Effects of exercise on practolol-treated asthmatic patients
The effects of mild exercise (Master double step exercise test) on ventilatory function in 10 normal subjects and 10 asthma patients was assessed by measuring FEV11.0 and VC. The measurements were repeated after treatment for 3 consecutive days either with a placebo or with practolol in a double blind crossover test. — No significant differences were observed in both the normals and the asthmatics between the results obtained after either the placebo or practolol 2 and 8 min after exercise. It was shown that mild exercise did not produce bronchospasm in asthmatic patients and that cardioselective β-adrenergic blockade with practolol did not sensitize these patients to the bronchoconstrictive effect of exercise.