Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

[Q]: Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression.
[A]: adverse drug event


[Q]: On the 3rd day, an inferior vena cava (IVC) filter was placed with a heparin flush, after which massive IVC thrombosis developed.
[A]: adverse drug event


[Q]: MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.
[A]:

Show your work and conclude with the exact phrasing "Therefore, the final answer is [answer]." where [answer] is just the final number or expression that solves the problem.
user
non-adverse drug event


