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### Question: Who is at highest risk for Hemolytic-uremic syndrome ?
### Response: HUS is most common in children. It is the most common cause of acute kidney failure in children. Several large outbreaks in 1992 and 1993 were linked to undercooked hamburger meat contaminated with E. coli.
Other risk factors for HUS are unknown, although some cases are due to a familial form of the disease. HUS may occur with a variety of other diseases and infections, and after taking certain medications such as mitomycin C or ticlopidine.
HUS is more complicated in adults. It is similar to another disease called thrombotic thrombocytopenic purpura (TTP).