The question can refer to the explanation of a specific "observation", as in "Why is the sky blue?", but can also be open-ended, as in "How can I design a drug to cure this particular disease?" This stage frequently involves looking up and evaluating evidence from previous experiments, personal scientific observations or assertions, and/or the work of other scientists. If the answer is already known, a different question that builds on the previous evidence can be posed. When applying the scientific method to scientific research, determining a good question can be very difficult and affects the final outcome of the investigation.

External review
Formulation of a question
Properties of scientific inquiry
Testing