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### Question: What are the symptoms of Niemann-Pick disease?
### Response: Type A usually begins in the first few months of life. Symptoms may include:
Abdominal (belly area) swelling within 3 - 6 months Cherry red spot in the eye Feeding difficulties Loss of early motor skills (gets worse over time)
Type B symptoms are usually milder and occur in late childhood or adolescence. Abdominal swelling may occur in early childhood, but there is almost no brain and nervous system involvement, such as loss of motor skills. Some patients may have repeated respiratory infections.
Type C usually affects school-aged children, but the disease may occur any time between early infancy to adulthood. Symptoms may include:
Difficulty moving limbs (dystonia) Enlarged spleen Enlarged liver Jaundice at (or shortly after) birth Learning difficulties and intellectual decline (dementia) Seizures Slurred, irregular speech Sudden loss of muscle tone which may lead to falls (cataplexy) Tremors Trouble moving the eyes up and down (vertical supranuclear gaze palsy) Unsteady gait, clumsiness, walking problems (ataxia)
Symptoms of Type D are similar to Type C.
Type E occurs in adults. Symptoms include swelling of the spleen and brain and nervous system (neurological) problems. Little is known about this rare type of Niemann-Pick disease.
Symptoms and disease progression of all forms of Niemann-Pick vary from person to person. Other, more common, diseases may cause symptoms similar to Niemann-Pick.
A person in the early stages of the disease may show only a few symptoms. Not every symptom will be seen in the later stages of the disease.