Pharmacologically active metabolite of diazepam, [[q.v.]]
[[File:Temazepam synthesis.svg|center|700px|thumb|Prepn: S. C. Bell, (1965 to Am. Home. Prod.). See also: E. Reeder et al., and (1967, 1968, both to [[Hoffmann-La Roche]]).]]
N-oxides are prone to undergo the [[Polonovski reaction|Polonovski rearrangement]] when treated with [[acetic anhydride]], and this was illustrated by the synthesis of [[oxazepam]]. It is not surprising that the N-methyl analogue (1) also undergoes this process, and hydrolysis of the resulting acetate gives temazepam (2). Care must be exacted with the conditions, or the inactive rearrangement product (3) results.

Medical research issues
বিশেষ সতর্কতা প্রয়োজন
Availability
Synthesis