Question: Context: The Cori cycle (also known as the Lactic acid cycle), named after its discoverers, Carl Ferdinand Cori and Gerty Cori, refers to the metabolic pathway in which lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to glucose, which then returns to the muscles and is metabolized back to lactate.

Question: the cori cycle is a metabolic pathway that involves?
Answer: To answer the question, consider the following: The Cori cycle (also known as the Lactic acid cycle), named after its discoverers, Carl Ferdinand Cori and Gerty Cori, refers to the metabolic pathway in which lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to glucose, which then returns to the muscles and is metabolized back to lactate. The answer is lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to glucose , which then returns to the muscles and is metabolized back to lactate.

Question: Laverne Cox is an American actress and LGBT advocate. She became known for her portrayal of Sophia Burset on the Netflix television series Orange Is the New Black, for which she became the first openly transgender person to be nominated for a Primetime Emmy Award in the acting category, and the first to be nominated for an Emmy Award since composer / musician Angela Morley in 1990. In 2015, she won a Daytime Emmy Award in Outstanding Special Class Special as Executive Producer for Laverne Cox Presents: The T Word. This made her the first openly transgender woman to win a Daytime Emmy as an Executive Producer; as well, The T Word is the first trans documentary to win a Daytime Emmy. Also in 2015, she became the first openly transgender person to have a wax figure of herself at Madame Tussauds. In 2017, she became the first transgender person to play a transgender series regular on broadcast TV as Cameron Wirth on Doubt on CBS.

Based on this passage, orange is the new black cast transgender actress?
Answer: The relevant sentence in the passage is: She became known for her portrayal of Sophia Burset on the Netflix television series Orange Is the New Black, for which she became the first openly transgender person to be nominated for a Primetime Emmy Award in the acting category, and the first to be nominated for an Emmy Award since composer / musician Angela Morley in 1990. The answer is Laverne Cox.

Question: Muslims believe that Islam is the complete and universal version of a primordial faith that was revealed many times before through prophets including Adam, Abraham, Moses and Jesus. As for the Quran, Muslims consider it to be the unaltered and final revelation of God. Like other Abrahamic religions, Islam also teaches a final judgment with the righteous rewarded paradise and unrighteous punished in hell. Religious concepts and practices include the Five Pillars of Islam, which are obligatory acts of worship, and following Islamic law, which touches on virtually every aspect of life and society, from banking and welfare to women and the environment. The cities of Mecca, Medina and Jerusalem are home to the three holiest sites in Islam.

Answer this question: what is the holy book of lslam called?
Answer: The relevant information is: As for the Quran, Muslims consider it to be the unaltered and final revelation of God. The answer is the Quran.

Question: The first and second drafts of the pilot script by Benioff and Weiss were submitted in August 2007 and June 2008, respectively. Although HBO liked both drafts, a pilot was not ordered until November 2008; the 2007 -- 2008 Writers Guild of America strike may have delayed the process. The pilot episode, "Winter Is Coming", was first shot in 2009; after a poor reception in a private viewing, HBO demanded an extensive re-shoot (about 90 percent of the episode, with cast and directorial changes).

When did they start filming game of thrones?
Answer:

Show your work and conclude with the exact phrasing "Therefore, the final answer is [answer]." where [answer] is just the final number or expression that solves the problem.
user
The relevant sentence in the passage is: The pilot episode, "Winter Is Coming", was first shot in 2009; after a poor reception in a private viewing, HBO demanded an extensive re-shoot (about 90 percent of the episode, with cast and directorial changes). The answer is 2009.