Reaction of aldoses with amino compounds.
Abstract A solubility method for measuring aldose-amino interaction has been extended to the study of the kinetics of glucose condensation with leucylglycine, β-lactoglobulin, and p -aminobenzoic acid. The primary reaction rate and secondary reversible and irreversible decomposition of the respective Schiff bases have been characterized and their reaction constants calculated. These compounds were found to react more rapidly than the common aliphatic amino acids, at pH values within the biological range, and this form of aldose-amino condensation may therefore have physiological significance.