Let's answer this question slowly: Did the first Duke of Valentinois play a key role in the Hundred Years' War?

Show your work and conclude with the exact phrasing "Therefore, the final answer is [answer]." where [answer] is just the final number or expression that solves the problem.
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The Hundred Years' War was a conflict between England and France from 1337-1453. Cesare Borgia, the son of Pope Alexander VI, was the first Duke of Valentinois. Cesare Borgia was born in 1475. So the answer is no.