The feasibility of testing experimentally the dietary fat-breast cancer hypothesis.
Breast cancer is the commonest cause of death from cancer in women in most of the Western world, and the leading cause of death from all causes among women aged less than 50 (Silverberg & Lubra, 1988). Mortality from the disease has not changed appreciably over an extended period of time (Bailar & Smith, 1986). There is, however, considerable evidence that breast cancer risk can be modified, and that diet, particularly dietary fat, may play a major role in influencing risk for the disease. The evidence that breast