Could clopidogrel's platelet inhibition be enhanced by an increased loading dose and eptifibatide?
DESIGN This prospective, randomized study included patients aged over 18 years who had undergone elective coronary stenting. Exclusion criteria included history of bleeding diathesis, elevated cardiac markers, an acute myocardial infarction within 48 h, a cerebrovascular event 3 months before treatment, chronic vessel occlusion or angiographically visible thrombus, hematocrit under 30%, platelet count under 100 × 109/l and prothrombin time over 1.5 times reference.