Efficacy of Epanolol versus Metoprolol in Angina Pectoris
114 patients aged between 43 and 79 (mean 61) years participated in the study, 86% of the patients were male. Ischaemic heart disease was documented by a previous myocardial infarction (53%), coronary arteriography (8%), exercise test (80%)or case history only (8%). Patients were given 200mg of epanolol or metoprolol daily. No other antianginal therapy was used apart .from short acting nitrates. The randomised double-blind crossover study design comprised a 4-week period on each drug. Bicycle ergometry was performed at the end of each treatment period. Exercise was commenced at 40 watts, with the work load being increased by 10 watts/minute until a symptom-limited maximum , e.g. pronounced ST segment depression (> 3mm) or significant tachyarrhythm ias, occurred. Heart rate, systolic blood pressure, ST segment changes, perceived exertion, anginal pain and dyspnoea (by use of standardised Borg-scales) were recorded continuously, 2. Results