The fourteenth century invasion by the Delhi Sultans caused a retaliatory reaction from the Hindus, who rallied to build a new kingdom, called the Vijayanagara Empire. Bukka, with his brother Harihara founded the Hindu Vijayanagara Empire based in the city of Vijayanagara in Karnataka. Under Bukka the empire prospered and continued to expand towards the south. Bukka and his son Kampana conquered most of the kingdoms of southern India. In 1371 the Vijayanagar empire defeated the short lived Madurai Sultanate, which had been established by the remnants of the invading Khilji army. Eventually the empire covered the entire south India. Vijayangara empire established local governors called Nayaks to rule in the various territories of the empire.

The Vijayanagar Empire declined in 1564 defeated by the Deccan sultans in the battle of Talikota. The local Nayak governors declared their independence and started their rule. The Nayaks of Madurai and Thanjavur were the most prominent of them. Ragunatha Nayak (1600–1645) was the greatest of the Tanjavur Nayaks. Raghunatha Nayak encouraged trade and permitted a Danish settlement in 1620 at Tarangambadi. This laid the foundation of future European involvement in the affairs of the country. The success of the Dutch inspired the English to seek trade with Thanjavur, which was to lead to far-reaching repercussions. Vijaya Raghava (1631–1675) was the last of the Thanjavur Nayaks. Nayaks reconstructed some of the oldest temples in the country and their contributions can be seen even today. Nayaks expanded the existing temples with large pillared halls, and tall gateway towers, which is representative of the religious architecture of this period.

In Madurai, Thirumalai Nayak was the most famous Nayak ruler. He patronised art and architecture creating new structures and expanding the existing landmarks in and around Madurai. On Thirumalai Nayak's death in 1659, the Madurai Nayak kingdom began to break up. His successors were weak rulers and invasions of Madurai recommenced. Shivaji Bhonsle, the great Maratha Ruler, invaded the south, as did Chikka Deva Raya of Mysore and other Muslim Rulers, resulting in chaos and instability. Rani Mangammal, a local ruler, tried to resist these invasions showing great courage.

Vijayanagar and Nayak period (1300–1650)
British rule (1850–1947)
Post Independence period
Cholas