hasniye yasa
22348443
Synthesis and elastase inhibition activities of novel aryl, substituted aryl, and heteroaryl oxime ester derivatives
Fifteen novel aryl, substituted aryl and heteroaryl g hydroxy (2a e) g methoxyimino (3a e) and g benzyloxyimino (4a e) butyric acid methyl esters were investigated for their enzyme inhibition, and the synthesis of 10 compounds (3a e, 4a e) is given in this study. The other five compounds (2a e) were synthesized before in another study. Compounds 3a e and 4a e were synthesized in this work as original compounds and characterized by 1H and 13C NMR, IR, mass, and elemental analyses. Their (E/Z) isomerisation ratios were analyzed by 1H and 13C NMR. All of them are of pure (E) configuration. Due to the literature survey, the elastase inhibition activity was not studied for these compounds. Elastase inhibition ability was investigated in this work for five g hydroxy (2a e) five g methoxy (3a e) and five g benzyloxyimino (4a e) butyric acid methyl esters. All these 15 compounds showed elastase inhibition activity. Compound 2b was the best one and exhibited a better activity than the standard ursolic acid whereas compound 2a worked like the standard. All these compounds can be novel elastase inhibitor agents in the pharmaceutical and cosmetic industries.
Archiv der Pharmazie
Belma Hasdemir Ozlem Sacan Hasniye Yasa Hatice B Kucuk Ayse S Yusufoglu Refiye Yanardag
102515111
Different bio/Lewis acid catalyzed stereoselective aldol reactions in various mediums
In this work eight different crude biocatalysts together with six Lewis and three Bronsted acids were used for asymmetric aldol reactions of aromatic, heteroaromatic, cyclic, and acyclic six ketones and eleven aldehydes. Optimum reaction conditions were determined by changing temperature and enzyme, ketone, aldehyde, solvent, cofactors types, amounts, and ratios. PPL (porcine pancreatic lipase) of animal and AL AN (amano lipase A from Aspergillus niger) of fungal origins were the best ones and compared with each other. CoCl2 was the best cofactor and catalyzed the enzymatic aldol reaction better than without cofactor. CoCl2 was not used before for enzymatic aldol reactions. The method in this study, using crude biocatalysts (PPL or AL AN) and CoCl2 in acetonitrile water was found as an conventionally useful biocatalytic way for asymmetric aldol reaction and has given better ee values than in the literature.Graphical abstract
Monatshefte fur Chemie Chemical Monthly
Tulay Yildiz Hasniye Yasa Belma Hasdemir Ayse S Yusufoglu
104099339
Detailed studies on the reduction of aliphatic 3 4 6 and 13 oximino esters: Synthesis of novel isomeric amino esters, oximino alcohols, and amino alcohols
ABSTRACT The preparation of novel 3 4 6 and 13 amino tetradecanoic acid methyl esters (2a d) obtained by the reduction of 3 4 6 and 13 oximino tetradecanoic acid methyl esters (1a d) was investigated. Oximino esters were reduced to afford the corresponding amino esters using NaBH4 ZrCl4 reducing system with good yields (58 82% However, the reduction of oximino esters with LiAlH4 and BH3. Tetrahydrofuran gave the corresponding novel 3 4 6 and 13 oximino alcohols (3a d) and 3 4 6 and 13 amino alcohols (4a d) respectively with good chemical yields. GRAPHICAL ABSTRACT
Hatice Baspinar Kucuk Hasniye Yasa Tulay Yildiz Ayse S Yusufoglu
99669496
Investigation of Antioxidant Activity of M.comminus L. from Turkey due to its Essential Oil Composition and Polyphenolic Content
In this study, it is aimed to investigate the chemical composition of the essential oils, antioxidant activity, and polyphenol content of methanol extracts of M.comminus L. leaves and berries. M.comminus L. Plant was collected from Yalova, Marmara region of Turkey. Its essential oil was prepared by hydrodistillation in a Clevenger type apparatus in 0.5% The chemical composition of the essential oil was analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC MS) using two columns with stationary phases of different polarity (polar ZB WaxMS/apolar ZB 5MS) On both columns monoterpenes were determined to be the dominant compounds. The myrtenyl acetate, a pinene, 1,8 cineole, linalool, and limonene were the remarkable substances. As polyphenol compounds, the flavanoids and anthocyanidins in leaves and berries were detected by HPLC and furthermore, their antioxidant activities were studied with DPPH, Cuprac and Folin Ciocalteu method of the methanolic extracts.
Belma Hasdemir Hasniye Yasa Hulya Celik Onar Ayse S Yusufoglu
97635736
Chemical Composition of the Essential Oil of Mentha pulegium L. from Bodrum, Turkey
Abstract The aim of this study was to investigate the chemical composition of Mentha pulegium L.'s essential oils from Bodrum, Turkey and to compare it with the literature values. The essential oils in this study were prepared by two different methods, by Clevenger and Steam Distillation. The yields of the essential oils, obtained by Clevenger and steam distillation were 1.6 and 1.1 respectively. The composition of the essential oils were analysed by GC and GC MS using Carbowax 20M as polar and DB 5 as apolar columns. The headspace analysis of this plant was examined, too. The basic components of steam distillation method on apolar DB 5 column, were isomenthone (42.1 pulegone (28.9 piperitenone (11.8 and piperitone (11.6 Analysis of Clevenger type method on the same column gave pulegone (34.6 piperitenone (31.4 isomenthone (17.9 and piperitone (9.7 as main components. The major components of headspace analysis of Mentha pulegium L. on DB5 column were isomenthone (52.6 pulegone (29.5 and menthol (3.6
Hasniye Yasa Hulya Celik Onar Ayse S Yusufoglu
53924300
Bir dogumevi gebe izlem polikliniginde gestasyonel diyabetes mellitus sikligi
Amac: Bu calismada rutin gebelik kontrolleri icin gebe izlem poliklinigine basvuran hastalarda gestasyonel diabetes mellitus (GDM) tarama testleri ile GDM sikliginin hesaplanmasi ve yasa gore sikliginin belirlenmesi amaclandi. Gerec ve yontem: Agustos 2009 ve Mart 2011 tarihleri arasinda poliklinige basvuran ve herhangi bir risk faktoru tasimayan 2617 gebe hasta calismaya dahil edildi. Oncelikle hastalara 24 28 haftalar arasi 50 g OGTT yapildi. Kan sekeri 140 mg/dl olan hastalara 100 g OGTT yapildi. 50 g OGTT degeri 200 mg/dl ya da 100 g OGTT 'de tek deger 200 mg/dl veya iki deger normal sinirin ustunde cikan hastalar GDM olarak kabul edildi. GDM sikligi yasa gore belirlendi. Bulgular: Toplam 2617 gebenin 110 tanesi GDM tanisi aldi. Bu oran tum OGTT yapilan gebelerin %4,2\'ni olusturmaktadir. Ayrica yaslara gore yapilan degerlendirmede 33 yas sonrasi GDM gelisme yuzdesi belirgin olarak yuksek bulundu. Ozellikle 44 yas itibariyle GDM gelisme riski %33 degeriyle en yuksek bulundu. Sonuc: Hastanemizde yapilan bu calismada rutin takiplerde GDM sikligi cesitli merkezlere gore %1 6 oraninda degisen literatur verileri ile uyumlu bulunmustur. Ileri yas gebeliklerinde GDM insidansi daha yuksek bulundu.
Abdulkadir Turgut Saadet Unsal Boran Zehra Nihal Dolgun Hasniye Celik Acioglu Neval Yaman Goruk
151047116
Psikolojide Lacanyen Soylem Analizi: Madde Bagimliligi ve Yasa Iliskisinin Terapi Surecinde Incelenmesi Ornegi
Gunumuzde bagimlilik oranlarinda ve turlerinde yuksek oranda artis gorulmektedir. Bu artisla es zamanli olarak bagimliligin onlenmesine yonelik kurumsal ve yasal bircok duzenleme ortaya cikmistir. Ancak diger yandan toplumsal soylemde, Ozne'nin keyif verici maddelere ulasmayi hak ettigine dair bircok ifade ortaya cikmaktadir. Bu calismada, madde bagimliligi ile yasa iliskisinin bir terapi surecinde tarihi, kulturel ve guncel degerlendirmeler isiginda soylemsel temelde incelenmesi amaclanmistir. Bu amacla, madde bagimliligini onleme merkezine yasal duzenlemeler sonucu gonderilmis bagimli kisiyle yurutulmus bir terapi sureci analiz edilmistir. Analiz Parker ve ekibinin Lacan'in teorisinden ortaya koydugu elestirel soylemsel yaklasimin isiginda ortaya cikan Lacanyen Soylem Analizi metodolojisine dayandirilmistir. Buna gore analizde, klasik soylem analizindeki sozlerin benzerlik ve farkliligindan ote; sozdeki karsitlik, yokluk, anlamin dustugu/bozuldugu an ve Ozne'nin Baska ile iliskilenirken konumlandigi yere odaklanilmistir. Sonuclara gore, kisinin kendi talebinin olmadigi ve guvenin yok oldugu kosullarda yurutulen gorusmelerde terapist ve kisi arasindaki guc ve otorite pozisyonlarinin onemli olcude etkilendigi gorulmustur. Diger yandan, maddenin kendisinin ne oldugunun yerine, onun iliskideki yerinin onemli oldugu ortaya cikmistir. Madde kullanip kullanmama konusunda suphenin zevk nesnesi halini aldigi durumlarda, terapistin bu suphe uzerinden kisi ile iliskilenmek yerine, bunun analizinin surmesine aracilik etmesi onemli gorulmustur. Son kisimda madde bagimliligi konusunda klinik uygulamaya yonelik degerlendirmeler toplumsal soylem isiginda verilmistir.
Ayna Klinik Psikoloji Dergisi
Sinem Baltaci Faruk Gencoz
198850805
Guncel Yargi Kararlari ve Yasa Degisiklikleri Isiginda Ifade Alma ve Sorgu Sirasinda Supheli/Sanigin Haklari
Supheli/sanigin beyanlari, salt maddi gercegin arastirilmasi faaliyeti degil, ayni zamanda savunma hakkinin kullanildigi en onemli ceza muhakemesi islemleridir. Bu nedenle ifade alma ve sorgu, bazi yukumluluklerle birlikte haklari da icinde barindirir. Her ne kadar ceza muhakemesinin klasik ve temel konularindan biri olsa da uygulamada, ifade alma ve sorguda kroniklesmis bir cok ihlalin yasanmasi da klasik sorunlar olarak ortaya cikmaktadir. Bu kapsamda yaptigimiz calismada, soz konusu sorunlarin yasa degisiklikleri ve yargi kararlarindaki durumu incelenecektir.
Marmara Universitesi Hukuk Fakultesi Hukuk Arastirmalari Dergisi
Ozge Apis
199488883
An Air Cooled YASA Motor for in Wheel Electric Vehicle Applications
In wheel motors present a range of opportunities for innovation in electric vehicle design as the torque produced at each of two or four wheels can be controlled individually. A high aspect ratio (large radius, short axial length) motor is required to fit within the wheel. Due to its location, liquid cooling of the in wheel motor is difficult and undesirable, but a high power density is required to reduce the mass which is particularly important as it is unsprung and fit the space envelope. Furthermore, a high torque density is required to eliminate the need for a gearbox. These constraints create a real challenge for the design of a machine for this application. An axial field machine using a Yokeless and Segmented Armature (YASA) topology is designed to fit these requirements as such a machine has clear advantages when considering the high aspect ratio. A soft magnetic composite (SMC) material is utilised to carry the flux in its non planar path without incurring excessive losses or requiring an impractical and difficult to manufacture lamination design. A novel cooling arrangement involving heat spreading elements on each armature segment is employed to improve heat dissipation and hence power density. The design, analysis, manufacturing and testing of the motor is described in this paper to verify the concept against the requirements outlined above.
2019 IEEE International Electric Machines Drives Conference (IEMDC)
Dave Winterborne N J Stannard Lars Sjoberg Glynn J Atkinson
193123965
6360 Sayili Yasa Sonrasi Yeni Buyuksehir Belediyelerindeki Cevre Sorunlarinin Irdelenmesi: Malatya Buyuksehir Belediyesi Ornegi
Turkiye'deki buyuksehirlerin daha da buyumesi sonucunda cevresel anlamdaki sorunlarda bir o kadar artma egilimi gostermistir. Buyuksehirlerde gorulen cevre sorunlarinin giderilmesine yonelik buyuksehir belediye yonetimleri tarafindan yeni duzenlemeler yapilmaya calisilmaktadir. Ozellikle 6360 sayili yasa sonrasi yetki ve sorumlulugu artan buyuksehir belediyeleri cevresel sorunlarin giderilmesine yonelik faaliyetlerini hizlandirmistir. Ancak yapilan calismalarin yerel halkin cevreye yonelik sorunlarinin karsilanmasi noktasinda yetersiz kaldigi soylenebilir. Calismamizda; 2012 tarihli ve 6360 sayili " On Dort Ilde Buyuksehir Belediyesi ve Yirmi Yedi Ilce Kurulmasi ile Bazi Kanun Hukmunde Kararnamelerde Degisiklik Yapilmasina Dair Kanun " sonrasinda yeni buyuksehir belediyesi olan illerdeki cevresel sorunlara dikkat cekmek istenmistir. Bu anlamda buyuksehir belediyeleri tarafindan cevresel sorunlari gidermeye yonelik yapilan faaliyetler ve bu konudaki yerel halkin memnuniyet duzeyleri olculmeye calisilmistir. Bu baglamda, 6360 sayili yasa sonrasi yeni buyuksehir belediyesi olan Malatya Buyuksehir Belediyesi orneklem olarak alinmistir. Arastirmada yontem olarak literatur taramasi, yerel ve ulusal basin, yazinsal ve gorsel kaynaklarla beraber veri toplama yontemi olarak anket yontemine basvurulmus olup, Malatya ili sinirlari icerisinde yasayan 384 katilimci ile anket calismasi yapilmistir. Anket calismasi sonrasi elde edilen verilerin analizi icin SPSS paket programindan faydalanilmis olup yapilan analizler hakkinda genel olarak bilgiler verilmistir. Calismada; Malatya buyuksehir belediyesinde gorulen cevre sorunlarinin degerlendirilmesi, yorumlanmasi ve cozum onerilerinin sunulmasinin yani sira, Turkiye'de buyuksehir belediyelerinin tarihsel sureci ve 6360 sayili yasa ile yapilan yasal duzenlemeler hakkinda bilgiler verilmistir.
Vedat Yilmaz Safak Kaypak