Turnover of human fat cells and their lipid content
Results Decreased turnover of fat cells and their lipid contents is associated with insulin resistance, dyslipidemia and altered metabolic function of fat cells. Low fat cell turnover leads to adipose hypertrophy which is linked to insulin resistance in subcutaneous fat and to dyslipidemia in visceral fat. A transcription factor (EBF-1) regulates hyperplasia/hypertrophy in human adipose tissue and in animal models. Changes in adipose EBF-1 expression is linked to abnormal metabolic function of fat cells and to in vivo insulin resistance.