commiphora myrrh commiphora molmol MN TEST
1598606
Differential cytotoxic activity of the petroleum ether extract and its furanosesquiterpenoid constituents from Commiphora molmol resin
Abstract This study revealed a differential cytotoxic activity of the petroleum ether extract (IC50=5 mg/mL) of the resinous exudates of Commiphora molmol against two mouse cell lines KA31T and NIH3T3 (untransformed and transformed mouse fibroblasts, respectively) Four new compounds (1 4) and five known compounds (5 9) were isolated from the petroleum ether extract. The identity of these new compounds was determined as g elemane lactone (1) 5 aH,8 bH eudesma 1,3,7(11) trien 8,12 olide (2) 2 hydroxy 11,12 dihydrofuranodiene (3) and 2 hydroxyfuranodiene (4) 1 and 2 displayed the highest cytotoxic activity against NIH3T3 cells. 7 and 9 exhibited moderate cytotoxic activity against KA31T cells. Compounds 3 6 showed weak cytotoxic activities against both cell lines. These results may explain the high efficacy of the petroleum ether fraction in several myrrh derived pharmaceutical preparations.
Zeitschrift fur Naturforschung. C, Journal of biosciences
Seif-Eldin Nasr Ayyad Thomas R Hoye Walied M Alarif Sana'a M Al Ahmadi Salim A Basaif Mohamed A Ghandourah Farid A Badria
21228485
Effect of Mirazid on the Micronuclei Polychromatic Erythrocyte Cells MNPCEs In the Bone Marrow Cells of Schistosoma Infected and Non Infected Mice
In the present investigation, the efficacy of Commiphora molmol (Mirazid (r) in treating schistosomiasis was cytogenetically studied by bone marrow cells. The percentage frequency of micronuclei polychromatic erythrocyte cells (MNPCEs) in bone marrow cells of mice infected mice with Schistosoma was higher than the other groups. The MNPCEs of non infected treated and recovery groups was higher than control. The percentage of MNPCEs of infected treated recovery group was similar to that of the infected treated group. The bone marrow activity reached a maximum value in the infected group and decreased in the other groups. Keywords Mirazid (r) schistosomiasis, micronucleus test. Mice.
Fawzia A Zayed Hasanate E Ali A A Mahmoud
4319461
Comparison of Antibacterial Efficacy Chlorohexidine Gluconate and Saudi Myrrh Mouthwashes in the Oral Cavity
Myrrh have been traded in the Middle East and North Africa for 5,000 years, Myrrh is an Oleo gum resin, phytotoxically safe raw material obtained from the stem of various species of the genus Commiphora, in recent years it has been used in pharmaceuticals, food industries. Chlorhexidine gluconate mouthwash is preferably prescribed by dentist as an effective mouthwash. Aim of the study to investigate the antibacterial effect of myrrh aqueous mouthwash (homemade) solution against some selected microbial flora and comparison of the activity with that of commercial chlorohexidine gluconate mouthwash by participation of 9 female volunteers. Antimicrobial activity of Myrrh was investigated and compared with 0.2% chlorohexidine gluconate mouthwash using agar diffusion method. Escherichia coli 25922, Salmonella 25566, Klebsiella pneumonia 13883, Pseudomonas 27853, Proteus, Staphylococcus aureus 25923, Bacillus, Streptococcus mutans and Candida albicans were used in this study and adjusted according to the Clinical and Laboratory Standards Institute (CLSI) The results revealed that Myrrh produced antimicrobial activity against oral flora and other species of microorganisms which was to some extent comparable with that of Chlorohexidine gluconate. Microbial load detection showed that home made myrrh mouthwash aqueous solution is an effective as clinically proved mouthwash. keywords: Myrrh, Chlorohexidine, Mouthwash, Antibacterial.
Zainah Mohamad Sambawa Fawzia Haif Alkahtani Fadilah Sfouq Aleanizy Fulwah Yahya Alqahtani
10284491
Myrrh attenuates oxidative and inflammatory processes in acetic acid induced ulcerative colitis
The pathogenesis of ulcerative colitis (UC) has been associated with a weakened antioxidant capacity and increased inflammatory processes. Myrrh is traditionally used for the treatment of inflammatory diseases due to its antioxidant and anti inflammatory properties. The present study aimed to evaluate the effects of myrrh on an experimental rat model of UC. UC was induced in rats using acetic acid (AA) after pre treatment with myrrh (125, 250 or 500 mg/kg/day) or mesalazine (MES; 300 mg/kg/day) for 7 days. The levels of various inflammatory cytokines, prostaglandin E2 (PGE2) and nitric oxide (NO) in the rat colon tissues were assessed. In addition, the colonic levels of thiobarbituric acid reactive substances (TBARS) and non protein sulfhydryl groups (NP SH) as well as the activities of superoxide dismutase (SOD) and catalase (CAT) were estimated. Furthermore, total protein (TP) contents and the levels of DNA and RNA were measured, and histopathological changes in colonic tissues were analyzed. The results indicated that the levels of pro inflammatory cytokines, PGE2, NO and TBARS were markedly increased. By contrast, the levels of interleukin 10, NP SH, TP and nucleic acids, and the enzymatic activities of SOD and CAT were significantly decreased in the AA model group. In addition, pretreatment with myrrh and MES was able to attenuate the impaired oxidative stress response and upregulation of inflammatory biomarkers. Furthermore, the enzymatic activities of SOD and CAT were near to normal in the myrrh and MES pretreated groups. The ability of myrrh to protect against UC was further confirmed by histopathological analysis, and the high dose of myrrh exerted an effect comparable to MES. In conclusion, the results of the present study suggested that myrrh has potent therapeutic value in the amelioration of experimental colitis in laboratory animals by downregulating the expression of proinflammatory mediators and improving endogenous antioxidative activities.
Experimental and therapeutic medicine
Amal Jamil Fatani Fatima Salih Alrojayee Mihir Yogeshkumar Parmar Hatem M Abuohashish Mohammed Mahboobuddin Ahmed Salim S Al-Rejaie
17486527
Biological Activities and Valuable Compounds from Five Medicinal Plants
Currently, there are more than 85,000 plant species that have been documented for medical use globally. This implies, plant derived natural products hold great promise for discovery and development of new pharmaceuticals in diverse human ailments. Among these divers medicinal species Aframomum corrorima, Commiphora myrrha, Nigella sativa, Ocimum lamiifolium and Olea europaea are one of very well known valuable plants in serving the local people as spice, flavor, fumigants, and sources of traditional and modern medicines. In modern science their medicinal activities have been corroborated by phytochemical and biological research investigations. As the biological studies revealed they have antibacterial, antioxidant, antifungal, antimicrobial and anti inflammatory properties even though further investigation required on in vivo and animal model to ascertain those in vitro activities are really valuable in life. The phytochemical investigations have also shown that these plants are holder of diversified useful compound classes like terpene, steroid, flavonoid, glycoside, fatty acid and alkaloids. However, their pharmacology and pharmacokinetics activities have to be further investigated in order to make sure their metabolic effect upon their usage because some compounds have ability to be metabolized during in vivo analysis, and to see whether these compounds have synergic or additive effects. Therefore, the purpose of this review paper is to present the compiled and unified scientific studies which have been done on the above well known medicinal plants about their description, medicinal uses, volatile and extracted active compounds, and chemical structures of isolated compounds in justification with scientific researches.
Million Getasetegn Yirefu Tefera
174782282
Role of Commiphora Mol Mol and Doxycycline in Prophylaxis of Spontaneous Bacterial Peritonitis in Egyptians Cirrhotic Patients
Aims: this study aimed to evaluate the role of commiphora mol mol and doxycycline in the prophylaxis of spontaneous bacterial peritonitis in cirrhotic patients. Methodology: sixty ascetic cirrhotic patients f r o m National Liver Institute, Menofiya University (Shebeen El KomEgypt) with a history of at least one previous episode of SBP were included in blinded randomized clinical study. Patients were divided into four groups in a fashion; each group consists of 15 patients. Group one received ciprofloxacin (control group) group two received doxycycline, group three received commiphora mol mol and group four received a combination of commiphora mol mol and doxycycline for six months. Serum interleukin 6 (IL 6) and C Reactive Protein (CRP) level were the primary inflammatory markers of the study to evaluate the effect of the studied medications. Results: both IL 6 and CRP levels showed significant decrease three and six months after treatment in all studied groups (P<0.05) Group four showed a significant decrease in IL 6 and CRP level compared with other three groups (P<0.05) Conclusion: the results of the current study strongly support the efficacy of doxycycline and Commiphora molmol as a primary prophylactic therapy in patients with SBP. Furthermore, commiphora mol mol/doxycycline combination was the most effective and showed synergistic effect which may be useful in decrease emergence of resistant strains.
Tarek Mohammed Mostafa Osama Mohamed Ibrahim Gamal A Badra Eman I El-Berri
102426825
Evaluation of the composition, physico chemical characteristics, surfactant and anti microbial potential of commiphora abyssinica gum resin
J G Waweru
24202806
The effects of dietary lead on growth, bioaccumulation and antioxidant capacity in sea cucumber, Apostichopus japonicus.
Three different diets amended with lead nitrate [Pb(NO3)2] (100, 500 and 1000mg Pb/kg dry weight) and a Pb free control diet (1.03mg Pb/kg dry weight) were fed to sea cucumber (Apostichopus japonicus) for 30 days. The patterns of Pb accumulation over time were determined in various tissues (body wall, intestine and respiratory tree) as well as growth performance and antioxidant enzymes activities. Pb accumulation in body wall and intestine increased with time in all dietary Pb treatments. When fed the highest Pb diet, the body wall exhibited the greatest Pb burden (16.37mg Pb/kg tissue wet weight) while Pb content in the intestine (2.68mg Pb/kg tissue wet weight) and the respiratory tree (1.78mg Pb/kg tissue wet weight) were lower than Pb content in the body wall by day 30. The body weight gain (BWG) specific growth rate (SGR) and survival rate (SR) had not been affected by 30 days oral administration of Pb supplemented diet. However, the antioxidant enzymes activities [superoxide dismutase (SOD) and glutathione peroxidase (GSH Px) of test groups were lower than control group in body wall and malondialdehyde (MDA) concentration in the body wall was opposite after 30 days in sea cucumbers. In summary, this work reports toxic effects in sea cucumber, A. japonicus, after dietary exposure to Pb.
Environmental toxicology and pharmacology
Jing Wang Tongjun Ren Yuzhe Han Yang Zhao Mingling Liao Fuqiang Wang Zhiqiang Jiang
70350923
Effectiveness of Herbal and Non Herbal Toothpastes in Reducing Dental Plaque Accumulation
Maintaining good oral hygiene in orthodontic patients is important and as the community interest in herbal ingredients increases, herbal toothpaste was developed. Its effectiveness against dental plaque accumulation is still under debate. Herbal toothpaste has not been tested in fixed orthodontic patients. Objective: To study the effectivenes differences between herbal toothpaste and non herbal toothpaste. Methods: This randomized, double blind clinical trial was participated by 16 subjects aged range 15 35 years who were planned for fixed orthodontic. The subjects were divided into two groups based on the type of toothpaste used. Plaque accumulations were measured according to Loe and Sillness plaque index on Ramfjord teeth before and two weeks after bonding. Results: Wilcoxon test result showed there was no significant reduction of plaque index on herbal toothpaste usage nor significant increase on non herbal toothpaste usage. Mann Whitney test showed no significant differences between herbal and non herbal toothpaste. Conclusion: There was no significant differences in plaque acummulation between usage of herbal toothpaste nor usage of non herbal toothpaste. There was no significant effectiveness differences between those toothpastes in fixed orthodontic patients, although herbal toothpaste usage showed a reduction of plaque index, whereas non herbal toothpaste usage showed an increase of plaque index. DOI: 10.14693/jdi.v19i3.143
Citra L Yuwono Benny M Soegiharto Fadli Jazaldi
53623037
Plantas com efeito antiinflamatorio e analgesico
Resumo: Patents secured on antiinflammatory plant drugs derived from 38 plants are reviewed. An attempt has been made to compare the modern and traditional use of plant drugs and to establish the relevance of folk claims in developing modern drugs. The role of plant botanicals such as polysaccharides, terpenes, curcuminoids, alkaloids, etc. in alleviating inflammatory diseases including arthritis, rheumatism, acne skin allergy and ulcers is highlighted. Chemicals that alleviate swelling are derived from plants including grape, boswellia, turmeric, devil's claw and some essential oils such as clove, eucalyptus, rosemary, lavender, mint, myrrh, millefolia and pine have been patented and used as mixed formulations. Plants containing polysaccharides are the most potent in curing inflammatory diseases.
Paula Vinas Jose de Felippe