Amiodarone infusion in the treatment of acute atrial fibrillation or flutter: high versus low dose treatment.
I ntravenous amiodarone is a recognised treatment alternative for the conversion of atrial fibrillation to sinus rhythm. Consensus regarding dosage and duration of treatment has not been reached. 5 Our coronary care unit routinely uses intravenous amiodarone for conversion of supraventricular arrhythmia in various clinical settings. Following a loading dose of 300 mg/30 mins, two alternative dosages of intravenous maintenance treatment—50 mg/hour and 100 mg/hour—employed. We compared the efficacy and safety of these two regimens in an open randomised study.