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### Question: What causes Buerger's disease?
### Response: Thromboangiitis obliterans (Buerger's disease) is caused by vasculitis (inflammation of the blood vessels).
The blood vessels of the hands and feet are especially affected. They tighten or become totally blocked. The average age when symptoms begin is around 35 years. Woman and older adults are affected less often.
Thromboangiitis obliterans mostly affects men ages 20 to 40 who have a history of heavy smoking or chewing tobacco. Only 1 out of 10 patients are women.
The condition may also be related to a history of Raynaud's disease.
This disorder is very uncommon in children, but it may occur in children with autoimmune diseases.