Mesoamerica was a region and cultural area in the Americas, extending from approximately central Mexico through Belize, Guatemala, El Salvador, Honduras, Nicaragua, and northern Costa Rica, and within which pre-Columbian societies flourished before the Spanish colonization of the Americas in the 15th and 16th centuries. It is one of six areas in the world where ancient civilization arose independently, and the second in the Americas along with Norte Chico (Caral-Supe) in present-day northern coastal Peru. 

As a cultural area, Mesoamerica is defined by a mosaic of cultural traits developed and shared by its indigenous cultures. Beginning as early as 7000 BC, the domestication of cacao, maize, beans, tomato, squash and chili, as well as the turkey and dog, caused a transition from paleo-Indian hunter-gatherer tribal grouping to the organization of sedentary agricultural villages. In the subsequent Formative period, agriculture and cultural traits such as a complex mythological and religious tradition, a vigesimal numeric system, and a complex calendric system, a tradition of ball playing, and a distinct architectural style, were diffused through the area. Also in this period, villages began to become socially stratified and develop into chiefdoms with the development of large ceremonial centers, interconnected by a network of trade routes for the exchange of luxury goods, such as obsidian, jade, cacao, cinnabar, "Spondylus" shells, hematite, and ceramics. While Mesoamerican civilization did know of the wheel and basic metallurgy, neither of these technologies became culturally important.
What civilization was aware of the wheel?
Were they familiar with metallurgy?
Did either of those make much impact on Mesoamerica?
Is it diverse in culture?
When did they start growing cacao?
Was that the same time as maize?
What animals were being domesticated around that time?
That helped transform them from a hunter-gatherer tribe to what?
What period came after that?
Besides a vigesimal numeric system, what's another thing that came to be?
Did they create a calendar?
Mesoamerican civilization
While Mesoamerican civilization did know of the wheel 
yes
While Mesoamerican civilization did know of the wheel and basic metallurgy, 
no
While Mesoamerican civilization did know of the wheel and basic metallurgy, neither of these technologies became culturally important.
yes
by a mosaic of cultural traits developed and shared by its indigenous cultures.
as early as 7000 BC
 as early as 7000 BC, the domestication of cacao
yes
Beginning as early as 7000 BC, the domestication of cacao, maize,
turkeys and dogs
 as well as the turkey and dog,
to sedentary agricultural villages
 the organization of sedentary agricultural villages
the Formative period
 In the subsequent Formative period
a complex calendric system
a vigesimal numeric system, and a complex calendric system,
yes
and a complex calendric system