Atomic magnetometer Magnetic nanoparticles  mice
84600184
Biocompatibility, biodistribution and efficacy of magnetic nanohydrogels in inhibiting growth of tumors in experimental mice models.
We report in vivo evaluation of a thermo responsive poly(N isopropylacrylamide) chitosan based magnetic nanohydrogel (MNHG) incorporated with Fe3O4 nanoparticles (NPs) in mice models with expandible scope for use in localized delivery of chemotherapeutics. Biocompatibility and biodistribution of the MNHG are studied in normal Swiss mice while efficacy in tumor growth inhibition is studied in a subcutaneous fibrosarcoma tumor. The ex vivo time dependent pattern of accumulated MNHG into vital organs; lung, liver, spleen, kidney and brain collected at 1 h, 48 h, 7 d and 14 d post intravenous administration are investigated using both a vibrating sample magnetometer (VSM) and inductively coupled plasma atomic emission spectroscopy (ICP AES) method. The doses of MNHG (dose I 650 and dose II 325 mg g 1 body wt) used in the study are determined based on induced thermal activation of MNHG under an AC magnetic field (AMF) Fibrosarcoma tumor bearing mice are subjected to hyperthermia with a field of 325 Oe and 265 kHz for 30 min following intratumoral administration of dose I. Tumor size measured at an interval of 72 h for a period of 2 weeks reveals that the NPs mediated therapy decelerated the growth of the transplanted tumor by about three fold (size, 1545 720 mm3) as compared to the exponential growth of the tumor (size, 4510 735 mm3) in control mice. These results suggest the feasibility of using poly(NIPAAm) chitosan hydrogels loaded with NPs for combined thermo chemotherapy where the efficacy may further be improved by temperature dependent release of the drugs from the magneto hydrogels.
Biomaterials science
Manish K Jaiswal Manashjit Gogoi Haladhar Dev Sarma Rangan Banerjee Dhirendra Bahadur
138127569
Structure and Magnetic Properties of Perovskite LaFeO3 Nanocrystals Synthesized Via
Orthorhombic structure perovskite LaFeO3 (LFO) nanoparticles (NPs) were prepared by reverse micelles method. The control of particle size was achieved by varying the water to surfactant molar ratio. The dried precipitate was transformed to pure LaFeO3 phase by calcinations at 750 oC. The average particle size was found to increase with increase in water to surfactant ratio(R) The nanostructure properties were studied by using contact mode of atomic force microscopy (AFM) X ray diffraction (XRD) and scanning electron microscopy (SEM) equipped with energy dispersive X ray spectrometer (EDS) techniques. These techniques led themselves very well to investigate the structure of NPs and to find out properties and structure on surface of LFO. At room temperature the magnetic properties (M H) were measured using a vibrating sample magnetometer (VSM) with a maximum magnetic field of 20 kOe.
Reverse Micelle Technique Abdullah A Saad Wasi Khan Pooja Dhiman A H Naqvi M Singh
197618387
Remote Detection of Magnetic Signals with a Compact Atomic Magnetometer Module Towards Human MRI MPI Hybrid Systems
This study demonstrates the possibility of remotely detecting magnetic fields generated from superparamagnetic iron oxide nanoparticles using a compact optically pumped atomic magnetometer (OPAM) module with a flux transformer (FT) during the development of magnetic resonance imaging magnetic particle imaging (MRI MPI) hybrid systems. Results of previous studies particularly demonstrated odd harmonics of the magnetic nanoparticle (MNP) signals. In addition, studies have demonstrated that the magnitude of odd harmonics was proportional to the quantity of magnetic nanoparticles, and the minimum MNP quantity can possibly be estimated from signal measurements. In conclusion, experimental results suggested that MNP signals from the Resovist solution with Fe of 0.01 umol could be detected using a compact OPAM module with FT as an ultra low field magnetic resonance imaging detector. Int. J. Mag. Part. Imag. 5(1 2) 2019, Article ID: 1906001, DOI: 10.18416/IJMPI.2019.1906001
Takenori Oida Kentaro Kato Yosuke Ito Tetsuo Kobayashi
40852108
AC susceptometry of magnetic nanoparticles using an atomic RF magnetometer
Existing magnetic particle imaging (MPI) instruments detect the oscillating magnetic field produced by harmonically excited magnetic nanoparticles (MNPs) with receive coils that pick up magnetic flux changes. The direct measurement of MNP produced magnetic flux was recently demonstrated using fluxgate magnetometers as magnetic field sensors. Here we present an alternative approach to AC magnetic field sensing based on a laser pumped atomic magnetometer operated as an rf field detector (atomic rf magnetometer, ARFM) We have developed an ARFM prototype and deploy it as field sensor in an AC magnetic susceptometer. Here we report on its current performance.
2015 5th International Workshop on Magnetic Particle Imaging (IWMPI)
Simone Colombo Vladimir Dolgovskiy Zoran Grujic Victor Lebedev Antoine Weis
233901596
Quantitative analysis of magnetic cobalt particles with an optically pumped atomic magnetometer
Magnetic particles (MPs) a group of engineered particles in the nanometer and microscale, are valuable tools for separation of chemical or biological substance in environmental research, for target delivery of antibodies or proteins in biomedical applications, and for quantification of cells or biomolecules in biological systems. Despite the estimation of the amount of magnetic nanoparticles that were realized by magnetic particle spectroscopy, accurate quantification of MPs at single particle resolution is still a challenge. Here, we used an elliptically optically pumped Mx atomic magnetometer combined with a peristaltic pump system to perform magnetic field measurements to quantify magnetic particles at the single particle level under aqueous solution condition. Quantitative analysis of cobalt micro nanoparticles revealed the volume field linear character of magnetic particles. From the measured intensity of the magnetic field generated by MPs, we calculated the geometric parameters and numbers of MPs and estimated the detection limit of our developed atomic magnetometer. Our work paves a way for the practical use of MPs in the biomedical field as well as other applications in industry.
Xin Bi Li-Tao Ruan Zehua Liu Yi Ruan Qiang Lin
213277948
Magnetic nanoparticles supported palladium catalyzed Suzuki Miyaura cross coupling
Abstract A new magnetic nanoparticles supported palladium(II) nanomagnetic catalyst (Pd AcAc Am Fe3O4@SiO2) was synthesized and characterized using attenuated total reflectance infrared spectroscopy (ATR IR) inductively coupled plasma atomic emission spectroscopy (ICP AES) energy dispersive X ray spectroscopy (EDS) field emission scanning electron microscopy (FE SEM) transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) The nanomagnetic catalyst was used as an efficient catalyst for the Suzuki Miyaura cross coupling of various aryl bromides/chlorides/iodides with phenylboronic acid. The effect of varying solvents, base, temperature, reaction time and catalyst amount on the performance of the Suzuki Miyaura cross coupling is investigated. The notable advantages of heterogeneous nanomagnetic catalyst are excellent yields, mild reaction conditions, short reaction time, easy magnetic work up and recyclability. Moreover, the new nanomagnetic catalyst could be easily recovered with an external magnet and reused at least six times without significant loss of its catalytic activity.
Sandip P Vibhute Pradeep M Mhaldar Rajendra V Shejwal Dattaprasad M Pore
224851284
Simultaneous extraction of chromium and cadmium from bean samples by SrFe12O19@CTAB magnetic nanoparticles and determination by ETAAS: An experimental design methodology
Abstract In the present study, dispersive micro solid phase extraction (DMSPE) integrated with electrothermal atomic absorption spectrometry (ETAAS) as a novel method was proposed for the simultaneous analysis of cadmium and chromium in bean samples. In this method, strontium hexaferrite (SrFe12O19) modified by cetyltrimethylammonium bromide (CTAB) along with chelating agent diethyldithiocarbamate (DDTC) were used to produce SrFe12O19@CTAB nanoparticles (NPs) as a magnetic adsorbent. This adsorbent was characterized using field emission scanning electron microscope (FESEM) Fourier transform infrared spectroscopy (FTIR) X ray diffraction (XRD) vibrating sample magnetometer (VSM) thermogravimetric analysis (TGA) and differential scanning calorimetric (DSC) Response surface methodology (RSM) based on the central composite design CCD was applied to design the experiments and study of effective factors on the extraction efficiency. The experimental parameters include pH, shaking rate, adsorbent dosage, amount of ligand, and CTAB. The detection limits for chromium and cadmium ions were 0.08 and 0.09 ug kg 1 under the optimal experimental conditions, with standard deviations in the range of 1.7 5% and 1.2 6% respectively (n 4) The linear calibration was obtained in the range of 1 150 and 1 250 ug L 1 for chromium and cadmium ions, respectively. Also, the recovery values of all samples were found in the range of 96 to 100% and 91 to 99%
Vahid M Nik Elaheh Konoz Alireza Feizbakhsh Amir Abdollah Mehrdad Sharif
222151532
Immobilized Ag NPs on chitosan biguanidine coated magnetic nanoparticles for synthesis of propargylamines and treatment of human lung cancer.
The magnetically isolable nanobiocomposites have significant impact as the modified new generation catalysts in recent days. This has persuaded us to design and synthesis of a novel Ag NPs decorated biguanidine chitosan (Bigua CS) dual biomolecular functionalized core shell type magnetic nanocomposite (Ag/Bigua CS@Fe3O4) Bigua CS could be introducing polysaccharide materials as potential coating agent to immobilizing and stabilizing metal nanoparticles. The material was characterized using several advanced techniques like fourier transformed infrared spectroscopy (FT IR) inductively coupled plasma (ICP) field emission scanning electron microscopy (FE SEM) energy dispersive X ray spectroscopy (EDX) atomic mapping, high resolution transmission electron microscopy (HR TEM) vibrating sample magnetometer (VSM) and X ray diffraction (XRD) Towards the chemical applications of the material, we headed the multicomponent synthesis of diverse propargylamines by A3 coupling in water, which ended up with excellent yields. Due to strong paramagnetism, the catalyst was easily isolable and reused in 9 cycles without any leaching and considerable change in reactivity. In addition, the catalyst was engaged in biological assays like study of anti oxidant properties by DPPH mediated free radical scavenging test using BHT as a reference molecule. Thereafter, on having a significant IC50 value in radical scavenging assay, we extended the bio application of the catalyst in anticancer study of adenocarcinoma cells of human lungs. The three different cancer cell lines, PC 14, LC 2/ad and HLC 1 were used in this regard. The best result was achieved in the case of PC 14 cell line with strong IC50 values.
International journal of biological macromolecules
Dongyang Ma Deqiang Gong Tongtong Han Mohammad Javadi Hanieh Mohebi Mohammad Ali Karimian Naser Abbasi Hori Ghaneialvar Mohammad Mahdi Zangeneh Akram Zangeneh Marjan Shahriari Feng Zhang Junfeng Sun Yuhui Liu
195696060
Self Assembled Au@Fe Core/Satellite Magnetic Nanoparticles for Versatile Biomolecule Functionalization.
Although the functionalization of magnetic nanoparticles (MNPs) with biomolecules has been widely explored for various biological applications, achieving efficient bioconjugations with a wide range of biomolecules through a single, universal, and versatile platform remains a challenge, which may significantly impact their applications' outcomes. Here, we report a novel MNP platform composed of Au@Fe core/satellite nanoparticles (CSNPs) for versatile and efficient bioconjugations. The engineering of the CSNPs is facilely formed through the self assembly of ultrasmall gold nanoparticles (AuNPs, 2 3 nm in diameter) around MNPs with a polysiloxane containing polymer coating. The formation of the hybrid magnetic nanostructure is revealed by absorption spectroscopy, dynamic light scattering (DLS) transmission electron microscopy (TEM) element analysis using atomic absorption spectroscopy, and vibrating sample magnetometer. The versatility of biomolecule loading to the CSNP is revealed through the bioconjugation of a wide range of relevant biomolecules, including streptavidin, antibodies, peptides, and oligonucleotides. Characterizations including DLS, TEM, lateral flow strip assay, fluorescence assay, giant magnetoresistive nanosensor array, high performance liquid chromatography, and absorption spectrum are performed to further confirm the efficiency of various bioconjugations to the CSNP. In conclusion, this study demonstrates that the CSNP is a novel MNP based platform that offers versatile and efficient surface functionalization with various biomolecules.
ACS applied materials interfaces
Hongwei Chen Hongxiang Hu C Tao Ryan M Clauson Ila Moncion Xin Luan Sangyeul Hwang Ashley Sough Kanokwan Sansanaphongpricha Jinhui Liao Hayley J Paholak Nicholas O Stevers Guoping Wang Bing Nan Liu Duxin Sun
198998926
Synthesis and correction of albumin magnetic nanoparticles with organic compounds for absorbing and releasing doxorubicin hydrochloride.
In an ideal delivery system, carrier nanoparticles are used as a promising alternative with minimized adverse effects to treat a variety of diseases. The purpose of this study was to create a targeted delivery system for doxorubicin hydrochloride (DOX HCl) using Fe3O4 L@HSA b cyclodextrin (b CD)/Allyl amine nanoparticles. In this study, magnetite nanoparticles (Fe3O4) were produced by co precipitation, while albumin nanoparticles (HSA) were produced by the desolvation method. The properties of the nanoparticles were studied by scanning electron microscopy (SEM) Fourier transform infrared spectroscopy (FT IR) X ray diffraction (XRD) and vibrating sample magnetometer (VSM) To evaluate the loading of the drug on the synthesized nanoparticles, ultraviolet visible spectrophotometry (UV Vis) and atomic force microscopy (AFM) were used. DOX HCl loading was studied by two experiments: an optimization method (OM) and a one factor at a time method (OFATM) Response surface methodology (RSM) was utilized to optimize the parameters. The optimal conditions for drug loading of nanoparticles in OM and OFATM methods were 81.46% and 77% respectively. The release of DOX HCl drug from the synthesized nanoparticles at a temperature of 37 degC and specific time in pH 5.3 and pH 7.4 was 83.35% and 38.39% respectively. To examine the cytotoxicity of nanoparticles with drugs, the MTT assay was performed using MCF 7 cancer cells. Finally, cell uptake was tested using inductively coupled plasma mass spectrometry (ICP MS)
Colloids and surfaces. B, Biointerfaces
Negin Hormozi Akbar Esmaeili