Answer this question truthfully
### Question: What causes Leukoplakia?
### Response: Leukoplakia mainly affects the mucus membranes of the mouth. It is thought to be caused by irritation, but the causes is not always known.
Irritation in the mouth may be caused by:
Rough teeth Rough places on dentures, fillings, and crowns Smoking or other tobacco use (smoker's keratosis), especially pipes Holding chewing tobacco or snuff in your mouth for a long period of time
"Hairy" leukoplakia of the mouth is a different disorder that is seen mostly in HIV-positive people. It may be one of the first signs of HIV infection. It can also appear in other people whose immune system is not working well, such as after a bone marrow transplant. It is caused by the Epstein-Barr virus, but is not harmful by itself. The most common symptoms of hairy leukoplakia are painless, fuzzy white patches on the side of the tongue.