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### Question: What causes Glanzmann's thrombasthenia?
### Response: In the hereditary type of Glanzmann's thrombasthenia GPIIb/IIIa (ITG αIIbβ3) is qualitative or quantitative disorder. The autoantibodies production is the main cause of acquired Glanzmann's thrombasthenia It can be produced in the of following conditions:
Acute lymphoblastic leukemia Non-Hodgkin lymphoma Multiple myeloma Hairy cell leukemia Myelodysplastic syndrome Immune thrombocytopenic purpura (ITP) Pregnancy Autoimmune diseases (eg, systemic lupus erythematosus, Immune thrombocytopenia) Drugs: Anti-thrombotic drugs use, like abciximab, eptifibatide, and tirofiban which all antagonize αIIbβ3 Platelet transfusions