Supplementary feeding with either ready-to-use fortified spread or corn-soy blend in wasted adults starting antiretroviral therapy in Malawi: randomised, investigator blinded, controlled trial
OBJECTIVE
To investigate the effect of two different food supplements on body mass index (BMI) in wasted Malawian adults with HIV who were starting antiretroviral therapy.


DESIGN
Randomised, investigator blinded, controlled trial.


SETTING
Large, public clinic associated with a referral hospital in Blantyre, Malawi.


PARTICIPANTS
491 adults with BMI <18.5.


INTERVENTIONS
Ready-to-use fortified spread (n=245) or corn-soy blend (n=246).


MAIN OUTCOME MEASURES



PRIMARY OUTCOMES
changes in BMI and fat-free body mass after 3.5 months.


SECONDARY OUTCOMES
survival, CD4 count, HIV viral load, quality of life, and adherence to antiretroviral therapy.


RESULTS
The mean BMI at enrolment was 16.5. After 14 weeks, patients receiving fortified spread had a greater increase in BMI and fat-free body mass than those receiving corn-soy blend: 2.2 (SD 1.9) v 1.7 (SD 1.6) (difference 0.5, 95% confidence interval 0.2 to 0.8), and 2.9 (SD 3.2) v 2.2 (SD 3.0) kg (difference 0.7 kg, 0.2 to 1.2 kg), respectively. The mortality rate was 27% for those receiving fortified spread and 26% for those receiving corn-soy blend. No significant differences in the CD4 count, HIV viral load, assessment of quality of life, or adherence to antiretroviral therapy were noted between the two groups.


CONCLUSION
Supplementary feeding with fortified spread resulted in a greater increase in BMI and lean body mass than feeding with corn-soy blend.


TRIAL REGISTRATION
Current Controlled Trials ISRCTN67515515.