Answer this question truthfully
### Question: What causes Focal segmental glomerulosclerosis?
### Response: The cause of focal segmental glomerulosclerosis is usually unknown.
The condition affects both children and adults. Men and boys are affected slightly more often than women and girls, and it also occurs more often in African Americans. Focal segmental glomerulosclerosis causes about 20 - 25% of all cases of nephrotic syndrome.
Known causes include:
Heroin use HIV Inherited genetic problems Obesity Reflux nephropathy (a condition in which urine flows backward from the bladder to the kidney) Sickle cell disease