Verapamil in angina: a double-blind trial.
Three cases of multiple sclerosis are reported, all of which developed chorea, choreo-athetosis, or athetosis during the course of their illness. The diagnoses were based on the association of diffuse and disseminated neurological lesions, a history of remission and relapse, a strongly paretic Lange curve in the C.S.F. with a negative Wassermann reaction, together with marked increase in the gammaglobulin fraction. Two cases responded well to corticotrophin and one improved spontaneously. Follow-up showed satisfactory remission of the whole clinical picture and of voluntary movements in particular. I am grateful to Dr. J. MacDonald Holmes for permission to report his cases. I am indebted to Dr. E. R. Bickerstaff for permission to publish the case under his care and for his criticism and guidance in preparing this paper. I am thankful to Miss G. M. Griffiths and Miss S. Ray for their help at various stages.