Tobacco has been used as an antispasmodic, a diuretic, an emetic, an expectorant, a sedative, and a sialagogue, and in homeopathy.

Tobacco has a long history of use by medical herbalists as a relaxant, though since it is a highly addictive drug it is seldom employed internally or externally at present. The leaves act as antispasmodics, discutients, diuretics, emetics, expectorants, irritants, sedatives and sialagogues. They are used externally in the treatment of rheumatic swelling, skin diseases and scorpion stings. The plant should be used with great caution, when taken internally it is addictive. The active ingredients can also be absorbed through the skin. Wet tobacco leaves can be applied to stings in order to relieve the pain. They are also a certain cure for painful piles. A homeopathic remedy is made from the dried leaves. It is used in the treatment of nausea and travel sickness. Some other activities reported for "Nicotiana tabacum" are: Analgesic activity, anesthetic activity, angiogenesis inhibition, antibacterial activity, anti convulsant activities, anti estrogenic effect, antifungal activity, antiglaucomic activity, antioxidant activity, antistress effect, antiviral activity, aromatase inhibition, arrhythmogenic effect, carcinogenic activity, bronchoconstrictor activity, bupivacaine kinetics,

The regions that have histories of use of the plant include:













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