url: =Xiaodong Huang - researchr alias\nPublications by 'Xiaodong Huang'\nA fully discrete positivity-preserving and energy-dissipative finite difference scheme for Poisson-Nernst-Planck equationsJingwei Hu, Xiaodong Huang. nm, 145(1):77-115, 2020. [doi]\nDirection-of-Arrival Estimation Based on Quantized Matrix RecoveryXiaodong Huang, Suzhi Bi, Bin Liao. icl, 24(2):349-353, 2020. [doi]\nOne-Bit MUSICXiaodong Huang, Bin Liao. spl, 26(7):961-965, 2019. [doi]\n基于改进双流卷积网络的火灾图像特征提取方法 (Fire Images Features Extraction Based on Improved Two-stream Convolution Network)Deng Xu, Xiaodong Huang. jsjkx, 46(11):291-296, 2019. [doi]\nEffects of Moisture Absorption on the Electrical Behaviors of InGaZnO Thin Film TransistorsChao Zhang, Xiaodong Huang. icicdt 2019: 1-3 [doi]\nAutomatic video superimposed text detection based on Nonsubsampled Contourlet TransformXiaodong Huang. mta, 77(6):7033-7049, 2018. [doi]\nDeterminants of early afterdepolarization properties in ventricular myocyte modelsXiaodong Huang, Zhen Song, Zhilin Qu. ploscb, 14(11), 2018. [doi]\nApplication of Gold-Nanoparticle Colorimetric Sensing to Rapid Food Safety ScreeningGuangyang Liu, Meng Lu, Xiaodong Huang, Tengfei Li, Donghui Xu. sensors, 18(12):4166, 2018. [doi]\nVisual and Colorimetric Sensing of Metsulfuron-Methyl by Exploiting Hydrogen Bond-Induced Anti-Aggregation of Gold Nanoparticles in the Presence of MelamineGuangyang Liu, Ruonan Zhang, Xiaodong Huang, Lingyun Li, Naixin Liu, Jing Wang, Donghui Xu. sensors, 18(5):1595, 2018. [doi]\nMulti-objective topology optimization of a vehicle door using multiple material tailor-welded blank (TWB) technologyGuangyong Sun, Dongdong Tan, Xiaojiang Lv, Xiaolei Yan, Qing Li, Xiaodong Huang. aes, 124:1-9, 2018. [doi]\nSnow Disaster Early Warning in Pastoral Areas of Qinghai Province, ChinaJinglong Gao, Xiaodong Huang, Xiaofang Ma, Qisheng Feng, Tiangang Liang, Hongjie Xie. remotesensing, 9(5):475, 2017. [doi]\nEvaluation of Remote Sensing Inversion Error for the Above-Ground Biomass of Alpine Meadow Grassland Based on Multi-Source Satellite DataBaoping Meng, Jing Ge, Tiangang Liang, Shuxia Yang, Jinglong Gao, Qisheng Feng, Xia Cui, Xiaodong Huang, Hongjie Xie. remotesensing, 9(4):372, 2017. [doi]\nAn Adaptive Two-Component Model-Based Decomposition on Soil Moisture Estimation for C-Band RADARSAT-2 Imagery Over Wheat Fields at Early Growing StagesXiaodong Huang, Jinfei Wang, Jiali Shang. lgrs, 13(3):414-418, 2016. [doi]\nAn Integrated Surface Parameter Inversion Scheme Over Agricultural Fields at Early Growing Stages by Means of C-Band Polarimetric RADARSAT-2 ImageryXiaodong Huang, Jinfei Wang, Jiali Shang. tgrs, 54(5):2510-2528, 2016. [doi]\nMulti-view collaborative modeling method for complex systemXiaodong Huang, Li Zhang, Jing Zhou, Yaofei Ma. ijmssc, 7(3):1650030, 2016. [doi]\nToward Improved Daily Cloud-Free Fractional Snow Cover Mapping with Multi-Source Remote Sensing Data in ChinaJie Deng, Xiaodong Huang, Qisheng Feng, Xiaofang Ma, Tiangang Liang. remotesensing, 7(6):6986-7006, 2015. [doi]\nSurface parameter inversion scheme over agricultural fields with crop residues and under low vegetation cover from RADARSAT-2 imageryXiaodong Huang, Jinfei Wang, Jiali Shang. igarss 2015: 3203-3206 [doi]\nBi-directional evolutionary optimization for photonic band gap structuresFei Meng, Xiaodong Huang, Baohua Jia. jcphy, 302:393-404, 2015. [doi]\nSpatio-Temporal Change of Snow Cover and Its Response to Climate over the Tibetan Plateau Based on an Improved Daily Cloud-Free Snow Cover ProductWei Wang, Xiaodong Huang, Jie Deng, Hongjie Xie, Tiangang Liang. remotesensing, 7(1):169-194, 2015. [doi]\nAn efficient deblocking filter algorithm for HEVCRunlong Kang, Wei Zhou, Xiaodong Huang, BingChao Dong. chinasip 2014: 379-383 [doi]\nA four-component decomposition integrating selective deorientation and generalized volume scatteringXiaodong Huang, Xiuguo Liu, Qihao Chen. igarss 2013: 2447-2450 [doi]\nAdaptive detection of range-spread targets without secondary data in multichannel autoregressive processTao Jian, You He, Feng Su, Xiaodong Huang, Dianfa Ping. dsp, 23(5):1686-1694, 2013. [doi]\n41.7BN-pixels/s reconfigurable intra prediction architecture for HEVC 2560×1600 encoderZhenyu Liu, Dongsheng Wang, Hongxiang Zhu, Xiaodong Huang. icassp 2013: 2634-2638 [doi]\nGARSS: A Generic Annotation and Recommendation Service System for Digital RepositoriesXiaodong Huang, Yong Zhang, Chunxiao Xing. compsac 2012: 32-37 [doi]\nPaxos-Based Memory Data Replication in Stock Trading SystemXiaodong Huang, Yong Zhang, Chunxiao Xing, Yinfei Huang, Jianfeng Wu, Shuo Bai. compsac 2012: 340-341 [doi]\nResearch of non-servo valve electro-hydraulic servo systemGeqiang Li, Hanjie Wang, Xiaodong Huang. emeit 2011: 871-874 [doi]\nResearch on the control scheme of direct drive electro-hydraulic position servo systemGeqiang Li, Hanjie Wang, Xiaodong Huang, Hongyan Yang. emeit 2011: 3221-3224 [doi]\nAutomatic Detection and Localization of Natural Scene Text in VideoXiaodong Huang, Huadong Ma. icpr 2010: 3216-3219 [doi]\nParallel algorithm design for remote sensing image processing in the PC cluster environmentHongping Wang, Juan Zhang, Xiuguo Liu, Xiaodong Huang. geoinformatics 2010: 1-5 [doi]\nAutomatic detection and restoration of frame pixel-shift in videosHaidong Yuan, Huadong Ma, Xiaodong Huang. mta, 47(2):307-323, 2010. [doi]\nA new video text extraction approachXiaodong Huang, Huadong Ma, He Zhang. icmcs 2009: 650-653 [doi]\nModeling Emergency Service Centers with Simulation and System DynamicsYing Su, Xiaodong Huang, Zhanming Jin. uksim 2009: 305-310 [doi]\nStudy on Web-Based Tool for Regional Agriculture Industry Structure Optimization Using AjaxXiaodong Huang, Yeping Zhu. ifip12 2009: 1543-1550 [doi]\nSystems analysis of quantitative shRNA-library screens identifies regulators of cell adhesionXiaodong Huang, Jean Y. J. Wang, Xin Lu. bmcsb, 2:49, 2008. [doi]\nVideo Mosaic Block Detection Based on Template Matching and SVMXiaodong Huang, Huadong Ma, Haidong Yuan. icycs 2008: 1082-1086 [doi]\nA Novel Video Text Detection and Localization ApproachXiaodong Huang, Huadong Ma, Haidong Yuan. pcm 2008: 525-534 [doi]\nAssuring Quality of Geo-information for Disaster ManagementYing Su, Zhanming Jin, Xiaodong Huang. iq 2008: 341-355 [doi]\nAutomatic pixel-shift detection and restoration in videosHaidong Yuan, Huadong Ma, Xiaodong Huang. icmcs 2008: 1541-1544 [doi]\nEdge-based synthetic discriminant function for distortion invariant object recognitionHaidong Yuan, Huadong Ma, Xiaodong Huang. icip 2008: 2352-2355 [doi]\nSurvivable Wireless Access Network Design with Dual-homing CapabilitiesMohammad Masud Hasan, Xiaodong Huang, Jason P. Jue. globecom 2006: [doi]\n3D Reconstruction Based on a Hybrid Disparity Estimation AlgorithmXiaodong Huang, Eric Dubois. icip 2006: 1025-1028 [doi]\nRegion-Based Motion Analysis and 3D Reconstruction for a Translational Video SequenceXiaodong Huang, Eric Dubois. 3dpvt 2006: 838-845 [doi]\nSmall Girou Multicast with Deflection Routing in Optical Burst Switched NetworksXiaodong Huang, Qingya She, Tao Zhang, Kejie Lu, Jason P. Jue. broadnets 2006: [doi]\nMaximum Survivability using Two Disjoint Paths under Multiple Failures in Mesh NetworksQingya She, Xiaodong Huang, Jason P. Jue. globecom 2006: [doi]\nThree-view dense disparity estimation with occlusion detectionXiaodong Huang, Eric Dubois. icip 2005: 393-396 [doi]\nDisparity estimation for the intermediate view interpolation of stereoscopic imagesXiaodong Huang, Eric Dubois 0002. icassp 2005: 881-884 [doi]\nEfficient Online Traffic Grooming Algorithms in WDM Mesh Networks with Drop-and-Continue Node ArchitectureFarid Farahmand, Xiaodong Huang, Jason P. Jue. broadnets 2004: 180-189 [doi]\nStatistical Multiplexing of Self-Similar Traffic with Different QoS RequirementsXiaodong Huang, Yuanhua Zhou. ieicet, 87-D(9):2171-2178, 2004. [doi]\nA multiscale model for MPEG-4 varied bit rate video trafficXiaodong Huang, Yuanhua Zhou, Rongfu Zhang. tbc, 50(3):323-334, 2004. [doi]\nAn algorithm for traffic grooming in WDM mesh networks with dynamically changing light-treesXiaodong Huang, Farid Farahmand, Jason P. Jue. globecom 2004: 1813-1817 [doi]


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url: ="Improving Face Clustering in Videos" by SouYoung Jin\nHome > ETDS > Doctoral Dissertations > 1835\nSouYoung Jin, University of Massachusetts AmherstFollow\nJin, SouYoung, "Improving Face Clustering in Videos" (2020). Doctoral Dissertations. 1835.


url: =Bond Stress and Local Slip of Reinforced Concrete--《Journal of Shantou University(Natural Science Edition)》1986年01期\n《Journal of Shantou University(Natural Science Edition)》 1986-01\nBond Stress and Local Slip of Reinforced Concrete\nZhang Chong (Architectural Engineering Department) Ding Dajun(Honorary Professor of Shantou University)\nIn this paper,the fundamental conditions are analyzed and the 2nd order differential equation of the relationship between bond stress and local slip as well as six boundary conditions are obtained,which are the basic equations for exploring the inherent laws of bond state.It is, however,too difficult to solve them by using methods in current use. According to mathematical similarity,an analytical model of the fictitious cantilever beam is put forward,and the equations of important variables including local slip at any section,crack width,the difference between steelbar strain and concrete strain,total elongations of both steel bar and concrete between two adjacent cracks,average strain of steel bar,the factor of non-uniform strain of steel bar and the average rigidity of bonded bar can all be conveniently acquired. The proposed method can be used in the analyses of cracks,deformations, bond behaviour and finite element methods.\n1 Jiang Dewen Qiu Hongxing(Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education,Southeast University,Nanjing 210096,China);Simplified solution of the slip between rebar and concrete based on pull-out test[J];Journal of Southeast University(Natural Science Edition);2009-04\n2 CHEN Jing1,2,LIU Xila1(1.Department of Civil Engineering,Shanghai Jiaotong University,Shanghai 200240,China;2.College of Civil Engineering,Nantong University,Nantong 226007,China);Bond-slip constitutive model of corroded reinforced concrete member[J];Sichuan Building Science;2008-04\n3 LI Qiu-yi,LI Yun-xia,ZHU Chong-ji(School of Civil Engineering,Qingdao Technological University,Qingdao 266033,China);The study on the classification method of the recycled coarse aggregate based on the ratio of water dosage and the ratio of compressive strength[J];Materials Science and Technology;2007-04\n4 WEI Jun1,2,ZHANG Hua2,XU Gang3,WANG Wei2,HUANG Ying1,WANG Teng1 (1.School of Civil and Architectural Engineering,Central South University,Changsha 410075,China;2.School of Civil Engineering and Mechanics,Huazhong University of Science and Technology,Wuhan 430074,China;3.School of Civil Engineering and Hydraulic,Three Gorges University,Yichang 443002,China);Experimental study on the bond behavior between concrete and corroded steel bars[J];Journal of Railway Science and Engineering;2009-04\n5 WANG Dong-sheng1,Feng Qi-min2,ZHAI Tong1(1.Institute of Engineering Mechanics,China Seismological Bureau,Harbin 150080,China;2. Qingdao University of Ocean,Qingdao 266071,China);Performance of reinforced concrete bridge pierssubjected to near-fault ground notions[J];Earthquake Engineering and Engineering Vibration;2003-01\n6 SI Bingjun1,LI Hongnan1,WANG Dongsheng2,SUN Zhiguo2,WANG Qingxiang1(1.State Key Laboratory of Coastal and Offshore Engineering,Dalian University of Technology,Dalian 116024,China;2.Institute of Road and Bridge Engineering,Dalian Maritime University,Dalian,116026,China);Experimental evaluation of the seismic performance of reinforced concrete bridge piers designed on the basis of displacement(I): Quasi-static test[J];Journal of Earthquake Engineering and Engineering Vibration;2008-01\n7 Song Yupu, Zhao Guofan (The Research Section of Structure, DIT);Study of Bond-Slip Property between Steel Bars and the Concrete[J];;1987-02\n8 Song Qi-gen;Study of Reinforced Concrete Bond Specimens by Finite Element Method[J];;1981-04\n9 Jiang Dewen Qiu Hongxing(Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education,Southeast University,Nanjing 210096,China);Simplified solution of the slip between rebar and concrete based on pull-out test[J];Journal of Southeast University(Natural Science Edition);2009-04\n10 ;Research on Performance Improvement of Confined Recycled Aggregate Concrete[J];Coal Ash;2009-02\n1 WANG Chen-xia;WEI Hong-gang;WU-Jin;WANG Xi-jun;Department of Civil Engineering,Nanjing University of Aeronautics and Astronautics;Architecture and Civil School,Inner Mongolia University of Science and Technology;Metal Structure Installation Engineering Company,China Second Metallurgy(Group) Corp;Limited Liability Company of Inner Mongolia Construction Engineering;;Experimental research and numerical simulation on bond behavior between recycled concrete and rebar[J];Journal of Guangxi University(Natural Science Edition);2013-04\n2 ZHOU Fu-chuan;WANG Xiao-wei;Chongqing Jiaotong University;;Research on Displacement of Soil Anchor for Landslide Treatment[J];Highway;2014-04\n3 LEI Bin;XU Yuan-wei;HU Ming-yu;YAN Yu-song;School of Building Engineering,Nanchang University;Department of Capital Construction,Nanchang University;;Ductility of Recycled Concrete Frame Structure[J];Bulletin of the Chinese Ceramic Society;2015-09\n4 ZHOU Fu-chuan;WANG Xiao-wei;Chongqing Jiaotong University;;The Research on the Displacement of the Soil Anchor in the Landslide Treatment[J];Science Technology and Engineering;2014-15\n5 LU Qun;ZHANG Bo;WANG Li;School of Civil Engineering,Tianjin Chengjian University;Tianjin Key Laboratory of Soft Soil Characteristics and Engineering Environment;;Experimental study on strength and deformation performance of fiber recycled concrete under conventional triaxial compression[J];World Earthquake Engineering;2015-03\n6 KUANG Jian1,XIE Chao2,LIU You-wen2 (1.Jiandong Corporation for Project Supervision of Guangdong,Guangzhou 510500,China; 2.College of Mechanical and Vehicle Engineering,Hunan University,Changsha 410082,China);Quasi-static analysis solution of bond stress between rebar and concrete subjected to incidence of shear wave along rebar length direction[J];Journal of Central South University(Science and Technology);2012-02\n7 Gong Liangying1,3,Peng Bofeng2,3,Zhao Yingxin3,Liu Youwen3(1.Overseas Engineering Company,Hunan Construction Engineering Group,Changsha 410004,China; 2.Engineering Department,Changsha Dongjing Building Stock Company Ltd,Changsha 410004,China; 3.College of Mechanical and Vehicle Engineering,Hunan University,Changsha 410082,China);Static Analysis of Bond Stress and Slip between Corroded Rebar and Concrete[J];Journal of Hunan University of Technology;2012-03\n8 Maziar RAMEZANI;Juan VILCHES;Thomas NEITZERT;Centre for Advanced Manufacturing Technology (CAMTEC),School of Engineering, Auckland University of Technology;;Evaluation of the pull-out strength of galvanised steel strips in a cement-based material[J];浙江大学学报A辑(应用物理与工程)(英文版);2013-12


url: = henan yi machinery equipment crusher\nQuality AAC Equipment for sale, AAC Equipment & Crusher provided by China Suppliers - Henan Yigong Machinery & Equipment Co., Ltd..\nIndustrial biomass crusher plant, View biomass crusher\nIndustrial biomass crusher plant, US $ 999 - 1500 / Set, New, Henan, China, YiBao.Source from Henan Yibao Machinery Equipment Co., Ltd. on Alibaba.com.\n17-12-2014· Henan Yigong Machinery & Equipment Co., Ltd. is a manufacturer specialize in building material equipment, mining machines, stone plant equipments,etc. that is founded in 2008 by restructuring. The\nHammer crusher is one of the main equipments for medium crushing and fine Working principle of hammer crusher: When the hammer crusher or hammer crushing machine works, the motor drives the rotor to spin at high speed, Henan Kailide Machinery Co., Ltd .\n<< Previous:Sand Gold Mineral Processing Equipment\n>> Next:Primary Jaw Crusher Machinepe 900 1200 Jaw Stone Crusher\nused vibratory screen for sale barite beneficiation plant for sale top sell carbide tips replacement grinder teeth used mobile crusher in karnataka rock crusher mill rock uha2r2 mining equipment import from china to canada crusher plant operational manual supplier dry ball mill manufacturers for sale plant gold ball mill rod for mine gambar roller tyre for raw mill white people with gold mining holding gold mining companies in middle east portable gold mining mill in uk iron mining process flow chart diagram impact crusher limeston multi stage starch washing hydrocyclone unit industrial industrial grinding machines energy requirement mobile crusher of a gold separator background of pedestal grinding machine vida util molinos de bolas limestone used limestone crushers


url: =Page 3 of Religious Sites attractions - 99 great attractions in Libo - Travel with Trip.com\n157.6km from Libo ·\n"Wanshou Palace in Qingyan Ancient Town, Guiyang, is characterized by eight fairy reliefs across the sea on the gate, which are indeed more exquisite and lifelike. Wanshou Palace is free to visit, and there are staff at the door to maintain order."\n174.5km from Libo ·\n"Don't look at it very small, there is a lot of content. Although there is nothing special about the part of the historical building, some temporary exhibitions made inside are very good. The duty uncle is also very enthusiastic to invite tourists to visit. In addition to the temporary exhibition, the regular exhibition mainly introduces Wang Yangming's life, and it is also very good."\nRanked #6 in Zhijin Can't Miss Attractions\n252.3km from Libo ·\n"Ancient Buddhist temple in Zhijin, next to the ancient Buddha Road, came here in the drizzle morning, not open, the appearance is quite new."\nRanked #1 in Zhijiang Local History\n287.7km from Libo ·\n"The Tianhou Palace of Lijiang River is located on the west bank of Maishui River, across the river from the county town, with pleasant scenery, beautiful scenery, unique architectural style, unique charm, historical and cultural heritage, is the most representative relics of Lijiang River, and also the most famous green stone relief, great."\n272.7km from Libo ·\n296.2km from Libo ·\n296.7km from Libo ·\n173.9km from Libo ·\n"Dongshan Temple in the cherry palace has an entrance, the previous period is being repaired, from the foot of the mountain to look up, the scale is grand, long want to go to observe a bit. The sunset, the heat is no longer, just suitable for climbing. Follow the winding mountain climbing trail, rested a few times, finally climbing up the mountain. Unfortunately, I missed the opening hours and didn't get in. Another angle to see the sunset at a higher level, and the street view also has a taste."\nShrine of Mr. Liu Tongzhi\n174.6km from Libo ·\n"In Baisha Alley near Huguo Road in Guiyang, it is now a kindergarten, a very magnificent ancient building, but unfortunately not allowed to visit, because the children are studying. Guiyang is still a city with a strong cultural atmosphere"\nTweed Heads Travel | Tongren Travel | Nelson Bay Travel | Tokyo Travel | Fingal Travel | Mui Ne Travel | Jakarta Travel | Viti Levu Travel | Hakuba Travel | Seoul Travel | Daylesford Travel | Pekanbaru Travel | Echuca Travel | Guadalajara Travel | Kiama Travel | Sallanches Travel | Ratchaburi Travel | Shiraoi Travel | Arabako Lautada Travel | Paju-si Travel | Pu'er Travel | Laoag Travel | Canyon Lake Travel | Holbaek Travel | Le Puy Travel | Paralimni Travel | Salina Travel | Dalarna Travel | Lima Province Travel | Cashiers Travel


url: =已选条件： 资源类型: 期刊论文 × 数据来源: 万方 × 数据来源: CNKI × 数据来源: 维普 × 数据来源: CSSCI × 出版年: 2014 × 机构: 物理学院 × 机构: 信息科学与工程... ×\n2. TDDB characteristic and breakdown mechanism of ultra-thin SiO_2/HfO_2 bilayer gate dielectrics\n作者机构：[陶芬芬;杨红;唐波;唐兆云;徐烨锋;许静;王卿璞;闫江]School of Physics,Shandong University;[陶芬芬;杨红;唐波;唐兆云;徐烨锋;许静;王卿璞;闫江]Key Laboratory of Microelectronics Devices and Integrated Technology,Institute of Microelectronics,Chinese Academy of Sciences\n来源：Journal of Semiconductors,2014,Issue.06,36-41\n3. Multi-polar resistance switching and memory effect in copper phthalocyanine junctions EI SCOPUS SCIE\n作者机构：[Qiao, S.-Z] School of Physics, State Key Lab of Crystal Materials, Shandong University, Jinan 250100, China;[ Kang, S.-S] School of Physics, State Key Lab of Crystal Materials, Shandong University, Jinan 250100, China;[ Qin, Y.-F] Department of Applied Physics, School of Information Science and Engineering, Shandong Agricultural University, Taian 271018, China;[ Li, Q] School of Physics, State Key Lab of Crystal Materials, Shandong University, Jinan 250100, China;[ Zhong, H] School of Physics, State Key Lab of Crystal Materials, Shandong University, Jinan 250100, China;[ Kang, Y] School of Physics, State Key Lab of Crystal Materials, Shandong University, Jinan 250100, China;[ Yu, S.-Y] School of Physics, State Key Lab of Crystal Materials, Shandong University, Jinan 250100, China;[ Han, G.-B] School of Physics, State Key Lab of Crystal Materials, Shandong University, Jinan 250100, China;[ Yan, S.-S] School of Physics, State Key Lab of Crystal Materials, Shandong University, Jinan 250100, China;[ Mei, L.-M] School of Physics, State Key Lab of Crystal Materials, Shandong University, Jinan 250100, China\n来源：中国物理B,CHINESE PHYSICS B,2014,Vol.23,Issue.5,627-633\n来源：Journal of Measurement Science and Instrumentation,Journal of Measurement Science and Instrumentation,2014,Issue.03,94-102\n5. Preparation and characterization of single crystalline In_2O_3 films deposited on MgO (110) substrates by MOCVD EI SCOPUS SCIE\n作者：Zhao Li;Cansong Zhao;Wei Mi\n作者机构：[Li, Z] School of Physics, Shandong University, Jinan 250100, China;[ Zhao, C] School of Physics, Shandong University, Jinan 250100, China;[ Mi, W] School of Physics, Shandong University, Jinan 250100, China;[ Luan, C] School of Physics, Shandong University, Jinan 250100, China;[ Feng, X] School of Physics, Shandong University, Jinan 250100, China;[ Ma, J] School of Physics, Shandong University, Jinan 250100, China\n来源：CERAMICS INTERNATIONAL,CERAMICS INTERNATIONAL,2014,Vol.40,Issue.3,4203-4206\n6. Structural and optical properties of Al2xIn2-2xO3 films prepared by metal-organic chemical vapor deposition EI SCOPUS SCIE\n作者：Li, Zhao;Zhao, Cansong;Du, Xuejian;Mi, Wei;Luan, Caina;Feng, Xianjin;Ma, Jin\n作者机构：[Li, Z] School of Physics, Shandong University, Jinan, 250100, China;[ Zhao, C] School of Physics, Shandong University, Jinan, 250100, China;[ Du, X] School of Physics, Shandong University, Jinan, 250100, China;[ Mi, W] School of Physics, Shandong University, Jinan, 250100, China;[ Luan, C] School of Physics, Shandong University, Jinan, 250100, China;[ Feng, X] School of Physics, Shandong University, Jinan, 250100, China;[ Ma, J] School of Physics, Shandong University, Jinan, 250100, China\n来源：RSC Advances,RSC ADVANCES,2014,Vol.4,Issue.97,54300-54306\n7. 一种适合低信噪比投影栅的时空二维相移算法 EI CSCD SCOPUS\n作者机构：[周灿林] 山东大学物理学院, 济南, 山东 250100, 中国.;[刘业鹏] 山东大学物理学院, 济南, 山东 250100, 中国.;[司书春] 山东大学物理学院, 济南, 山东 250100, 中国.;[刘同川] 山东大学物理学院, 济南, 山东 250100, 中国.;[杨允鑫] 山东大学物理学院, 济南, 山东 250100, 中国\n来源：光电子·激光,Guangdianzi Jiguang/Journal of Optoelectronics Laser,2014,Vol.25,Issue.7,1389-1394\n8. Different influences of Schottky metal on the strain and relative permittivity of barrier layer between AlN/GaN and AlGaN/GaN heterostructure Schottky diodes\n作者机构：[吕元杰;冯志红;顾国栋;敦少博;尹甲运;王元刚;徐鹏;韩婷婷;宋旭波;蔡树军;栾崇彪;林兆军]National Key Laboratory of Application Specific Integrated Circuit,Hebei Semiconductor Research Institute;[吕元杰;冯志红;顾国栋;敦少博;尹甲运;王元刚;徐鹏;韩婷婷;宋旭波;蔡树军;栾崇彪;林兆军]School of Physics,Shandong University\n来源：Chinese Physics B,2014,Issue.02,430-434\n9. Interview Rate Distortion Analysis-Based Coarse to Fine Bit Allocation Algorithm for 3-D Video Coding EI SCOPUS SCIE\n10. Adaptive data acquisition algorithm in Raman distributed temperature measurement system EI SCOPUS SCIE\n作者：Z.L. Wang;S.S. Zhang;J. Chang;G.P. Lv;W.J. Wang;S. Jiang;X.Z. Liu;X.H. Liu;S. Luo;Y.N. Liu\n作者机构：[Wang, Z.L] School of Information Science and Engineering, Shandong Provincial Key Laboratory of Laser Technology and Application, Shandong University, Jinan 250100, China;[ Zhang, S.S] School of Information Science and Engineering, Shandong Provincial Key Laboratory of Laser Technology and Application, Shandong University, Jinan 250100, China;[ Chang, J] School of Information Science and Engineering, Shandong Provincial Key Laboratory of Laser Technology and Application, Shandong University, Jinan 250100, China;[ Lv, G.P] School of Information Science and Engineering, Shandong Provincial Key Laboratory of Laser Technology and Application, Shandong University, Jinan 250100, China;[ Wang, W.J] School of Information Science and Engineering, Shandong Provincial Key Laboratory of Laser Technology and Application, Shandong University, Jinan 250100, China;[ Jiang, S] School of Information Science and Engineering, Shandong Provincial Key Laboratory of Laser Technology and Application, Shandong University, Jinan 250100, China;[ Liu, X.Z] Institute of Automation Shandong, Academy of Sciences, Jinan 250014, China;[ Liu, X.H] School of Information Science and Engineering, Shandong Provincial Key Laboratory of Laser Technology and Application, Shandong University, Jinan 250100, China;[ Luo, S] School of Information Science and Engineering, Shandong Provincial Key Laboratory of Laser Technology and Application, Shandong University, Jinan 250100, China;[ Liu, Y.N] School of Information Science and Engineering, Shandong Provincial Key Laboratory of Laser Technology and Application, Shandong University, Jinan 250100, China\n来源：Optik: Zeitschrift fur Licht- und Elektronenoptik: = Journal for Light-and Electronoptic,OPTIK,2014,Vol.125,Issue.7,1821-1824\n11. 基于ANSYS的IGBT模块的失效模式 CSCD\n作者机构：[董少华] 中国科学院微电子研究所, 北京 100029, 中国.;[朱阳军] 中国科学院微电子研究所, 北京 100029, 中国.;[丁现朋] 山东大学物理学院, 济南, 山东 250100, 中国\n来源：物理与工程,Physics and Engineering,2014,Issue.S1,14-15+18\n13. Rectifying, giant magnetoresistance, spin-filtering, newgative differential resistance, and switching effects in single-molecule magnet Mn(dmit)_2-based molecular device with graphene nanoribbon electrodes EI SCOPUS SCIE\n作者：Qiu-Hua Wu;Peng Zhao;De-Sheng Liu;Shu-Juan Li;Gang Chen\n作者机构：[Wu, Q.-H] School of Physics and Technology, University of Jinan, Jinan, 250022, China;[ Zhao, P] School of Physics and Technology, University of Jinan, Jinan, 250022, China;[ Liu, D.-S] School of Physics, State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, China, Department of Physics, Jining University, Jining, 273155, China;[ Li, S.-J] School of Physics and Technology, University of Jinan, Jinan, 250022, China;[ Chen, G] School of Physics and Technology, University of Jinan, Jinan, 250022, China\n来源：Organic electronics,ORGANIC ELECTRONICS,2014,Vol.15,Issue.12,3615-3623\n15. 光电倍增管批量测试平台多协议软件系统的开发 CSCD SCOPUS\n17. Fabrication of Biomorphic La_(1-x)Sr_xFeO_3 Hollow Fibers with Gas Sensing Properties EI SCOPUS\n作者：Xiaofeng Wang;Jinliang Pei;Lihui Sun;Changmin Shi;Jifan Hu;Hongwei Qin\n作者机构：[Wang, X] School of Physics, State Key Laboratory for Crystal Materials, Shandong University, Jinan, 250100, China, School of Science, Dalian University of Technology at Panjin, Panjin, 124221, China;[ Pei, J] School of Physics, State Key Laboratory for Crystal Materials, Shandong University, Jinan, 250100, China;[ Sun, L] School of Physics, State Key Laboratory for Crystal Materials, Shandong University, Jinan, 250100, China;[ Shi, C] School of Physics, State Key Laboratory for Crystal Materials, Shandong University, Jinan, 250100, China;[ Hu, J] School of Physics, State Key Laboratory for Crystal Materials, Shandong University, Jinan, 250100, China;[ Qin, H] School of Physics, State Key Laboratory for Crystal Materials, Shandong University, Jinan, 250100, China\n来源：Sensor Letters: A Journal Dedicated to all Aspects of Sensors in Science, Engineering, and Medicine,Sensor Letters,2014,Vol.12,Issue.12,1689-1693\n来源：物理与工程,Physics and Engineering,2014,Issue.S1,173-175\n20. Spin-charge disparity of polarons in organic ferromagnets EI SCOPUS SCIE\n作者：G.C. Hu;H. Wang;J.F. Ren;S.J. Xie;C. Timm\n作者机构：[Hu, G.C] College of Physics and Electronics, Shandong Normal University, Jinan 250014, China, Institute of Theoretical Physics, Technische Universität Dresden, 01062 Dresden, Germany;[ Wang, H] College of Physics and Electronics, Shandong Normal University, Jinan 250014, China;[ Ren, J.F] College of Physics and Electronics, Shandong Normal University, Jinan 250014, China;[ Xie, S.J] School of Physics, Shandong University, Jinan 250100, China;[ Timm, C] Institute of Theoretical Physics, Technische Universität Dresden, 01062 Dresden, Germany\n来源：Organic electronics,ORGANIC ELECTRONICS,2014,Vol.15,Issue.1,118-125


url:
=Feizhou cao yuan tao sheng ji : Lions at lunchtime (Work) - San Francisco Public Library\nThe work Feizhou cao yuan tao sheng ji : Lions at lunchtime represents a distinct intellectual or artistic creation found in San Francisco Public Library. This resource is a combination of several types including: Work, Language Material, Books.\nThe Resource Feizhou cao yuan tao sheng ji : Lions at lunchtime\nContext of Feizhou cao yuan tao sheng ji : Lions at lunchtime\n
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url: =Study Development of Sophora japonic--《Guangdong Trace Elements Science》2006年06期\n《Guangdong Trace Elements Science》 2006-06\nStudy Development of Sophora japonic\nWU Hongji,LAN Changyun,CHEN Yuan (College of Materials and Chemical Engineering,Chengdu University of Technology,Chengdu 610059,China)\nSophora japonica is the flowers and buds of Sophora japonica L.mostly used in resisting inflammation,hemostasia,antivirus,and so on.A review with 39 references is given on study and development including chemical constituents,pharmacology,mensurations of the effective components and clinic application of Sophora japonica,etc.\n2 CHEN Yi, ZHANG Yin-zhu, SUN Shi-lei, YAO Wei-rong (School of Food Science & Technology, Jiangnan University, Wuxi 214122, China);Chemical Composition and Antimicrobial Activity of Essential Oil from Flos Sophorae Immaturus[J];Modern Food Science and Technology;2008-04\n3 XU Meng-meng,SHEN Jing,XU Chun,WANG Dong-shuo,WANG Hong,SUN Qi-ling*(College of Life Sciences,Key Laboratory of Biotesources and Eco-environment of Ministry of Education,Sichuan University,Chengdu 610064,China);Study on Increasing the Content of Quercetin in Flos Sophorae Immaturus by Solid State Fermentation[J];Lishizhen Medicine and Materia Medica Research;2008-03\n4 WANG Li-hua,DUAN Yu-feng,MA Yan-li,DING Hong-jun,LI Er-chun(Department of Food Engineering,Shaanxi Normal University,Xi'an,Shaanxi 710062,China);Studies on extraction and antioxidant function of polysaccharides from Sophora japonica[J];Journal of Northwest A & F University(Natural Science Edition);2008-08\n5 Rong XU Fu-lun LI Lin-ling ZHANG Xun SONG Jing-lin ZHU Bin LI Department of Dermatology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Herba Saxifragae cream in treatment of chronic eczema:a randomized controlled trial[J];Journal of Chinese Integrative Medicine;2008-12\n1 He Caixia,Cui Hua ,Zhao Xiaoyu,Zhao Huazhang and Zhao Guiwen (Department of Chemistry,University of Science and Technology of China,Hefei 230026);Determination of Rutin by Flow Injection with Chemiluminescence Detection[J];ANALYTICAL LABORATORY;1999-01\n2 CUI Hui TAO Xu-Quan ZHANG Ai-Mei JIA Li-Ping (Department of Chemistry,Liaocheng University,Liaocheng Shangdong 252059,P.R.China);Determination of Rutin by Catalytic Kinetic Spectrophotometry[J];Chinese Journal of Spectroscopy Laboratory;2003-05\n3 CHEN Gang 1, YE Jian nong 1, ZHANG Jian xia 2 (1. Department of Chemistry, East China Normal University, Shanghai 200062, China; 2. Department of Chemistry, Fudan University, Shanghai 200032, China);Determination of Rutin and Quercertin in Flos Sophorae Buds by Capillary Zone Electrophoresis with Electrochemical Detection[J];Journal of Eastchina Normal University(Natural Science);2001-04\n4 Dong Weihua;Zheng Zhimin;Liu Guiting Department of Pathophysiology;The research on the mutagenic effect of water extracts of Radix et Rhizoma Rhei,Flos Sophorae Immaturus and Flos Carthami[J];;1991-04\n5 QIAN Yan cong, LIU Jing deng, RONG Wen hui, ZHANG Shu feng (Department of Pharmacy, Bethune Military Medical College, Shijiazhuang 050081,China);Determination Content of Rutin by TLC Scanning from Leaf of Sophora japonica L.f. pendula Lound. Arb. Brit.[J];Primary Journal of Chinese Materia Medica;2002-01\n6 QIAN Yan cong 1,LIU Jing dong 1,Zhang Shu feng 1,Zou Chen yan 2,YU wen peng 1 (1.Bethune Military College, Shijiazhuang 050081,China; 2.The First Sanatorium of Hebei Provincial Military Region,Shijiazhuang 050000,China);Determination of Rutin in Flowers of Sophora japonica L. f. pendula Lound. Arb. Brit.[J];Research and Practice of Chinese Medicines;2003-03\n7 Song Yongfang Luo Jialiang Xie Hefeng (Research Institute of Chemical Processing and Utilization of Forest Products, CAF Nanjing 210037);STUDY ON THE CHEMICAL COMPOSITION CF ROBINIA PS EU DO AC ACIA FLOWERS[J];Chemistry & Industry of Forest Products;1992-04\n8 Fu Qiang, Liang Mingjin, ChangChun, He Langchong(College of Pharmacy, Xian Jiaotong University, Xian 710061);Determination of rutin in flor sophorae by thin layer chromatography-chemical deviation fluorospectrophotometry[J];Chinese Journal of Modern Applied Pharmacy;2002-02\n9 HS CHIH-FONG (Chinese Medical Academy,Shanghai First Medical College);THE CHEMICAL CONSTITUTION OF A CHINESE DRUG“HWAI-HUA-ME”(槐花米)——PART Ⅰ.HWAI-HUA-MENINE-A(or SORPHORINE A).[J];Acta Pharmaceutica Sinica;1957-03\n10 HSU CHIH-FONG (Department of Pharmacy,Medical Academy of China,Department of Pharmacy,First Medical College of Shanghai;THE CHEMICAL CONSTITUTION OF A CHINESE DRUG “HWAI-HWA-ME”PART Ⅲ.HWAI-HWA-MENINE-C(OR SORDHORINE C)[J];Acta Pharmaceutica Sinica;1957-04\n1 WANG Cong(1,2),WANG Guang-feng1,CHEN Dao-lei1,FANG Bin1 (1.School of Chemistry and Materials Science,Anhui Normal University, Wuhu,Anhui 241000,China;2.Lab of Photoelectric Chemistry,Department of Chemistry-Biology,Suzhou College,Suzhou,Anhui 234000,China);Electrocatalysis of Rutin at Aminylferrocene/Nanogold Modified Electrode[J];Journal of Anhui Normal University(Natural Science);2007-01\n2 WANG Mei-fang1,2,ZHANG Wei1,FANG Bin1 (1.College of Chemistry and Materials,Anhui Normal University,Wuhu 241000,China;2.Department of Chemistry,Wannan Medical College,Wuhu 241000,China);CeO_2 Nanorods Modified Glassy Carbon Electrode and Its Application for Electrochemical Determination of Rutin[J];Journal of Anhui Normal University(Natural Science);2009-02\n3 Li Baoxin, Liu Wei,Zhang Zhujun (Department of Chemistry, Shaanxi Normal University, Xi'an 710062);Fe(CN)_6~3- Chemiluminescence System for the Determination of Rutin[J];Chinese Journal of Analytieal Chemistry;2001-04\n4 Liu Daojie *, Zhang Aimei, Tian Linqin (Department of Chemistry, Liaocheng University, Liaocheng 252059);Catalytic Kinetic Spectrophotometric Determination of Rutin by Potassium Peridate-Butyl Rhodamine B System[J];Chinese Journal of Analytical Chemistry;2003-10\n5 Yan Jun, Liu Zhong-Fang, Liu Shao-Pu*(School of Chemistry and Chemical Engineering, Southwest China University, Chongqing 400715);Resonance Rayleigh Scattering Method for the Determination of Quercetin with Hg(Ⅱ)-Quercetin Chelate[J];Chinese Journal of Analytical Chemistry;2007-01\n6 CAI Ru xiu, HE Zhi ke and LIU Zhi hong (Department of Chemistry, Wuhan University, Wuhan 430072);Photometric analysis[J];Analytical Laboratory;2001-05\n8 LAI Xiao-qi and LUO Guo-tian(Department of Chemistry and Life Science,Gannan Teacher′s College,Ganzhou 341000);Study on determination of quercetin by discoloring kinetic spectrophotometry of methyl orange[J];Chinese Journal of Analysis Laboratory;2006-07\n9 SHAO Cheng-bin~,WU Si-wei,TIAN Long and ZHANG Zhong(Environmental and Biological engineering College,Chongqing Technology and Business University,Chongqing 400067);Determination of rudin in Chinese herb medicines by its polarographic catalytic wave[J];Chinese Journal of Analysis Laboratory;2006-11\n10 CUI Hui TAO Xu-Quan ZHANG Ai-Mei JIA Li-Ping (Department of Chemistry,Liaocheng University,Liaocheng Shangdong 252059,P.R.China);Determination of Rutin by Catalytic Kinetic Spectrophotometry[J];Chinese Journal of Spectroscopy Laboratory;2003-05\n1 ;clinical observation of the effects of BaoShao Ointment on wound healing after anal fistula operation[A];[C];2007\n2 FENG Ting,HE Cong-fen,ZHAO Hua,DONG Yin-mao(College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, China);REVIEW ON STUDIES OF PLANT POLYSACCHARIDES[J];Journal of Beijing Technology and Business University (Natural Science Edition);2004-05\n3 Yin Che ngzeng(Northeast Forestry University, Harbin 150040, P. R. China);Qualitative Analysis of Volatile Substances from Lilac[J];Journal of Northeast Forestry University;2005-02\n4 Chen Feiyan. People's Hospital of Maoming City, Guangdong Province 525000;CLININCAL CONTROLLED TRIAL OF OPEN AND CLOSED HEMORRHOIDECTOMY[J];Journal of Coloproctological Surgery;2001-04\n5 Fan Xiaohua,Ren Donglin,Luo Zhanbin,Zhang Xun.Department of Colorectal Surgery,the Second Affiliated Hospital,Guangzhou University of Traditional Chinese Medicine (Guangzhou,510120);Evaluation of Clinical Curative Effect of Combined Operation in PPH[J];Journal of Coloproctological Surgery;2003-04\n6 Cheng Chaowen,Zhan Xuebing,Chen Hong,the 3rd Affiliated Hospital of Peclsing University Beijing 100020 China;Preliminary Exploration of Small-dose Caudal Block for Surgery of Anorectal Diseases[J];Journal of Coloproctological Surgery;2004-02\n7 Lu Bing,Lui Yu Xiang,Zhou Kun,et al.Department of General Surgery,Shanghai Corps Hospital,Chinese People's Armed Police Forces,Shanghai 201103 China;Evaluation of the Combined Therapy of Segmental External Hemorrhoids Resected and Injection of Internal Hemorrhoids with Dentate Line Retainted[J];Journal of Coloproctological Surgery;2005-01\n8 MA Chun,DONG Xiu-ping,ZHU Bei-wei(School of Biological & Foodstuff Engineering, Dalian Institute of Light Industry,Dalian 116034,China);Extraction of Intracellular polysaccharides from Agaricus blazei Murill by compound hydrolyzation[J];Journal of Dalian Institute of Light Industry;2005-03\n9 MA Yan-ming~(1,2),Abulimiti·Yi-li~1,LIAO Li-xin~1,HajiAkber·Aisa~(1*)(1 Xinjiang Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Urumqi 830011,China;2 Graduate School of the Chinese Academy of Sciences,Beijng 100039,China);Analysis of Essential Oil from Seriphidium transiliense by GC-MS[J];Acta Botanica Boreali-occidentalia Sinica;2005-05\n10 YU Hai-qin,ZHANG Tian-zhu,WEI Chun-yan~*,LI Zhi-jian (Institute of Grassland Science of Northeast Normal University,Key Laboratory of Ecological Restoration and Ecosystem Management of Jilin Province,Changchun 130024,China);Fat Contents and Fatty Acid Composition in the Seeds of Three species of Suaeda[J];Acta Botanica Boreali-occidentalia Sinica;2005-10\n1 YUAN Er-dong1,XIAO Zi-jun2,LIU Ben-guo 3,NING Zheng-xiang1,XIE Mei-fang1(1.College of Light Industry and Food Science,South China University of Technology,Guangzhou 510640,China)(2.Collgege of Food Science and Engineer,Shaoguan University,Shaoguan 512005,China)(3.School of Food Science,Henan Institute of Science and Technology,Xinxiang 453003,China);Extraction and Antimicrobial Activity of Flavonoids from Adinandra nitida Leaves[J];Modern Food Science and Technology;2009-03\n2 YI Yong-tao et al(Zhengzhou Tobacco Research Institute,Zhengzhou,Henan 450001);Study on Extraction of Volatile Components from Morinda officinalis How by Different Methods[J];Journal of Anhui Agricultural Sciences;2009-24\n3 KANG Wen-yi 1,2 WU Xiao-hong (1.Institute of Natural Products,Henan University,Kaifeng,Henan 475004,China;2.Pharmaceutical College of Henan University,Kaifeng 475004,China);Analysis of fatty acids from flower,bud and leaves of Sophora japonica L. by GC-MS[J];Journal of Henan University(Medical Science);2009-01\n4 LIU Hong-bo,et al (College of Forestry and Biotechnology, Zhe Jiang Forestry University, Lin'an 311300,China);Research Progress of Antibacterial Activity of Plant Essential Oil[J];Animal Husbandry and Feed Science;2009-01\n5 YANG Jie,Li Zhong-hai,HUANG Ling,LI Ji-lie,WEN Rong,CUI Pei-wu(Central South University of Forestry & Technology,Changsha 410004,China);Antimicrobial Activity of the Volatile Oil from Valeriana officinalis L.[J];Lishizhen Medicine and Materia Medica Research;2009-07\n6 HUANG Haixia,FU Qiang,CHEN Xiao,CHANG Shengxin,ZHANG Xiaotong,LIU Meijia and ZHANG Tao(Agricultural College,He′nan University of Science and Technology,Luoyang 471003,China);Study on Antioxidant Capacities of Paeonia lactiflora Extracts[J];Acta Agriculturae Boreali-Occidentalis Sinica;2009-04\n2 Nie Feng,Li Liqing,Feng Manliang and Lu Jiuru  (Department of Chemistry,Shannxi Normal University,Xi'an 710062);An Investigation of Chemiluminescence Reaction in Sodium Hypochlorite Rutin Semicarbazide Hydrochloride System[J];ANALYTICAL LABORATORY;1999-01\n3 Zhang Hongzhi;Guan Zhengxue;Tian Xiaoya(Commission for Integrated Survey of Natural Resources, The Chinese Academy of Sciences, Beijing 100101,P.R.China);Determination of Rutin in Fagopyrum by Spectrophotometric Method[J];CHINESE JOURNAL OF SPECTROSCOPY LABORATORY;1996-03\n4 WANGTian_shi,YANGWen_wei,LIUAi_lian (BiologyDepartment,Henanuniversity,Kaifeng 475 0 0 1,Henan,China);Effects of Flos Sophorae Solution on Myocardium Monophasic Action Potential sand Vigor of Cardiac Contractionin Frog[J];JOURNAL OF HENAN UNIVERSITY (NATURAL SCIENCE);2000-01\n5 Qian Guangsheng;Li Zhangwan;Liu Sankang(School of Pharmacy,West China University of Medical Sciences Chengdu 610041)Rong Ailan(Institute for Control of Kun Ming Kunming 650034);DETERMINATION OF RUTIN IN PRODUCTS OF GINKGO BILODA L.AND FAGOPYRUM ESCULENTUM MOENCH BY RP-HPLC[J];WEST CHINA JOURNAL OF PHARMACEUTCAL SCIENCES;1996-01\n6 WANG SHU-RU AND CHEN QIONG-HUA (Nanking College of Pharmacy,Nanking);STUDIES OF CHINESE RHUBARB——ⅫⅠ.INTERACTION OF ANTHRAQUINONE DERIVATIVES OF CHINESE RHUBARB WITH DNA[J];生物化学与生物物理学报;1977-01\n7 Gu Xiaoman and Li Lei (Center of Analysis and Testing , Wuhan Institute of Chemical Technology,Wuhan, 430074);Measurement of Rutinum in Leaves of Ginkgo Biloba with Reversed-Phase High Performance Liquid Chromatography(HPLC)[J];CHINESE JOURNAL OF CHROMATOGRAPHY;1995-03\n8 QIAN Yan-cong, LIU Jing-dong, HUANG Fan, QU Jun, WANG Fang (Department of Pharmacy, Bethune Military Medical College, Shijiazhuang 050081, China);The Identification of Rutin in the Flower of Sophora japonica L. f. pendula Loud. Arb. Brit. by TLC and UV[J];LiShiZhen Medicine and Materia Medica Research;2003-02\n9 Li Wci￣1 ; Du Nianshen￣1; Zhao Ying￣2 1Department of Pharmacy,Xinjiang Medical College 2Department of Organic Chemistry,Xinjiang University;Determination of Rutin in Saussurea Involucrata byTLCS[J];Journal of Xinjiang Medical University;1995-02\n10 Liu Dcxiang ct al.;An Observation of Cell Chromosome Damage on Datura Alkaloids[J];Hereditas(Beijing);1988-01


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url: =Guifang Chen; Xiaofei Sun; Yunqi Feng; Zhanlong Song；Lin Cui；Yanpeng Mao；Chunyuan Ma; Shouyan Chen*, Desorption of CO2, SO2, and NH3 in the vacuum evaporation of desulfurization wastewater, Environmental science and pollution research, 2021, (28): 6664-6674.\nGuifang Chen, Xinfei Yang, Shouyan Chen, Yong Dong, Lin Cui, Yong Zhang, Peng Wang, Xiqiang Zhao, Chunyuan Ma*, Transformation of heavy metals in lignite during supercritical water gasification, Applied Energy, 2017,187:272-280\nGuifang Chen, Shouyan Chen, Yong Zhang, Yongqiang Hong, Zhanlong Song, Xiqiang Zhao, Chunyuan Ma*, Transformation of potassium and sodium during the supercritical water gasification process, Journal of Analytical and Applied Pyrolysis, 2016,120:231-237\nGuifang Chen, Shouyan Chen, Zhanlong Song, Xiqiang Zhao, Chunyuan Ma*, Lignite sulfur transformation during the supercritical water gasification process, Journal of Analytical and Applied Pyrolysis, 2015, 116:161-167\n洪永强, 陈桂芳*, 马春元, 毛岩鹏, 杨德萍, 刘晓, 沈荣胜, 湿法脱硫废水液柱蒸发特性研究, 化工进展, 2017, 36(7): 2698-2706\n洪永强, 陈桂芳*, 毛岩鹏, 马春元, 湿法脱硫浆液的真空蒸馏特性, 2016, 35（8）:2561-2568\nGuifang Chen, Yong Zhang, Shouyan Chen,et al.Element transformation and gaseous products distribution in supercritical water[J].Applied Mechanics and Materials,2014,448-453: 2999-3004(EI)\nGuifang Chen, Yong Zhang, Shouyan Chen,et al.Content and speciation of heavy metals in residues of used tires treated with supercritical water [J].Applied Mechanics and Materials,2014,448-453:3082-3087(EI)\nYuzhong Li* , Min Yan, Liqiang Zhang, Guifang Chen, Lin Cui, Zhanlong Song, Jingcai Chang, Chunyuan Ma. Method of flash evaporation and condensation - heat pump for deep cooling of coal-fired power plant flue gas: Latent heat and water recovery, Applied Energy, 2016, 172: 107-117\nJiaming Zhang, Chunyuan Ma*, Fengming Zhang, Guifang Chen. Supercritical water oxidation of N-phenylglycinonitrile wastewater, Desalination and Water Treatment, 2013, 51:3398-3407.\nXiqiang Zhao, Bingwen Guo, Wenlong Wang, Guifang Chen, Zhanlong Song*.Experimental study on microwave pyrolysis of three Chinese lignite, Journal of Analytical and Applied Pyrolysis,2017,124:303-309\n陈桂芳,马春元,毛岩鹏,闫云涛,陈守燕,闫敏,洪永强,万象明,基于真空蒸发兼热能利用的有机含盐废水处理系统, 2017.09.22,中国, ZL201720023952.4\n马春元,李玉忠,张立强,陈桂芳,崔琳,常景彩,杜谦,高秀丽,刘晓,高建民,一种燃煤电厂烟气回热系统及节能节水超净排放方法, 2017.06.13,中国, ZL 20151 0368606.5\n马春元,陈桂芳,崔琳,张立强,常景彩,李玉忠,刘晓,高秀丽,一种基于湿法脱硫的浆液真空蒸馏系统及工艺, 2017.5.17,中国, ZL201510309835.X\n马春元,张凤鸣,陈桂芳,徐纯燕,陈守燕, 一种超临界水氧化流体注采工艺, 2014.07.16,中国,ZL201110151407.0


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url: =Effect of antisense oligodeoxynucleotides against hTERT on proliferation and apoptosis of human Tca8113 cancer cell--《Acta Academiae Medicinae Militaris Tertiae》2006年24期\nEffect of antisense oligodeoxynucleotides against hTERT on proliferation and apoptosis of human Tca8113 cancer cell\nYAO Chen 1,YAO Hua 2,WU Qiu-liang 2,TAN Long-yi 1,FAN Jun 3,SHI Zhang-ying4(1Department of Experimental Diagnosis,Changzheng Hospital,Second Military Medical University,Shanghai 200003;2Department of Stomatology,The First Affiliated Hospital,3Research Institute of Infectious Disease,College of Medicine,Zhejiang University,Hangzhou 310003,4Department of Laboratory Medicine,No.113 Hospital of PLA,Ningbo 315040,China)\nObjective To study the effect of antisense oligodeoxynualeotides against hTERT on proliferation and apoptosis of human tongue Tca8113 cancer cell.Methods Morphology of Tca8113 cells was observed under microscope.The proliferation of Tca8113 cells was detected by MTT assay.Cell cycles and apoptosis were examined by flow cytometry(FCM).DNA of Tca8113 cells was extracted and identified by gel electrophoresis for evidence “DNA ladder”.The data were analyzed by one-way ANOVA of SPSS 11.0 for windows.Results ASODN inhibited the proliferation of Tca8113 cells significantly,as compared with controls(P0.05),in both time-dependent and dose-dependent manner.The cells of control groups kept exponential reproduce ability.FCM analysis and the DNA ladder also showed that cells treated with ASODN arrested in G_1/G_0,the ratio of cells in S period was reduced and apoptosis rate of Tca8113 cells treated with ASODN for 72 h was significantly increased in comparison with control groups(P0.05).No significant difference was found among the control groups.Conclusion Antisense oligodeoxynucleotides against hTERT could inhibit the proliferation of human Tca8113 cancer cell and promote cell apoptosis.\n1 TIAN Feng-Jun1, WANG Zhi-Yong2, MA Jun-Yi3, ZHAO Yun-Xia1, LU Wei11. Department of Respiratory Medicine, The Third Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050051, P.R.China2. Department of Critical Care Medicine, The Third Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050051, P.R.China3. Department of Respiratory Medicine, The second Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050051, P.R.China;Inhibitory Effect of hTERT dsRNA on Telomerase Activity in Lung Carcinoma Cell Line A549[J];Chinese Journal of Cancer;2005-03\n1 JING Kang-zhen reviewing,GAO Jian-ping,CHENG Wen checking(Department of Urology,School of Medicine,Second Military Medical University,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China);Gene therapy for bladder cancer: past and future[J];Journal of Medical Postgraduates;2007-08\n2 WANG Guo-yu1,XIA Wei1,ZHANG Yu-na1,LI Yan2,ZHU Xue-ping1,WANG Ying3,NI Jing1 1.Department of Nuclear Medicine,Shanghai Putuo District People's Hospital,Shanghai 200060,P.R.China 2.Central Laboratory,Shanghai First Maternity and Infant Hospital,Tongji University,Shanghai 200040,P.R.China 3.Department of Nuclear Medicine,Shanghai Xuhui District Central Hospital,Shanghai 200031,P.R.China;Anti-cancer effect of siRNA targeting human telomerase reverse transcriptase in SW480 cells[J];Chinese Journal of Cancer Prevention and Treatment;2011-21\n3 HU Wei, HAO Jun-yuan, ZHANG Hui-ying, et al (Department of Biochemistry and Moelecular Biology, College of Life Science, Jilin Agriculture University, Changchun 130118, China);Induction of Tumor Cell Apoptosis by HSV-TK Suicide Gene System under Control of hTERT Core Promoter[J];Chinese Journal of Biologicals;2008-09\n4 Zhao Jiao Yu Hong Zhao Xiaoping et al Department of Biology and Genetics,Luzhou Medical College (Luzhou 646000);Effect evaluation of siRNA expression vector to hTERT[J];Shaanxi Medical Journal;2009-01\n1 Tian Feng Jun1, Wang Zhi Yong2, Ma Jun Yi3, Zhao Yun Xia1, Lu Wei1 1.Department of Respiratory Disease, The Third Hospital of Hebei Medical University, Shijiazhuang,Hebei,050051, P.R.China 2.Department of Emergency, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, P.R.China 3.Department of Respiration, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, P.R.China;Inhibition of Anti-sense Human Telomerase Reverse Transcriptase (hTERT) Retroviral Vector on Lung Cancer Cells[J];Chinese Journal of Cancer;2004-05


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url: =About: Shen Prefecture\nAbout: Shen Prefecture Goto Sponge NotDistinct Permalink\nShenzhou or Shen Prefecture (Chinese: 深州) was a zhou (prefecture) in imperial China centering in modern Shenzhou, Hebei, China. It existed (intermittently) from 596 to 1913. The modern city Shenzhou, established in 1994, retains its name.\n深州，中国隋朝时始置的州。 开皇十六年（595年）置，以故深城为名，治所在安平县（今属河北省）。大业二年（605年）省。唐朝武德四年（621年）析定州、地复置，仍治安平县，同年为反唐军阀刘黑闼所据，徙治饶阳县（今属河北省）。贞观十七年（643年）又省。先天二年（713年）分瀛、冀、定三州地复置，治所在（即今河北省深州市西南旧州），辖境相当今河北省深州、安平、饶阳、辛集等市县地。 北宋雍熙四年（987年）徙治（今深州市南）。南宋嘉定八年（1215年），领导在此战败金兵，攻克州城。 元朝时，深州辖境缩小，仅有今深州、衡水二市地。明朝永乐十年（1412年），省静安县入州，徙治今深州市。清朝雍正二年（1724年）升深州直隶州，辖境相当今深州、安平、饶阳、武强等县地。1913年，省州改为深县。 这是一个关于的小作品。你可以通过编辑或修订扩充其内容。


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url: =AI作为一种强大的数据挖掘和分析技术已经涉及新药研发的各个阶段，有望推动创新药物先导分子的筛选、设计和发现，但基于AI的数据驱动式创新药物设计和筛选方法仍存在若干亟待解决的问题。我们课题组的核心研究方向是围绕药物设计中的难点问题，应用大数据和AI技术发展高精度及高效的活性分子虚拟筛选方法、成药性预测方法、全新结构设计方法、逆合成预测方法以及靶标预测方法等，并开发整合的高精度药物设计和筛选软件平台。例如，我们开发了基于知识图谱和推荐系统的药物-靶标相互作用预测方法KGE-NFM，其在多个基准数据集上比传统方法表现出更优的预测精度 ；发展了基于Transformer、知识蒸馏（knowledge distillation）和强化学习的多约束分子生成新方法MCMG，其可以高效遍历复杂的化学空间以寻找满足多种性质约束的新型化合物，为先导结构的发现提供了功能强大的计算工具（图1）[2~3]；发展了一种新型的基于图表示学习的蛋白-小分子相互作用的打分方法IGN，其性能显著优于同类机器学习打分方法和分子对接程序 ；系统研究了机器学习打分函数中的若干关键问题，开发了蛋白-小分子相互作用特征提取、个性化打分函数构建以及虚拟筛选在线计算平台ASFP [4~8]；创造性提出了计算生物靶标谱（CBFP）的概念，并将其作为新型分子表征实现骨架跃迁的新思路，成功发现具有全新骨架的强效PARP1抑制剂和DprE1抑制剂，证明其与传统化学表征相比具有更优的新骨架发现能力 [9~10]。\n图 1. MCMG方法的工作流程图。\n开发出一系列ADMET和成药性理论预测方法和模型，包括水溶性（logS）、油/水分配系数（logP）、Caco-2渗透性、肠吸收、口服生物利用度、hERG心脏毒性、血脑屏障（BBB）、P-gp蛋白转运、孕烷X受体激活、呼吸毒性、泌尿系统毒性、急性毒性、频繁命中化合物、类药性等 [11~16]；针对小样本成药性数据预测精度差的难题，运用迁移学习、多任务学习、自监督学习等新型AI技术发展了快速精准的成药性预测方法（如多任务图注意力框架MGA和基于预训练的图网络模型MG-BERT和K-BERT），有效提升了多个成药性任务的预测精度，特别是对于样本较少的任务提升幅度更为显著 [17~19]；在长期方法学研究基础上，开发了关键成药性参数在线软件平台ADMETLab2.0，可实现17种物化性质、13种药物化学性质、24种成药性参数、27种毒性性质及8种毒性团规则的系统性评价，是目前国际上成药性参数评价最多、速度最快、预测精度最为优秀的免费在线计算平台之一 。\n图 2. ADMETlab 2.0的预测结果展示页面。\n1. Qing Ye, Chang-Yu Hsieh, Ziyi Yang, Yu Kang, Jiming Chen, Dongsheng Cao*, Shibo He*, Tingjun Hou*, A unified drug-target interaction prediction framework based on knowledge graph and recommendation system, Nature Communications, 2021, 12, 6775.\n2. Jike Wang, Chang-Yu Hsieh, Mingyang Wang, Xiaorui Wang, Zhenxing Wu, Dejun Jiang, Benben Liao, Xujun Zhang, Bo Yang, Qiaojun He, Dongsheng Cao*, Xi Chen*, Tingjun Hou*, Multi-constraint molecular generation based on conditional transformer, knowledge distillation and reinforcement learning, Nature Machine Intelligence, 2021, 3, 914-922.\n3. Mingyang Wang, Zhe Wang, Huiyong Sun, Jike Wang, Chao Shen, Gaoqi Weng, Xin Chai, Honglin Li*, Dongsheng Cao*, Tingjun Hou*, Deep learning approaches for de novo drug design: an overview, Current Opinion in Structural Biology, 2022, 72, 135-144.\n4. Dejun Jiang, Chang-Yu Hsieh, Zhenxing Wu, Yu Kang, Jike Wang, Ercheng Wang, Ben Liao, Chao Shen, Lei Xu, Jian Wu*, Dongsheng Cao*, Tingjun Hou*, InteractionGraphNet: a novel and efficient deep graph representation learning framework for accurate protein-ligand interaction predictions, Journal of Medicinal Chemistry, 2021, 64, 18209-18232.\n5. Chao Shen, Ye Hu, Zhe Wang, Xujun Zhang, Haiyang Zhong, Gaoang Wang, Xiaojun Yao, Lei Xu, Dongsheng Cao*, Tingjun Hou*, Can machine learning consistently improve the scoring power of classical scoring functions? Insights into the role of machine learning in scoring functions, Briefings in Bioinformatics, 2021, 22, 497-514.\n6. Chao Shen, Ye Hu, Zhe Wang, Xujun Zhang, Jinping Pang, Gaoang Wang, Haiyang Zhong, Lei Xu, Dongsheng Cao*, Tingjun Hou*, Beware of the generic machine learning-based scoring functions in structure-based virtual screening, Briefings in Bioinformatics, 2021, 22, bbaa070.\n7. Chao Shen, Junjie Ding, Zhe Wang, Dongsheng Cao, Xiaoqin Ding, Tingjun Hou*, From machine learning to deep learning: advances in scoring functions for computational docking, WIRES Computational Molecular Science, 2020, 10, e1429.\n8. Xujun Zhang, Chao Shen, Xueying Guo, Zhe Wang, Gaoqi Weng, Qing Ye, Gaoang Wang, Qiaojun He, Bo Yang*, Dongsheng Cao*, Tingjun Hou*, ASFP (Artificial Intelligence based Scoring Function Platform): a web server for the development of customized scoring functions, Journal of Cheminformatics, 2021, 13, 6.\n9. Guoli Xiong, Yue Zhao, Lu Liu, Zhongye Ma, Aiping Lu, Yan Cheng, Tingjun Hou*, Dongsheng Cao*, Computational bioactivity fingerprint similarities to navigate the discovery of novel scaffolds, Journal of Medicinal Chemistry, 2021, 64, 7544-7554.\n10. Xueping Hu, Liu Yang, Xin Chai, Yixuan Lei, Md Shah Alam, Lu Liu, Chao Shen, Dejun Jiang, Zhe Wang, Zhiyong Liu, Lei Xu, Kanglin Wan, Tianyu Zhang, Yuelan Yin, Dongsheng Cao*, Dan Li*, Tingjun Hou*, Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening, Acta Pharmacologica Sinica, 2022, in press.\n11. Sheng Tian, Junmei Wang, Youyong Li, Dan Li, Lei Xu, Tingjun Hou*, The application of in silico drug-likeness predictions in pharmaceutical research, Advanced Drug Delivery Reviews, 2015, 86, 2-10.\n12. 12. Tailong Lei, Huiyong Sun, Yu Kang, Feng Zhu. Hui Liu, Wenfang Zhou, Zhe Wang, Dan Li, Youyong Li, Tingjun Hou*, ADMET evaluation in drug discovery. 18. Reliable prediction of chemical-induced urinary tract toxicity by boosting machine learning approaches, Molecular Pharmaceutics,2017, 14, 3935-3953.\n13. Tailong Lei, Fu Chen, Hui Liu, Huiyong Sun, Yu Kang, Dan Li, Youyong Li, Tingjun Hou*, ADMET evaluation in drug discovery. 17. Development of quantitative and qualitative prediction models for chemical-induced respiratory toxicity, Molecular Pharmaceutics, 2017, 14, 2407-2421.\n14. Zhenxing Wu, Tailong Lei, Chao Shen, Zhe Wang, Dongsheng Cao, Tingjun Hou*, ADMET Evaluation in Drug Discovery. 19. Reliable Prediction of Human Cytochrome P450 Inhibition Using Artificial Intelligence Approaches, Journal of Chemical Information and Modeling, 2019, 59, 4587-4601.\n15. 15. Ziyi Yang, Junhong He, Aiping Lu, Tingjun Hou*, Dongsheng Cao*, The Application of Negative Design to Design More Desirable Virtual Screening Library, Journal of Medicinal Chemistry, 2020, 63, 4411-4429.\n16. Tailong Lei, Huiyong Sun, Yu Kang, Feng Zhu. Hui Liu, Wenfang Zhou, Zhe Wang, Dan Li, Youyong Li, Tingjun Hou*, ADMET evaluation in drug discovery. 18. Reliable prediction of chemical-induced urinary tract toxicity by boosting machine learning approaches, Molecular Pharmaceutics, 2017, 14, 3935-3953.\n17. Zhenxing Wu, Dejun Jiang, Jike Wang, Chang-Yu Hsieh*, Dongsheng Cao*, Tingjun Hou*, Mining Toxicity Information from Large Amounts of Toxicity Data, Journal of Medicinal Chemistry, 2021, 64, 6924-6936.\n18. Xiaochen Zhang, Chengkun Wu, Zhijiang Yang, Zhenxing Wu, Jiacai Yi, Changyu Hsieh, Tingjun Hou*, Dongsheng Cao*, MG-BERT: leveraging unsupervised atomic representation learning for molecular property prediction, Briefings in Bioinformatics, 2021, 22, bbab152.\n19. Zhenxing Wu, Dejun Jiang, Jike Wang, Xujun Zhang, Hongyan Du, Lurong Pan, Changyu Hsieh*, Dongsheng Cao*, Tingjun Hou*, Knowledge-based BERT: a method to extract molecular features like computational chemists, Briefings in Bioinformatics, 2022, bbac131.\n20. Guoli Xiong, Zhenxing Wu, Jiacai Yi, Li Fu, Zhijiang Yang, Changyu Hsieh, Mingzhu Yin, Xiangxiang Zeng, Chengkun Wu, Aiping Lu, Xiang Chen, Tingjun Hou*, Dongsheng Cao*, ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties, Nucleic Acids Research, 2021, 49(W1), W5-W14.\n基于分子对接的虚拟筛选成本低、效率高，已成为药物发现的关键技术。分子对接采用的打分函数计算效率高但准确性相对较低，而且其往往忽略了靶蛋白柔性的影响。为提高虚拟筛选的预测精度，申请人围绕靶标-配体相互作用预测展开了深入系统的方法学研究，开发了一系列针对药物设计和筛选的计算工具和软件，并应用于多个重要靶标的药物研究。我们从2009年起对MM/PB(GB)SA方法中的若干核心理论问题进行了系统研究，深入探讨和评估了分子力场、溶剂化模型、原子电荷、构象熵、动力学采样时间等多种因素对MM/GBSA预测精度的影响，并针对不同体系提出了最优的预测策略 [1~11]；针对传统MM/GBSA方法无法有效表征蛋白-配体相互作用界面的非均一极性环境的这一固有缺陷，创造性地发展了基于可变介电的VD-MM/GBSA结合自由能预测方法，其根据残基的物化性质和化学环境对其介电常数进行优化，有效提升了蛋白-配体结合自由能的预测精度 [12~13]；在长期方法学研究的基础上，开发了CaFE、farPPI和HawkDock等一系列基于MM/PB(GB)SA方法的药物设计和筛选计算工具 [14~16]。\n图 3. 整合的虚拟筛选策略流程图。\n1. Ercheng Wang, Huiyong Sun, Junmei Wang, Zhe Wang, Hui Liu, John Z.H. Zhang*, Tingjun Hou*, End-Point binding free energy calculation with MM/PBSA and MM/GBSA: strategies and applications in drug design, Chemical Reviews, 2019, 119, 9478-9508.\n2. Ercheng Wang, Gaoqi Weng, Huiyong Sun, Hongyan Du, Feng Zhu, Fu Chen, Zhe Wang, Tingjun Hou*, Assessing the performance of the MM/PBSA and MM/GBSA methods. 10. Impacts of Enhanced Sampling and Variable Dielectric Model on Protein-Protein Interactions, Physical Chemistry Chemical Physics, 2019, 21, 18958-18969.\n3. Gaoqi Weng, Ercheng Wang, Fu Chen, Huiyong Sun, Zhe Wang, Tingjun Hou*, Assessing the performance of the MM/PBSA and MM/GBSA methods. 9. Prediction reliability of binding affinities and binding poses for protein-peptide complexes, Physical Chemistry Chemical Physics, 2019, 21, 10135-10145.\n4. Fu Chen, Huiyong Sun, Junmei Wang, Feng Zhu, Hui Liu, Zhe Wang, Tailong Lei, Youyong Li, Tingjun Hou*, Assessing the performance of MM/PBSA and MM/GBSA methods. 8. Predicting binding free energies and poses of protein-RNA complexes, RNA, 2018, 24, 1183-1194.\n5. Huiyong Sun, Lili Duan, Fu Chen, Hui Liu, Zhe Wang, Peichen Pan, Feng Zhu, John Z. H. Zhang, Tingjun Hou*, Assessing the performance of MM/PBSA and MM/GBSA methods. 7. Entropy effects on the performance of end-point binding free energy calculation approaches, Physical Chemistry Chemical Physics, 2018, 20, 14450-14460.\n6. Fu Chen, Hui Liu, Huiyong Sun, Peichen Pan, Youyong Li, Dan Li, Tingjing Hou*, Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein-protein binding free energies and re-rank binding poses generated by protein-protein docking, Physical Chemistry Chemical Physics, 2016, 18, 22129-22139.\n7. Huiyong Sun, Youyong Li, Mingyun Shen, Sheng Tian, Lei Xu, Peichen Pan, Yan Guan, Tingjun Hou*, Assessing the Performance of MM/PBSA and MM/GBSA Methods. 5. Improved Docking Performance by Using High Solute Dielectric Constant MM/GBSA and MM/PBSA Rescoring, Physical Chemistry Chemical Physics, 2014, 16, 22035-22045.\n8. Huiyong Sun, Youyong Li, Sheng Tian, Lei Xu, Tingjun Hou*, Assessing the Performance of MM/PBSA and MM/GBSA Methods. 4. Accuracies of MM/PBSA and MM/GBSA Methodologies Evaluated by Various Simulation Protocols using PDBbind Data Set, Physical Chemistry Chemical Physics, 2014, 16, 16719-16729.\n9. Lei Xu, Huiyong Sun, Youyong Li, Junmei Wang, Tingjun Hou*, Assessing the Performance of MM/PBSA and MM/GBSA Methods. 3. The Impact of Force Fields and Ligand Charge Models, Journal of Physical Chemistry B, 2013, 117, 8408-8421.\n10. Tingjun Hou*, Junmei Wang, Youyong Li, Wei Wang*, Assessing the performance of the Molecular Mechanics/Poisson Boltzmann Surface Area and Molecular Mechanics/ Generalized Born Surface Area methods. II. The accuracy of ranking poses generated from docking, Journal of Computational Chemistry, 2011, 32, 866-877.\n11. Tingjun Hou*, Junmei Wang, Youyong Li, Wei Wang*, Assessing the performance of the MM/PBSA and MM/GBSA methods: I. The accuracy of binding free energy calculations based on molecular dynamics simulations, Journal of Chemical Information and Modeling, 2011, 51, 69-82.\n12. Ercheng Wang, Weitao Fu, Dejun Jiang, Huiyong Sun, Junmei Wang, Xujun Zhang, Gaoqi Weng, Hui Liu, Peng Tao, and Tingjun Hou*, VAD-MM/GBSA: A Variable Atomic Dielectric MM/GBSA Model for Improved Accuracy in Protein–Ligand Binding Free Energy Calculations, Journal of Chemical Information and Modeling, 2021, 61, 2844-2856.\n13. Ercheng Wang, Hui Liu, Junmei Wang, Gaoqi Weng, Huiyong Sun, Zhe Wang, Yu Kang, Tingjun Hou*, Development and Evaluation of MM/GBSA Based on a Variable Dielectric GB Model for Predicting Protein-Ligand Binding Affinities, Journal of Chemical Information and Modeling, 2020, 60, 5353-5365.\n14. Gaoqi Weng, Ercheng Wang, Zhe Wang, Hui Liu, Feng Zhu, Dan Li, Tingjun Hou*, HawkDock: a web server to predict and analyze the protein-protein complex based on computational docking and MM/GBSA, Nucleic Acids Research, 2019, 47, W322-W330.\n15. Hui Liu, Tingjun Hou*, CaFE: a tool for binding affinity prediction using end-point free energy methods, Bioinformatics, 2016, 32, 2216-2218.\n16. Zhe Wang, Xuwen Wang, Youyong Li, Tailong Lei, Ercheng Wang, Dan Li, Yu Kang, Feng Zhu, Tingjun Hou*, farPPI: a webserver for accurate prediction of protein-ligand binding structures for small-molecule PPI inhibitors by MM/PB(GB)SA methods, Bioinformatics, 2019, 35, 1777-1779.\n17. Tingjun Hou*, Nan Li, Youyong Li, Wei Wang*, Characterization of domain-peptide interaction interface: prediction of SH3 domain-mediated protein-protein interaction network in yeast by generic structure-based models, Journal of Proteome Research, 2012, 11, 2982-2995.\n18. Zheng Xu#, Tingjun Hou# (co-first author), Nan Li, Yang Xu, Wei Wang, Proteome-wide detection of Abl1 SH3 binding peptides by integrating computational prediction and peptide microarray, Molecular & Cellular Proteomics, 2012, 11, O111.010389.\n19. Sheng Tian, Huiyong Sun, Youyong Li, Dan Li, Tingjun Hou*, Development and evaluation of an integrated virtual screening strategy by combining molecular docking and pharmacophore searching based on multiple protein structures, Journal of Chemical Information and Modeling, 2013, 53, 2743-2756.\n20. Xiaotian Kong, Huiyong Sun, Peichen Pan, Feng Zhu, Shan Chang, Lei Xu, Youyong Li, Tingjun Hou*, Importance of protein flexibility in molecular recognition: a case study on Type-I1/2 inhibitors of ALK, Physical Chemistry Chemical Physics, 2018, 20, 4851-4863.\n先导化合物的发现和优化是新药开发中不可或缺的关键环节。计算机虚拟筛选（VS）技术能帮助我们有效发现结构新颖的活性分子，在药物开发的早期阶段发挥显著作用。我们课题组通过整合计算模拟以及体内/体外生物活性评价，针对多个重要药物靶点进行了先导化合物的筛选与优化。我们的优势在于广泛并深入涉足药物临床前开发的各个阶段，包括先导化合物的发现、化学合成优化、化学/生物活性检测、成药性和安全性评价等，能加快药物发现和开发的速度，并降低药物开发的成本。目前我们研究的药物靶点包括AR、GR、ALK、ROCK、PI3K、MIF、ALK、Tie-2和A2A等 [1~15]。例如：我们采用MIEC-SVM预测模型、分子对接、结合自由能计算等多种CADD方法设计并合成了一类新型的抗耐药性ALK “桥联”小分子，该类抑制剂可同时靶向ATP活性位点和邻近的疏水别构口袋；该类抑制剂在分子层面以及细胞层面均表现出优异的生物活性，是目前已报导的体外活性最强的I1/2型ALK抑制剂（001-017：IC50=0.27 nM），较已上市药物克唑替尼和色瑞替尼体外活性更好，其中001-017对多种ALK耐药突变体仍表现出很强的抑制活性及高度的激酶选择性，有望进入临床前研究 。\n图 4. 新型ALK抑制剂的发现流程。\n1. Rui Shi, Peichen Pan, Rui Lv, Chongqing Ma, Enhui Wu, Ruochen Guo, Zhihao Zhao, Hexing Song, Joe Zhou, Yang Liu, Guoqiang Xu, Tingjun Hou*, Zhenhui Kang*, Jian Liu*, High-throughput glycolytic inhibitor discovery targeting glioblastoma by graphite dots-assisted LDI mass spectrometry, Science Advances, 2022, 8, eabl4923.\n2. Xin Chai, Huiyong Sun, Wenfang Zhou, Changwei Chen, Luhu Shan, Yuhui Yang, Junzhao He, Jinping Pang, Liu Yang, Xinyue Wang, Sunliang Cui, Yaqin Fu, Xiaohong Xu, Lei Xu, Xiaojun Yao, Dan Li*, Tingjun Hou*, Discovery of N-(4-(Benzyloxy)-phenyl)-sulfonamide Derivatives as novel antagonists of the human androgen receptor targeting the activation function 2, Journal of Medicinal Chemistry, 2022, 65, 2507-2521.\n3. Jinping Pang, Chao Shen, Wenfang Zhou, Yunxia Wang, Luhu Shan, Xin Chai, Ying Shao, Xueping Hu, Feng Zhu, Danyan Zhu, Li Xiao, Lei Xu, Xiaohong Xu, Dan Li*, Tingjun Hou*, Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays, Acta Pharmacologica Sinica, 2022, 43, 229-239.\n4. Weitao Fu, Minkui Zhang, Jianing Liao, Qing Tang, Yixuan Lei, Zhou Gong, Luhu Shan, Mojie Duan, Xin Chai, Jinping Pang, Chun Tang, Xuwen Wang, Xiaohong Xu, Dan Li*, Rong Sheng*, Tingjun Hou*, Discovery of a novel androgen receptor antagonist manifesting evidence to disrupt the dimerization of the ligand-binding domain via attenuating the hydrogen-bonding network, Journal of Medicinal Chemistry, 2021, 64, 17221-17238.\n5. Qin Tang, Weitao Fu, Minkui Zhang, Ercheng Wang, Lvhu Shan, Xin Chai, Jinping Pang, Xuwen Wang, Xiaohong Xu, Lei Xu, Dan Li*, Rong Sheng*, Tingjun Hou*, Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation, European Journal of Medicinal Chemistry, 2020, 192, 112156.\n6. Wenfang Zhou, Mojie Duan, Weitao Fu, Jinping Pang, Qin Tang, Huiyong Sun, Lei Xu, Shan Chang, Dan Li*, Tingjun Hou*, Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays, Genomics, Proteomics & Bioinformatics, 2019, 16, 416-427.\n7. Xueping Hu, Jinping Pang, Jintu Zhang, Chao Shen, Xin Chai, Ercheng Wang, Haiyi Chen, Xuwen Wang, Mojie Duan, Weitao Fu, Lei Xu, Yu Kang, Dan Li*, Hongguang Xia*, Tingjun Hou*, Discovery of novel GR ligands towards druggable GR antagonist conformations identified by MD Simulations and Markov state model analysis, Advanced Science, 2022, 9, 2102435.\n8. Weitao Fu, Ercheng Wang, Di Ke, Hao Yang, Lingfeng Chen, Jingjing Shao, Xueping Hu, Lei Xu, Na Liu*, Tingjun Hou*, Discovery of a novel Fusarium Graminearum Mitogen-activated Protein Kinase (FgGpmk1) inhibitor for the treatment of fusarium head blight, Journal of Medicinal Chemistry, 2021, 64, 13841-13852.\n9. Yuan Wang, ZheWang, Jiacheng Liu, Yunwen Wang, Rui Wu, Rong Sheng*, Tingjun Hou*, Discovery of novel HBV capsid assembly modulators by structure-based virtual screening and bioassays, Bioorganic & Medicinal Chemistry, 2021, 36, 116096.\n10. Yangshun Tang, Bo Feng, Yi Wang, Huiyong Sun, Yi You, Jie Yu, Bing Chen, Cengli Xu, Yeping Ruan, Sunliang Cui, Gang Hu, Tingjun Hou*, Zhong Chen*, Structure‐based discovery of caspase‐1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility, British Journal of Pharmacology, 2020, 17, 3519-3534.\n11. Xiaotian Kong, Peichen Pan, Huiyong Sun, Hongguang Xia, Xuwen Wang, Youyong Li, Tingjun Hou*, Drug discovery targeting anaplastic lymphoma kinase (ALK), Journal of Medicinal Chemistry, 2019, 62, 10927-10954.\n12. Peichen Pan, Huidong Yu, Qinglan Liu, Xiaotian Kong, Hu Chen, Jiean Chen, Qi Liu, Dan Li, Yu Kang, Huiyong Sun, Wenfang Zhou, Sheng Tian, Sunliang Cui, Feng Zhu, Youyong Li, Yong Huang*, Tingjun Hou*, Combating drug-resistant mutants of ALK with potent and selective Type-I1/2 inhibitors by stabilizing unique DFG-shifted loop conformation, ACS Central Science, 2017, 3, 1208-1220.\n13. Peichen Pan, Jiean Chen, Xijian Li, Miyang Li, Huidong Yu, Jean J Zhao, Jing Ni, Xuwen Wang, Huiyong Sun, Sheng Tian, Feng Zhu, Feng Liu, Yong Huang*, Tingjun Hou*, Structure-based Drug Design and Identification of H2O-soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in both Cancer and Lethal Inflammation Models In Vivo, Journal of Medicinal Chemistry, 2018, 61,8613–8624.\n14. Lei Xu, Yu Zhang, Longtai Zheng, Chunhua Qiao,Youyong Li, Dan Li, Xuechu Zhen*, Tingjun Hou*, Discovery of novel inhibitors targeting macrophage migration inhibitory factor via structure-based virtual screening and bioassays, Journal of Medicinal Chemistry, 2014, 57, 3737-3745.\n15. Jingyu Zhu, Kan Li, Li Yu, Yun Chen, Yanfei Cai, Jian Jin*, Tingjun Hou*, Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors, Medicinal Research Reviews, 2021, 43, 1599-1621.\n传统实验方法（X-ray和NMR）可以有效地表征蛋白或蛋白-配体的静态或准静态结构，但是无法描述配体−靶标之间的动态识别过程。在这种情况下，全原子模拟（包括常规动力学模拟和增强采样动力学模拟）可以辅助实验技术捕捉原子层次的动力学和热力学作用机制。我们采用常规动力学模拟和增强采样动力学模拟技术（如元动力学、伞形采样、适配性偏向力等方法）揭示了许多复杂的分子机制，开展了药物分子耐药性机制、ABC转运蛋白作用机制、小分子保留时间计算等方面的理论分析 [1-15]。例如，通过元动力学模拟对小分子抑制剂结合与解离过程中势能面的表征，我们发现ROS1激酶中G2032R突变可以从两方面影响crizotinib的结合，其中ROS1中僵硬的P-loop区既可以直接降低crizotinib的结合，同时又可以显著缩减crizotinib在G2032R突变型ROS1中的保留时间，从而产生强烈耐药性 （图5）。\n图 5. Crizotinib 从 G2032R-ROS1 解离的能景图\n图 6. AR-LBD 和 激动剂或拮抗剂结合的自由能特征.\n1. Haiyi Chen, Rui Zhou, Jinping Pang, Yue Guo, Jiawen Chen, Yu Kang*, Mojie Duan*, Tingjun Hou*, Molecular view on the dissociation pathways and transactivation regulation mechanism of nonsteroidal GR ligands, Journal of Chemical Information and Modeling, 2022, in press.\n2. Haiyi Chen, Yu Kang, Mojie Duan*, Tingjun Hou*, Regulation mechanism for the binding between the SARS-CoV-2 spike protein and host angiotensin-converting enzyme II, The Journal of Physical Chemistry Letters, 2021, 12, 6252-6261.\n3. Yongchang Xu, Haiyi Chen, Huimin Zhang, Saif Ullah, Tingjun Hou*, Youjun Feng*, The MCR-3 inside linker appears as a facilitator of colistin resistance, Cell Reports, 2021, 35, 109135.\n4. Ye Jin, Mojie Duan, Xuwen Wang, Xiaotian Kong, Wenfang Zhou, Huiyong Sun, Hui Liu, Dan Li, Huidong Yu, Youyong Li*, Tingjun Hou*, Communication between the ligand-binding pocket (LBP) and the activation function-2 (AF2) domain of androgen receptor revealed by molecular dynamics simulations, Journal of Chemical Information and Modeling, 2019, 59, 842-857.\n5. Na Liu, Wenfang Zhou, Yue Guo, Junmei Wang, Weitao Fu, Huiyong Sun, Dan Li, Mojie Duan*, Tingjun Hou*, Molecular Dynamics Simulations Revealed the Regulation of Ligands to the Interactions between Androgen Receptor and Its Coactivator, Journal of Chemical Information and Modeling, 2018, 58, 1652-1661.\n6. Huiyong Sun, Youyong Li, Mingyun Shen, Dan Li, Yu Kang. Tingjun Hou*, Characterizing drug-target residence time with metadynamics: how to achieve dissociation rate efficiently without losing accuracy against much time-consuming approaches, Journal of Chemical Information and Modeling, 2017, 57, 1895-1906.\n7. Mojie Duan, Na Liu, Wenfang Zhou, Dan Li, Minghui Yang*, Tingjun Hou*, Structural diversity of ligand-binding androgen receptors revealed by microsecond long molecular dynamics simulations and enhanced sampling, Journal of Chemical Theory and Computation, 2016, 12, 4611-4619.\n8. Huiyong Sun, Pengcheng Chen, Dan Li, Youyong Li, Tingjun Hou*, Directly-binding rather than induced-fit dominated binding affinity difference in (S) and (R)-crizotinib bound MTH1, Journal of Chemical Theory and Computation, 2016, 12, 851-860.\n9. Hui Liu, Dan Li, Youyong Li, Tingjun Hou*, Atomistic molecular dynamics simulations of ATP-binding cassette transporters, WIREs Computational Molecular Science, 2016, 6, 255-265.\n10. Nan Li, Richard I. Ainsworth, Bo Ding, Tingjun Hou*, and Wei Wang*, Using Hierarchical Virtual Screening to Combat Drug Resistance of the HIV-1 Protease, Journal of Chemical Information and Modeling, 2015, 55, 1400-1412.\n11. Huiyong Sun, Youyong Li, Sheng Tian, Junmei Wang, Tingjun Hou*, P-loop Conformation Governed Crizotinib Resistance in G2032R-mutated ROS1 Tyrosine Kinase: Clues from Free Energy Landscape, PLoS Computational Biology, 2014, 10, e1003729.\n12. Yan Guan, Huiyong Sun, Youyong Li, Peichen Pan, Dan Li, Tingjun Hou*, The competitive binding between inhibitors and substrates of HCV NS3/4A protease: a general mechanism of drug resistance, Antiviral Research, 2014, 103, 60-70.\n13. Huiyong Sun, Youyong Li*, Dan Li, Tingjun Hou*, Insight into Crizotinib Resistance Mechanisms Caused by Three Mutations in ALK Tyrosine Kinase using Free Energy Calculation Approaches, Journal of Chemical Information and Modeling, 2013, 53, 2376-2389.\n14. Peichen Pan, Youyong Li, Huidong Yu, Tingjun Hou*, Molecular principle of topotecan resistance by topoisomerase I mutations through molecular modeling approaches, Journal of Chemical Information and Modeling, 2013, 53, 997-1006.\n15. Jing Zhang#, Tingjun Hou# (Co-first author), Wei Wang, Jun S. Liu, Detecting and understanding combinatorial mutation patterns responsible for HIV drug resistance, Proceedings of the National Academy of Sciences, 2010, 107, 1321-1326.


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