patient compliance. All the batches showed Mixed Matrix and Peppas best fitted model for release kinetics, which showed that,the release of the drug from the prepared tablets is sustained by swelling, followed by drug diffusion and slow erosion of the polymer.
Kamlesh Wadher Shrikant W Bute Milind J Umekar
28954519
FORMULATION AND EVALUATION OF PANTOPRAZOLE FLOATING TABLET BY USING NATURAL GUM
The objective of this research work was to formulate and evaluate the floating drug delivery system containing Pantoprazole tablets were prepared by direct compression technique. Formulations contained Limonia acidissima, Xanthan gum, and gas generating agent such as sodium bicarbonate and citric acid. Physical parameters like hardness, weight variation, thickness and friability were within pharmacopoeial limit. Percentage drug content in all floating tablet formulations was found to be 90% to 110% A lesser floating lag time and a prolonged floating duration could be achieved by varying the amount of effervescent and using different polymer combinations. The in vitro drug release profiles obtained for tablets (F3) made with combinations of Limonia gum and xanthan gum showed lesser floating lag time(46 s) and a prolonged floating duration (18 hrs) which was a sustained release characteristic 94.30% for 18h. Hydrophilic polymer like Limonia gum (10% and Xanthan gum (10% was found to be optimum. Xanthan gum was useful in the formation of matrix and Limonia gum was used as a drug release retardant. Among all the formulation, F4 showed drug release upto 94.30% at the end of 18 hours.
Bharat W Tekade Umesh T Jadhao Pankaj H Bari Dipali G Chaudhary Vijay R Patil