Infliximab-induced seizures in patients with Crohn's disease are extremely rare and the mechanism of infliximab-induced seizures is unclear.
A 60-year-old woman with Crohn's disease experienced infliximab-induced seizures, diagnosed on normal magnetic resonance imaging of the brain. Moreover, the rechallenge with infliximab was positive.
Neurological assessment and tight clinical monitoring before and during therapy with infliximab should be performed in patients with pre-existing seizure disorders.