tokens: Acknowledgements The authors contributed in the following way to this paper. DS undertook the calibration and completion of all simulations; the development of all analysis codes, including the ANN; the production of all figures and the first draft of the paper. II supervised the project and helped with the interpretation of results and feedback on the first draft. KD provided guidance throughout and significant feedback on the first draft. DS would like to thank Joakim Rosdahl for valuable technical feedback, Scott J. Clay for advice and feedback on the first draft, Peter A. Thomas, Paul R. Shapiro, and Benoît Fournier for useful discussions and feedback. This work used the DiRAC Data Centric system at Durham University, operated by the Institute for Computational Cosmology on behalf of the Science and Technology Facilities Council (STFC) DiRAC High-performance computing (HPC) Facility ( www.dirac.ac.uk ). The DiRAC system is funded by BIS National E-infrastructure capital grant ST/K00042X/1, STFC capital grant ST/H008519/1, STFC DiRAC Operations grant ST/K003267/1, and Durham University. DiRAC is part of the National E-Infrastructure. We acknowledge PRACE for awarding us computational time under project PRACE4LOFAR grant 2014102339 and ‘Multi-scale simulations of Cosmic Reionization’ grants 2014102281, 2015122822, and 2016153528 to resource Curie based in France at CEA and to resource Marenostrum based in Spain at BSC. This work was supported by the Science and Technology Facilities Council (grant numbers ST/F002858/1 and ST/I000976/1) and the Southeast Physics Network (SEPNet). Some of the analysis was done on the Apollo cluster at The University of Sussex. We made extensive use of the pymses (Guillet, Chapon Labadens 2013 ) and pynbody (Pontzen et al. 2013 ) python modules when developing our own analysis pipeline.
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