is consumption of whey protein harmful
201996368
Chronic Obstructive Pulmonary Disease and Protein Consumption: What is the Connection
Chronic obstructive pulmonary disease is characterized by obstruction to pulmonary airflow and dyspnoea. These characteristics are a consequence of exposure to harmful gases and particles that lead to oxidative stress in the lungs along with an exaggerated inflammatory response. In addition to respiratory impairment, chronic obstructive pulmonary disease presents systemic manifestations, nutritional alterations and exercise limitation. Whey protein supplementation, concomitant with physical activity for patients with chronic obstructive pulmonary disease, is intended to stimulate protein synthesis and decrease muscle catabolism that may be caused by exercise.
International Journal of Food Science, Nutrition and Dietetics
Zanella Pb
137614627
Dietary protein source and butyrylated high amylose maize starch included in a high protein diet determines the urinary metabolome of rats
Abstract Intake of red and processed meat increases the risk of colorectal cancer (CRC) whereas dairy product consumption and the intake of dietary fibre are negatively associated with this risk. We investigated the effect of (i) low protein diets with either whey or cooked meat (beef) as the protein source and (ii) high protein diets with cooked meat (beef) either without or with the inclusion of 10% butyrylated high amylose maize starch (HAMSB) on the urinary metabolome of rats. Urine samples from rats were analysed using untargeted LC MS metabolomics. The level and source of the dietary protein affected the urinary excretion of numerous metabolites indicating that several metabolic pathways were changed. The inclusion of HAMSB in a high protein diet caused significant alterations in the excretion of several metabolites. HAMSB reduced urinary excretion of potentially harmful metabolites resulting from a high level of meat consumption. Graphical Abstract
International journal of food sciences and nutrition
Zahra Sattari Najafabadi Tina Skau Nielsen Mette Skou Hedemann
203720408
Bioremediation of a Common Product of Food Processing by a Human Gut Bacterium.
Dramatic increases in processed food consumption represent a global health threat. Maillard reaction products (MRPs) which are common in processed foods, form upon heat induced reaction of amino acids with reducing sugars and include advanced glycation end products with deleterious health effects. To examine how processed foods affect the microbiota, we fed gnotobiotic mice, colonized with 54 phylogenetically diverse human gut bacterial strains, defined sugar rich diets containing whey as the protein source or a matched amino acid mixture. Whey or fructoselysine, an MRP in whey and many processed foods, selectively increases Collinsella intestinalis absolute abundance and induces Collinsella expression of genomic loci directing import and metabolism of fructoselysine to innocuous products. This locus is repressed by glucose in C. aerofaciens, whose abundance decreases with whey, but is not repressed in C. intestinalis. Identifying gut organisms responding to and degrading potentially harmful processed food components has implications for food science, microbiome science, and public health.
Cell host microbe
Ashley R Wolf Darryl A Wesener Jiye Cheng Alexandra N Houston-Ludlam Zachary W Beller Matthew C Hibberd Richard J Giannone Samantha L Peters Robert L Hettich Semen A Leyn Dmitry A Rodionov Andrei L Osterman Jeffrey I Gordon
34206879
Effects of dairy protein and fat on the metabolic syndrome and type 2 diabetes.
The incidence of the metabolic syndrome (MetS) and type 2 diabetes (T2D) is increasing worldwide. Evidence supports a negative relationship between the consumption of dairy products and risk of MetS and T2D. Dairy proteins are known to have a directly beneficial effect on hypertension, dyslipidemia, and hyperglycemia, but a detailed understanding of the underlying mechanisms is missing. It has been confirmed by observations that the insulinotropic effect of dairy proteins is associated with the amino acid composition; in particular branched chain amino acids (BCAA) seem to be of vital importance. Dairy protein derived peptides may also contribute to the insulinotropic effect via dipeptidyl peptidase 4 (DPP 4) inhibitory activity, and may lower the blood pressure (BP) The lipid metabolism may be improved by whey protein (WP) which acts to reduce the postprandial triglyceride (TG) response. The effect of dairy fat is much more controversial because of the potentially harmful effect exerted by saturated fatty acid (SFA) on metabolic health. Recent observations suggest less adverse effects of SFA on metabolic health than previous assumed. However, little is known about dairy lipid fractions belonging to the groups of monounsaturated fatty acids (MUFA) polyunsaturated fatty acids (PUFA) and phospholipids (PL) Dairy fat seems to act differently depending on the dairy product and the composition of macronutrients in the meal. Therefore, for a better understanding of the mechanisms behind the dairy protein and fat effect on MetS, we suggest that more human studies should be carried out to clarify the interactions of dairy protein and fat with macronutrients in the meal and other dairy components, such as micronutrients and microorganisms from fermented products.
The review of diabetic studies RDS
Ann Bjornshave Kjeld Hermansen
33415415
Casein: A Milk Protein with Diverse Biologic Consequences
Summary The consequences of bovine milk consumption are diverse, some of which are potentially deleterious. Although certain cultures shun cow's milk or milk based products, Western societies consume large quantities of cow's milk. Although there are stronger similarities between bovine whey proteins and human whey proteins, the quantity and nature of casein in cow's milk differ markedly from human milk. We propose that the consequences of diets based on bovine casein should be more closely evaluated and certainly expanded beyond the simplistic approach of growth. What is good for the goose may be good for the gander, but what is good for the cow could be harmful to the human.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
Mark J S Miller Steven A Witherly David A Clark
79945744
Qualidade de suplementos proteicos: avaliacao da composicao e rotulagem
The consumption of dietary supplements for physical activity practitioners has become common, highlighting the protein source supplements. However, the indiscriminate use of these supplements is a topic of concern in Brazil, because diet with high protein levels can be harmful to health. An aggravating is the fact that recent surveys on the quality of protein supplements showed a significant number of non compliance products considering the regulated requirements. In this context, the objective of this study was to evaluate the compliance of protein supplements for athletes, whey protein type, in relation to the chemical composition and regulated requirements for labelling. The parameters related to composition that were in disagreement with the Brazilian regulations were total lipids (70 and carbohydrates (30 Nonconformities were found in labelling of 100 of samples, being more frequent those related to household measure information, validity, therapeutic indication and sale name. An important aspect of the labelling was the lack of standardization in the recommendations for use by the manufactures because some of which could lead the users to excessive protein intake. The results of this study indicated the urgent need of quality assurance of protein supplements consumed in Brazil.
L V Silva Scheilla Vitorino Carvalho de Souza
85966833
Resistant starch opposes colonic DNA damage induced by dairy and non dairy dietary protein.
Recent epidemiological evidence suggests that consumption of diets high in red or processed meats and low in dietary fibre may contribute to the high incidence of colorectal disease in western societies. To increase our understanding of the dietary factors which could contribute to colorectal diseases we have carried out a series of studies using rats to examine the effects of consuming high levels of a range of different dietary proteins, with and without resistant starch (RS) on colonic health markers. We have shown that dietary protein sources differ in their capacity to increase colonic DNA damage and mucus barrier thinning but that inclusion of RS in the diet protected completely or partly against these effects. High levels of dietary casein increased DNA damage but the damage was not as great as for cooked beef or a soy isolate. A whey protein isolate did not increase colonic DNA damage when consumed at high levels. Our results suggest that dietary protein of dairy origin may be less harmful to the integrity of the large bowel than a number of other protein sources and also that addition of RS to the diet appears to counteract protein induced damage irrespective of the source.
Michael Allan Conlon David L Topping Shusuke Toden Anthony R Bird
202880316
Carbonated drink protein and preparation process.
Beverage composition protein suitable carbonated whey for human consumption, comprising: more than 2% by weight to 15% by weight whey protein, wherein the source of said whey protein is isolated from whey protein it is essentially free of caseinate and lactose; 0.1 volumes to 4 volumes of carbon dioxide gas present per volume of liquid beverage composition whey protein; wherein the said beverage composition with carbonated whey protein is essentially free of caseinate; wherein the said beverage composition carbonated whey protein having a pH between 2.0 and 3.4, in which both the time of packing of the beverage carbonated whey protein as during subsequent storage without refrigeration for a period of at least one year after packaging, substantial solubility of the whey protein is maintained in the beverage composition, and said protein drink carbonated whey is essentially free of known active microbes be harmful to human health.
DavidJ A Jenkins Shawn Sherwood
1135321
Whey protein film with oxygen scavenging function by incorporation of ascorbic acid.
UNLABELLED Residual O(2) in a package headspace can be removed by an O(2) absorbing sachet, which can be harmful if swallowed by the consumer, or by a chemically active plastic packaging film, which is difficult to recycle. An edible, O(2) absorbing film would avoid these disadvantages. The objective of our research was to assess the O(2) scavenging potential of an edible whey protein isolate (WPI) film incorporating ascorbic acid (AA) AA at 0.05, 0.1, or 0.2 M was added to 5% (w/w) heat denatured WPI film forming solutions with WPI glycerol (Gly) ratio of 1: 1.00, 1: 0.80, or 1: 0.67. The pH of solutions was then adjusted to 3.5 (below pK(a1) of AA) to stabilize AA against oxidation, before film casting. The mechanical properties, O(2) permeabilities, and thermal transitions of films were measured. Activation of the O(2) scavenging function of the AA incorporated films was accomplished by adjustment of the films to pH 7. O(2) scavenging ability of AA incorporated WPI films was determined by measuring residual O(2) in the headspace of a high barrier container. Incorporation of AA into WPI film decreased film tensile strength and further reduced O(2) permeability at each WPI Gly ratio. AA containing films adjusted to pH 7 demonstrated O(2) absorption proportional to AA content, consistent with theoretical O(2) scavenging capacity. Thermal transition measurements indicated that AA was involved in WPI structural modification and decreased the degradation temperature of WPI based film. The demonstrated O(2) scavenging function, improved O(2) barrier and acceptable mechanical properties of AA incorporated films indicate potential commercial usefulness. PRACTICAL APPLICATION Ascorbic acid incorporated whey protein film with oxygen scavenging function can be used to extend shelf lives of a wide variety of oxygen sensitive products by eliminating headspace oxygen as well as oxygen permeating through the packaging wall over time. Edible oxygen scavenger film has the advantages of avoiding both accidental consumption and nonrecyclability of conventional oxygen scavenger systems.
Journal of food science
Theeranun Janjarasskul Kanitha Tananuwong John M Krochta
212493166
THE EFFECT OF THE BODYBUILDING PROTEIN ON MALE FERTILITY "IN VIVO TEST ON MALE RABBITS"
Male infertility is multi causal; there are complex environmental factors such as exposure to chemicals, as well as behavioral factors such as the use of laptops too close to the genitals, or exposure of the male fetus to Tobacco during pregnancy. Moreover, the newest of causes is the consumption of bodybuilding proteins, which was the objective of our study. We tested a muscle building protein called "Whey Isolate 95" on male rabbits to see its effect on weight evolution on sexual maturity by calculating the maturity indices and finally the course of the spermatogenesis where we made cuts Histological from the testicles to see the seminiferous tubules. Our results showed that these proteins had an effect on weight growth; the Gonadosomatic index (GSI) was lower than that of the control group. As a result, these bodybuilding proteins can have a negative effect on sexual maturity. However, the histological sections of the seminiferous tubules revealed no abnormalities. Therefore, we concluded that these proteins are not so aggressive on spermatogenesis, but this is recorded with proteins that are extracted from the whey that are considered the purest. It is possible that with other types of bodybuilding protein the effect will be more harmful.
Zemri Khalida Sennour Karima Zemri Mohamed Benhaddoudi Imadeddine Khettab Bilal Belarbi Mohamed