Comparative Trial of Trimipramine versus Doxepin in Depressed Hospitalised Patients
This paper summarises the results of a randomised, double-blind study, in which trimipramine was compared with doxepin , with respect to antidepressant , anxiolytic and cardio vascular effects in hospital ised patients with major depression and anxiety". Previous comparati ve studies have shown trimipramine to possess similar efficacy to imipramine but fewer side effects (Rifkin et al. 1980), and efficacy similar to or less than that of amitriptyline but greater tolerance and superior anxiolytic effect (Pecknold et al. 1979; Rickels et al. 1970). Doxepin has a more rapid onset of action than amitriptyline but more side effects and stronger sedative action (Castrogiovanni et al. 1971 ; Grof et al. 1974; Mendels & Secunda 1980; Richelson 1974).