Evaluation of disposable filtration systems for harvesting high cell density fed batch processes
Introduction In the underlying study we evaluated different single-use filtration systems for cell separation and harvest clarification in 1,000 L scale. A screening of different depth filters was carried out with various single-use filters from Pall, Cuno (3M), Millipore and Sartorius Stedim. In total, we included 85 depth filtrations in the screening. Out of that, two single-use filtration systems were chosen and further tested in 200 L scale. Based on these results, a single-use filtration set-up for harvesting production scale fed batch processes was determined.