Double-Blind Multicentre Isradipine Dose-Confirmation Study in Pakistan
Isradipine 2.5mg twice daily was more effective than the 1.25mg twice daily dose in achieving normalisation of blood pressure and overall response. Larger reductions in blood pressure occurred sooner after starting isradipine 2.5mg twice daily than after the 1.25mg twice daily dose. Thus, this study confirms the results of European and American studies. Isradipine 2.5mg twice daily appears to be the optimal dosage for Pakistani patients with hypertension.