Change of Virchow-Robin spaces in idiopathic normal pressure hydrocephalus and its pathogenetic significance
Introduction Idiopathic normal pressure hydrocephalus (iNPH) is a disorder of aged adults, but it pathogenesis is still unknown. Recently, Virchow-Robin Spaces (VRS) are interested in anatomical structure for interaction between interstitial fluid (ISF) and cerebrospinal fluid (CSF). VRS are known to observe mainly in the basal ganglia and the subcortical white matter and they increase in number with aging. In the present study, we investigated morphological features of VRS in the brain in the aged healthy adults and patients with probable iNPH.