Medical data from astronauts in low earth orbits for long periods, dating back to the 1970s, show several adverse effects of a microgravity environment: loss of bone density, decreased muscle strength and endurance, postural instability, and reductions in aerobic capacity. Over time these deconditioning effects can impair astronauts’ performance or increase their risk of injury.

In a weightless environment, astronauts put almost no weight on the back muscles or leg muscles used for standing up, which causes them to weaken and get smaller. Astronauts can lose up to twenty per cent of their muscle mass on spaceflights lasting five to eleven days. The consequent loss of strength could be a serious problem in case of a landing emergency. Upon return to Earth from long-duration flights, astronauts are considerably weakened, and are not allowed to drive a car for twenty-one days.

Astronauts experiencing weightlessness will often lose their orientation, get motion sickness, and lose their sense of direction as their bodies try to get used to a weightless environment. When they get back to Earth, or any other mass with gravity, they have to readjust to the gravity and may have problems standing up, focusing their gaze, walking and turning. Importantly, those body motor disturbances after changing from different gravities only get worse the longer the exposure to little gravity. These changes will affect operational activities including approach and landing, docking, remote manipulation, and emergencies that may happen while landing. This can be a major roadblock to mission success.

In addition, after long space flight missions, male astronauts may experience severe eyesight problems. Such eyesight problems may be a major concern for future deep space flight missions, including a crewed mission to the planet Mars.

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