Further observations on respiratory flow-volume loops: clinical evaluation of a new oral bronchodilator, CP-12,521-1.
PRESSUBE, VOLUME, AND FLOW DATA obtained during spirometry and plotted as pressure-volume or flow-volume loops have been used in the study of respiratory mechanics. Pressure-volume loops are used for the display of data generated in the measurement of static and dynamic compliance of the lungs and/or chest wall. 1-~ Flow-volume loops have been used for the quick pattern-recognition of various pulmonary diseases ~-6 and in the evaluation of the effects of drugs on the lower airways. 7,8 Based on a technical modiflcation 9 of the original method described by Fry and Hyatt, we evaluated a new oral bronehodilator, cp-12,521-1 (Fig. 1) in the management of patients with asthma.