Comparative Trial of Pinacidil versus Prazosin in Mild to Moderate Arterial Hypertension
This paper' summarises the results of a randomised, non-blind study, in which pinacidil was compared with prazosin, with respect to antihypertensive efficacy and side effects in patients with mild to moderate arterial hypertension. The major haemodynamic change in patients with arterial hypertension seems to be an increase in total peripheral resistance (Lund-Johansen 1967). Therefore, drugs that reduce total peripheral resistance are a logical therapeutic approach. Since hypertension is primarily diagnosed and treated in general practice, the study was carried out by a group of general practitioners in Denmark.