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### Question: Who is at highest risk for Wolff-Parkinson-White syndrome ?
### Response: Mutations in the PRKAG2 gene cause Wolff-Parkinson-White syndrome. Most cases of Wolff-Parkinson-White syndrome occur in people with no apparent family history of the condition. These cases are described as sporadic and are not inherited. Familial Wolff-Parkinson-White syndrome accounts for only a small percentage of all cases of this condition.