Without proper shielding, the crews of missions beyond low Earth orbit (LEO) might be at risk from high-energy protons emitted by solar flares. Lawrence Townsend of the University of Tennessee and others have studied the most powerful solar flare ever recorded. That flare was seen by the British astronomer Richard Carrington in September 1859. Radiation doses astronauts would receive from a Carrington-type flare could cause acute radiation sickness and possibly even death.

Another type of radiation, galactic cosmic rays, presents further challenges to human spaceflight beyond low Earth orbit.

There is also some scientific concern that extended spaceflight might slow down the body’s ability to protect itself against diseases. Some of the problems are a weakened immune system and the activation of dormant viruses in the body. Radiation can cause both short and long term consequences to the bone marrow stem cells which create the blood and immune systems. Because the interior of a spacecraft is so small, a weakened immune system and more active viruses in the body can lead to a fast spread of infection.

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