Is oxaliplatin combined with weekly bolus 5-fluorouracil and leucovorin an option for stage II and III colon cancer?
BACKGROUND The Multicenter International Study of Oxaliplatin/5-Fluorouracil, Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) study reported that the addition of oxaliplatin to a regimen of bolus and continuous-infusion 5-fluorouracil (5-FU) combined with leucovorin (LV)—the FOLFOX4 regimen—improved 3-year disease-free survival (DFS) in comparison with FULV (5-FU and LV administered alone).