After the close of the Sangam era, from about 300 to about 600 CE, there is an almost total lack of information regarding occurrences in the Tamil land. Some time about 300 CE, the whole region was upset by the appearance of the Kalabhras. These people are described in later literature as 'evil rulers' who overthrew the established Tamil kings and got a strangle hold of the country. Information about their origin and details about their reign is scarce. They did not leave many artefacts or monuments. The only source of information on them is the scattered mentions in Buddhist and Jain literature.

Historians speculate that these people followed Buddhist or Jain faiths and were antagonistic towards the Hindu and Brahminical religions adhered by the majority of inhabitants of the Tamil region during the early centuries C.E. As a result Hindu scholars and authors who followed their decline in the 7th and 8th century may have expunged any mention of them in their texts and generally tended to paint their rule in a negative light. It is perhaps due to this reason, the period of their rule is known as a 'Dark Age'—an interregnum. Some of the ruling families migrated northwards and found enclaves for themselves away from the Kalabhras. Jainism and Buddhism, took deep roots in the society, giving birth to a large body of ethical poetry.

Writing became very widespread and "vatteluttu" evolved from the Tamil-Brahmi became a mature script for writing Tamil. While several anthologies were compiled by collecting bardic poems of earlier centuries, some of the epic poems such as the "Cilappatikaram" and didactic works such as the "Tirukkural" were also written during this period. The patronage of the Jain and Buddhist scholars by the Kalabhra kings influenced the nature of the literature of the period, and most of the works that can be attributed to this period were written by the Jain and Buddhist authors. In the field of dance and music, the elite started patronising new polished styles, partly influenced by northern ideas, in the place of the folk styles. A few of the earliest rock-cut temples belong to this period. Brick temples (known as "kottam", "devakulam", and "palli") dedicated to various deities are referred to in literary works. Kalabhras were displaced around the 7th century by the revival of Pallava and Pandya power.

Even with the exit of the Kalabhras, the Jain and Buddhist influence still remained in Tamil Nadu. The early Pandya and the Pallava kings were followers of these faiths. The Hindu reaction to this apparent decline of their religion was growing and reached its peak during the later part of the seventh century. There was a widespread Hindu revival during which a huge body of Saiva and Vaishnava literature was created. Many Saiva Nayanmars and Vaishnava Alvars provided a great stimulus to the growth of popular devotional literature. Karaikkal Ammaiyar who lived in the sixth century CE was the earliest of these Nayanmars. The celebrated Saiva hymnists Sundaramurthi, Thirugnana Sambanthar and Thirunavukkarasar were of this period. Vaishnava Alvars such as Poigai Alvar, Bhoothathalvar and Peyalvar produced devotional hymns for their faith and their songs were collected later into the four thousand poems of "Naalayira Divyap Prabhandham".

Independence struggle
Pallavas
Interregnum (300–600)
Vijayanagar and Nayak period (1300–1650)