Antidepressant Ef fi cacy of Ketamine in Treatment-Resistant Major Depression : A Two-Site Randomized Controlled Trial
Sanjay J. Mathew, M.D. Objective: Ketamine, a glutamate Nmethyl-D-aspartate (NMDA) receptor antagonist, has shown rapid antidepressant effects, but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion. The authors evaluated the rapid antidepressant efficacy of ketamine in a large group of patients with treatment-resistant major depression.