Juvenile generalized pustular psoriasis is a rare, severe type of psoriasis that can be life-threatening. Thus far, treatment for juvenile generalized pustular psoriasis has been challenging, and no standardized guidelines are available. Here, we describe two Chinese boys with juvenile generalized pustular psoriasis who were successfully treated with infusions of infliximab. During 12 months of follow-up, no recurrence or exacerbation was observed in either patient. Herpes zoster was observed as an adverse effect in one patient, following the initial infusion of infliximab; the other patient did not experience any adverse reaction. Although infliximab is effective therapy for patients with juvenile generalized pustular psoriasis, there is a need for close monitoring of adverse effects in these patients.