In terms of ancestry, the majority of Gujaratis share similar genes with the rest of the northern Indian populations, but show a significant relationship with central Eurasian groups. 

A 2004 Stanford study conducted with a wide sampling from India, found that over 33% of genetic markers in Gujarat were of West Asian origin, the third highest amongst the sampled group of South Asians with Punjabis at 42%, Sindhis at 41% and Kashmiris at 30%. 

Haplogroup U7 is found only in Iran, the Near East,Afghanistan, India, and Pakistan; with extremely low frequencies in neighboring countries Turkmenistan, Kazakhstan, Uzbekistan, and Iraq. Its frequency peaks at over 12% in Gujarat, 9% in Punjab, 6% in Pakistan, 6% in Afghanistan and 9% in Iran. Elsewhere in India, its frequency is very low (0.00% to 0.90%). Outside of the Near East, Iran, Afghanistan, Pakistan, and the Northwestern Indian states, Haplogroup U7 is non-existent. Expansion times and haplotype diversities for the Indian and Near and Middle Eastern U7 mtDNAs are strikingly similar. The possible homeland of this haplogroup likely spans the coverage of Iran to Western India. From there its frequency declines steeply both to the east and to the west. If the origin were in Iran rather than in India, then its equally high frequency as well as diversity in Gujarat favors a scenario whereby U7 has been introduced to the coastal Gujarat either very early, or by multiple founders.

Some preliminary conclusions from these varying tests support some of the highest degrees of west Eurasian mtDNAs found in India, with a particular close relationship between Iran and Gujarat, supporting a theory of trade contact and migrations out of Iran into Gujarat.

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