Answer this question truthfully
### Question: What causes Acute tubular necrosis?
### Response: Acute tubular necrosis is caused by lack of blood supply (ischemia) and oxygenation to the kidneys. It is also caused by various medications such as aminoglycosides, amphotericin B, NSAIDs, and also caused by exposure to radiocontrast media (the dye used for x-ray and other radiographic studies) The internal structures of the kidney, particularly the tissues of the kidney tubule, become damaged or destroyed. Acute tubular necrosis is one of the most common structural changes that can lead to acute kidney injury.