MENTAL FUNCTIONING AND PREMARIN THERAPY IN CARDIOVASCULAR AND CEREBROVASCULAR DISEASE.
SummaryTested a second time was the hypothesis that mental impairment decreases in patients with cardio- or cerebrovascular disease treated with Premarin. Forty-five men with myocardial infarction and 32 with cerebral thrombosis were studied by means of the Rorschach test, which was first administered at the time either Premarin or placebo treatment was begun, and was repeated after 6 to 16 months. Each patient received a score denoting amount of increase or decrease in impairment following treatment. There was considerable overlap in scores between Premarin and placebo groups, and gains were relatively small for individual patients. The results paralleled findings from the earlier study in showing improved mental functioning in Premarin-treated patients with cerebral thrombosis compared with placebo-treated controls, but they were at variance with the previous findings regarding similar improvement in cardiac patients. Analysis of the results with the 153 male patients from the 2 studies combined showed ...