A New Porous Metal–Organic Framework Constructed from 2, 5-Thiophenedicarboxylate and Melamine Ligands: Catalysis Dye Degradation and Anti-tumor Activity in Myocardioma
A new three-dimensional transition Co(II)–organic framework {[Co2L2MA]·(DMA)(MeOH)}n (MA = melamine, H2L = 2,5-thiophenedicarboxylic acid) bearing the rigid S-containing organic ligand 2,5-thiophenedicarboxylic acid and the N-rich organic linker melamine has been synthesized and structurally characterized. The presence of abundant micropores in the resulting activated 1a has been confirmed via the N2 sorption experiments at 77 K, which reflects a BET surface area of 925 m2/g and a pore size distribution of 7.4 A. Furthermore, the catalytic activities of complex 1 for the degradation of methyl orange in a Fenton-like process have also investigated, which reveals that complex 1 could behave as effective as heterogeneous catalyst to activate persulfate anions and to degrade methyl orange. To evaluate the inhibitory effect of compound 1 on H9C2 myocardioma cells, the viability of cells after compound treatment was detected by CCK-8 assay, and the proliferation of cells were observed by colony formation assay. Next, the detail mechanism of compound 1 was further explored, the western blot was performed to determine the relative expression of apoptotic protein Blc-2 and Bax.