A comparative crossover evaluation of amlodipine and nifedipine GITS before and after a missed dose: 48-h blood pressure profiles.
Missing one or more days of medication on these “drug holidays” can disrupt the steady level of the drug and lead to rebound reactions when the dose is suddenly stopped, and restarting the full dose of the drug can evoke exaggerated effects. 2 A number of ways to compensate for these missed doses have been suggested, including antihypertensive drugs with 36, 48, and even 72 h of action prescribed every 24 h. 1