Htlv dominican
228099906
Seroprevalence and Trends of HTLV 1/2 among Blood Donors of Santo Domingo, Dominican Republic, 2012 2017
ABSTRACT Objectives Being a Caribbean country, the Dominican Republic is considered endemic for HTLV 1. Viral screening in blood banks is recommended for this blood borne infection. The purpose of this work is to analyze the seroprevalence and trends of HTLV 1/2 in the Dominican Republic blood donors; it is focused on Santo Domingo, the capital of the country, which has the largest blood donation activity. We also aim at comparing our findings with published data from neighboring countries. Patients and methods We performed a retrospective cross sectional study of 10 blood centers of Santo Domingo, which reported HTLV and the other blood transmitted infections in full. They represent more than 40% of the province's blood donations. Annual seroprevalence of HTLV 1/2, period prevalence (2012 2017) and time trend were determined. Results A total of 352,960 blood donations were evaluated. The HTLV 1/2 period prevalence was 0.26% (929/352,960) (95% CI: 0.24 0.28% We also found a marked predominance of replacement donation (90.4% in comparison to voluntary contributions (9.6% Therefore, this blood donor study may provide clues on the general prevalence of the infection. Conclusions Seroprevalence of HTLV 1/2 in blood donors of Santo Domingo, Dominican Republic, showed a relatively low and steady trend in the studied period.
Revista espanola de quimioterapia publicacion oficial de la Sociedad Espanola de Quimioterapia
Emiliana Eusebio-Ponce Francisco Javier Candel Robert Paulino-Ramirez Irene Serrano-Garcia Eduardo Anguita
84185219
Human T cell lymphotropic virus 1/2 and human immunodeficiency virus antibodies identification among transactional sex workers and drug users in the Dominican Republic.
BACKGROUND Human immunodeficiency virus (HIV) increases the risk of acquiring human T cell lymphotropic virus (HTLV) and subsequently HTLV's progression to tropical spastic paraparesis/HTLV 1 associated myelopathy (TSP/HAM) Existing data have exclusively reported generalized rates of HIV and HTLV 1 chronic viral infections in the Dominican Republic. To our knowledge, no published studies have focused on the rates of HTLV 1/2 in transactional sex workers and drug users, both higher risk groups, in the Dominican Republic. METHODS From December 2012 to April 2013 we conducted a study to estimate the seroprevalence of HTLV 1/2 immunoglobulin G (IgG) and HIV antibodies among transactional sex workers and intravenous drug users in Santo Domingo, Dominican Republic. Serological status was analysed with behaviour and demographic data. RESULTS We collected and analysed plasma from 200 participants with a mean age of 27.4 y in men and 25.2 y in women. The overall weighted seroprevalence of HTLV 1/2 IgG antibodies was 13.91% (95% CI 7.59 to 20.23) in men and 10.59% (95% CI 4.05 to 17.13) in women. The overall weighted seroprevalence of HIV 1 was 13.91% (95% CI 7.59 to 20.23% in men and 17.65% (95% CI 9.55 to 25.75) in women. Male intravenous drug users had an exceptionally high rate of HTLV positive HIV co infection, at 75% (95% CI 44.99 to 105.01) Although there an association has been found between HTLV/HIV co infections and sex work, the adjusted odds revealed a confounding role of HIV infection. CONCLUSIONS The results highlight the urgent need for enhanced public health preventive strategies among high risk populations in the Dominican Republic and other resource constrained Caribbean settings, as well as global adoption of routine screening for HTLV associated infections, particularly in these high risk, underserved populations.
Transactions of the Royal Society of Tropical Medicine and Hygiene
Robert Paulino-Ramirez Leandro Tapia Carlos Ruiz-Matuk Rebecca Charow Henna Budhwani Jean-Pierre Routy
8971130
HUMAN T LYMPHOTROPIC VIRUS 1 (HTLV 1) AND HUMAN T LYMPHOTROPIC VIRUS 2 (HTLV 2) GEOGRAPHICAL RESEARCH TRENDS AND COLLABORATION NETWORKS (1989 2012)
Publications are often used as a measure of research work success. Human T lymphotropic virus (HTLV) type 1 and 2 are human retroviruses, which were discovered in the early 1980s, and it is estimated that 15 20 million people are infected worldwide. This article describes a bibliometric review and a coauthorship network analysis of literature on HTLV indexed in PubMed in a 24 year period. A total of 7,564 documents were retrieved, showing a decrease in the number of documents from 1996 to 2007. HTLV manuscripts were published in 1,074 journals. Japan and USA were the countries with the highest contribution in this field (61% followed by France (8% Production ranking changed when the number of publications was normalized by population (Dominican Republic and Japan) by gross domestic product (Guinea Bissau and Gambia) and by gross national income per capita (Brazil and Japan) The present study has shed light on some of the defining features of scientific collaboration performed by HTLV research community, such as the existence of core researchers responsible for articulating the development of research in the area, facilitating wider collaborative relationships and the integration of new authors in the research groups.
Revista do Instituto de Medicina Tropical de Sao Paulo
Gregorio Gonzalez-Alcaide Jose Manuel Ramos Charles Huamani Carmen de Mendoza Vicente Soriano
19198719
Prevalence of HTLV infection in the Dominican Republic: association with neurological disease.
The presence of the human T cell leukemia virus (HTLV) in Dominican blood donors and patients with tropical spastic paraparesis (TSP) was first detected in 1987. To define further the seroprevalence in the country, nearly 4,000 samples from high and low risk populations, as well as patients with neurological disease and with leukemia or lymphoma were tested for HTLV antibodies. A 1 2% seropositivity rate was found among the low risk population, a 2 5% in the high risk, and at least 87% in those with TSP. A few patients with malignancy also had antibodies to HTLV. An increase in seropositivity with age and a predominance of female seropositive individuals were found. Infectious virus was isolated from TSP patients, prostitutes, and family members of index patients. These data indicate the substantial level of HTLV infection in another Caribbean country and its relation to neurologic disease.
AIDS research and human retroviruses
R Ellen Koenig M L D de L Tolentino L Taveras F Ferro C Zornoso J Ferreiras Goncalo Espirito Santo Matos Cheri Ann Oquist Maria Rosa Capellan Cristina Amoros
24655299
HIV 1 and HTLV I in sexually transmitted disease clinics in the Dominican Republic.
A cross sectional seroprevalence study of human immunodeficiency virus type 1 (HIV 1) and human T cell lymphotropic virus type I (HTLV I) was undertaken among 494 attendees in two Santo Domingo sexually transmitted disease clinics in 1989. All participants were evaluated for Neisseria gonorrhoeae, Chlamydia trachomatis, syphilis, and genital ulcers. Of the 494 participants, 15 (3.0% were positive for HIV 1 and 14 (2.8% were positive for HTLV I. Twelve of 371 (3.2% men were HIV 1 seropositive: 0 of 68 homosexual/bisexual and 12 (4.0% of 302 heterosexual men (one seronegative male could not be classified) Three (2.4% of 123 women were HIV 1 seropositive. One (1.5% homosexual/bisexual man, five (1.7% heterosexual men, and eight (6.5% women were HTLV I seropositive. Among heterosexual men, HIV 1 was associated with multiple lifetime sex partners (O.R. 5.9; 95% C.I. 1.4, 23; p 0.007) HIV 1 was associated with genital ulcer disease among women (p 0.004) Among women, HTLV I was associated with professional sex work (O.R. 18; 95% C.I. 2.1, 100; p 0.001) These findings suggest the need for control of sexually transmitted diseases and targeted educational programs for prevention of HIV 1 and HTLV I among individuals with high risk behaviors in the Dominican Republic.
Journal of acquired immune deficiency syndromes
E M Rodriguez E Antonio de Moya Esther Guerrero Edgar R Monterroso Thomas C Quinn E Puello Margarita Rosado de Quinones B D Thorington Philip Glasner Fernando Zacarias
164536968
Measuring incidence of HTLV 1: th e other human retrovirus
1 Armstrong P, Hennessey M, Adams M, et al. Travel Associated Zika virus disease cases among U.S. residents United States, January 2015 February 2016. MMWR Morb Mortal Wkly Rep 2016; 65: 286 89. 2 Duijster JW, Goorhuis A, van Genderen PJ, et al. Zika virus infection in 18 travellers returning from Surinam and the Dominican Republic, The Netherlands, November 2015 March 2016. Infection 2016; published online May 21. DOI:10.1007/s15010 016 0906 y. 3 Maria AT, Maquart M, Makinson A, et al. Zika virus infections in three travellers returning from South America and the Caribbean respectively, to Montpellier, France, December 2015 to January 2016. Euro Surveill 2016; 21: 1. 4 Li J, Xiong Y, Wu W, et al. Zika Virus in a traveler returning to China from Caracas, Venezuela, February 2016. Emerg Infect Dis 2016; 22: 1133 36. 5 Massad E, Tan SH, Khan K, et al. Estimated Zika virus importations to Europe by travellers from Brazil. Glob Health Action 2016; 9: 31669. 6 Centers for Disease Control and Prevention. Florida investigation links four recent Zika cases to local mosquito borne virus transmission. http:/www. cdc.gov/media/releases/2016/p0729 fl orida zika cases.html (accessed Aug 4, 2016) 7 Tomasello D, Schlagenhauf P. Chikungunya and dengue autochthonous cases in Europe, 2007 2012. Travel Med Infect Dis 2013; 11: 274 84. 8 Bogoch II, Brady OJ, Kraemer MUG, et al. Potential for Zika virus introduction and transmission in resource limited countries in Africa and Asia Pacifi c: a modelling study. Lancet Infect Dis 2016; published online Sept 1. http:/dx.doi.org/10.1016/S1473 3099(16)30270 5. 9 Duff y MR, Chen TH, Hancock WT, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 2009; 360: 2536 43. 10 Wikan N, Smith DR. Zika virus: history of a newly emerging arbovirus. Lancet Infect Dis 2016; 16: e119 26. 11 Halstead SB. Reappearance of chikungunya, formerly called dengue, in the Americas. Emerg Infect Dis 2015; 21: 557 61. 12 WHO. WHO confi rms Zika virus strain imported from the Americas to Cabo Verde. May 20, 2016. http:/www.who.int/mediacentre/news/ releases/2016/zika cabo verde/en/ (accessed Aug 22, 2016) 13 Reuters. Guinea Bissau confi rms three cases of Zika virus, government says. http:/www.reuters.com/article/us health zika bissau idUSKCN0ZH5NK (accessed Aug 22, 2016)
Abraham Goorhuis Martin Peter Grobusch
21119916
Sexual Practices, Drug Use Behaviors, and Prevalence of HIV, Syphilis, Hepatitis B and C, and HTLV 1/2 in Immigrant and Non immigrant Female Sex Workers in Argentina
Objective To study socio demographics, sexual practices, drug use behaviors, and prevalences of HIV, syphilis, hepatitis B and C, HTLV 1 and HTLV 2 in immigrant (foreigner) and non immigrant (local/native) female sex workers (FSW) Design This was a cross sectional study in immigrant and non immigrant FSW living in Buenos Aires, Argentina. Participants were interviewed using a standardized questionnaire. Results A total of 625 FSW were enrolled, of whom 169 (27% were immigrant FSW from Paraguay, the Dominican Republic, Brazil, Peru, and Uruguay. The prevalence of syphilis and hepatitis C was significantly higher among Argentinean FSW than among immigrant FSW. However, hepatitis B prevalence was higher among immigrant FSW. Adjusted risk factor analysis comparing immigrant FSW with Argentinean FSW indicated that marital status (single) occupation (none) fee per sex act =US$7) workplace (bar and cabaret) and anal sex with clients were significantly associated with immigrant FSW status. Conclusions Effective HIV/STI prevention and medical care programs need to be tailored to the specific needs of both FSW groups in Argentina.
Journal of Immigrant and Minority Health
Christian T Bautista Maria A Pando Elena Reynaga Ruben O Marone Warren B Sateren Silvia M Montano Jose L Sanchez Maria Mercedes Avila
78253883
A Multicenter Clinicopathologic Experience of HTLV 1 ATLL: A Retrospective 15 Year Review Reveals Little Progress.
Adult T cell Leukemia/Lymphoma (ATLL) is a rare manifestation of Human T Lymphotropic Virus type 1 (HTLV 1) which is endemic in Japan, the Caribbean, and regions of Africa and Latin America. Endemic regions have also been identified in the US, primarily where immigrants of endemic countries reside. The NYC metropolitan area has the greatest number of Caribbean born immigrants to the US which has formed the basis for this retrospective review. A diagnosis of ATLL was made according to the following criteria: a clinical history consistent with ATLL; a positive HTLV 1 antibody by ELISA and Western Blot, or evidence of HTLV 1 proviral integration by PCR; and histological findings compatible with ATLL. A total of 89 patients were identified at 3 institutions in NYC from 8/92 to 5/07. There were 37 men and 52 women with a median age of 50y (range 22 to 82y) All but 6 patients had immigrated to the US from the Caribbean, Latin America or Africa, and the majority were from Jamaica (25.8% and the Dominican Republic (19.1% The acute subtype predominated (68.5% followed by the lymphomatous (20.2% chronic (6.8% and smoldering (4.5% subtypes. The most common presenting symptoms were lymphadenopathy (80.9% and skin rash (39.3% and the median ECOG performance status was 3. WBC counts ranged from 3.0 to 334.0 x 109/l (median of 12.5 X 109/l) Hypercalcemia was seen in 71.9% of patients (median calcium level of 13.5 mg/dl, range 9.8 to 27.0 mg/dl) Twenty eight patients (31.5% had CNS involvement during their course. The median International Prognostic Index (IPI) was 4. Most patients received a combination alkylator based chemotherapy regimen in the frontline setting (ex: CHOP) (61.3% with an overall response rate (ORR) to the frontline treatment of 58.2% Twenty patients (20.2% received AZT and IFN at sometime during their course with an ORR of 25% Twelve patients (13.5% received a biologically based therapy at sometime during their course, with only two patients achieving a partial response (to alemtuzamab and denileukin diftitox) Despite initial responses to therapy, the median overall survival for all subtypes was 6 mos (range 0.5 to 78.5 mos) Median survival for specific subtypes was noted to be: 4 mos for the acute subtype (range 0.5 to 78.5 mos) 9 mos for the lymphomatous subtype (range 1 to 63 mos) 17 months for the chronic subtype (range 5 to 22 mos) and 34 mos for the smoldering subtype (range 16 to 48 mos) Conclusion: This retrospective series represents one of the largest North American experiences to date among primarily Caribbean descendants. Interestingly, when placed into the context of other experiences published over the past 30 years, it is clear there has been little to no change in the outcome of patients diagnosed with this disease. In fact, this population, with a median overall survival of only 6 mos, represents one of the poorest outcomes reported for any sub type of lymphoma. These data suggest that radically new ATLL directed therapies are needed. The recent development of several new T cell active agents, in addition to other strategies (ex: transplantation) need to be specifically studied in this population.
Adrienne A Phillips Iuliana Shapira Robert D Willim Jasotha Sanmugarajah William B Solomon Steven M Horwitz David G Savage Gerald A Soff Owen A O'Connor
49640192
Case Report: Orbital Tumor Revealing Adult T Cell Leukemia/Lymphoma Associated with Human T Cell Lymphotropic Virus Type 1.
Adult T cell Leukemia/Lymphoma (ATLL) is a sight and life threatening complication of human T cell lymphotropic virus type 1 (HTLV 1) infection. Ophthalmic manifestations include uveitis, optic nerve oedema, retinal vasculitis, and lymphomatous infiltration. Orbital lesions are rare. We report the case of an orbital tumor revealing systemic ATLL in a 45 year old Dominican patient who died despite treatment. Apart from late grade cutaneous T cell lymphoma, ATLL is the only T lymphoma to develop in the orbit. Diagnosis is based on serologic evidence of HTLV 1 infection, cytology, and blood sample analysis. Biopsy is deemed necessary. Given the poor prognosis of ATLL and the worldwide presentation of HTLV 1, physicians should consider ATLL in the differential diagnosis of orbital malignant tumor and look for HTLV 1 infection in populations at risk.
The American journal of tropical medicine and hygiene
Selim Fares Rabih Hage Jean Pegliasco Samy Chraibi Harold Merle
84430793
Introduction to special issue: Viruses and neoplasia
Keywords: viral infections; HIV 1; HTLV 1; HIAP 1; SLE; HCV; HSV; EVB; MMTV; prions; spiroplasm bacteria; TSE; membrane rafts; dengue virus; Dominican Republic; UTESA; Tulane University; Brown University; lymphomas
Cesar D Fermin Robert F Garry