Did the first Duke of Valentinois play a key role in the Hundred Years' War?
Rationale first then the answer.
The Hundred Years' War was a conflict between England and France from 1337-1453. Cesare Borgia, the son of Pope Alexander VI, was the first Duke of Valentinois. Cesare Borgia was born in 1475.. The answer is: no.

Could a sloth hypothetically watch an entire episode of Scrubs underwater?
Rationale first then the answer.
Sloths can hold their breath underwater for up to 40 minutes. The running time of a Scrubs episode is between 20-23 minutes.. The answer is: yes.

Would a week be enough time to watch every episode of Ugly Betty?
Rationale first then the answer.

Show your work and conclude with the exact phrasing "Therefore, the final answer is [answer]." where [answer] is just the final number or expression that solves the problem.
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There are 168 hours in a week. The entire Ugly Betty series is 85 hours long.. The answer is: yes.