Head and neck cancer.
Results: From 275 pts with sinonasal cancer, 31 were SNA. Patient median age was 70 yrs (49-108), 54.8% male. 38.7% had professional exposure to leather dust/wood/cork. Primary sites at diagnosis were: nasal cavity (48.4%), maxillary sinus (3.3%), ethmoid sinus (3.3%). Nasal obstruction (74.3%), epistaxis (45.2%) were the most common presenting symptoms. Most pts (54.8%) presented with stage III and stage IV disease at diagnosis and 45.2% with stage I/II. The Intestinal-Type SNA (ITAC) was the most common type of adenocarcinoma (61.3%) followed by tubulopapillary (22.6%). The median time between the first symptom and the definitive diagnosis was 5 months (0-39) and from the diagnosis to the initial treatment was 2 months (0-9). Surgery was the primary treatment in 77.4%. Adjuvant radiation was performed in 51.6% and chemotherapy in 3.3%. Recurrence was seen in 13 pts (41.9%): 28.7% recurred locally, 6.6% systemically, and 6.6% both. The median follow-up, overall survival (OS) and progression free-survival (PFS) were 3.5 yrs, 5.45 yrs and 3.41 yrs, respectively. Mucinous ITAC subtype had a dismal outcome (7/8 pts died), with a median OS and PFS of 4.76 yrs and 2.8 yrs, respectively.