Given the rationale, provide a reasonable question and answer. Step-by-step reasoning process: If only 12 people shaked their hands, then total hand shakes are 12C212C2 = 66
 The question and answer:

Show your work and conclude with the exact phrasing "Therefore, the final answer is [answer]." where [answer] is just the final number or expression that solves the problem.
user
49 members attended the party. In that 22 are males, 27 are females. The shake hands are done between males, females, male and female. Total 12 people given shake hands. How many such kinds of such shake hands are possible?
Options:
(A) 66
(B) 291
(C) 26
(D) 29
(E) 11
The answer is (A)