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### Question: Who is at highest risk for Ankylosing spondylitis ?
### Response: The cause of ankylosing spondylitis is not clear. Researches demonstrate the following factors may be associated with this disease.
Heredity: Almost 90% of patients with ankylosing spondylitis are born with the HLA-B27 gene. Recent data demonstrate gene ARTS1 and IL23R are associated with ankylosing spondylitis. Gender: Male Age: 10~40 years old.