You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
In this task, you are given a sentence in the English language. Your job is to translate the English sentence into the Spanish language.

It is NOT a function of the intermediate filaments
Solution: NO es una función de los filamentos intermedios
Why? The language translation is correct. The given input in English is a negative sentence, therefore the polarity of the output must be negative. Looking at the output it’s clear that the sentence polarity is negative.

New input: Rolitetracycline is a prodrug of tetracycline of Mannich base nature, how does the activation of this prodrug take place ?
Solution:

Show your work and conclude with the exact phrasing "Therefore, the final answer is [answer]." where [answer] is just the final number or expression that solves the problem.
user
La rolitetraciclina es un profármaco de la tetraciclina de naturaleza de base de Mannich, ¿cómo tiene lugar la activación de este profármaco?