Synergistic effect of some pharmaceutical compounds on cobalt-60 complexes.
Synergism in the extraction of cobalt from acetate 0.1 M aqueous medium, pH = 5.3 has been investigated using a mixture of thenoyl-trifluoro acetone and antipyrine, 4-iodoantipyrine or 4-aminopyrine (AAPy), synergism was observed in all the cases. The maximum synergistic effect was observed in the case of 4-(AAPy). The nature of the extracted species has been determined and the equilibrium constants for the adducts have been evaluated. The thermodynamic parameters of these reactions have been calculated to elucidate the mechanism of formation of the extracted species. These compounds were found to be good donors capable in strength to other alkyl phosphorus donors.