Answer this question truthfully
### Question: What causes Gaucher's disease?
### Response: The lack of the glucocerebrosidase enzyme causes harmful substances to build up in the liver, spleen, bones, and bone marrow. The substances prevent cells and organs from working properly.
There are three main subtypes of Gaucher disease:
Type 1 disease is most common. It involves bone disease, anemia, an enlarged spleen and thrombocytopenia. Type I affects both children and adults. It is most common in the Ashkenazi Jewish population. Type 2 disease usually begins in infancy with severe neurologic involvement. This form can lead to rapid, early death. Type 3 disease may cause liver, spleen, and brain problems. Patients may live into adulthood.