The National Highway 2 enters Uttar Pradesh from Delhi in Mathura district, and a part of it is known as Mathura Road. Before Mathura it covers Palwal and Faridabad city in Haryana. After Mathura it reaches Agra which is about from Delhi. In Agra it covers about . After leaving Agra it enters Etawah where 15  km bypass of city is made. After leaving Etawah it enters Kanpur city where a and 12 lane Kanpur over-bridge has been built which is also one of the largest over-bridges in the Asia. In Kanpur it covers industrial belts (Akbarpur-Maharajpur) around and then it reaches Fatehpur District and covers area of Fatehpur City and it also covers a long area of Malwan Industrial Area of UPSIDC Fatehpur district where many major industries are situated & the world's famous Mohan Malwan Peda is also Situated on NH-2 Near Malwan Fatehpur

, Fatehpur have 3 by-pass section in NH-2, 1st is Kanpur by-pass 2nd is Lucknow by-pass and 3rd is Allahabad by-pass Fatehpur is a major district between Kanpur and Allahabad and then it reaches Allahabad via Kaushambhi and covers in city then reachesVaranasi-Mughalsarai covers and thus leaves U.P. This national highway has given a new life to public transport in Northern India. The overbridges built in Agra, Kanpur, Fatehpur and Allahabad have reduced city traffic problems. Allahabad Bypass Expressway is also the country's longest bypass section.

NH 2 in Uttar Pradesh
NH 2 in Bihar
NH 2 in West Bengal
NH 2 in Jharkhand